IT1392249B1 - Derivati di [(3-idrossi-4-piron-2-il)metil]-amina e loro uso come farmaci anti-neoplastici - Google Patents

Derivati di [(3-idrossi-4-piron-2-il)metil]-amina e loro uso come farmaci anti-neoplastici

Info

Publication number
IT1392249B1
IT1392249B1 ITTO2008A000888A ITTO20080888A IT1392249B1 IT 1392249 B1 IT1392249 B1 IT 1392249B1 IT TO2008A000888 A ITTO2008A000888 A IT TO2008A000888A IT TO20080888 A ITTO20080888 A IT TO20080888A IT 1392249 B1 IT1392249 B1 IT 1392249B1
Authority
IT
Italy
Prior art keywords
pyron
hydroxy
amine
derivatives
methyl
Prior art date
Application number
ITTO2008A000888A
Other languages
English (en)
Inventor
Vieri Fusi
Mirco Fanelli
Original Assignee
Univ Degli Studi Urbino
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Degli Studi Urbino filed Critical Univ Degli Studi Urbino
Priority to ITTO2008A000888A priority Critical patent/IT1392249B1/it
Priority to EP09799386A priority patent/EP2367809B1/en
Priority to PCT/IB2009/007579 priority patent/WO2010061282A1/en
Priority to US13/132,013 priority patent/US9145381B2/en
Publication of ITTO20080888A1 publication Critical patent/ITTO20080888A1/it
Application granted granted Critical
Publication of IT1392249B1 publication Critical patent/IT1392249B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/40—Oxygen atoms attached in positions 3 and 4, e.g. maltol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ITTO2008A000888A 2008-11-28 2008-11-28 Derivati di [(3-idrossi-4-piron-2-il)metil]-amina e loro uso come farmaci anti-neoplastici IT1392249B1 (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ITTO2008A000888A IT1392249B1 (it) 2008-11-28 2008-11-28 Derivati di [(3-idrossi-4-piron-2-il)metil]-amina e loro uso come farmaci anti-neoplastici
EP09799386A EP2367809B1 (en) 2008-11-28 2009-11-27 Derivatives of [(3-hydroxy-4 pyron-2-yl)methyl]-amine and use thereof as anti-neoplastic drugs
PCT/IB2009/007579 WO2010061282A1 (en) 2008-11-28 2009-11-27 Derivatives of [(3-hydroxy-4 pyron-2-yl)methyl]-amine and use thereof as anti-neoplastic drugs
US13/132,013 US9145381B2 (en) 2008-11-28 2009-11-27 Derivative of [(3-hydroxy-4-pyron-2-yl)-methyl]-amine and use thereof as anti-neoplastic drugs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITTO2008A000888A IT1392249B1 (it) 2008-11-28 2008-11-28 Derivati di [(3-idrossi-4-piron-2-il)metil]-amina e loro uso come farmaci anti-neoplastici

Publications (2)

Publication Number Publication Date
ITTO20080888A1 ITTO20080888A1 (it) 2010-05-29
IT1392249B1 true IT1392249B1 (it) 2012-02-22

Family

ID=41137407

Family Applications (1)

Application Number Title Priority Date Filing Date
ITTO2008A000888A IT1392249B1 (it) 2008-11-28 2008-11-28 Derivati di [(3-idrossi-4-piron-2-il)metil]-amina e loro uso come farmaci anti-neoplastici

Country Status (4)

