IT1405012B1 - Composizioni di beclometasone dipropionato in microsfere gastroresistenti a rilascio modificato e processo per il loro ottenimento - Google Patents

Composizioni di beclometasone dipropionato in microsfere gastroresistenti a rilascio modificato e processo per il loro ottenimento

Info

Publication number
IT1405012B1
IT1405012B1 ITMI2010A001512A ITMI20101512A IT1405012B1 IT 1405012 B1 IT1405012 B1 IT 1405012B1 IT MI2010A001512 A ITMI2010A001512 A IT MI2010A001512A IT MI20101512 A ITMI20101512 A IT MI20101512A IT 1405012 B1 IT1405012 B1 IT 1405012B1
Authority
IT
Italy
Prior art keywords
dipropionionato
beclometasone
objection
compositions
modified release
Prior art date
Application number
ITMI2010A001512A
Other languages
English (en)
Inventor
Carla Labruzzo
Original Assignee
Sofar Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ITMI2010A001512A priority Critical patent/IT1405012B1/it
Application filed by Sofar Spa filed Critical Sofar Spa
Priority to PCT/IB2011/053430 priority patent/WO2012017385A2/en
Priority to PT15195081T priority patent/PT3009130T/pt
Priority to EP11754741.4A priority patent/EP2600852A2/en
Priority to CA2806519A priority patent/CA2806519C/en
Priority to EP15195081.3A priority patent/EP3009130B1/en
Priority to DK15195081.3T priority patent/DK3009130T3/en
Priority to US13/814,642 priority patent/US10028917B2/en
Priority to ES15195081T priority patent/ES2701264T3/es
Publication of ITMI20101512A1 publication Critical patent/ITMI20101512A1/it
Application granted granted Critical
Publication of IT1405012B1 publication Critical patent/IT1405012B1/it
Priority to HK16112003.2A priority patent/HK1223570B/en
Priority to CY181101257T priority patent/CY1120931T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ITMI2010A001512A 2010-08-06 2010-08-06 Composizioni di beclometasone dipropionato in microsfere gastroresistenti a rilascio modificato e processo per il loro ottenimento IT1405012B1 (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
ITMI2010A001512A IT1405012B1 (it) 2010-08-06 2010-08-06 Composizioni di beclometasone dipropionato in microsfere gastroresistenti a rilascio modificato e processo per il loro ottenimento
PT15195081T PT3009130T (pt) 2010-08-06 2011-08-02 Composições de dipropionato de beclometasona em micro-esferas gastrorresistentes de libertação modificada
EP11754741.4A EP2600852A2 (en) 2010-08-06 2011-08-02 Beclomethasone dipropionate compositions in modified-release gastro-resistant microspheres and process for obtaining them
CA2806519A CA2806519C (en) 2010-08-06 2011-08-02 Beclomethasone dipropionate compositions in modified-release gastro-resistant microspheres and process for obtaining them
PCT/IB2011/053430 WO2012017385A2 (en) 2010-08-06 2011-08-02 Beclomethasone dipropionate compositions in modified-release gastro-resistant microspheres and process for obtaining them
EP15195081.3A EP3009130B1 (en) 2010-08-06 2011-08-02 Beclomethasone dipropionate compositions in modified-release gastro-resistant microspheres
DK15195081.3T DK3009130T3 (en) 2010-08-06 2011-08-02 BECLOMETHASON-DIPROPIONATE COMPOSITIONS IN MODIFIED-RELEASED GASTROR-RESISTANT MICROBUGS
US13/814,642 US10028917B2 (en) 2010-08-06 2011-08-02 Beclomethasone dipropionate compositions in modified-release gastro-resistant microspheres and process for obtaining them
ES15195081T ES2701264T3 (es) 2010-08-06 2011-08-02 Composiciones de dipropionato de beclometasona en microesferas gastrorresistentes de liberación sostenida
HK16112003.2A HK1223570B (en) 2010-08-06 2016-10-18 Beclomethasone dipropionate compositions in modified-release gastro-resistant microspheres
CY181101257T CY1120931T1 (el) 2010-08-06 2018-11-27 Συνθεσεις διπροπιονικης βεκλομεθαζονης σε τροποποιημενης-απελευθερωσης γαστρο-ανθεκτικες μικροσφαιρες

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2010A001512A IT1405012B1 (it) 2010-08-06 2010-08-06 Composizioni di beclometasone dipropionato in microsfere gastroresistenti a rilascio modificato e processo per il loro ottenimento

Publications (2)

Publication Number Publication Date
ITMI20101512A1 ITMI20101512A1 (it) 2012-02-07
IT1405012B1 true IT1405012B1 (it) 2013-12-16

Family

ID=43707817

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI2010A001512A IT1405012B1 (it) 2010-08-06 2010-08-06 Composizioni di beclometasone dipropionato in microsfere gastroresistenti a rilascio modificato e processo per il loro ottenimento

Country Status (9)

Country Link
US (1) US10028917B2 (it)
EP (2) EP3009130B1 (it)
CA (1) CA2806519C (it)
CY (1) CY1120931T1 (it)
DK (1) DK3009130T3 (it)
ES (1) ES2701264T3 (it)
IT (1) IT1405012B1 (it)
PT (1) PT3009130T (it)
WO (1) WO2012017385A2 (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201202433D0 (en) 2012-02-13 2012-03-28 Diurnal Ltd Controlled drug release

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57500432A (it) * 1980-03-20 1982-03-11
IL92343A0 (en) * 1988-12-20 1990-07-26 Gist Brocades Nv Granulate for multiparticulate controlled release oral compositions,their preparation and oral pharmaceutical compositions containing them
JP3469926B2 (ja) * 1993-11-04 2003-11-25 太田製薬株式会社 大腸内放出型医薬製剤用粒状物
US5958458A (en) * 1994-06-15 1999-09-28 Dumex-Alpharma A/S Pharmaceutical multiple unit particulate formulation in the form of coated cores
KR19990077278A (ko) * 1996-01-16 1999-10-25 마이클 오코넬 약물의 하부 위장관으로의 국소적 전달
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
AU2002254205B2 (en) * 2001-03-15 2007-05-10 Enteron Pharmaceuticals, Inc. Method of treating inflammatory disorders of the gastrointestinal tract using topical active corticosteroids
US8238554B2 (en) 2004-07-22 2012-08-07 Sanyo Electric Co., Ltd. Method for transmission/reception of contents usage right information in encrypted form, and device thereof
US9149439B2 (en) 2005-03-21 2015-10-06 Sandoz Ag Multi-particulate, modified-release composition
US20080081070A1 (en) * 2006-09-15 2008-04-03 Auriga Laboratories, Inc. Pharmaceutical formulation with enhanced solubility for the delivery of corticosteroids

Also Published As

Publication number Publication date
EP2600852A2 (en) 2013-06-12
EP3009130A1 (en) 2016-04-20
EP3009130B1 (en) 2018-10-10
CY1120931T1 (el) 2019-12-11
CA2806519A1 (en) 2012-02-09
HK1223570A1 (en) 2017-08-04
US10028917B2 (en) 2018-07-24
ES2701264T3 (es) 2019-02-21
DK3009130T3 (en) 2018-12-17
WO2012017385A2 (en) 2012-02-09
PT3009130T (pt) 2018-12-14
WO2012017385A3 (en) 2012-04-19
CA2806519C (en) 2019-03-26
ITMI20101512A1 (it) 2012-02-07
US20130142880A1 (en) 2013-06-06

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