IT1291892B1 - Uso del nerve growth factor nella conservazione di cornee in coltura, nella produzione di tessuti corneali e congiuntivali in vitro e nella - Google Patents

Uso del nerve growth factor nella conservazione di cornee in coltura, nella produzione di tessuti corneali e congiuntivali in vitro e nella

Info

Publication number
IT1291892B1
IT1291892B1 IT97RM000238A ITRM970238A IT1291892B1 IT 1291892 B1 IT1291892 B1 IT 1291892B1 IT 97RM000238 A IT97RM000238 A IT 97RM000238A IT RM970238 A ITRM970238 A IT RM970238A IT 1291892 B1 IT1291892 B1 IT 1291892B1
Authority
IT
Italy
Prior art keywords
corneal
production
vitro
culture
conjunctival
Prior art date
Application number
IT97RM000238A
Other languages
English (en)
Inventor
Alessandro Lambiase
Original Assignee
Alessandro Lambiase
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alessandro Lambiase filed Critical Alessandro Lambiase
Publication of ITRM970238A0 publication Critical patent/ITRM970238A0/it
Priority to IT97RM000238A priority Critical patent/IT1291892B1/it
Priority to JP54538598A priority patent/JP3973697B2/ja
Priority to DE69705643T priority patent/DE69705643T2/de
Priority to IL13247397A priority patent/IL132473A0/xx
Priority to US09/403,568 priority patent/US6537808B2/en
Priority to DK97946052T priority patent/DK0973872T3/da
Priority to PCT/IT1997/000292 priority patent/WO1998048002A1/en
Priority to CA002287780A priority patent/CA2287780C/en
Priority to EA199900968A priority patent/EA002986B1/ru
Priority to AT97946052T priority patent/ATE203054T1/de
Priority to PT97946052T priority patent/PT973872E/pt
Priority to EP97946052A priority patent/EP0973872B1/en
Priority to AU51350/98A priority patent/AU734801B2/en
Priority to ES97946052T priority patent/ES2162331T3/es
Publication of ITRM970238A1 publication Critical patent/ITRM970238A1/it
Application granted granted Critical
Publication of IT1291892B1 publication Critical patent/IT1291892B1/it
Priority to GR20010401725T priority patent/GR3036859T3/el
Priority to US10/337,853 priority patent/US7429483B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Materials For Medical Uses (AREA)
IT97RM000238A 1997-04-24 1997-04-24 Uso del nerve growth factor nella conservazione di cornee in coltura, nella produzione di tessuti corneali e congiuntivali in vitro e nella IT1291892B1 (it)

Priority Applications (16)

