IT1274018B - Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica - Google Patents

Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica

Info

Publication number
IT1274018B
IT1274018B ITMI940326A ITMI940326A IT1274018B IT 1274018 B IT1274018 B IT 1274018B IT MI940326 A ITMI940326 A IT MI940326A IT MI940326 A ITMI940326 A IT MI940326A IT 1274018 B IT1274018 B IT 1274018B
Authority
IT
Italy
Prior art keywords
octano
analgesic activity
diazabicycle
derivatives
diazabicycle derivatives
Prior art date
Application number
ITMI940326A
Other languages
English (en)
Inventor
Giorgio Cignarella
Original Assignee
Riace Ets
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riace Ets filed Critical Riace Ets
Priority to ITMI940326A priority Critical patent/IT1274018B/it
Publication of ITMI940326A0 publication Critical patent/ITMI940326A0/it
Priority to US08/696,948 priority patent/US5672601A/en
Priority to AU18085/95A priority patent/AU1808595A/en
Priority to EP95909700A priority patent/EP0746560A1/en
Priority to PCT/EP1995/000476 priority patent/WO1995023152A1/en
Publication of ITMI940326A1 publication Critical patent/ITMI940326A1/it
Application granted granted Critical
Publication of IT1274018B publication Critical patent/IT1274018B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Si descrivono composti di formula generale (I): (FORMULA I) dove R e R1, diversi fra loro, sono un gruppo acile o un gruppo -CH2-(A)-B, dove A e B sono come definiti di seguito. I composti di formula (I) sono analgesici ad attività centrale.
ITMI940326A 1994-02-23 1994-02-23 Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica IT1274018B (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ITMI940326A IT1274018B (it) 1994-02-23 1994-02-23 Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica
US08/696,948 US5672601A (en) 1994-02-23 1995-02-10 3-8-diazabicyclo 3.2.1! octane derivatives having analgesic activity
AU18085/95A AU1808595A (en) 1994-02-23 1995-02-10 3,8-diazabicyclo{3.2.1}octane derivatives having analgesic activity
EP95909700A EP0746560A1 (en) 1994-02-23 1995-02-10 3,8-diazabicyclo 3.2.1]octane derivatives having analgesic activity
PCT/EP1995/000476 WO1995023152A1 (en) 1994-02-23 1995-02-10 3,8-diazabicyclo[3.2.1]octane derivatives having analgesic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI940326A IT1274018B (it) 1994-02-23 1994-02-23 Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica

Publications (3)

Publication Number Publication Date
ITMI940326A0 ITMI940326A0 (it) 1994-02-23
ITMI940326A1 ITMI940326A1 (it) 1995-08-23
IT1274018B true IT1274018B (it) 1997-07-14

Family

ID=11367953

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI940326A IT1274018B (it) 1994-02-23 1994-02-23 Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica

Country Status (5)

Country Link
US (1) US5672601A (it)
EP (1) EP0746560A1 (it)
AU (1) AU1808595A (it)
IT (1) IT1274018B (it)
WO (1) WO1995023152A1 (it)

Families Citing this family (38)

