IT201700083055A1 - “uso della proteina inibitore 2 della dissociazione di rho gdp come marcatore diagnostico e prognostico delle malattie infiammatorie intestinali” - Google Patents

“uso della proteina inibitore 2 della dissociazione di rho gdp come marcatore diagnostico e prognostico delle malattie infiammatorie intestinali”

Info

Publication number
IT201700083055A1
IT201700083055A1 IT102017000083055A IT201700083055A IT201700083055A1 IT 201700083055 A1 IT201700083055 A1 IT 201700083055A1 IT 102017000083055 A IT102017000083055 A IT 102017000083055A IT 201700083055 A IT201700083055 A IT 201700083055A IT 201700083055 A1 IT201700083055 A1 IT 201700083055A1
Authority
IT
Italy
Prior art keywords
dissociazione
diagnostic
inflammatory diseases
protein inhibitor
prognostic marker
Prior art date
Application number
IT102017000083055A
Other languages
English (en)
Inventor
Laura Stronati
Roberta Vitali
Salvatore Cucchiara
Original Assignee
Laura Stronati
Roberta Vitali
Salvatore Cucchiara
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laura Stronati, Roberta Vitali, Salvatore Cucchiara filed Critical Laura Stronati
Priority to IT102017000083055A priority Critical patent/IT201700083055A1/it
Priority to EP18750514.4A priority patent/EP3655781A1/en
Priority to US16/632,709 priority patent/US20200141949A1/en
Priority to PCT/IB2018/055326 priority patent/WO2019016719A1/en
Publication of IT201700083055A1 publication Critical patent/IT201700083055A1/it

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875Nucleoproteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G01N2001/2866Grinding or homogeneising
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/06Gastro-intestinal diseases
    • G01N2800/065Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/06Gastro-intestinal diseases
    • G01N2800/067Pancreatitis or colitis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IT102017000083055A 2017-07-20 2017-07-20 “uso della proteina inibitore 2 della dissociazione di rho gdp come marcatore diagnostico e prognostico delle malattie infiammatorie intestinali” IT201700083055A1 (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IT102017000083055A IT201700083055A1 (it) 2017-07-20 2017-07-20 “uso della proteina inibitore 2 della dissociazione di rho gdp come marcatore diagnostico e prognostico delle malattie infiammatorie intestinali”
EP18750514.4A EP3655781A1 (en) 2017-07-20 2018-07-18 Use of the rho gdp dissociation inhibitor 2 protein as a diagnostic and prognostic marker of intestinal inflammatory diseases
US16/632,709 US20200141949A1 (en) 2017-07-20 2018-07-18 Use of the rho gdp dissociation inhibitor 2 protein as a diagnostic and prognostic marker of intestinal inflammatory diseases
PCT/IB2018/055326 WO2019016719A1 (en) 2017-07-20 2018-07-18 USE OF RHO GDP DISSOCIATION INHIBITORY PROTEIN 2 AS A DIAGNOSTIC AND PROGNOSTIC MARKER FOR INFLAMMATORY BOWEL DISEASES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102017000083055A IT201700083055A1 (it) 2017-07-20 2017-07-20 “uso della proteina inibitore 2 della dissociazione di rho gdp come marcatore diagnostico e prognostico delle malattie infiammatorie intestinali”

Publications (1)

Publication Number Publication Date
IT201700083055A1 true IT201700083055A1 (it) 2019-01-20

Family

ID=60990955

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102017000083055A IT201700083055A1 (it) 2017-07-20 2017-07-20 “uso della proteina inibitore 2 della dissociazione di rho gdp come marcatore diagnostico e prognostico delle malattie infiammatorie intestinali”

Country Status (4)

Country Link
US (1) US20200141949A1 (it)
EP (1) EP3655781A1 (it)
IT (1) IT201700083055A1 (it)
WO (1) WO2019016719A1 (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7217351B2 (ja) * 2019-07-08 2023-02-02 富士フイルム株式会社 画像処理装置、内視鏡システム、及び画像処理装置の作動方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1865071A1 (en) * 2006-06-09 2007-12-12 Rheinische Friedrich-Wilhelms-Universität Bonn Method for early diagnosis of proliferative diabetic retinopathy
WO2007140508A1 (en) * 2006-06-09 2007-12-13 Proteome Systems Limited Diagnostic and prognostic marker of an acute pulmonary exacerbation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8642349B1 (en) 2006-08-11 2014-02-04 H. Lee Moffitt Cancer Center And Research Institute, Inc. Artificial neural network proteomic tumor classification
EP2391891A1 (en) 2009-01-27 2011-12-07 Proteogenix, Inc. Biomarkers for detection of neonatal sepsis in biological fluid
IT1406051B1 (it) 2010-08-05 2014-02-06 D M G Italia S R L Uso di hmgb1 come marcatore biologico di infiammazione intestinale umana, metodo non invasivo per la sua rilevazione in campioni fecali e kit relativo.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1865071A1 (en) * 2006-06-09 2007-12-12 Rheinische Friedrich-Wilhelms-Universität Bonn Method for early diagnosis of proliferative diabetic retinopathy
WO2007140508A1 (en) * 2006-06-09 2007-12-13 Proteome Systems Limited Diagnostic and prognostic marker of an acute pulmonary exacerbation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANNA SHKODA ET AL: "Differential Protein Expression Profile in the Intestinal Epithelium from Patients with Inflammatory Bowel Disease", JOURNAL OF PROTEOME RESEARCH., vol. 6, no. 3, 1 March 2007 (2007-03-01), US, pages 1114 - 1125, XP055466501, ISSN: 1535-3893, DOI: 10.1021/pr060433m *
JEAN-PIERRE SEGAIN ET AL: "Rho kinase blockade prevents inflammation via nuclear factor kappaB inhibition: Evidence in Crohn's disease and experimental colitis", vol. 124, no. 5, 1 May 2003 (2003-05-01), pages 1180 - 1187, XP002699002, ISSN: 0016-5085, Retrieved from the Internet <URL:http://www.sciencedirect.com/science/article/pii/S001650850300283X> DOI: 10.1016/S0016-5085(03)00283-X *
NOAH P. ZIMMERMAN ET AL: "Cyclic AMP dysregulates intestinal epithelial cell restitution through PKA and RhoA* :", INFLAMMATORY BOWEL DISEASES, vol. 18, no. 6, 1 June 2012 (2012-06-01), US, pages 1081 - 1091, XP055466516, ISSN: 1078-0998, DOI: 10.1002/ibd.21898 *

Also Published As

Publication number Publication date
EP3655781A1 (en) 2020-05-27
WO2019016719A1 (en) 2019-01-24
US20200141949A1 (en) 2020-05-07

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