IT201700105948A1 - Metodo e sistema microfluidico per il recupero di particelle - Google Patents

Metodo e sistema microfluidico per il recupero di particelle

Info

Publication number
IT201700105948A1
IT201700105948A1 IT102017000105948A IT201700105948A IT201700105948A1 IT 201700105948 A1 IT201700105948 A1 IT 201700105948A1 IT 102017000105948 A IT102017000105948 A IT 102017000105948A IT 201700105948 A IT201700105948 A IT 201700105948A IT 201700105948 A1 IT201700105948 A1 IT 201700105948A1
Authority
IT
Italy
Prior art keywords
recovery
particles
microfluid system
microfluid
Prior art date
Application number
IT102017000105948A
Other languages
English (en)
Inventor
Gianni Medoro
Alex Calanca
Original Assignee
Menarini Silicon Biosystems Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Silicon Biosystems Spa filed Critical Menarini Silicon Biosystems Spa
Priority to IT102017000105948A priority Critical patent/IT201700105948A1/it
Priority to SG11202001962WA priority patent/SG11202001962WA/en
Priority to EP18789477.9A priority patent/EP3684509B1/en
Priority to SI201830410T priority patent/SI3684509T1/sl
Priority to PL18789477T priority patent/PL3684509T3/pl
Priority to JP2020514690A priority patent/JP7220707B2/ja
Priority to US16/648,646 priority patent/US11292001B2/en
Priority to AU2018335606A priority patent/AU2018335606B2/en
Priority to IL273447A priority patent/IL273447B2/en
Priority to CN201880061817.6A priority patent/CN111132766A/zh
Priority to CN202110396603.8A priority patent/CN113058670B/zh
Priority to KR1020207010235A priority patent/KR102676275B1/ko
Priority to CA3074954A priority patent/CA3074954A1/en
Priority to DK18789477.9T priority patent/DK3684509T3/da
Priority to PT187894779T priority patent/PT3684509T/pt
Priority to HUE18789477A priority patent/HUE056185T2/hu
Priority to PCT/IB2018/057312 priority patent/WO2019058326A1/en
Priority to ES18789477T priority patent/ES2892315T3/es
Publication of IT201700105948A1 publication Critical patent/IT201700105948A1/it
Priority to SA520411575A priority patent/SA520411575B1/ar

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0424—Dielectrophoretic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0436—Moving fluids with specific forces or mechanical means specific forces vibrational forces acoustic forces, e.g. surface acoustic waves [SAW]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0442—Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
    • B01L2400/0451—Thermophoresis; Thermodiffusion; Soret-effect
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1028—Sorting particles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Extraction Or Liquid Replacement (AREA)
IT102017000105948A 2017-09-21 2017-09-21 Metodo e sistema microfluidico per il recupero di particelle IT201700105948A1 (it)

Priority Applications (19)

Application Number Priority Date Filing Date Title
IT102017000105948A IT201700105948A1 (it) 2017-09-21 2017-09-21 Metodo e sistema microfluidico per il recupero di particelle
CN201880061817.6A CN111132766A (zh) 2017-09-21 2018-09-21 用于回收颗粒的微流体系统和方法
CN202110396603.8A CN113058670B (zh) 2017-09-21 2018-09-21 用于回收颗粒的微流体系统和方法
SI201830410T SI3684509T1 (sl) 2017-09-21 2018-09-21 Mikrofluidični sistem in postopek za ponovno pridobivanje delcev
PL18789477T PL3684509T3 (pl) 2017-09-21 2018-09-21 Układ mikroprzepływowy oraz sposób odzyskiwania cząstek
JP2020514690A JP7220707B2 (ja) 2017-09-21 2018-09-21 粒子回収のためのマイクロ流体システムおよび方法
US16/648,646 US11292001B2 (en) 2017-09-21 2018-09-21 Microfluidic system and method for the recovery of particles
AU2018335606A AU2018335606B2 (en) 2017-09-21 2018-09-21 Microfluidic system and method for the recovery of particles
IL273447A IL273447B2 (en) 2017-09-21 2018-09-21 Microfluidic system and method for the recovery of particles
SG11202001962WA SG11202001962WA (en) 2017-09-21 2018-09-21 Microfluidic system and method for the recovery of particles
EP18789477.9A EP3684509B1 (en) 2017-09-21 2018-09-21 Microfluidic system and method for the recovery of particles
KR1020207010235A KR102676275B1 (ko) 2017-09-21 2018-09-21 입자 회수를 위한 미세유체 시스템 및 방법
CA3074954A CA3074954A1 (en) 2017-09-21 2018-09-21 Microfluidic system and method for the recovery of particles
DK18789477.9T DK3684509T3 (da) 2017-09-21 2018-09-21 Mikrofluidsystem og fremgangsmåde til genvinding af partikler
PT187894779T PT3684509T (pt) 2017-09-21 2018-09-21 Sistema e método microfluídico para a recuperação de partículas
HUE18789477A HUE056185T2 (hu) 2017-09-21 2018-09-21 Mikrofluidikai rendszer és eljárás részecskék visszanyerésére
PCT/IB2018/057312 WO2019058326A1 (en) 2017-09-21 2018-09-21 MICROFLUIDIC SYSTEM AND METHOD FOR RECOVERING PARTICLES
ES18789477T ES2892315T3 (es) 2017-09-21 2018-09-21 Sistema y método de microfluidos para la recuperación de partículas
SA520411575A SA520411575B1 (ar) 2017-09-21 2020-03-19 نظام موائع جزيئية وطريقة لاستعادة الجسيمات

