IT1399671B1 - Combinazione di inibitori del fattore hif-1 e agonisti del recettore tlr3 per la terapia di tumori solidi - Google Patents

Combinazione di inibitori del fattore hif-1 e agonisti del recettore tlr3 per la terapia di tumori solidi

Info

Publication number
IT1399671B1
IT1399671B1 ITRM2010A000185A ITRM20100185A IT1399671B1 IT 1399671 B1 IT1399671 B1 IT 1399671B1 IT RM2010A000185 A ITRM2010A000185 A IT RM2010A000185A IT RM20100185 A ITRM20100185 A IT RM20100185A IT 1399671 B1 IT1399671 B1 IT 1399671B1
Authority
IT
Italy
Prior art keywords
hif
combination
solid tumor
receptor agonists
tumor therapy
Prior art date
Application number
ITRM2010A000185A
Other languages
English (en)
Inventor
Antonio Filippini
Anna Riccioli
Alessio Paone
Elio Ziparo
Original Assignee
Univ Roma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Roma filed Critical Univ Roma
Priority to ITRM2010A000185A priority Critical patent/IT1399671B1/it
Priority to PCT/EP2011/056006 priority patent/WO2011128436A1/en
Priority to EP11715912.9A priority patent/EP2558096B1/en
Publication of ITRM20100185A1 publication Critical patent/ITRM20100185A1/it
Application granted granted Critical
Publication of IT1399671B1 publication Critical patent/IT1399671B1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ITRM2010A000185A 2010-04-16 2010-04-16 Combinazione di inibitori del fattore hif-1 e agonisti del recettore tlr3 per la terapia di tumori solidi IT1399671B1 (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ITRM2010A000185A IT1399671B1 (it) 2010-04-16 2010-04-16 Combinazione di inibitori del fattore hif-1 e agonisti del recettore tlr3 per la terapia di tumori solidi
PCT/EP2011/056006 WO2011128436A1 (en) 2010-04-16 2011-04-15 Combination of hypoxia-inducible factor-1 inhibitors and toll-like receptor-3 agonists for treating solid tumors
EP11715912.9A EP2558096B1 (en) 2010-04-16 2011-04-15 Combination of hypoxia-inducible factor-1 inhibitors and toll-like receptor-3 agonists for treating solid tumors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM2010A000185A IT1399671B1 (it) 2010-04-16 2010-04-16 Combinazione di inibitori del fattore hif-1 e agonisti del recettore tlr3 per la terapia di tumori solidi

Publications (2)

Publication Number Publication Date
ITRM20100185A1 ITRM20100185A1 (it) 2011-10-17
IT1399671B1 true IT1399671B1 (it) 2013-04-26

Family

ID=43016638

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM2010A000185A IT1399671B1 (it) 2010-04-16 2010-04-16 Combinazione di inibitori del fattore hif-1 e agonisti del recettore tlr3 per la terapia di tumori solidi

Country Status (3)

Country Link
EP (1) EP2558096B1 (it)
IT (1) IT1399671B1 (it)
WO (1) WO2011128436A1 (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110665007A (zh) * 2019-09-19 2020-01-10 邦世（苏州）生物医药科技有限公司 一种治疗癌症用组合药物及其用途
KR102563495B1 (ko) * 2022-08-19 2023-08-10 경북대학교 산학협력단 스테포게닌을 유효성분으로 포함하는 암 예방, 개선, 또는 치료용 조성물

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2262452A1 (en) * 2008-03-13 2010-12-22 Enbio Limited Surface modification of nitinol

Also Published As

Publication number Publication date
EP2558096A1 (en) 2013-02-20
EP2558096B1 (en) 2019-06-05
WO2011128436A1 (en) 2011-10-20
ITRM20100185A1 (it) 2011-10-17

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