IT1303787B1 - "nanosfere lipidiche solide atte ad una rapida internalizzazione nellecellule" - Google Patents

"nanosfere lipidiche solide atte ad una rapida internalizzazione nellecellule"

Info

Publication number: IT1303787B1
Authority: IT; Italy
Prior art keywords: cells; solid lipid; acid; lipid nanospheres; tocopherol
Prior art date: 1998-11-25

Application number

IT1998MI002557A

Other languages

English (en)

Inventor

Maria Rosa Gasco

Original Assignee

Maria Rosa Gasco

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-25

Filing date

1998-11-25

Publication date

2001-02-23

1998-11-25 Priority to IT1998MI002557A priority Critical patent/IT1303787B1/it

1998-11-25 Application filed by Maria Rosa Gasco filed Critical Maria Rosa Gasco

1999-11-24 Priority to AT99959320T priority patent/ATE283039T1/de

1999-11-24 Priority to EP99959320A priority patent/EP1133286B1/en

1999-11-24 Priority to PCT/EP1999/009072 priority patent/WO2000030620A1/en

1999-11-24 Priority to CA002352149A priority patent/CA2352149C/en

1999-11-24 Priority to DE69922243T priority patent/DE69922243T2/de

1999-11-24 Priority to US09/856,266 priority patent/US6685960B1/en

1999-11-24 Priority to AU16542/00A priority patent/AU1654200A/en

1999-11-24 Priority to ES99959320T priority patent/ES2234322T3/es

2000-05-25 Publication of ITMI982557A1 publication Critical patent/ITMI982557A1/it

2001-02-23 Application granted granted Critical

2001-02-23 Publication of IT1303787B1 publication Critical patent/IT1303787B1/it

Links

239000002077 nanosphere Substances 0.000 title abstract 2
239000007787 solid Substances 0.000 title abstract 2
150000002632 lipids Chemical class 0.000 title 1
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 abstract 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 2
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 abstract 2
GZIFEOYASATJEH-VHFRWLAGSA-N δ-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-VHFRWLAGSA-N 0.000 abstract 2
GZIFEOYASATJEH-UHFFFAOYSA-N D-delta tocopherol Natural products OC1=CC(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-UHFFFAOYSA-N 0.000 abstract 1
KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 1
239000013543 active substance Substances 0.000 abstract 1
229940087168 alpha tocopherol Drugs 0.000 abstract 1
208000007502 anemia Diseases 0.000 abstract 1
KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 abstract 1
150000001735 carboxylic acids Chemical class 0.000 abstract 1
235000012000 cholesterol Nutrition 0.000 abstract 1
235000010389 delta-tocopherol Nutrition 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
230000007170 pathology Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
235000019260 propionic acid Nutrition 0.000 abstract 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
229960000984 tocofersolan Drugs 0.000 abstract 1
230000001173 tumoral effect Effects 0.000 abstract 1
239000002076 α-tocopherol Substances 0.000 abstract 1
235000004835 α-tocopherol Nutrition 0.000 abstract 1
239000002446 δ-tocopherol Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
- Y10S977/775—Nanosized powder or flake, e.g. nanosized catalyst
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/778—Nanostructure within specified host or matrix material, e.g. nanocomposite films
- Y10S977/783—Organic host/matrix, e.g. lipid
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/788—Of specified organic or carbon-based composition
- Y10S977/797—Lipid particle
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/788—Of specified organic or carbon-based composition
- Y10S977/797—Lipid particle
- Y10S977/798—Lipid particle having internalized material
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/788—Of specified organic or carbon-based composition
- Y10S977/797—Lipid particle
- Y10S977/798—Lipid particle having internalized material
- Y10S977/799—Containing biological material
- Y10S977/801—Drug
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/908—Mechanical repair performed/surgical
- Y10S977/912—Cancer cell repair
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Emergency Medicine (AREA)
Nanotechnology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Optics & Photonics (AREA)
Diabetes (AREA)
Hematology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

IT1998MI002557A 1998-11-25 1998-11-25 "nanosfere lipidiche solide atte ad una rapida internalizzazione nellecellule" IT1303787B1 (it)

Priority Applications (9)

