IT1274018B - Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica - Google Patents

Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica

Info

Publication number
IT1274018B
IT1274018B ITMI940326A ITMI940326A IT1274018B IT 1274018 B IT1274018 B IT 1274018B IT MI940326 A ITMI940326 A IT MI940326A IT MI940326 A ITMI940326 A IT MI940326A IT 1274018 B IT1274018 B IT 1274018B
Authority
IT
Italy
Prior art keywords
octano
analgesic activity
diazabicycle
derivatives
diazabicycle derivatives
Prior art date
Application number
ITMI940326A
Other languages
English (en)
Inventor
Giorgio Cignarella
Original Assignee
Riace Ets
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riace Ets filed Critical Riace Ets
Priority to ITMI940326A priority Critical patent/IT1274018B/it
Publication of ITMI940326A0 publication Critical patent/ITMI940326A0/it
Priority to EP95909700A priority patent/EP0746560A1/en
Priority to PCT/EP1995/000476 priority patent/WO1995023152A1/en
Priority to AU18085/95A priority patent/AU1808595A/en
Priority to US08/696,948 priority patent/US5672601A/en
Publication of ITMI940326A1 publication Critical patent/ITMI940326A1/it
Application granted granted Critical
Publication of IT1274018B publication Critical patent/IT1274018B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Si descrivono composti di formula generale (I): (FORMULA I) dove R e R1, diversi fra loro, sono un gruppo acile o un gruppo -CH2-(A)-B, dove A e B sono come definiti di seguito. I composti di formula (I) sono analgesici ad attività centrale.
ITMI940326A 1994-02-23 1994-02-23 Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica IT1274018B (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ITMI940326A IT1274018B (it) 1994-02-23 1994-02-23 Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica
EP95909700A EP0746560A1 (en) 1994-02-23 1995-02-10 3,8-diazabicyclo 3.2.1]octane derivatives having analgesic activity
PCT/EP1995/000476 WO1995023152A1 (en) 1994-02-23 1995-02-10 3,8-diazabicyclo[3.2.1]octane derivatives having analgesic activity
AU18085/95A AU1808595A (en) 1994-02-23 1995-02-10 3,8-diazabicyclo{3.2.1}octane derivatives having analgesic activity
US08/696,948 US5672601A (en) 1994-02-23 1995-02-10 3-8-diazabicyclo 3.2.1! octane derivatives having analgesic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI940326A IT1274018B (it) 1994-02-23 1994-02-23 Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica

Publications (3)

Publication Number Publication Date
ITMI940326A0 ITMI940326A0 (it) 1994-02-23
ITMI940326A1 ITMI940326A1 (it) 1995-08-23
IT1274018B true IT1274018B (it) 1997-07-14

Family

ID=11367953

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI940326A IT1274018B (it) 1994-02-23 1994-02-23 Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica

Country Status (5)

Country Link
US (1) US5672601A (it)
EP (1) EP0746560A1 (it)
AU (1) AU1808595A (it)
IT (1) IT1274018B (it)
WO (1) WO1995023152A1 (it)

