IT1277835B1 - Composti biciclici, loro preparazione ed uso in composizioni farmaceutiche - Google Patents

Composti biciclici, loro preparazione ed uso in composizioni farmaceutiche

Info

Publication number
IT1277835B1
IT1277835B1 IT95FI000044A ITFI950044A IT1277835B1 IT 1277835 B1 IT1277835 B1 IT 1277835B1 IT 95FI000044 A IT95FI000044 A IT 95FI000044A IT FI950044 A ITFI950044 A IT FI950044A IT 1277835 B1 IT1277835 B1 IT 1277835B1
Authority
IT
Italy
Prior art keywords
preparation
pharmaceutical compositions
bicycle compounds
bicycle
compounds
Prior art date
Application number
IT95FI000044A
Other languages
English (en)
Inventor
Federico Arcamone
Carlo Alberto Maggi
Laura Quartara
Danilo Giannotti
Original Assignee
Menarini Farma Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11351134&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IT1277835(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Menarini Farma Ind filed Critical Menarini Farma Ind
Priority to IT95FI000044A priority Critical patent/IT1277835B1/it
Publication of ITFI950044A0 publication Critical patent/ITFI950044A0/it
Priority to ARP960101616A priority patent/AR004476A1/es
Priority to IL11739596A priority patent/IL117395A/xx
Priority to HU9801835A priority patent/HU222051B1/hu
Priority to KR1019970706419A priority patent/KR100405009B1/ko
Priority to BR9607348A priority patent/BR9607348A/pt
Priority to DK96907421T priority patent/DK0815126T3/da
Priority to EE9700230A priority patent/EE03618B1/xx
Priority to PT96907421T priority patent/PT815126E/pt
Priority to SK1212-97A priority patent/SK281899B6/sk
Priority to PL96322105A priority patent/PL184147B1/pl
Priority to DE69611438T priority patent/DE69611438T2/de
Priority to RO97-01700A priority patent/RO118297B1/ro
Priority to CA002215372A priority patent/CA2215372C/en
Priority to AT96907421T priority patent/ATE198481T1/de
Priority to AU51059/96A priority patent/AU696528B2/en
Priority to CNB961937629A priority patent/CN1189477C/zh
Priority to GEAP19963873A priority patent/GEP20002271B/en
Priority to PCT/EP1996/001028 priority patent/WO1996028467A1/en
Priority to ES96907421T priority patent/ES2155187T3/es
Priority to MX9706927A priority patent/MX9706927A/es
Priority to JP52726796A priority patent/JP4618821B2/ja
Priority to UA97104990A priority patent/UA48962C2/uk
Priority to SI9630276T priority patent/SI0815126T1/xx
Priority to NZ303982A priority patent/NZ303982A/en
Priority to EP96907421A priority patent/EP0815126B1/en
Priority to CZ19972862A priority patent/CZ287372B6/cs
Priority to EA199700223A priority patent/EA000697B1/ru
Priority to ZA9601983A priority patent/ZA961983B/xx
Priority to TW085103008A priority patent/TW565572B/zh
Priority to HR960117A priority patent/HRP960117B1/xx
Publication of ITFI950044A1 publication Critical patent/ITFI950044A1/it
Priority to BG101849A priority patent/BG63208B1/bg
Priority to NO19974057A priority patent/NO319290B1/no
Priority to US08/929,215 priority patent/US6150325A/en
Publication of IT1277835B1 publication Critical patent/IT1277835B1/it
Application granted granted Critical
Priority to GR20010400526T priority patent/GR3035676T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IT95FI000044A 1995-03-13 1995-03-13 Composti biciclici, loro preparazione ed uso in composizioni farmaceutiche IT1277835B1 (it)

Priority Applications (35)