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102017000105948A IT201700105948A1 (it) 2017-09-21 2017-09-21 Metodo e sistema microfluidico per il recupero di particelle

Publications (1)

Publication Number Publication Date
IT201700105948A1 true IT201700105948A1 (it) 2019-03-21

Family

ID=61024881

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102017000105948A IT201700105948A1 (it) 2017-09-21 2017-09-21 Metodo e sistema microfluidico per il recupero di particelle

Country Status (18)

Country Link
US (1) US11292001B2 (it)
EP (1) EP3684509B1 (it)
JP (1) JP7220707B2 (it)
KR (1) KR102676275B1 (it)
CN (2) CN113058670B (it)
AU (1) AU2018335606B2 (it)
CA (1) CA3074954A1 (it)
DK (1) DK3684509T3 (it)
ES (1) ES2892315T3 (it)
HU (1) HUE056185T2 (it)
IL (1) IL273447B2 (it)
IT (1) IT201700105948A1 (it)
PL (1) PL3684509T3 (it)
PT (1) PT3684509T (it)
SA (1) SA520411575B1 (it)
SG (1) SG11202001962WA (it)
SI (1) SI3684509T1 (it)
WO (1) WO2019058326A1 (it)

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US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
CA2935960C (en) 2014-01-08 2023-01-10 Bart Lipkens Acoustophoresis device with dual acoustophoretic chamber
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
WO2018183744A1 (en) 2017-03-29 2018-10-04 The Research Foundation For The State University Of New York Microfluidic device and methods
SG11202003907WA (en) 2017-12-14 2020-05-28 Flodesign Sonics Inc Acoustic transducer drive and controller

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US20100044232A1 (en) * 2007-04-05 2010-02-25 Adam Yuh Lin Particle-Based Microfluidic Device for Providing High Magnetic Field Gradients
US20120184010A1 (en) * 2009-03-17 2012-07-19 Silicon Biosystems S.P.A. Microfluidic Device for Isolation of Cells
US20150165346A1 (en) * 2013-12-16 2015-06-18 General Electric Company Systems for separation of particulates and associated methods and devices
US20150198517A1 (en) * 2012-07-27 2015-07-16 Auckland Uniservices Limited Method and System for Microfluidic Particle Orientation and/or Sorting
US20160016180A1 (en) * 2013-03-08 2016-01-21 Duke University Devices, systems, and methods for acoustically-enhanced magnetophoresis

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ITBO20050643A1 (it) 2005-10-24 2007-04-25 Si Bio S R L Metodo ed apparato per la manipolazione di particelle in soluzioni conduttive
CN100551550C (zh) * 2006-09-25 2009-10-21 瑞鼎科技股份有限公司 流体微粒分离装置
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US20100044232A1 (en) * 2007-04-05 2010-02-25 Adam Yuh Lin Particle-Based Microfluidic Device for Providing High Magnetic Field Gradients
US20120184010A1 (en) * 2009-03-17 2012-07-19 Silicon Biosystems S.P.A. Microfluidic Device for Isolation of Cells
US20150198517A1 (en) * 2012-07-27 2015-07-16 Auckland Uniservices Limited Method and System for Microfluidic Particle Orientation and/or Sorting
US20160016180A1 (en) * 2013-03-08 2016-01-21 Duke University Devices, systems, and methods for acoustically-enhanced magnetophoresis
US20150165346A1 (en) * 2013-12-16 2015-06-18 General Electric Company Systems for separation of particulates and associated methods and devices

Also Published As

Publication number Publication date
JP2020534141A (ja) 2020-11-26
JP7220707B2 (ja) 2023-02-10
US11292001B2 (en) 2022-04-05
CA3074954A1 (en) 2019-03-28
IL273447B2 (en) 2024-06-01
WO2019058326A1 (en) 2019-03-28
KR20200067842A (ko) 2020-06-12
DK3684509T3 (da) 2021-09-20
EP3684509A1 (en) 2020-07-29
CN113058670A (zh) 2021-07-02
SI3684509T1 (sl) 2021-12-31
SG11202001962WA (en) 2020-04-29
PL3684509T3 (pl) 2022-01-03
US20200276585A1 (en) 2020-09-03
SA520411575B1 (ar) 2023-10-22
CN111132766A (zh) 2020-05-08
AU2018335606B2 (en) 2023-06-08
PT3684509T (pt) 2021-09-21
HUE056185T2 (hu) 2022-01-28
KR102676275B1 (ko) 2024-06-19
AU2018335606A1 (en) 2020-04-30
IL273447B1 (en) 2024-02-01
EP3684509B1 (en) 2021-09-08
CN113058670B (zh) 2023-03-21
IL273447A (en) 2020-05-31
ES2892315T3 (es) 2022-02-03

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