IT1274175B - Procedimento per la preparazione di una combinazione chimica farmacologicamente attiva - Google Patents

Procedimento per la preparazione di una combinazione chimica farmacologicamente attiva

Info

Publication number
IT1274175B
IT1274175B ITMI942362A ITMI942362A IT1274175B IT 1274175 B IT1274175 B IT 1274175B IT MI942362 A ITMI942362 A IT MI942362A IT MI942362 A ITMI942362 A IT MI942362A IT 1274175 B IT1274175 B IT 1274175B
Authority
IT
Italy
Prior art keywords
procedure
preparation
pharmacologically active
chemical combination
active chemical
Prior art date
Application number
ITMI942362A
Other languages
English (en)
Inventor
Francesco Sannicolo'
Soldato Piero Del
Tiziana Benincori
Original Assignee
Lab Alchemia Srl
Soldato Piero Del
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lab Alchemia Srl, Soldato Piero Del filed Critical Lab Alchemia Srl
Priority to ITMI942362A priority Critical patent/IT1274175B/it
Publication of ITMI942362A0 publication Critical patent/ITMI942362A0/it
Priority to EP95940211A priority patent/EP0793507A2/en
Priority to AU41741/96A priority patent/AU4174196A/en
Priority to EP00105715A priority patent/EP1038534A3/en
Priority to PCT/EP1995/004556 priority patent/WO1996015809A2/en
Priority to US08/836,756 priority patent/US6369260B1/en
Publication of ITMI942362A1 publication Critical patent/ITMI942362A1/it
Application granted granted Critical
Publication of IT1274175B publication Critical patent/IT1274175B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Procedimento per la preparazione di una combinazione chimica farmacologicamente attiva costituita dall'associazione, mediante legami chimici, di unità uguali tra loro, ciascuna unità risultando dotata di attività farmacologica propria, avente formula generale:M-A-X-B-M (I)dove M indica detta unità dotata di attività farmacologica propria, X indica una struttura "bidentata" atta ad interconnettere le unità M, A e B indicano gruppi funzionali uguali o diversi tra loro che consentono la interconnessione tra M ed X.
ITMI942362A 1994-11-22 1994-11-22 Procedimento per la preparazione di una combinazione chimica farmacologicamente attiva IT1274175B (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ITMI942362A IT1274175B (it) 1994-11-22 1994-11-22 Procedimento per la preparazione di una combinazione chimica farmacologicamente attiva
EP95940211A EP0793507A2 (en) 1994-11-22 1995-11-20 Process for the preparation of a pharmacologically active chemical combination
AU41741/96A AU4174196A (en) 1994-11-22 1995-11-20 Process for the preparation of a pharmacologically active chemical combination
EP00105715A EP1038534A3 (en) 1994-11-22 1995-11-20 Process for the preparation of a conjugate of pharmacologically active substances
PCT/EP1995/004556 WO1996015809A2 (en) 1994-11-22 1995-11-20 Process for the preparation of a pharmacologically active chemical combination
US08/836,756 US6369260B1 (en) 1994-11-22 1995-11-20 Process for the preparation of a pharmacologically active chemical combination

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI942362A IT1274175B (it) 1994-11-22 1994-11-22 Procedimento per la preparazione di una combinazione chimica farmacologicamente attiva

Publications (3)

Publication Number Publication Date
ITMI942362A0 ITMI942362A0 (it) 1994-11-22
ITMI942362A1 ITMI942362A1 (it) 1996-05-22
IT1274175B true IT1274175B (it) 1997-07-15

Family

ID=11369887

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI942362A IT1274175B (it) 1994-11-22 1994-11-22 Procedimento per la preparazione di una combinazione chimica farmacologicamente attiva

Country Status (5)