Application Number Priority Date Filing Date Title
IT97RM000238A IT1291892B1 (it) 1997-04-24 1997-04-24 Uso del nerve growth factor nella conservazione di cornee in coltura, nella produzione di tessuti corneali e congiuntivali in vitro e nella
EA199900968A EA002986B1 (ru) 1997-04-24 1997-11-21 Применение фактора роста нервов для хранения, продуцирования и лечения роговицы и конъюнктивы
PT97946052T PT973872E (pt) 1997-04-24 1997-11-21 Utilizacao de factor de crescimento de nervos para a armazenagem cultura ou tratamento da cornea
IL13247397A IL132473A0 (en) 1997-04-24 1997-11-21 Use of nerve growth factor for the storage culture or treatment of cornea
US09/403,568 US6537808B2 (en) 1997-04-24 1997-11-21 Use of nerve growth factor for the storage, culture or treatment of cornea
DK97946052T DK0973872T3 (da) 1997-04-24 1997-11-21 Anvendelse af nervevækstfaktor til opbevaring, dyrkning eller behandling af cornea
PCT/IT1997/000292 WO1998048002A1 (en) 1997-04-24 1997-11-21 Use of nerve growth factor for the storage, culture or treatment of cornea
CA002287780A CA2287780C (en) 1997-04-24 1997-11-21 Use of nerve growth factor for the storage, culture or treatment of cornea
JP54538598A JP3973697B2 (ja) 1997-04-24 1997-11-21 角膜の保存培養または治療のための神経成長因子の使用
AT97946052T ATE203054T1 (de) 1997-04-24 1997-11-21 Anwendungen des nervenwachstumfaktors zur aufbewahrung, kultivierung oder behandlung von cornea
DE69705643T DE69705643T2 (de) 1997-04-24 1997-11-21 Anwendungen des nervenwachstumfaktors zur aufbewahrung, kultivierung oder behandlung von cornea
EP97946052A EP0973872B1 (en) 1997-04-24 1997-11-21 Use of nerve growth factor for the storage, culture or treatment of cornea
AU51350/98A AU734801B2 (en) 1997-04-24 1997-11-21 Use of nerve growth factor for the storage, culture or treatment of cornea
ES97946052T ES2162331T3 (es) 1997-04-24 1997-11-21 Utilizacion del factor de crecimiento del tejido nervioso para conservacion, cultivo o tratamiento de la cornea.
GR20010401725T GR3036859T3 (en) 1997-04-24 2001-10-10 Use of nerve growth factor for the storage, culture or treatment of cornea
US10/337,853 US7429483B2 (en) 1997-04-24 2003-01-08 Use of nerve growth factor for the storage, culture or treatment of cornea

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97RM000238A IT1291892B1 (it) 1997-04-24 1997-04-24 Uso del nerve growth factor nella conservazione di cornee in coltura, nella produzione di tessuti corneali e congiuntivali in vitro e nella

Publications (3)

Publication Number Publication Date
ITRM970238A0 ITRM970238A0 (it) 1997-04-24
ITRM970238A1 ITRM970238A1 (it) 1998-10-24
IT1291892B1 true IT1291892B1 (it) 1999-01-21

Family

ID=11405005

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97RM000238A IT1291892B1 (it) 1997-04-24 1997-04-24 Uso del nerve growth factor nella conservazione di cornee in coltura, nella produzione di tessuti corneali e congiuntivali in vitro e nella

Country Status (15)

