IT201700028184A1 - Composti e composizioni per il trattamento della fibrosi cistica - Google Patents
Composti e composizioni per il trattamento della fibrosi cisticaInfo
- Publication number
- IT201700028184A1 IT201700028184A1 IT102017000028184A IT201700028184A IT201700028184A1 IT 201700028184 A1 IT201700028184 A1 IT 201700028184A1 IT 102017000028184 A IT102017000028184 A IT 102017000028184A IT 201700028184 A IT201700028184 A IT 201700028184A IT 201700028184 A1 IT201700028184 A1 IT 201700028184A1
- Authority
- IT
- Italy
- Prior art keywords
- compositions
- compounds
- treatment
- cystic fibrosis
- cystic
- Prior art date
Links
- 201000003883 Cystic fibrosis Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102017000028184A IT201700028184A1 (it) | 2017-03-14 | 2017-03-14 | Composti e composizioni per il trattamento della fibrosi cistica |
| EP18712677.6A EP3596074B1 (en) | 2017-03-14 | 2018-03-14 | Heterocyclic derivatives for the treatment of cystic fibrosis |
| PCT/IB2018/051709 WO2018167690A1 (en) | 2017-03-14 | 2018-03-14 | Heterocyclic derivatives for the treatment of cystic fibrosis |
| ES18712677T ES2938642T3 (es) | 2017-03-14 | 2018-03-14 | Derivados heterocíclicos para el tratamiento de la fibrosis quística |
| CA3056355A CA3056355A1 (en) | 2017-03-14 | 2018-03-14 | Heterocyclic derivatives for the treatment of cystic fibrosis |
| US16/493,532 US10745407B2 (en) | 2017-03-14 | 2018-03-14 | Heterocyclic derivatives for the treatment of cystic fibrosis |
| US16/993,821 US10968225B2 (en) | 2017-03-14 | 2020-08-14 | Compounds and compositions for the treatment of cystic fibrosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102017000028184A IT201700028184A1 (it) | 2017-03-14 | 2017-03-14 | Composti e composizioni per il trattamento della fibrosi cistica |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IT201700028184A1 true IT201700028184A1 (it) | 2018-09-14 |
Family
ID=59381610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT102017000028184A IT201700028184A1 (it) | 2017-03-14 | 2017-03-14 | Composti e composizioni per il trattamento della fibrosi cistica |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10745407B2 (it) |
| EP (1) | EP3596074B1 (it) |
| CA (1) | CA3056355A1 (it) |
| ES (1) | ES2938642T3 (it) |
| IT (1) | IT201700028184A1 (it) |
| WO (1) | WO2018167690A1 (it) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10968225B2 (en) * | 2017-03-14 | 2021-04-06 | Fondazione Istituto Italiano Di Tecnologia | Compounds and compositions for the treatment of cystic fibrosis |
| CN112538082B (zh) * | 2019-09-20 | 2023-05-09 | 鲁南制药集团股份有限公司 | 作为btk抑制剂的吡唑并氧代二氮杂类化合物 |
| CN113264931B (zh) * | 2020-02-17 | 2022-06-07 | 成都先导药物开发股份有限公司 | 一种1,4,6,7-四氢-5H-吡唑并[4,3-c]吡啶衍生物的制备方法 |
| IT202100003794A1 (it) | 2021-02-18 | 2022-08-18 | Fondazione St Italiano Tecnologia | Metodo per la preparazione di derivati del pirazolo come modulatori della proteina cftr |
| US20240270743A1 (en) * | 2021-08-11 | 2024-08-15 | Landos Biopharma, Inc. | Tetrahydropyrazolopyridine-analog ligands of nlrx1 and uses thereof |
| WO2024054851A1 (en) | 2022-09-07 | 2024-03-14 | Sionna Therapeutics | Macrocyclic compounds, compositions and methods of using thereof |
| JP2025530153A (ja) | 2022-09-07 | 2025-09-11 | シオナ セラピューティクス インコーポレイテッド | 大環状化合物、組成物、及びそれらの使用方法 |
| WO2024054845A1 (en) | 2022-09-07 | 2024-03-14 | Sionna Therapeutics | Macrocycic compounds, compositions, and methods of using thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004080972A1 (en) * | 2003-03-12 | 2004-09-23 | Vertex Pharmaceuticals Incorporated | Pirazole modulators of atp-binding cassette transporters |
| WO2005075435A1 (en) * | 2004-01-30 | 2005-08-18 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
-
2017
- 2017-03-14 IT IT102017000028184A patent/IT201700028184A1/it unknown
-
2018
- 2018-03-14 WO PCT/IB2018/051709 patent/WO2018167690A1/en not_active Ceased
- 2018-03-14 US US16/493,532 patent/US10745407B2/en active Active
- 2018-03-14 CA CA3056355A patent/CA3056355A1/en active Pending
- 2018-03-14 EP EP18712677.6A patent/EP3596074B1/en active Active
- 2018-03-14 ES ES18712677T patent/ES2938642T3/es active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004080972A1 (en) * | 2003-03-12 | 2004-09-23 | Vertex Pharmaceuticals Incorporated | Pirazole modulators of atp-binding cassette transporters |
| WO2005075435A1 (en) * | 2004-01-30 | 2005-08-18 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
Non-Patent Citations (2)
| Title |
|---|
| BERTUZZI G ET AL: "Straightforward synthesis of a novel ring-fused pyrazole-lactam and in vitro cytotoxic activity on cancer cell lines", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 117, 5 April 2016 (2016-04-05), pages 1 - 7, XP029532810, ISSN: 0223-5234, DOI: 10.1016/J.EJMECH.2016.04.006 * |
| KE ZHENG ET AL: "Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives", JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, no. 23, 11 December 2014 (2014-12-11), pages 10013 - 10030, XP055397947, ISSN: 0022-2623, DOI: 10.1021/jm501256y * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3596074A1 (en) | 2020-01-22 |
| US20200002348A1 (en) | 2020-01-02 |
| US10745407B2 (en) | 2020-08-18 |
| EP3596074B1 (en) | 2022-12-14 |
| WO2018167690A1 (en) | 2018-09-20 |
| ES2938642T3 (es) | 2023-04-13 |
| CA3056355A1 (en) | 2018-09-20 |
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