IT1275571B - Substrati fluorogenici suscettibili di fotoattivazione previa trasformazione per via enzimatica atti alla diagnosi ed alla terapia fotodinamica dei tumori - Google Patents

Substrati fluorogenici suscettibili di fotoattivazione previa trasformazione per via enzimatica atti alla diagnosi ed alla terapia fotodinamica dei tumori

Info

Publication number
IT1275571B
IT1275571B ITMI951560A ITMI951560A IT1275571B IT 1275571 B IT1275571 B IT 1275571B IT MI951560 A ITMI951560 A IT MI951560A IT MI951560 A ITMI951560 A IT MI951560A IT 1275571 B IT1275571 B IT 1275571B
Authority
IT
Italy
Prior art keywords
photoactivation
diagnosis
cancer therapy
fluorogenic substrates
enzymatic transformation
Prior art date
Application number
ITMI951560A
Other languages
English (en)
Inventor
Giovanni Bottiroli
Anna Cleta Croce
Piero Baglioni
Monica Monici
Original Assignee
Consiglio Nazionale Ricerche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consiglio Nazionale Ricerche filed Critical Consiglio Nazionale Ricerche
Priority to ITMI951560A priority Critical patent/IT1275571B/it
Publication of ITMI951560A0 publication Critical patent/ITMI951560A0/it
Priority to US09/011,347 priority patent/US6036941A/en
Priority to CA002227212A priority patent/CA2227212A1/en
Priority to PCT/EP1996/003201 priority patent/WO1997003697A2/en
Priority to AU67351/96A priority patent/AU6735196A/en
Priority to EP96927559A priority patent/EP0839051A1/en
Publication of ITMI951560A1 publication Critical patent/ITMI951560A1/it
Application granted granted Critical
Publication of IT1275571B publication Critical patent/IT1275571B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ITMI951560A 1995-07-19 1995-07-19 Substrati fluorogenici suscettibili di fotoattivazione previa trasformazione per via enzimatica atti alla diagnosi ed alla terapia fotodinamica dei tumori IT1275571B (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ITMI951560A IT1275571B (it) 1995-07-19 1995-07-19 Substrati fluorogenici suscettibili di fotoattivazione previa trasformazione per via enzimatica atti alla diagnosi ed alla terapia fotodinamica dei tumori
US09/011,347 US6036941A (en) 1995-07-19 1996-07-19 Fluorogenic substrates for diagnosis and photodynamic treatment of tumors
CA002227212A CA2227212A1 (en) 1995-07-19 1996-07-19 Fluorogenic substrates for diagnosis and photodynamic treatment of tumours
PCT/EP1996/003201 WO1997003697A2 (en) 1995-07-19 1996-07-19 Fluorogenic substrates for diagnosis and photodynamic treatment of tumours
AU67351/96A AU6735196A (en) 1995-07-19 1996-07-19 Fluorogenic substrates for diagnosis and photodynamic treatment of tumours
EP96927559A EP0839051A1 (en) 1995-07-19 1996-07-19 Fluorogenic substrates for diagnosis and photodynamic treatment of tumours

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI951560A IT1275571B (it) 1995-07-19 1995-07-19 Substrati fluorogenici suscettibili di fotoattivazione previa trasformazione per via enzimatica atti alla diagnosi ed alla terapia fotodinamica dei tumori

Publications (3)

Publication Number Publication Date
ITMI951560A0 ITMI951560A0 (it) 1995-07-19
ITMI951560A1 ITMI951560A1 (it) 1997-01-19
IT1275571B true IT1275571B (it) 1997-08-07

Family

ID=11372009

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI951560A IT1275571B (it) 1995-07-19 1995-07-19 Substrati fluorogenici suscettibili di fotoattivazione previa trasformazione per via enzimatica atti alla diagnosi ed alla terapia fotodinamica dei tumori

Country Status (6)

Country Link
US (1) US6036941A (it)
EP (1) EP0839051A1 (it)
AU (1) AU6735196A (it)
CA (1) CA2227212A1 (it)
IT (1) IT1275571B (it)
WO (1) WO1997003697A2 (it)

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US8974363B2 (en) 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
US7648695B2 (en) 1998-08-06 2010-01-19 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US8557298B2 (en) * 1998-08-06 2013-10-15 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US20090117199A1 (en) * 1998-08-06 2009-05-07 Scott Timothy C Method of treatment of cancer
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US7384623B1 (en) 1998-12-21 2008-06-10 Provectus Pharmatech, Inc. High energy phototherapeutic agents
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Also Published As

Publication number Publication date
ITMI951560A1 (it) 1997-01-19
ITMI951560A0 (it) 1995-07-19
EP0839051A1 (en) 1998-05-06
WO1997003697A3 (en) 1997-04-10
WO1997003697A2 (en) 1997-02-06
US6036941A (en) 2000-03-14
AU6735196A (en) 1997-02-18
CA2227212A1 (en) 1997-02-06

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