Country Link
US (2) US6537808B2 (it)
EP (1) EP0973872B1 (it)
JP (1) JP3973697B2 (it)
AT (1) ATE203054T1 (it)
AU (1) AU734801B2 (it)
CA (1) CA2287780C (it)
DE (1) DE69705643T2 (it)
DK (1) DK0973872T3 (it)
EA (1) EA002986B1 (it)
ES (1) ES2162331T3 (it)
GR (1) GR3036859T3 (it)
IL (1) IL132473A0 (it)
IT (1) IT1291892B1 (it)
PT (1) PT973872E (it)
WO (1) WO1998048002A1 (it)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6849612B2 (en) * 1993-01-21 2005-02-01 Isis Pharmaceuticals, Inc. Oligonucleotide modulation of cell adhesion
IT1305294B1 (it) * 1999-01-29 2001-05-04 Alessandro Lambiase Uso del nerve growth factor nella terapia di patologie a carico deitessuti intraoculari.
DE60139874D1 (de) * 2000-07-28 2009-10-22 Christopher J Murphy Medium für transplantat
FR2825273B1 (fr) * 2001-05-29 2006-11-24 Oreal Composition pour le traitement des signes cutanes du vieillissement
DE10313341A1 (de) * 2003-03-25 2004-10-14 Scil Proteins Gmbh Verwendung von proNGF, insbesondere zur Wundheilung der Cornea und der Haut
CN1950397B (zh) 2004-03-30 2012-05-16 Ns基因公司 生长因子NsG33的治疗用途
US20070218105A1 (en) * 2004-10-19 2007-09-20 Salomon Esquenazi Topical Treatment with NGF and DHA in Damaged Corneas
ITRM20050447A1 (it) * 2005-08-19 2007-02-20 Anabasis S R L Uso del nerve growth factor in collirio nella terapia di patologie del sistema nervoso centrale, quali la malattia di alzheimer e il morbo di parkinson.
RU2440801C1 (ru) * 2010-11-25 2012-01-27 Надежда Анатольевна Левченко Способ лечения глубоких стромальных кератитов
US9574171B2 (en) * 2010-12-02 2017-02-21 Technion Research & Development Foundation Ltd. Methods of generating corneal cells and cell populations comprising same
US9974646B2 (en) 2012-09-05 2018-05-22 University Of Miami Keratoprosthesis, and system and method of corneal repair using same
MA41906A (fr) * 2015-04-10 2018-02-13 Dompe Farm Spa Dispositif de distribution de gouttes oculaires
ITUA20162072A1 (it) 2016-06-30 2017-12-30 Platinum Corp Srl Dropper a volume controllato
CN107137698A (zh) * 2017-03-03 2017-09-08 北京大学第三医院 一种包含gdnf的用于治疗角膜上皮损伤的药物组合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959319A (en) 1985-08-01 1990-09-25 Skelnik Debra L Process of corneal enhancement
NZ226171A (en) * 1987-09-18 1990-06-26 Ethicon Inc Gel formulation containing polypeptide growth factor
DE3827477A1 (de) 1988-08-12 1990-02-22 Biotechnolog Forschung Gmbh Verfahren zur isolierung und zur alleinigen zuechtung von endothelialzellen der menschlichen hornhaut (hcec)
US5360611A (en) * 1988-10-03 1994-11-01 Alcon Laboratories, Inc. Pharmaceutical compositions and methods of treatment of the cornea following ultraviolet laser irradiation
AU8532691A (en) * 1990-08-01 1992-03-02 Chiron Ophthalmics Inc. Method for treating corneal endothelial wounds
US5641479A (en) * 1991-02-12 1997-06-24 Richardson-Vicks Inc. Cosmetic compositions comprising an imidazolium derivative and branched polyethylene glycol
US5272135A (en) 1991-03-01 1993-12-21 Chiron Ophthalmics, Inc. Method for the stabilization of methionine-containing polypeptides
IT1255657B (it) 1992-05-29 1995-11-09 Colture di tessuto di mucosa congiuntivale differenziata, procedimentoper la loro preparazione e supporti per il loro uso.
US5641749A (en) * 1995-11-29 1997-06-24 Amgen Inc. Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product
US6063757A (en) * 1995-11-29 2000-05-16 Urso; Richard G. Wound treatment method with nerve growth factor
IT1283911B1 (it) 1996-02-05 1998-05-07 Farmigea Spa Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo

Also Published As

Publication number Publication date
US20020037584A1 (en) 2002-03-28
JP2002507190A (ja) 2002-03-05
AU734801B2 (en) 2001-06-21
EP0973872B1 (en) 2001-07-11
ITRM970238A0 (it) 1997-04-24
ES2162331T3 (es) 2001-12-16
CA2287780C (en) 2010-01-05
JP3973697B2 (ja) 2007-09-12
ITRM970238A1 (it) 1998-10-24
IL132473A0 (en) 2001-03-19
CA2287780A1 (en) 1998-10-29
EP0973872A1 (en) 2000-01-26
ATE203054T1 (de) 2001-07-15
AU5135098A (en) 1998-11-13
GR3036859T3 (en) 2002-01-31
WO1998048002A1 (en) 1998-10-29
PT973872E (pt) 2002-01-30
US20030096413A1 (en) 2003-05-22
EA002986B1 (ru) 2002-12-26
US7429483B2 (en) 2008-09-30
DK0973872T3 (da) 2001-11-05
EA199900968A1 (ru) 2000-06-26
DE69705643T2 (de) 2002-05-29
US6537808B2 (en) 2003-03-25
DE69705643D1 (de) 2001-08-16

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