Application Number Priority Date Filing Date Title
IT95FI000044A IT1277835B1 (it) 1995-03-13 1995-03-13 Composti biciclici, loro preparazione ed uso in composizioni farmaceutiche
ARP960101616A AR004476A1 (es) 1995-03-13 1996-03-01 Compuestos biciclicos, su preparacion y su utilizacion en composiciones farmaceuticas
IL11739596A IL117395A (en) 1995-03-13 1996-03-07 Bicyclic compounds containing at least one hydrophilic group their preparation and use in pharmaceutical compositions as tachykinin antagonists
EA199700223A EA000697B1 (ru) 1995-03-13 1996-03-11 Бициклические антагонисты тахикининов, их получение и применение в фармацевтической композиции
GEAP19963873A GEP20002271B (en) 1995-03-13 1996-03-11 Bicyclic Tachykinins Antagonists, Pharmaceutical Composition on Its Basis and Their Use
MX9706927A MX9706927A (es) 1995-03-13 1996-03-11 Antagonistas biciclicos de taquicininas, preparacion de los mismos y su uso en composiciones farmaceuticas.
BR9607348A BR9607348A (pt) 1995-03-13 1996-03-11 Compostos biciclicos composições farmacéuticas e processos para o tratamento de artrite asma inflamações crescimento tumoral hipermotilidade gastrointestinal doença de huntigton neurite neuralgia hemicrania hipertens o incotinéncia urinária urticária sintomas de sindrome de carcinóide gripe e resfriado
DK96907421T DK0815126T3 (da) 1995-03-13 1996-03-11 Bicykliske tachykinin-antagonister, fremstilling deraf og deres anvendelse i farmaceutiske præparater
EE9700230A EE03618B1 (et) 1995-03-13 1996-03-11 Bitsüklilised tahhükiniini antagonistid, nende valmistamine ja kasutamine ravimsegus
PT96907421T PT815126E (pt) 1995-03-13 1996-03-11 Antagonistas biciclicos de taquiquininas preparacao destes e sua utilizacao cuma composicao farmaceutica
SK1212-97A SK281899B6 (sk) 1995-03-13 1996-03-11 Bicyklické peptidy, farmaceutický prostriedok s ich obsahom a ich použitie
PL96322105A PL184147B1 (pl) 1995-03-13 1996-03-11 Antagoniści bicyklicznych tachokinin i farmaceutyczna kompozycja zawierająca te związki
DE69611438T DE69611438T2 (de) 1995-03-13 1996-03-11 Bizyclische tachykinin-antagonisten, deren herstellung und deren verwendung in pharmazeutischen zusammmensetzungen
RO97-01700A RO118297B1 (ro) 1995-03-13 1996-03-11 Peptide biciclice si compozitie farmaceutica cu acestea
CA002215372A CA2215372C (en) 1995-03-13 1996-03-11 Bicyclic tachykinins antagonists, preparation thereof and their use in pharmaceutical composition
AT96907421T ATE198481T1 (de) 1995-03-13 1996-03-11 Bizyclische tachykinin-antagonisten, deren herstellung und deren verwendung in pharmazeutischen zusammmensetzungen