Country Link
US (1) US9145381B2 (it)
EP (1) EP2367809B1 (it)
IT (1) IT1392249B1 (it)
WO (1) WO2010061282A1 (it)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8202248B2 (en) 2004-08-18 2012-06-19 Sequana Medical Ag Dialysis implant and methods of use
US8585635B2 (en) 2012-02-15 2013-11-19 Sequana Medical Ag Systems and methods for treating chronic liver failure based on peritoneal dialysis
CN104530057B (zh) * 2014-12-10 2017-06-06 北京工业大学 2,5,8,11‑四氮杂四星烷类化合物及其制备方法和应用
WO2017083434A1 (en) * 2015-11-09 2017-05-18 Forge Therapeutics, Inc. Pyrone based compounds for treating bacterial infections
EP3374350B1 (en) 2015-11-09 2022-01-05 Forge Therapeutics, Inc. Hydroxypyridinone and hydroxypyrimidinone based compounds for treating bacterial infections
ITUA20164811A1 (it) * 2016-06-30 2017-12-30 Univ Degli Studi Di Urbino Carlo Bo Composizione farmaceutica di derivati di [(3-idrossi-4-piron-2-il)metil]-amina e agenti demetilanti del dna e loro uso come farmaci anti-neoplastici
JP7071338B2 (ja) 2016-08-26 2022-05-18 セクアナ メディカル エヌブイ 埋め込み型装置によって生成されたデータを管理及び分析するためのシステム及び方法
US11021471B2 (en) 2017-05-10 2021-06-01 Forge Therapeutics, Inc. Antibacterial compounds
US10918778B2 (en) 2017-05-24 2021-02-16 Sequana Medical Nv Direct sodium removal method, solution and apparatus to reduce fluid overload in heart failure patients
US11559618B2 (en) 2017-05-24 2023-01-24 Sequana Medical Nv Formulations and methods for direct sodium removal in patients having severe renal dysfunction
CN111386276B (zh) * 2017-10-06 2023-06-23 盐野义制药株式会社 制备取代的多环吡啶酮衍生物的立体选择性方法
AU2019345150A1 (en) 2018-09-20 2021-05-13 Blacksmith Medicines, Inc. Antibacterial compounds
WO2021195260A1 (en) 2020-03-25 2021-09-30 Forge Therapeutics, Inc. Lpxc inhibitor and methods of making
TW202322818A (zh) 2021-09-28 2023-06-16 美商福吉醫療公司 Lpxc抑制劑及其用途

Also Published As

Publication number Publication date
WO2010061282A1 (en) 2010-06-03
EP2367809B1 (en) 2013-03-13
US20120035255A1 (en) 2012-02-09
ITTO20080888A1 (it) 2010-05-29
EP2367809A1 (en) 2011-09-28
US9145381B2 (en) 2015-09-29

Similar Documents

Publication Publication Date Title
IT1392249B1 (it) Derivati di [(3-idrossi-4-piron-2-il)metil]-amina e loro uso come farmaci anti-neoplastici
BRPI1012333A2 (pt) atropisômeros de derivados de 2-purinil-3-tolil-quinazolinonas e métodos de uso
HRP20161312T1 (hr) Postupak za pripravu farmaceutske formulacije kontrastnih sredstava
BRPI0909077A2 (pt) Artigos multicamadas e métodos de preparo e uso dos mesmos
BR112012003842A2 (pt) composição farmacêutica, método de formulação e uso da mesma
BRPI1011876A2 (pt) "composição farmacêutica estável e métodos de uso da mesma"
SMT201600258B (it) Composto indolico e suo uso farmaceutico
BR112012013148A2 (pt) formulação farmacêutica e uso
BRPI0916769A2 (pt) derivados de benzilbenzeno deuterados e métodos de uso
BR112012002331A2 (pt) composição antiviral, composição farmacêutica e uso de quantidade efetiva de composição farmacêutica
BRPI0917535A2 (pt) uso de insulina de ação ultra rápida
BRPI0821115A2 (pt) Composto derivado de aminotriazol, medicamento, composição farmacêutica e uso do composto
BR112013011448A2 (pt) composto, composição farnmacêutica, e, uso do composto
SMT201500097B (it) Derivati di 4-amminopirimidina e loro uso come antagonsiti del recettore di adenosina a2a
SMT201500316B (it) Derivati di benzotiazolo come agenti anticancro
BRPI0917579A2 (pt) composto, composição farmacêutica, métodos, e, uso de um composto
DOP2011000059A (es) Composiciones de antagonistas de pd-1 y metodos de uso
BRPI1010024A2 (pt) derivados de aminopirrolidinona e uso dos mesmos
BR112012006404A2 (pt) derivados de di-hidropteridinona, processo de preparação e uso farmacêutico dos mesmos
BR112012018329A2 (pt) agentes de coloração e métodos de uso destes
BRPI0915120A2 (pt) composto derivado de oxima, uso do referido composto e composição farmacêutica
SMT201400084B (it) Nuovi derivati di 6-(osso-1,6diiro-pirimidin-2-il)-ammide, loro preparazione e loro uso farmaceuticocome inibitori di fosforilazione di akt
BRPI0920355A2 (pt) composições farmacêuticas tópicas estáveis de ozenoxacina e uso de ozenoxacina
IL214406A0 (en) Derivatives of 6-(6-o-substituted-triazolopyridazine-sulfanyl) benzothiazoles and benzimidazoles, preparation thereof, use thereof as drugs, and use thereof as met inhibitors
HRP20171892T1 (hr) Makrociklički derivati indola korisni kao inhibitori virusa hepatitisa c