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IT1291632B1 (it) * 1997-04-22 1999-01-11 Univ Degli Studi Milano Derivati di 9,10-diazatriciclo (4.2.1.1 alla 2,5)decano e di 9,10- diazatriciclo (3.3.1.1 alla 2,6) decano ad attivita' analgesica
US7214686B2 (en) * 1997-06-30 2007-05-08 Targacept, Inc. Pharmaceutical compositions and methods for effecting dopamine release
US7265115B2 (en) 1999-01-29 2007-09-04 Abbott Laboratories Diazabicyclic CNS active agents
IT1317841B1 (it) * 2000-02-18 2003-07-15 Univ Degli Studi Milano Derivati del 3,9-diazabiciclo(3.3.1)nonano ad attivita' analgesica.
US6809105B2 (en) 2000-04-27 2004-10-26 Abbott Laboratories Diazabicyclic central nervous system active agents
SE0003795D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Pharmaceutically useful compounds
BR0312414A (pt) * 2002-07-05 2005-05-10 Targacept Inc Compostos de n-aril diazaespirociclico e métodos para a preparação e uso dos mesmos
AU2003254016A1 (en) 2002-07-19 2004-02-09 Catholic Healthcare West Methods and compositions relating to chimeric nicotinic receptor subunits
AU2003280306B2 (en) * 2002-07-26 2009-05-21 Neurosearch A/S Diazabicyclononane and -decane derivatives and their use as opioid receptor ligands
US7098331B2 (en) * 2003-03-05 2006-08-29 Targacept, Inc. Arylvinylazacycloalkane compounds and methods of preparation and use thereof
PT1678172E (pt) * 2003-10-15 2010-03-03 Targacept Inc Composições farmacêuticas e métodos para alívio da dor e tratamento de perturbações do sistema nervoso central
US7816356B2 (en) 2003-11-14 2010-10-19 Daniel Yohannes Aryl and heteroaryltetrahydrocyclobutapyrroles as nicotinic acetylcholine receptor ligands
ITMI20040954A1 (it) * 2004-05-12 2004-08-12 Univ Degli Studi Milano Derivati del 3,6-diazabiciclo 3.1.i.eptano ad attivita' analgesica
CN101044134A (zh) * 2004-09-20 2007-09-26 塔加西普特公司 具有烟碱性胆碱能受体活性的氮杂螺烯和氮杂螺烷化合物
UA88792C2 (ru) * 2004-11-10 2009-11-25 Таргасепт, Інк. Гидроксибензоатные соли метаникотиновых соединений
US7459469B2 (en) 2004-11-10 2008-12-02 Targacept, Inc. Hydroxybenzoate salts of metanicotine compounds
EP1819709B1 (en) * 2004-11-30 2009-02-11 Neurosearch A/S Novel diazabicyclic aryl derivatives as cholinergy ligands
US7732607B2 (en) * 2005-08-22 2010-06-08 Anatoly Mazurov Heteroaryl-substituted diazatricycloalkanes and methods of use thereof
TWI389889B (zh) * 2006-05-09 2013-03-21 Targacept Inc （２ｓ）-（４ｅ）-ｎ-甲基-５-〔３-（５-異丙氧基吡啶）基〕-４-戊烯-２-胺之新穎多晶型
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EP2112923A1 (en) * 2007-01-22 2009-11-04 Targacept Inc. Intranasal, buccal, and sublingual administration of metanicotine analogs
KR20100052490A (ko) * 2007-07-31 2010-05-19 타가셉트 인코포레이티드 (2ｓ)-(4ｅ)-ｎ-메틸-5-(3-(5-이소프로폭시피리딘)일)-4-펜텐-2-아민의 경피투여
DE602008005928D1 (de) * 2007-10-01 2011-05-12 Comentis Inc 1h-indol-3-carbonsäure-chinuclidin-4-ylmethylesterderivate als liganden für den nikotinischen alpha-7-acetylcholinrezeptor zur behandlung von alzheimer-krankheit
IT1395452B1 (it) * 2009-02-25 2012-09-21 Neuroscienze Pharmaness S C A Rl Microemulsioni
IT1390850B1 (it) * 2008-07-31 2011-10-19 Neuroscienze Pharmaness S C A R L Microemulsioni
IT1390848B1 (it) * 2008-07-31 2011-10-19 Neuroscienze Pharmaness S C A R L Composti farmaceutici
EP2149370A1 (en) 2008-07-31 2010-02-03 Neuroscienze Pharmaness S.C. A R.L. Diazabicyclic compounds and microemulsions thereof
MX2012006484A (es) 2009-12-07 2012-08-01 Targacept Inc 3,6-diazabiciclo [3.1.1] heptanos como ligandos de receptores nicotinicos neuronales de acetilcolina.
IT1396951B1 (it) * 2009-12-18 2012-12-20 Neuroscienze Pharmaness S C A R L Composti farmaceutici
AU2011256866B2 (en) 2010-05-20 2014-05-22 Astrazeneca Ab New process for the preparation of aryl substituted olefinic amines
EP3166940A4 (en) 2014-07-11 2018-04-25 Alpharmagen, LLC Quinuclidine compounds for modulating alpha7 -nicotinic acetylcholine receptor activity
WO2016181408A2 (en) * 2015-05-11 2016-11-17 Cadila Healthcare Limited NOVEL SHORT-CHAIN PEPTIDES AS KAPPA (κ) OPIOID RECEPTORS (KOR) AGONIST
PT3448859T (pt) 2017-03-20 2019-10-25 Forma Therapeutics Inc Composições de pirrolopirrole como ativadores de piruvato quinase (pkr).
ES2989438T3 (es) 2018-09-19 2024-11-26 Novo Nordisk Healthcare Ag Activación de la piruvato cinasa R
US12053458B2 (en) 2018-09-19 2024-08-06 Novo Nordisk Health Care Ag Treating sickle cell disease with a pyruvate kinase R activating compound
CN114615977B (zh) 2019-09-19 2025-01-14 诺沃挪第克健康护理股份公司 丙酮酸激酶r(pkr)活化组合物
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB949088A (en) * 1961-06-26 1964-02-12 Lepetit Spa Diazabicyclo-octane derivatives
IT1271350B (it) * 1993-01-29 1997-05-27 Riace Establischment Derivati di 3,8 diazabiciclo (3,2,1) - ottani quali medicamenti ad attivita' analgesica centrale

Also Published As

Publication number Publication date
EP0746560A1 (en) 1996-12-11
US5672601A (en) 1997-09-30
WO1995023152A1 (en) 1995-08-31
ITMI940326A1 (it) 1995-08-23
AU1808595A (en) 1995-09-11
ITMI940326A0 (it) 1994-02-23

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Legal Events

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970226