IT1293510B1 - Anticorpi monoclonali catalitici per la trasformazione in vivo di profarmaci di corticosteroidi - Google Patents

Anticorpi monoclonali catalitici per la trasformazione in vivo di profarmaci di corticosteroidi

Info

Publication number
IT1293510B1
IT1293510B1 IT97MI001825A ITMI971825A IT1293510B1 IT 1293510 B1 IT1293510 B1 IT 1293510B1 IT 97MI001825 A IT97MI001825 A IT 97MI001825A IT MI971825 A ITMI971825 A IT MI971825A IT 1293510 B1 IT1293510 B1 IT 1293510B1
Authority
IT
Italy
Prior art keywords
profarmaces
corticosteroid
catalytic antibodies
vivo transformation
monoclonal catalytic
Prior art date
Application number
IT97MI001825A
Other languages
English (en)
Inventor
Adriano Podesta
Silvia Trasciatti
Sergio Rosini
Original Assignee
Gentili Ist Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT97MI001825A priority Critical patent/IT1293510B1/it
Application filed by Gentili Ist Spa filed Critical Gentili Ist Spa
Priority to JP2000505278A priority patent/JP2001512006A/ja
Priority to PCT/EP1998/004682 priority patent/WO1999006536A1/en
Priority to EP98938707A priority patent/EP1003842A1/en
Priority to CN98808387A priority patent/CN1268174A/zh
Priority to AU87328/98A priority patent/AU736187B2/en
Priority to NZ502526A priority patent/NZ502526A/xx
Priority to CA002299623A priority patent/CA2299623A1/en
Publication of ITMI971825A1 publication Critical patent/ITMI971825A1/it
Application granted granted Critical
Publication of IT1293510B1 publication Critical patent/IT1293510B1/it
Priority to NO20000395A priority patent/NO20000395L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT97MI001825A 1997-07-30 1997-07-30 Anticorpi monoclonali catalitici per la trasformazione in vivo di profarmaci di corticosteroidi IT1293510B1 (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IT97MI001825A IT1293510B1 (it) 1997-07-30 1997-07-30 Anticorpi monoclonali catalitici per la trasformazione in vivo di profarmaci di corticosteroidi
PCT/EP1998/004682 WO1999006536A1 (en) 1997-07-30 1998-07-27 Catalytic monoclonal antibodies for the in vivo transformation of corticosteroid prodrugs
EP98938707A EP1003842A1 (en) 1997-07-30 1998-07-27 Catalytic monoclonal antibodies for the in vivo transformation of corticosteroid prodrugs
CN98808387A CN1268174A (zh) 1997-07-30 1998-07-27 用于体内转化皮质甾类前体药物的催化性单克隆抗体
JP2000505278A JP2001512006A (ja) 1997-07-30 1998-07-27 コルチコステロイドプロドラッグのｉｎｖｉｖｏでの変換用触媒性モノクローナル抗体
AU87328/98A AU736187B2 (en) 1997-07-30 1998-07-27 Catalytic monoclonal antibodies for the in vivo transformation of corticosteroid prodrugs
NZ502526A NZ502526A (en) 1997-07-30 1998-07-27 Catalytic monoclonal antibodies for the in vivo transformation of corticosteroid prodrugs
CA002299623A CA2299623A1 (en) 1997-07-30 1998-07-27 Catalytic monoclonal antibodies for the in vivo transformation of corticosteroid prodrugs
NO20000395A NO20000395L (no) 1997-07-30 2000-01-26 Katalytiske monoklonale antistoff for in vivo transformasjon av kortikosteroide prodroger

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI001825A IT1293510B1 (it) 1997-07-30 1997-07-30 Anticorpi monoclonali catalitici per la trasformazione in vivo di profarmaci di corticosteroidi

Publications (2)

Publication Number Publication Date
ITMI971825A1 ITMI971825A1 (it) 1999-01-30
IT1293510B1 true IT1293510B1 (it) 1999-03-01

Family

ID=11377677

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97MI001825A IT1293510B1 (it) 1997-07-30 1997-07-30 Anticorpi monoclonali catalitici per la trasformazione in vivo di profarmaci di corticosteroidi

Country Status (9)

Country Link
EP (1) EP1003842A1 (it)
JP (1) JP2001512006A (it)
CN (1) CN1268174A (it)
AU (1) AU736187B2 (it)
CA (1) CA2299623A1 (it)
IT (1) IT1293510B1 (it)
NO (1) NO20000395L (it)
NZ (1) NZ502526A (it)
WO (1) WO1999006536A1 (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2312348T3 (es) * 1999-06-16 2009-03-01 Boston Biomedical Research Institute Control inmunologico de niveles de beta-amiloide in vivo.
JO3076B1 (ar) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469689A (en) * 1983-03-30 1984-09-04 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
US4588718A (en) * 1984-03-28 1986-05-13 The Upjohn Company Carboxy containing ester prodrugs of corticosteroids
GB9510830D0 (en) * 1995-05-27 1995-07-19 Zeneca Ltd Proteins

Also Published As

Publication number Publication date
AU736187B2 (en) 2001-07-26
AU8732898A (en) 1999-02-22
EP1003842A1 (en) 2000-05-31
WO1999006536A1 (en) 1999-02-11
CN1268174A (zh) 2000-09-27
JP2001512006A (ja) 2001-08-21
NZ502526A (en) 2002-09-27
CA2299623A1 (en) 1999-02-11
ITMI971825A1 (it) 1999-01-30
NO20000395L (no) 2000-03-28
NO20000395D0 (no) 2000-01-26

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