Application Number	Priority Date	Filing Date	Title
IT1998MI002557A IT1303787B1 (it)	1998-11-25	1998-11-25	"nanosfere lipidiche solide atte ad una rapida internalizzazione nellecellule"
EP99959320A EP1133286B1 (en)	1998-11-25	1999-11-24	Solid lipidic nanospheres suitable to a fast internalization into cells
PCT/EP1999/009072 WO2000030620A1 (en)	1998-11-25	1999-11-24	Solid lipidic nanospheres suitable to a fast internalization into cells
CA002352149A CA2352149C (en)	1998-11-25	1999-11-24	Solid lipidic nanospheres suitable to a fast internalization into cells
AT99959320T ATE283039T1 (de)	1998-11-25	1999-11-24	Feste lipidnanosphären, die für eine schnelle einverleibung in zellen geeignet sind
DE69922243T DE69922243T2 (de)	1998-11-25	1999-11-24	Feste lipidnanosphären, die für eine schnelle einverleibung in zellen geeignet sind
US09/856,266 US6685960B1 (en)	1998-11-25	1999-11-24	Solid lipidic nanospheres suitable to a fast internalization into cells
AU16542/00A AU1654200A (en)	1998-11-25	1999-11-24	Solid lipidic nanospheres suitable to a fast internalization into cells
ES99959320T ES2234322T3 (es)	1998-11-25	1999-11-24	Nanoesferas solidas de lipidos apropiadas para su asimilacion rapida por las celulas.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT1998MI002557A IT1303787B1 (it)	1998-11-25	1998-11-25	"nanosfere lipidiche solide atte ad una rapida internalizzazione nellecellule"

Publications (2)

Publication Number	Publication Date
ITMI982557A1 ITMI982557A1 (it)	2000-05-25
IT1303787B1 true IT1303787B1 (it)	2001-02-23

Family

ID=11381135

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT1998MI002557A IT1303787B1 (it)	1998-11-25	1998-11-25	"nanosfere lipidiche solide atte ad una rapida internalizzazione nellecellule"

Country Status (9)

Country	Link
US (1)	US6685960B1 (it)
EP (1)	EP1133286B1 (it)
AT (1)	ATE283039T1 (it)
AU (1)	AU1654200A (it)
CA (1)	CA2352149C (it)
DE (1)	DE69922243T2 (it)
ES (1)	ES2234322T3 (it)
IT (1)	IT1303787B1 (it)
WO (1)	WO2000030620A1 (it)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
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US7153525B1 (en)	2000-03-22	2006-12-26	The University Of Kentucky Research Foundation	Microemulsions as precursors to solid nanoparticles
AU2002950713A0 (en)	2002-08-09	2002-09-12	Vital Health Sciences Pty Ltd	Carrier
US20060222694A1 (en) *	2003-06-27	2006-10-05	Oh Choon K	Stabilized topotecan liposomal composition and methods
US7611630B2 (en) *	2004-03-30	2009-11-03	Bend Research, Inc.	Method and device for evaluation of pharmaceutical compositions
ITMI20041151A1 (it) *	2004-06-09	2004-09-09	Maria Rosa Gasco	Nanoparticelle lipidiche come agenti veicolanti per acidi nucleici procedimento per la loro preparazione e loro uso
WO2006092024A1 (en) *	2005-03-03	2006-09-08	Vital Health Sciences Pty Ltd	Compounds having anti-cancer properties
ITMI20051024A1 (it) *	2005-06-01	2006-12-02	Maria Rosa Gasco	Nuovo uso di nanoparticelle lipidiche solide
MX2007015949A (es)	2005-06-17	2008-03-07	Vital Health Sciences Pty Ltd	Un vehiculo que comprende uno o mas derivados de fosfato de di- y/o mono-(agentes de transferencia de electrones) o complejos de los mismos.
US20100062073A1 (en) *	2006-11-29	2010-03-11	Ronald Arthur Beyerinck	Pharmaceutical compositions comprising nanoparticles comprising enteric polymers casein
EP1955695A1 (en) *	2007-02-06	2008-08-13	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Nanocapsules of lipophilic complexes of nucleic acids
US20100119612A1 (en) *	2007-04-17	2010-05-13	Bend Research, Inc	Nanoparticles comprising non-crystalline drug
US8309129B2 (en) *	2007-05-03	2012-11-13	Bend Research, Inc.	Nanoparticles comprising a drug, ethylcellulose, and a bile salt
WO2008135852A2 (en) *	2007-05-03	2008-11-13	Pfizer Products Inc.	Pharmaceutical compositions comprising nanoparticles and casein
US8703204B2 (en) *	2007-05-03	2014-04-22	Bend Research, Inc.	Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer
EP2162120B1 (en) *	2007-06-04	2016-05-04	Bend Research, Inc	Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
WO2008149230A2 (en)	2007-06-04	2008-12-11	Pfizer Products Inc.	Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate
EP2178518A2 (en) *	2007-07-13	2010-04-28	Bend Research, Inc	Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers
US20090061009A1 (en) *	2007-08-29	2009-03-05	Joseph Schwarz	Composition and Method of Treatment of Bacterial Infections
EP2240162A4 (en) *	2007-12-06	2013-10-09	Bend Res Inc	NANOTE PARTICLES WITH A NON-IONIZABLE POLYMER AND AN AMIN-FUNCTIONALIZED METHACRYLATE COPOLYMER
EP2231169B1 (en) *	2007-12-06	2016-05-04	Bend Research, Inc.	Pharmaceutical compositions comprising nanoparticles and a resuspending material
WO2010080754A2 (en) *	2009-01-06	2010-07-15	Pharmanova, Inc.	Nanoparticle pharmaceutical formulations
US10071030B2 (en)	2010-02-05	2018-09-11	Phosphagenics Limited	Carrier comprising non-neutralised tocopheryl phosphate
JP5806287B2 (ja)	2010-03-30	2015-11-10	フォスファジェニクスリミティド	経皮送達パッチ
WO2012059936A1 (en)	2010-11-03	2012-05-10	Padma Venkitachalam Devarajan	Pharmaceutical compositions for colloidal drug delivery
WO2012122586A1 (en)	2011-03-15	2012-09-20	Phosphagenics Limited	New composition
GB201215289D0 (en) *	2012-08-28	2012-10-10	Medical Res Council	Nanoparticle formulation
WO2014037498A2 (en)	2012-09-07	2014-03-13	Bracco Imaging Spa	Paramagnetic solid lipid nanoparticles (pslns) containing metal amphiphilic complexes for mri.
MX383940B (es)	2015-12-09	2025-03-14	Phosphagenics Ltd	Formulación farmacéutica que contiene tocol fosfato.
JP7198754B2 (ja)	2016-12-21	2023-01-04	アベーチョバイオテクノロジーリミテッド	方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4544545A (en) *	1983-06-20	1985-10-01	Trustees University Of Massachusetts	Liposomes containing modified cholesterol for organ targeting
US5250236A (en) *	1991-08-05	1993-10-05	Gasco Maria R	Method for producing solid lipid microspheres having a narrow size distribution
CA2091152C (en) *	1993-03-05	2005-05-03	Kirsten Westesen	Solid lipid particles, particles of bioactive agents and methods for the manfuacture and use thereof
IT1292142B1 (it) *	1997-06-12	1999-01-25	Maria Rosa Gasco	Composizione farmaceutica in forma di microparticelle lipidiche solide atte alla somministrazione parenterale

