IT1277700B1 - Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura - Google Patents

Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura

Info

Publication number
IT1277700B1
IT1277700B1 IT95MI002735A ITMI952735A IT1277700B1 IT 1277700 B1 IT1277700 B1 IT 1277700B1 IT 95MI002735 A IT95MI002735 A IT 95MI002735A IT MI952735 A ITMI952735 A IT MI952735A IT 1277700 B1 IT1277700 B1 IT 1277700B1
Authority
IT
Italy
Prior art keywords
beta
diacyloss
alphaandrostans
diamino
structured
Prior art date
Application number
IT95MI002735A
Other languages
English (en)
Inventor
Stefano Poli
Ambrogio Magni
Paride Grisenti
Original Assignee
Poli Ind Chimica Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poli Ind Chimica Spa filed Critical Poli Ind Chimica Spa
Priority to IT95MI002735A priority Critical patent/IT1277700B1/it
Publication of ITMI952735A0 publication Critical patent/ITMI952735A0/it
Priority to US08/761,631 priority patent/US5817803A/en
Priority to NZ299964A priority patent/NZ299964A/en
Priority to AU76420/96A priority patent/AU724696B2/en
Publication of ITMI952735A1 publication Critical patent/ITMI952735A1/it
Priority to US08/958,456 priority patent/US5808051A/en
Application granted granted Critical
Publication of IT1277700B1 publication Critical patent/IT1277700B1/it
Priority to US09/165,242 priority patent/US6090957A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT95MI002735A 1995-12-22 1995-12-22 Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura IT1277700B1 (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IT95MI002735A IT1277700B1 (it) 1995-12-22 1995-12-22 Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura
US08/761,631 US5817803A (en) 1995-12-22 1996-12-06 Process for preparing neuromuscular blocking agents and intermediates useful therefor
NZ299964A NZ299964A (en) 1995-12-22 1996-12-18 Preparation of 2-beta,16-beta-diamino,3-alpha,17-beta-diacyloxy 5-alpha-androstanes, neuromuscular blocking agents with a steroidal structure.
AU76420/96A AU724696B2 (en) 1995-12-22 1996-12-20 Process for the preparation of 2-beta, 16-beta-diamino 3-alpha, 17-beta-diacloxy 5-alpha-androstanes, neuromuscular blocking agents with a steroidal structure
US08/958,456 US5808051A (en) 1995-12-22 1997-10-27 Process for preparing neuromuscular blocking agents and intermediates useful therefor
US09/165,242 US6090957A (en) 1995-12-22 1998-10-01 Process for preparing neuromuscular blocking agents and intermediates useful therefor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI002735A IT1277700B1 (it) 1995-12-22 1995-12-22 Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura

Publications (3)

Publication Number Publication Date
ITMI952735A0 ITMI952735A0 (it) 1995-12-22
ITMI952735A1 ITMI952735A1 (it) 1997-06-22
IT1277700B1 true IT1277700B1 (it) 1997-11-11

Family

ID=11372801

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95MI002735A IT1277700B1 (it) 1995-12-22 1995-12-22 Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura

Country Status (4)

