IT1274241B - Complessi agente terapeutico/matrice polimerica dotati di migliorate caratteristiche di sapore e composizioni farmaceutiche che li contengono - Google Patents

Complessi agente terapeutico/matrice polimerica dotati di migliorate caratteristiche di sapore e composizioni farmaceutiche che li contengono

Info

Publication number
IT1274241B
IT1274241B ITMI932540A ITMI932540A IT1274241B IT 1274241 B IT1274241 B IT 1274241B IT MI932540 A ITMI932540 A IT MI932540A IT MI932540 A ITMI932540 A IT MI932540A IT 1274241 B IT1274241 B IT 1274241B
Authority
IT
Italy
Prior art keywords
pharmaceutical compositions
therapeutic agent
compositions containing
polymer matrix
flavor characteristics
Prior art date
Application number
ITMI932540A
Other languages
English (en)
Inventor
Tiziana Crolla
Franco Francese
Massimo Maneschi
Diego Oldani
Original Assignee
Smithkline Beecham Farma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Farma filed Critical Smithkline Beecham Farma
Publication of ITMI932540A0 publication Critical patent/ITMI932540A0/it
Priority to ITMI932540A priority Critical patent/IT1274241B/it
Priority to CA002177721A priority patent/CA2177721A1/en
Priority to JP7515376A priority patent/JPH09505818A/ja
Priority to NZ277238A priority patent/NZ277238A/en
Priority to CN94194885A priority patent/CN1145586A/zh
Priority to AU12198/95A priority patent/AU693144B2/en
Priority to EP95903281A priority patent/EP0804168A1/en
Priority to PCT/EP1994/003903 priority patent/WO1995015155A1/en
Priority to ZA949567A priority patent/ZA949567B/xx
Publication of ITMI932540A1 publication Critical patent/ITMI932540A1/it
Application granted granted Critical
Publication of IT1274241B publication Critical patent/IT1274241B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6943—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a pill, a tablet, a lozenge or a capsule

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ITMI932540A 1993-12-03 1993-12-03 Complessi agente terapeutico/matrice polimerica dotati di migliorate caratteristiche di sapore e composizioni farmaceutiche che li contengono IT1274241B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ITMI932540A IT1274241B (it) 1993-12-03 1993-12-03 Complessi agente terapeutico/matrice polimerica dotati di migliorate caratteristiche di sapore e composizioni farmaceutiche che li contengono
CN94194885A CN1145586A (zh) 1993-12-03 1994-11-24 含药物/聚合物复合物的味掩蔽组合物
JP7515376A JPH09505818A (ja) 1993-12-03 1994-11-24 薬／ポリマー複合体含有の風味をマスクした組成物
NZ277238A NZ277238A (en) 1993-12-03 1994-11-24 Taste masked composition containing paroxetine complexed with a polymer
CA002177721A CA2177721A1 (en) 1993-12-03 1994-11-24 Taste masked composition containing a drug/polymer complex
AU12198/95A AU693144B2 (en) 1993-12-03 1994-11-24 Taste masked composition containing a drug/polymer complex
EP95903281A EP0804168A1 (en) 1993-12-03 1994-11-24 Taste masked composition containing a drug/polymer complex
PCT/EP1994/003903 WO1995015155A1 (en) 1993-12-03 1994-11-24 Taste masked composition containing a drug/polymer complex
ZA949567A ZA949567B (en) 1993-12-03 1994-12-01 Chewable taste masked complexes containing pharmaceuticals

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI932540A IT1274241B (it) 1993-12-03 1993-12-03 Complessi agente terapeutico/matrice polimerica dotati di migliorate caratteristiche di sapore e composizioni farmaceutiche che li contengono

Publications (3)

Publication Number Publication Date
ITMI932540A0 ITMI932540A0 (it) 1993-12-03
ITMI932540A1 ITMI932540A1 (it) 1995-06-03
IT1274241B true IT1274241B (it) 1997-07-15