1998
- 1998-11-25 IT IT1998MI002557A patent/IT1303787B1/it active
1999
- 1999-11-24 US US09/856,266 patent/US6685960B1/en not_active Expired - Fee Related
- 1999-11-24 ES ES99959320T patent/ES2234322T3/es not_active Expired - Lifetime
- 1999-11-24 CA CA002352149A patent/CA2352149C/en not_active Expired - Fee Related
- 1999-11-24 AT AT99959320T patent/ATE283039T1/de not_active IP Right Cessation
- 1999-11-24 DE DE69922243T patent/DE69922243T2/de not_active Expired - Lifetime
- 1999-11-24 WO PCT/EP1999/009072 patent/WO2000030620A1/en not_active Ceased
- 1999-11-24 EP EP99959320A patent/EP1133286B1/en not_active Expired - Lifetime
- 1999-11-24 AU AU16542/00A patent/AU1654200A/en not_active Abandoned

Also Published As

Publication number	Publication date
ES2234322T3 (es)	2005-06-16
DE69922243D1 (de)	2004-12-30
AU1654200A (en)	2000-06-13
ATE283039T1 (de)	2004-12-15
CA2352149C (en)	2008-07-29
EP1133286A1 (en)	2001-09-19
ITMI982557A1 (it)	2000-05-25
DE69922243T2 (de)	2005-12-22
US6685960B1 (en)	2004-02-03
WO2000030620A1 (en)	2000-06-02
EP1133286B1 (en)	2004-11-24
CA2352149A1 (en)	2000-06-02

Publication	Publication Date	Title
AU1654200A (en)	2000-06-13	Solid lipidic nanospheres suitable to a fast internalization into cells
YU13602A (sh)	2006-01-16	Čvrste lipidne smeše
AU2707497A (en)	1997-11-19	Oral pharmaceutical compositions containing sex hormones
CA2344350A1 (en)	2000-03-30	4-carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
EP1226104A4 (en)	2005-05-04	PHENOXY CARBOXYLIC ACID COMPOUNDS AND COMPOSITIONS USED TO DIFFUSER ACTIVE AGENTS
WO2000009639A3 (en)	2002-09-19	Fatty ester combinations
WO2002094210A3 (de)	2004-10-21	Kosmetische mittel
BR9904162A (pt)	2000-09-12	4-carboxiamino-2-metil-1,2,3,4-tetra-hidroquinolinas aneladas
PT956013E (pt)	2003-08-29	Preparacao farmaceutica compreendendo acido eicosapentaenoico e/ou acido estearidonico
AU2845599A (en)	1999-09-20	Pharmaceutical compositions and their use
ES2178997T3 (es)	2003-01-16	Composicion, particularmente cosmetica, que comprende una sapogenina.
AU3843200A (en)	2000-11-10	Conjugated fatty acid esters
DE69825137D1 (de)	2004-08-26	Liposomale Erythropoietin-Dispersion
UY26303A1 (es)	2001-03-16	Composiciones farmacéuticas para administración oral y tópica
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