IT1299583B1 - Uso di proteine hmg-i per la preparazione di medicamenti ad attivita' citotossica - Google Patents

Uso di proteine hmg-i per la preparazione di medicamenti ad attivita' citotossica

Info

Publication number
IT1299583B1
IT1299583B1 IT98MI001094A ITMI981094A IT1299583B1 IT 1299583 B1 IT1299583 B1 IT 1299583B1 IT 98MI001094 A IT98MI001094 A IT 98MI001094A IT MI981094 A ITMI981094 A IT MI981094A IT 1299583 B1 IT1299583 B1 IT 1299583B1
Authority
IT
Italy
Prior art keywords
hmg
protein
medications
preparation
cytotoxic activity
Prior art date
Application number
IT98MI001094A
Other languages
English (en)
Inventor
Alberto Bartorelli
Original Assignee
Vander Way Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT98MI001094A priority Critical patent/IT1299583B1/it
Application filed by Vander Way Limited filed Critical Vander Way Limited
Priority to PT99926330T priority patent/PT1079849E/pt
Priority to AU43631/99A priority patent/AU4363199A/en
Priority to DE69900756T priority patent/DE69900756T2/de
Priority to AT99926330T priority patent/ATE211391T1/de
Priority to PCT/EP1999/003431 priority patent/WO1999059609A2/en
Priority to ES99926330T priority patent/ES2171086T3/es
Priority to JP2000549273A priority patent/JP2002515445A/ja
Priority to DK99926330T priority patent/DK1079849T3/da
Priority to EP99926330A priority patent/EP1079849B1/en
Publication of ITMI981094A1 publication Critical patent/ITMI981094A1/it
Application granted granted Critical
Publication of IT1299583B1 publication Critical patent/IT1299583B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IT98MI001094A 1998-05-19 1998-05-19 Uso di proteine hmg-i per la preparazione di medicamenti ad attivita' citotossica IT1299583B1 (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IT98MI001094A IT1299583B1 (it) 1998-05-19 1998-05-19 Uso di proteine hmg-i per la preparazione di medicamenti ad attivita' citotossica
AU43631/99A AU4363199A (en) 1998-05-19 1999-05-19 Use of hmg proteins for the preparation of medicaments having cytotoxic activity
DE69900756T DE69900756T2 (de) 1998-05-19 1999-05-19 Verwendung von hmg proteinen zur herstellung von arzneimitteln mit zytotoxischer wirkung
AT99926330T ATE211391T1 (de) 1998-05-19 1999-05-19 Verwendung von hmg proteinen zur herstellung von arzneimitteln mit zytotoxischer wirkung
PT99926330T PT1079849E (pt) 1998-05-19 1999-05-19 Utilizacao de proteinas hmg para a preparacao de medicamentos com actividade citotoxica
PCT/EP1999/003431 WO1999059609A2 (en) 1998-05-19 1999-05-19 Use of hmg proteins for the preparation of medicaments having cytotoxic activity
ES99926330T ES2171086T3 (es) 1998-05-19 1999-05-19 Uso de proteinas hmg para la preparacion de medicamentos con actividad citotoxica.
JP2000549273A JP2002515445A (ja) 1998-05-19 1999-05-19 細胞毒性活性を有する医薬品調製のためのｈｍｇ蛋白質の使用
DK99926330T DK1079849T3 (da) 1998-05-19 1999-05-19 Anvendelse af HMG-proteiner til fremstilling af lægemidler med cytotoksisk virkning
EP99926330A EP1079849B1 (en) 1998-05-19 1999-05-19 Use of hmg proteins for the preparation of medicaments having cytotoxic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT98MI001094A IT1299583B1 (it) 1998-05-19 1998-05-19 Uso di proteine hmg-i per la preparazione di medicamenti ad attivita' citotossica

Publications (2)

Publication Number Publication Date
ITMI981094A1 ITMI981094A1 (it) 1999-11-19
IT1299583B1 true IT1299583B1 (it) 2000-03-16

Family

ID=11380053

Family Applications (1)

Application Number Title Priority Date Filing Date
IT98MI001094A IT1299583B1 (it) 1998-05-19 1998-05-19 Uso di proteine hmg-i per la preparazione di medicamenti ad attivita' citotossica

Country Status (10)

