IT1397233B1 - Procedimento migliorativo per la sintesi del mono-acetil ganciclovir, intermedio chiave per la sintesi del valganciclovir. - Google Patents

Procedimento migliorativo per la sintesi del mono-acetil ganciclovir, intermedio chiave per la sintesi del valganciclovir.

Info

Publication number: IT1397233B1
Authority: IT; Italy
Prior art keywords: synthesis; acetil; valganciclovir; ganciclovir; mono
Prior art date: 2010-01-08

Application number

ITMI2010A000006A

Other languages

English (en)

Inventor

Emilio Vecchio

Claudio Fuganti

Original Assignee

Fidia Farmaceutici

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-01-08

Filing date

2010-01-08

Publication date

2013-01-04

2010-01-08 Application filed by Fidia Farmaceutici filed Critical Fidia Farmaceutici

2010-01-08 Priority to ITMI2010A000006A priority Critical patent/IT1397233B1/it

2011-07-09 Publication of ITMI20100006A1 publication Critical patent/ITMI20100006A1/it

2013-01-04 Application granted granted Critical

2013-01-04 Publication of IT1397233B1 publication Critical patent/IT1397233B1/it

Links

230000015572 biosynthetic process Effects 0.000 title 2
238000003786 synthesis reaction Methods 0.000 title 2
WPVFJKSGQUFQAP-GKAPJAKFSA-N Valcyte Chemical compound N1C(N)=NC(=O)C2=C1N(COC(CO)COC(=O)[C@@H](N)C(C)C)C=N2 WPVFJKSGQUFQAP-GKAPJAKFSA-N 0.000 title 1
229960002963 ganciclovir Drugs 0.000 title 1
IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 title 1
238000000034 method Methods 0.000 title 1
229960002149 valganciclovir Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ITMI2010A000006A 2010-01-08 2010-01-08 Procedimento migliorativo per la sintesi del mono-acetil ganciclovir, intermedio chiave per la sintesi del valganciclovir. IT1397233B1 (it)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
ITMI2010A000006A IT1397233B1 (it)	2010-01-08	2010-01-08	Procedimento migliorativo per la sintesi del mono-acetil ganciclovir, intermedio chiave per la sintesi del valganciclovir.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI2010A000006A IT1397233B1 (it)	2010-01-08	2010-01-08	Procedimento migliorativo per la sintesi del mono-acetil ganciclovir, intermedio chiave per la sintesi del valganciclovir.

Publications (2)

Publication Number	Publication Date
ITMI20100006A1 ITMI20100006A1 (it)	2011-07-09
IT1397233B1 true IT1397233B1 (it)	2013-01-04

Family

ID=42135919

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ITMI2010A000006A IT1397233B1 (it)	2010-01-08	2010-01-08	Procedimento migliorativo per la sintesi del mono-acetil ganciclovir, intermedio chiave per la sintesi del valganciclovir.

Country Status (1)

Country	Link
IT (1)	IT1397233B1 (it)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN108373471A (zh) *	2018-04-29	2018-08-07	安徽海康药业有限责任公司	一种高纯度单乙酰更昔洛韦的合成方法
CN108383840A (zh) *	2018-04-29	2018-08-10	安徽海康药业有限责任公司	一种制备高纯度单乙酰更昔洛韦的方法
CN108503642A (zh) *	2018-04-29	2018-09-07	安徽海康药业有限责任公司	一种高纯度单乙酰更昔洛韦的制备方法
CN108503641A (zh) *	2018-04-29	2018-09-07	安徽海康药业有限责任公司	一种合成高纯度单乙酰更昔洛韦的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5840890A (en) *	1996-01-26	1998-11-24	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative

2010
- 2010-01-08 IT ITMI2010A000006A patent/IT1397233B1/it active

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN108373471A (zh) *	2018-04-29	2018-08-07	安徽海康药业有限责任公司	一种高纯度单乙酰更昔洛韦的合成方法
CN108383840A (zh) *	2018-04-29	2018-08-10	安徽海康药业有限责任公司	一种制备高纯度单乙酰更昔洛韦的方法
CN108503642A (zh) *	2018-04-29	2018-09-07	安徽海康药业有限责任公司	一种高纯度单乙酰更昔洛韦的制备方法
CN108503641A (zh) *	2018-04-29	2018-09-07	安徽海康药业有限责任公司	一种合成高纯度单乙酰更昔洛韦的方法

Also Published As

Publication number	Publication date
ITMI20100006A1 (it)	2011-07-09

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