AU51059/96A AU696528B2 (en) 1995-03-13 1996-03-11 Bicyclic tachykinins antagonists, preparation thereof and their use in pharmaceutical composition
CNB961937629A CN1189477C (zh) 1995-03-13 1996-03-11 二环速激肽拮抗剂,其制备和在药物组合物中的应用
HU9801835A HU222051B1 (hu) 1995-03-13 1996-03-11 Biciklusos tachikinin antagonisták, eljárás előállításukra és alkalmazásuk
PCT/EP1996/001028 WO1996028467A1 (en) 1995-03-13 1996-03-11 Bicyclic tachykinins antagonists, preparation thereof and their use in pharmaceutical composition
ES96907421T ES2155187T3 (es) 1995-03-13 1996-03-11 Antagonistas biciclicos de taquicinas, preparacion de estos antagonistas y su utilizacion en compuestos farmaceuticos.
KR1019970706419A KR100405009B1 (ko) 1995-03-13 1996-03-11 바이싸이클릭타치키닌길항제,그의약제,및약제학적조성물로사용하는그의용도
JP52726796A JP4618821B2 (ja) 1995-03-13 1996-03-11 二環式タキキニン系アンタゴニスト、その製法及び製剤組成物中でのその使用法
UA97104990A UA48962C2 (uk) 1995-03-13 1996-03-11 Біциклічні антагоністи тахікінінів, фармацевтична композиція та спосіб лікування
SI9630276T SI0815126T1 (en) 1995-03-13 1996-03-11 Bicyclic tachykinins antagonists, preparation thereof and their use in pharmaceutical composition
NZ303982A NZ303982A (en) 1995-03-13 1996-03-11 Bicyclic peptide compounds and their use as tachykinin antagonists
EP96907421A EP0815126B1 (en) 1995-03-13 1996-03-11 Bicyclic tachykinins antagonists, preparation thereof and their use in pharmaceutical composition
CZ19972862A CZ287372B6 (en) 1995-03-13 1996-03-11 Bicyclic peptides, their use and pharmaceutical preparation containing thereof
ZA9601983A ZA961983B (en) 1995-03-13 1996-03-12 Bicyclic compounds, preparation thereof and use in pharmaceutical compositions.
TW085103008A TW565572B (en) 1995-03-13 1996-03-13 Bicyclic compounds, preparation thereof and use in pharmaceutical compositions
HR960117A HRP960117B1 (en) 1995-03-13 1996-03-13 Bicyclic compounds, their preparation and use in pharmaceutical preparations
BG101849A BG63208B1 (bg) 1995-03-13 1997-08-22 Бициклични тахикининови антагонисти, тяхното приготовляване и използуване в фармацевтични състави
NO19974057A NO319290B1 (no) 1995-03-13 1997-09-03 Bisykliske forbindelser, farmasoytiske sammensetninger som inneholder disse og anvendelse av forbindelsen til fremstillingen av et legemiddel.
US08/929,215 US6150325A (en) 1995-03-13 1997-09-09 Bicyclic tachykinins antagonists, preparation thereof and their use in pharmaceutical compositions
GR20010400526T GR3035676T3 (en) 1995-03-13 2001-03-30 Bicyclic tachykinins antagonists, preparation thereof and their use in pharmaceutical composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95FI000044A IT1277835B1 (it) 1995-03-13 1995-03-13 Composti biciclici, loro preparazione ed uso in composizioni farmaceutiche