Family

ID=11367288

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI932540A IT1274241B (it) 1993-12-03 1993-12-03 Complessi agente terapeutico/matrice polimerica dotati di migliorate caratteristiche di sapore e composizioni farmaceutiche che li contengono

Country Status (9)

Country Link
EP (1) EP0804168A1 (it)
JP (1) JPH09505818A (it)
CN (1) CN1145586A (it)
AU (1) AU693144B2 (it)
CA (1) CA2177721A1 (it)
IT (1) IT1274241B (it)
NZ (1) NZ277238A (it)
WO (1) WO1995015155A1 (it)
ZA (1) ZA949567B (it)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548084B2 (en) * 1995-07-20 2003-04-15 Smithkline Beecham Plc Controlled release compositions
AU748804B2 (en) * 1995-07-20 2002-06-13 Smithkline Beecham Plc Paroxetine controlled release compositions
GB9514842D0 (en) * 1995-07-20 1995-09-20 Smithkline Beecham Plc Novel formulation
CA2206592A1 (en) * 1996-05-30 1997-11-30 Shu-Zhong Wang Method of producing amorphous paroxetine hydrochloride
US5965555A (en) * 1996-06-07 1999-10-12 Hoechst Aktiengesellschaft Xanthine compounds having terminally animated alkynol side chains
DE19631084A1 (de) 1996-08-01 1998-02-05 Basf Ag Verwendung von (Meth)acrylsäure-Copolymeren zur Erhöhung der Permeabilität der Schleimhaut
US6638948B1 (en) 1996-09-09 2003-10-28 Pentech Pharmaceuticals, Inc. Amorphous paroxetine composition
EE03970B1 (et) 1997-06-10 2003-02-17 Synthon B.V. 4-fenüülpiperidiinühend, selle valmistamine ja kasutamine ning seda sisaldav ravim
US5955475A (en) * 1997-06-30 1999-09-21 Endo Pharmaceuticals Inc. Process for manufacturing paroxetine solid dispersions
BR9813808A (pt) * 1997-12-19 2002-05-28 Smithkline Beecham Corp Processo para produção de comprimidos para dispersão na mordida
IT1298732B1 (it) * 1998-03-13 2000-02-02 Recordati Chem Pharm Composizioni farmaceutiche orali assumibili senza liquidi,contenenti complessi di inclusione
CH689805A8 (fr) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
ATE311883T1 (de) 1999-03-12 2005-12-15 Aesica Pharmaceuticals Ltd Stabile pharmazeutische anwendungsform für paroxetin-anhydrat
WO2003013470A1 (en) * 2001-08-09 2003-02-20 Smithkline Beecham Plc. Composition comprising paroxetine and a pharmaceutically acceptable glycyrrhizinate salt
GB0119467D0 (en) * 2001-08-09 2001-10-03 Smithkline Beecham Plc Novel compound
PT2802311T (pt) * 2011-10-25 2019-03-19 Expermed S A Composição farmacêutica sublingual contendo um agente anti-histamínico e método para a sua preparação

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT83241B (pt) * 1985-08-26 1988-07-01 Searle & Co Processo para a preparacao de composicoes de drogas de matriz polimerica, capazes de mascarar o sabor de um ingrediente activo, contendo um polimero tendo uma serie de grupos acido e ester carboxilicos

Also Published As

Publication number Publication date
AU1219895A (en) 1995-06-19
WO1995015155A1 (en) 1995-06-08
EP0804168A1 (en) 1997-11-05
CA2177721A1 (en) 1995-06-08
NZ277238A (en) 1998-04-27
CN1145586A (zh) 1997-03-19
AU693144B2 (en) 1998-06-25
ITMI932540A0 (it) 1993-12-03
JPH09505818A (ja) 1997-06-10
ITMI932540A1 (it) 1995-06-03
ZA949567B (en) 1995-10-10

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19981231