Country Link
US (3) US5817803A (it)
AU (1) AU724696B2 (it)
IT (1) IT1277700B1 (it)
NZ (1) NZ299964A (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005068487A2 (en) * 2004-01-15 2005-07-28 Chemagis Ltd. Processes for the preparation of rocuronium bromide and intermediates thereof
US20060009485A1 (en) * 2005-06-23 2006-01-12 Chemagis Ltd Method of reprocessing quaternary ammonium-containing neuromuscular blocking agents
DE602006019822D1 (de) 2005-09-13 2011-03-10 Sicor Inc Reines rocuroniumbromid
GB2445746A (en) * 2007-01-17 2008-07-23 Texcontor Ets Use of carbonated water as a solvent for freeze drying, and method of purification comprising dissolution of material in carbonated water and freeze drying
KR101016608B1 (ko) * 2008-12-03 2011-02-22 (주) 성운파마코피아 로큐로니움 브로마이드의 제조방법
CN102633858A (zh) * 2012-03-06 2012-08-15 连云港贵科药业有限公司 罗库溴铵关键中间体2α,3α-环氧-16β-(1-吡咯烷基)-5α-雄甾烷-17羟基的制备方法
CN103897013B (zh) * 2014-04-15 2016-06-29 武汉生物工程学院 3α,4α-环氧-16α-溴-5α-雄甾-17-酮及其制备方法
WO2016009442A1 (en) * 2014-07-14 2016-01-21 Neon Laboratories Ltd. Novel method for synthesis of neuromuscular blocking agents
CN104829676B (zh) * 2015-05-19 2016-11-30 南京工业大学 一种采用微通道模块化反应装置制备维库溴铵中间体的方法
CN110790810B (zh) * 2019-11-18 2022-01-28 重庆仁泽医药科技有限公司 一种罗库溴铵中间体及罗库溴铵的制备方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097200A (en) * 1962-01-03 1963-07-09 Syntex Corp 17-aminoandrostanes
GB1003681A (en) * 1962-03-09 1965-09-08 May & Baker Ltd Androstane and androstene derivatives
NL294500A (it) * 1962-07-09
US3238194A (en) * 1962-12-12 1966-03-01 Searle & Co Optionally n-substituted 17-oxygenated-2-amino-5alpha-androstan-3-ols
GB1138605A (en) * 1965-02-19 1969-01-01 Organon Labor Ltd Improvements in or relating to new 2-ß,16-ß-diamino-androstanes
US3380886A (en) * 1965-04-07 1968-04-30 Upjohn Co 7alpha-methyl-3beta-hydroxy-5-androstenes
US3458504A (en) * 1966-10-24 1969-07-29 Sterling Drug Inc Steroido(3,4-c)pyrazoles of the 5alpha- and 5beta-androstane series
HU168431B (it) * 1972-07-27 1976-04-28
GB1454749A (en) * 1972-11-29 1976-11-03 Akzo Nv 2beta, 16beta-diamino-androstanes and their preparation
HU171166B (hu) * 1975-07-15 1977-11-28 Richter Gedeon Vegyeszet Sposob poluchenija novykh ehpoksi-androstanov
HU172521B (hu) * 1975-08-01 1978-09-28 Richter Gedeon Vegyeszet Sposob poluchenija novykh proizvodnykh triamino-androstana i chetvertichnykh solejj
US4177190A (en) * 1975-08-01 1979-12-04 Richter Gedeon Vegyeszeti Gyar Rt. Diamino-androstanes and a process for the preparation of the said compounds
HU172522B (hu) * 1975-08-01 1978-09-28 Richter Gedeon Vegyeszet Sposob poluchenija novykh proizvodnykh 2beta, 16beta-diamino-androstana i ikh chetvertichnykh solej
AU506657B2 (en) * 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
ATE921T1 (de) * 1978-09-05 1982-05-15 Akzo N.V. Saeureadditionssalze von 2-beta, 16-beta-bis-piperidino-an drostan-16-beta-monoquaternaeren ammoniumderivaten und diese enthaltende pharmazeutische zusammensetzungen.
IE50675B1 (en) * 1979-12-12 1986-06-11 Akzo Nv Bis-and mono-quaternary ammonium derivatives of 2beta,16beta-dipiperidino-5alpha-androstanes,processes for their preparation and pharmaceutical preparations
DE3160797D1 (en) * 1980-07-16 1983-09-29 Glaxo Group Ltd 11-alpha-amino androstanes, pharmaceutical compositions containing them and processes for their preparation
CA1173433A (en) * 1980-07-16 1984-08-28 Gordon H. Phillipps 11.alpha.-AMINO-ANDROSTANES
EP0059637A1 (en) * 1981-03-02 1982-09-08 Glaxo Group Limited 11Alpha-amino-3 Beta-hydroxy-androstanes
DE3260539D1 (en) * 1981-05-29 1984-09-13 Glaxo Group Ltd 11-alpha-amino-androstanes
JPS57203100A (en) * 1981-05-29 1982-12-13 Glaxo Group Ltd 11 alpha-amino-androstanes
IE53463B1 (en) * 1981-06-15 1988-11-23 Akzo Nv Mono-and bisquaternary ammonium derivatives of 2 beta,16 beta-d-amino-5 alpha-androstane derivatives and pharmaceutical preparations containing same
HU195972B (en) * 1985-07-01 1988-08-29 Richter Gedeon Vegyeszet Process for producing new diamino-androstane derivatives and pharmaceutical compositions containing them
GB8708886D0 (en) * 1987-04-14 1987-05-20 Akzo Nv 2beta-morpholino-androstane derivatives
GB8709565D0 (en) * 1987-04-23 1987-05-28 Akzo Nv 2beta,16beta-diaminoandrostanes
US5030633A (en) * 1990-09-12 1991-07-09 Williams Charles H Use of androstane derivative against malignant hyperthermia
US5140022A (en) * 1990-10-01 1992-08-18 Anaquest, Inc. 3-acyclic or cyclicaminomethyl-17a-lower-alkyl-17a-aza-d-homo-5-alpha-androstanes
US5229511A (en) * 1990-10-01 1993-07-20 Anaquest, Inc. 3-substituted-aminomethyl-3-substituted-oxy-17A-methyl-17A-lower-alkyl-17A-aza-d-homo-5-alpha-androstanes
US5190924A (en) * 1991-02-13 1993-03-02 Boc Health Care, Inc. Peptide amides and amide dimers useful as muscle relaxants
US5418226A (en) * 1992-04-22 1995-05-23 Akzo N.V. Monoquaternary 2,16-bispiperidinylandrostane derivatives