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Publication number Priority date Publication date Assignee Title
IT1291632B1 (it) * 1997-04-22 1999-01-11 Univ Degli Studi Milano Derivati di 9,10-diazatriciclo (4.2.1.1 alla 2,5)decano e di 9,10- diazatriciclo (3.3.1.1 alla 2,6) decano ad attivita' analgesica
US7214686B2 (en) * 1997-06-30 2007-05-08 Targacept, Inc. Pharmaceutical compositions and methods for effecting dopamine release
US7265115B2 (en) 1999-01-29 2007-09-04 Abbott Laboratories Diazabicyclic CNS active agents
IT1317841B1 (it) * 2000-02-18 2003-07-15 Univ Degli Studi Milano Derivati del 3,9-diazabiciclo(3.3.1)nonano ad attivita' analgesica.
US6809105B2 (en) 2000-04-27 2004-10-26 Abbott Laboratories Diazabicyclic central nervous system active agents
SE0003795D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Pharmaceutically useful compounds
EA009789B1 (ru) * 2002-07-05 2008-04-28 Таргасепт, Инк. N-арилдиазаспирациклические соединения и способы их получения и применения
AU2003254016A1 (en) 2002-07-19 2004-02-09 Catholic Healthcare West Methods and compositions relating to chimeric nicotinic receptor subunits
ATE390427T1 (de) 2002-07-26 2008-04-15 Neurosearch As Diazabicylononan - und decanderivate und ihre verwendung als opioid-rezeptorligande
US7098331B2 (en) * 2003-03-05 2006-08-29 Targacept, Inc. Arylvinylazacycloalkane compounds and methods of preparation and use thereof
EP1678172B1 (en) * 2003-10-15 2009-12-09 Targacept, Inc. Azabicyclic compounds for relieving pain and treating central nervous system disorders
US7816356B2 (en) 2003-11-14 2010-10-19 Daniel Yohannes Aryl and heteroaryltetrahydrocyclobutapyrroles as nicotinic acetylcholine receptor ligands
ITMI20040954A1 (it) * 2004-05-12 2004-08-12 Univ Degli Studi Milano Derivati del 3,6-diazabiciclo 3.1.i.eptano ad attivita' analgesica
CN101044134A (zh) * 2004-09-20 2007-09-26 塔加西普特公司 具有烟碱性胆碱能受体活性的氮杂螺烯和氮杂螺烷化合物
UA88792C2 (ru) 2004-11-10 2009-11-25 Таргасепт, Інк. Гидроксибензоатные соли метаникотиновых соединений
US7459469B2 (en) 2004-11-10 2008-12-02 Targacept, Inc. Hydroxybenzoate salts of metanicotine compounds
WO2006058879A1 (en) * 2004-11-30 2006-06-08 Neurosearch A/S Novel diazabicyclic aryl derivatives as cholinergy ligands
CA2618700A1 (en) * 2005-08-22 2007-03-01 Targacept, Inc. Heteroaryl-substituted diazatricycloalkanes, methods for its preparation and use thereof
TWI389889B (zh) * 2006-05-09 2013-03-21 Targacept Inc （２ｓ）-（４ｅ）-ｎ-甲基-５-〔３-（５-異丙氧基吡啶）基〕-４-戊烯-２-胺之新穎多晶型
EP2021325A2 (en) * 2006-05-09 2009-02-11 AstraZeneca AB Salt forms of (2s)-(4e)-n-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-amine
AR062860A1 (es) * 2006-09-15 2008-12-10 Astrazeneca Ab Combinaciones terapeuticas 482
WO2008091588A1 (en) * 2007-01-22 2008-07-31 Targacept, Inc. Intranasal, buccal, and sublingual administration of metanicotine analogs
BRPI0815070A2 (pt) * 2007-07-31 2018-07-31 Astrazeneca Ab Administração transdérmica de (2s)-(4e)-n-metil-5-(3- (5-isopropoxipiridin) il-4-penten-2-amina
KR101565469B1 (ko) * 2007-10-01 2015-11-03 코멘티스, 인코포레이티드 알츠하이머병의 치료를 위한 알파 7 니코틴 아세틸콜린 수용체 리간드로서 퀴누클리딘-4-일메틸 1ｈ-인돌-3-카르복실레이트 유도체
IT1395452B1 (it) * 2009-02-25 2012-09-21 Neuroscienze Pharmaness S C A Rl Microemulsioni
IT1390850B1 (it) * 2008-07-31 2011-10-19 Neuroscienze Pharmaness S C A R L Microemulsioni
IT1390848B1 (it) 2008-07-31 2011-10-19 Neuroscienze Pharmaness S C A R L Composti farmaceutici
EP2149370A1 (en) * 2008-07-31 2010-02-03 Neuroscienze Pharmaness S.C. A R.L. Diazabicyclic compounds and microemulsions thereof
EP2509982A1 (en) 2009-12-07 2012-10-17 Targacept, Inc. 3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetylcholine receptor ligands
IT1396951B1 (it) * 2009-12-18 2012-12-20 Neuroscienze Pharmaness S C A R L Composti farmaceutici
CN103180277A (zh) 2010-05-20 2013-06-26 塔格塞普特股份有限公司 制备芳基取代的烯属胺的新方法
US20170166561A1 (en) 2014-07-11 2017-06-15 Alpharmagen, Llc Quinuclidine compounds for modulating alpha7-nicotinic acetylcholine receptor activity
JP6651546B2 (ja) * 2015-05-11 2020-02-19 カディラ・ヘルスケア・リミテッド カッパ（κ）オピオイド受容体（ＫＯＲ）アゴニストとしての新規の短鎖ペプチド
EP3680241A1 (en) 2017-03-20 2020-07-15 Forma Therapeutics, Inc. Pyrrolopyrrole compositions as pyruvate kinase (pkr) activators
WO2020061255A1 (en) 2018-09-19 2020-03-26 Forma Therapeutics, Inc. Activating pyruvate kinase r
US10675274B2 (en) 2018-09-19 2020-06-09 Forma Therapeutics, Inc. Activating pyruvate kinase R
HUE072832T2 (hu) 2019-09-19 2025-12-28 Novo Nordisk Healthcare Ag Piruvát kináz R-t (PKR) aktiváló készítmények
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB949088A (en) * 1961-06-26 1964-02-12 Lepetit Spa Diazabicyclo-octane derivatives
IT1271350B (it) * 1993-01-29 1997-05-27 Riace Establischment Derivati di 3,8 diazabiciclo (3,2,1) - ottani quali medicamenti ad attivita' analgesica centrale

Also Published As

Publication number Publication date
US5672601A (en) 1997-09-30
ITMI940326A1 (it) 1995-08-23
AU1808595A (en) 1995-09-11
EP0746560A1 (en) 1996-12-11
ITMI940326A0 (it) 1994-02-23
WO1995023152A1 (en) 1995-08-31

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970226