Publications (3)

Publication Number Publication Date
ITFI950044A0 ITFI950044A0 (it) 1995-03-13
ITFI950044A1 ITFI950044A1 (it) 1996-09-13
IT1277835B1 true IT1277835B1 (it) 1997-11-12

Family

ID=11351134

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95FI000044A IT1277835B1 (it) 1995-03-13 1995-03-13 Composti biciclici, loro preparazione ed uso in composizioni farmaceutiche

Country Status (33)

Country Link
US (1) US6150325A (it)
EP (1) EP0815126B1 (it)
JP (1) JP4618821B2 (it)
KR (1) KR100405009B1 (it)
CN (1) CN1189477C (it)
AR (1) AR004476A1 (it)
AT (1) ATE198481T1 (it)
AU (1) AU696528B2 (it)
BG (1) BG63208B1 (it)
BR (1) BR9607348A (it)
CZ (1) CZ287372B6 (it)
DE (1) DE69611438T2 (it)
DK (1) DK0815126T3 (it)
EA (1) EA000697B1 (it)
EE (1) EE03618B1 (it)
ES (1) ES2155187T3 (it)
GE (1) GEP20002271B (it)
GR (1) GR3035676T3 (it)
HR (1) HRP960117B1 (it)
HU (1) HU222051B1 (it)
IL (1) IL117395A (it)
IT (1) IT1277835B1 (it)
MX (1) MX9706927A (it)
NO (1) NO319290B1 (it)
NZ (1) NZ303982A (it)
PL (1) PL184147B1 (it)
PT (1) PT815126E (it)
RO (1) RO118297B1 (it)
SK (1) SK281899B6 (it)
TW (1) TW565572B (it)
UA (1) UA48962C2 (it)
WO (1) WO1996028467A1 (it)
ZA (1) ZA961983B (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6017705A (en) * 1995-03-14 2000-01-25 Ludwig Institute For Cancer Research Isolated nucleic acid molecules which are members of the MAGE-B family and uses thereof
IT1291776B1 (it) * 1997-02-07 1999-01-21 Menarini Ricerche Spa Composti monociclici a quattro residui bifunzionali, aventi azione nk-2 antagonista
IT1304888B1 (it) * 1998-08-05 2001-04-05 Menarini Ricerche Spa Composti monociclici ad azione nk-2 antagonista e formulazioni che licontengono
ATE367811T1 (de) * 2000-06-12 2007-08-15 Univ Rochester Methode zur behandlung von hitzewallungen, durch verwendung eines tachikinin-rezeptor antagonisten
EP1297826A1 (en) * 2001-09-27 2003-04-02 Menarini Ricerche S.p.A. Nasal pharmaceutical compositions containing a NK-2 antagonist
ITFI20020239A1 (it) * 2002-12-06 2004-06-07 Menarini Ricerche Spa Processo per la preparazione di composti peptidici biciclici.
ITFI20040221A1 (it) * 2004-10-27 2005-01-27 Guidotti & C Spa Composizioni farmaceutiche a base di nk2 antagonisti per uso pediatrico
ITRM20120331A1 (it) 2012-07-12 2014-01-13 Guidotti & C Spa Labor Composizioni pediatriche orali liquide contenenti nepadutant.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1262902B (it) * 1992-04-15 1996-07-22 Menarini Farma Ind Composti triciclici antagonisti delle tachichinine, loro preparazione e loro uso in composizioni farmaceutiche.

Also Published As

Publication number Publication date
PL322105A1 (en) 1998-01-05
BG63208B1 (bg) 2001-06-29
AU5105996A (en) 1996-10-02
JPH11501643A (ja) 1999-02-09
EP0815126A1 (en) 1998-01-07
ES2155187T3 (es) 2001-05-01
GEP20002271B (en) 2000-10-25
DK0815126T3 (da) 2001-05-07
EP0815126B1 (en) 2001-01-03
BR9607348A (pt) 1997-12-30
EE03618B1 (et) 2002-02-15
UA48962C2 (uk) 2002-09-16
WO1996028467A1 (en) 1996-09-19
HUP9801835A2 (hu) 1999-01-28
NZ303982A (en) 1998-04-27
GR3035676T3 (en) 2001-06-29
KR100405009B1 (ko) 2004-05-20
PL184147B1 (pl) 2002-09-30
ITFI950044A1 (it) 1996-09-13
ITFI950044A0 (it) 1995-03-13
BG101849A (en) 1998-04-30
HRP960117B1 (en) 2001-06-30
SK281899B6 (sk) 2001-09-11
CN1189477C (zh) 2005-02-16
DE69611438T2 (de) 2001-06-13
AR004476A1 (es) 1998-12-16
ZA961983B (en) 1997-09-29
KR19980703011A (ko) 1998-09-05
EA199700223A1 (ru) 1998-04-30
SK121297A3 (en) 1998-02-04
HUP9801835A3 (en) 2000-05-29
ATE198481T1 (de) 2001-01-15
HRP960117A2 (en) 1997-08-31
US6150325A (en) 2000-11-21
EA000697B1 (ru) 2000-02-28
NO974057L (no) 1997-11-07
CZ287372B6 (en) 2000-11-15
MX9706927A (es) 1997-11-29
PT815126E (pt) 2001-06-29
NO974057D0 (no) 1997-09-03
IL117395A0 (en) 1996-07-23
CN1183786A (zh) 1998-06-03
RO118297B1 (ro) 2003-04-30
AU696528B2 (en) 1998-09-10
DE69611438D1 (de) 2001-02-08
CZ286297A3 (cs) 1998-02-18
HU222051B1 (hu) 2003-04-28
JP4618821B2 (ja) 2011-01-26
EE9700230A (et) 1998-04-15
TW565572B (en) 2003-12-11
NO319290B1 (no) 2005-07-11
IL117395A (en) 1999-12-31

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