Country Link
EP (1) EP1079849B1 (it)
JP (1) JP2002515445A (it)
AT (1) ATE211391T1 (it)
AU (1) AU4363199A (it)
DE (1) DE69900756T2 (it)
DK (1) DK1079849T3 (it)
ES (1) ES2171086T3 (it)
IT (1) IT1299583B1 (it)
PT (1) PT1079849E (it)
WO (1) WO1999059609A2 (it)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303321B1 (en) 1999-02-11 2001-10-16 North Shore-Long Island Jewish Research Institute Methods for diagnosing sepsis
US7151082B2 (en) 1999-02-11 2006-12-19 The Feinstein Institute For Medical Research Antagonists of HMG1 for treating inflammatory conditions
EP1192963A4 (en) * 2000-04-05 2004-08-25 Toray Industries ADSORBENTS FOR PROTEINS OF THE HIGH MOBILITY PROTEIN AND PILLAR GROUP FOR CLEANING BODY LIQUIDS
US7220723B2 (en) 2001-05-15 2007-05-22 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
US7304034B2 (en) * 2001-05-15 2007-12-04 The Feinstein Institute For Medical Research Use of HMGB fragments as anti-inflammatory agents
ITMI20011986A1 (it) * 2001-09-25 2003-03-25 San Raffaele Centro Fond Metodo e composizione per l'attivazione di cellule presentanti l'antigene
DE50212280D1 (de) * 2001-12-19 2008-06-26 Alcedo Biotech Gmbh Verwendung von hmgb-proteinen und dafür codierenden nukleinsäuren
GB0226251D0 (en) * 2002-11-11 2002-12-18 San Raffaele Centro Fond Acetylated protein
US7696169B2 (en) 2003-06-06 2010-04-13 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
AU2004272607B2 (en) 2003-09-11 2008-11-06 Cornerstone Therapeutics Inc. Monoclonal antibodies against HMGB1
WO2007001422A2 (en) 2004-10-22 2007-01-04 Medimmune, Inc. High affinity antibodies against hmgb1 and methods of use thereof
US8129130B2 (en) 2004-10-22 2012-03-06 The Feinstein Institute For Medical Research High affinity antibodies against HMGB1 and methods of use thereof
WO2007076200A2 (en) 2005-11-28 2007-07-05 Medimmune, Inc. Antagonists of hmgb1 and/or rage and methods of use thereof
ES2643646T3 (es) 2010-01-21 2017-11-23 The Board Of Trustees Of The University Of Arkansas Vectores de vacuna y métodos para potenciar las respuestas inmunitarias
MX350306B (es) 2010-06-09 2017-09-04 Univ Arkansas Vacuna y metodos para reducir una infeccion por campylobacter.
AR094791A1 (es) 2013-02-14 2015-08-26 Univ Arkansas Composiciones y métodos para mejorar las respuestas inmunes ante una infección por eimeria o para limitar una infección por eimeria
AU2014239557B2 (en) 2013-03-15 2019-01-03 The Board Of Trustees Of The University Of Arkansas Compositions and methods of enhancing immune responses to enteric pathogens
KR102767638B1 (ko) 2016-05-03 2025-02-20 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 면역자극 및 항원 폴리펩티드를 포함하는 효모 백신 벡터, 및 그를 이용하는 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62166897A (ja) * 1986-01-20 1987-07-23 Toyo Soda Mfg Co Ltd 核内非ヒストン蛋白質に対するモノクロ−ナル抗体
EP0727487A1 (en) * 1995-02-17 1996-08-21 K.U. Leuven Research & Development Multiple-tumor aberrant growth genes
FR2739292B1 (fr) * 1995-09-28 1997-10-31 Rhone Poulenc Rorer Sa Composition pharmaceutique utile pour la transfection d'acides nucleiques et ses utilisations
JP3018313B2 (ja) * 1996-02-23 2000-03-13 雪印乳業株式会社 骨形成促進及び骨吸収防止剤

Also Published As

Publication number Publication date
JP2002515445A (ja) 2002-05-28
EP1079849A2 (en) 2001-03-07
WO1999059609A3 (en) 2000-01-27
WO1999059609A2 (en) 1999-11-25
ATE211391T1 (de) 2002-01-15
PT1079849E (pt) 2002-06-28
ES2171086T3 (es) 2002-08-16
DE69900756D1 (de) 2002-02-28
EP1079849B1 (en) 2002-01-02
AU4363199A (en) 1999-12-06
DK1079849T3 (da) 2002-04-22
ITMI981094A1 (it) 1999-11-19
DE69900756T2 (de) 2003-03-13

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