Country Link
US (1) US6369260B1 (it)
EP (2) EP1038534A3 (it)
AU (1) AU4174196A (it)
IT (1) IT1274175B (it)
WO (1) WO1996015809A2 (it)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP2002002582A0 (en) * 1999-12-23 2002-09-30 Nitromed Inc Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
EP1461122A4 (en) * 2001-12-10 2006-08-23 Control Delivery Sys Inc TREATMENT OF DISEASES OF THE UROGENITAL SYSTEM
CA2487414A1 (en) 2002-06-11 2003-12-18 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
US7244753B2 (en) * 2002-07-29 2007-07-17 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
WO2005009480A2 (en) * 2003-06-11 2005-02-03 Control Delivery Systems, Inc. Implants containing codrugs
EP1868653A2 (en) * 2005-04-12 2007-12-26 PSivida Inc. Hmgcoa reductase inhibitor codrugs and uses thereof
WO2007016306A2 (en) * 2005-08-01 2007-02-08 Psivida Inc. HMGCoA REDUCTASE INHIBITOR CODRUGS AND USES THEREOF
JP2007275193A (ja) * 2006-04-04 2007-10-25 Fujifilm Corp 光プローブおよび光断層画像化装置
GB2470187A (en) * 2009-05-11 2010-11-17 Pharmapatents Global Ltd Captopril polymers
CN110668947B (zh) * 2019-10-14 2021-05-18 新乡海盈生物科技有限责任公司 一种邻羟基苯甲酸聚二醇酯类化合物及其合成制备方法和医药用途
CN116655467B (zh) * 2023-06-09 2025-12-23 上海大学 一种芳基羧酸酯类化合物及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB872130A (en) * 1959-06-22 1961-07-05 Christian Jean Marie Warolin Improvements in and relating to a process for preparing acetylsalicyclic acid anhydride
US3025215A (en) * 1959-07-29 1962-03-13 Monsanto Chemicals Bis (8-quinolyl carbonate) derivatives
GB1013235A (en) * 1963-01-17 1965-12-15 Yoshitomi Pharmaceutical Method of preparing polyhydric alcohol esters of acetylsalicylic acid
DE1768345B2 (de) * 1968-05-03 1976-12-02 Hoechst Ag, 6000 Frankfurt Dimere steroid-21-alkylcarbonate und verfahren zu ihrer herstellung
CH583562A5 (it) * 1973-07-17 1977-01-14 Bracco Ind Chimica Spa
LU78106A1 (de) * 1977-05-11 1979-05-23 Ciba Geigy Ag Verfahren zur herstellung neuer substituierter phenylessigsaeureamidverbindungen
IL67445A (en) * 1982-12-09 1985-11-29 Teva Pharma Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids
DK8502611A (it) * 1985-08-08 1986-12-12
DK406686D0 (da) * 1986-08-26 1986-08-26 Hans Bundgaard Carboxylsyrederivater
AU655762B2 (en) 1989-12-26 1995-01-12 Nova Pharmaceutical Corporation Prodrug anhydrides of asprin, indomethacin and ibuprofen, their preparation, compositions, and anti-inflammatory method of use

Also Published As

Publication number Publication date
US6369260B1 (en) 2002-04-09
WO1996015809A3 (en) 1996-10-17
AU4174196A (en) 1996-06-17
EP1038534A2 (en) 2000-09-27
EP0793507A2 (en) 1997-09-10
EP1038534A3 (en) 2001-04-04
ITMI942362A0 (it) 1994-11-22
WO1996015809A2 (en) 1996-05-30
ITMI942362A1 (it) 1996-05-22

Similar Documents

Publication Publication Date Title
SI0769967T1 (sl) Konjugati vsebujoäśi protitumorna sredstva in njihova uporaba
IT1274175B (it) Procedimento per la preparazione di una combinazione chimica farmacologicamente attiva
FI961057L (fi) Tabletoitu moniyksikköannostusmuoto I
NO903762D0 (no) Fremgangsmaate for aa opprette diffusjonsbinding mellom korrosjonsbestandige materialer.
NO903926D0 (no) Aktive limsammensetninger.
CA2320706A1 (en) 20-hete antagonists and agonists
EP1154771A4 (en) NITROSED AND NITROSYLATED PROTON PUMP INHIBITORS, COMPOSITIONS AND USES OF USE
CA2302224A1 (en) Fibrinogen-based tissue adhesive
DE69625230D1 (de) Thrombininhibitoren
IT8920405A0 (it) Aminoimidazopiridine farmacologicamente attive.
IT9068000A0 (it) Oggetti lavorati a maglia che determinano una ridotta sensazione di umidita'.
USD444182S1 (en) Set of heximoes
DE68912252D1 (de) Imidazolantiarrythmische Mittel.
RU93049257A (ru) Изобутилзамещенные метансульфонил-хинолилметоксифенилциклоалкилуксусной кислоты
KR900700481A (ko) 1,4-치환된-2,3.5,6-테트라하이드로 [1,3,6]트리아조시노[1,2,-a] 벤즈이미다졸 및 이의 중간체
FR2757360B1 (fr) Dispositif modulaire d'agencement, notamment du type gondole
ITMI931806A0 (it) Composti inibitpri di acil enzima-a-colesterolo-o-acil transferasi ad attivita' terapeutica , loro uso e composizioni farmaceutiche che li contengono
IT1299865B1 (it) Unita' per la formazione di pile di articoli.
IT1229230B (it) Piperidinilimidazopiridine farmacologicamente attive.
ITBO940421A0 (it) Unita' modulare per il contenimento di fiale, fialoidi e similari.
FI945105A0 (fi) 17alfa- ja 17beta-substituoitu estra-1,3,5(10)-trieeni-3-karboksyylihappo
ITMI921865A1 (it) Glicerofosfoderivati farmacologicamente attivi
ITRM930264A0 (it) Principi attivi anti-infiammatori non steroidei senza effetti di perossidazione sulle membrane biologiche.
IT245892Y1 (it) Unita' espositiva modulare.
IT8422492U1 (it) Struttura di cravatte a piu' utilizzazioni.

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971028