Also Published As

Publication number Publication date
AU7642096A (en) 1997-06-26
US5808051A (en) 1998-09-15
ITMI952735A1 (it) 1997-06-22
AU724696B2 (en) 2000-09-28
NZ299964A (en) 1997-12-19
ITMI952735A0 (it) 1995-12-22
US5817803A (en) 1998-10-06
US6090957A (en) 2000-07-18

Similar Documents

Publication Publication Date Title
PT770615E (pt) Processo para a preparacao de di-haloazolopirimidinas
GB9605075D0 (en) Percarboxylic acid rinse method
PT739042E (pt) Processo de fabrico de um módulo solar
BR9505596A (pt) Processo de lavagem
DE69620107D1 (de) Kristallisationsverfahren
ITMI950056A0 (it) Processo per la produzione di 10-oxo-10,11-diidro-sh- -dibenz(b,f) azepin-5-carbossiammide
BR9606939A (pt) Processo de preparação de lactama
BR9601233A (pt) Processo de fabricação de dispositivos evidenciadores de transação
PT824517E (pt) Processo para a preparacao de cloridrato de lercanidipina
PT839138E (pt) Processo para a preparacao de 3-hidroxipirazois substituidos em n
GB9523387D0 (en) Production process
BR9602751A (pt) Processo de preparação de lactama
BR9606678A (pt) Processo de metalurgia
BR9603114A (pt) Processo de preparação de talharim
BR9602005A (pt) Processo de hidroxicarbonilação de butadieno
BR9602871A (pt) Processo de preparação de uma composição de catalisador
BR9602032A (pt) Processo de fabricação de 1,1-difluoroetano
IT1290477B1 (it) Processo per produrre un persale
PT871616E (pt) Processo de preparacao de drogas anti-malaria
BR9609891A (pt) Processo para a preparação de um molho
BR9600847A (pt) Processo para a mentilação de 2,2,6,6-Tetrametilpiperidin-4-Ona
BR9603223A (pt) Processo para a preparação de aminocarboniltriazolinonas substituídas
BR9600086A (pt) Processo para a produção de hidroxialcoxibenzofenonas
BR9611833A (pt) Processo para a preparação de dioxoazabiciclo-hexanos
BR9603738A (pt) Processo de produção

Legal Events

Date Code Title Description
0001 Granted