IT201900004041A1 - Procedimento per la preparazione di un derivato del fulvestrant - Google Patents

Procedimento per la preparazione di un derivato del fulvestrant

Info

Publication number: IT201900004041A1
Authority: IT; Italy
Prior art keywords: preparation; fulvestrant; derivative; fulvestrant derivative
Prior art date: 2019-03-20

Application number

IT102019000004041A

Other languages

English (en)

Inventor

Mauro Gaboardi

Cristina Manfrotto

Giacomo Mario Di

Original Assignee

Farmabios Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2019-03-20

Filing date

2019-03-20

Publication date

2020-09-20

2019-03-20 Application filed by Farmabios Spa filed Critical Farmabios Spa

2019-03-20 Priority to IT102019000004041A priority Critical patent/IT201900004041A1/it

2020-03-11 Priority to IL285262A priority patent/IL285262B2/en

2020-03-11 Priority to PCT/EP2020/056463 priority patent/WO2020187658A1/en

2020-03-11 Priority to ES20708504T priority patent/ES2944707T3/es

2020-03-11 Priority to JP2021549727A priority patent/JP7668739B2/ja

2020-03-11 Priority to CN202080015029.0A priority patent/CN113439086B/zh

2020-03-11 Priority to US17/426,689 priority patent/US20220106352A1/en

2020-03-11 Priority to EP20708504.4A priority patent/EP3941926B1/en

2020-09-20 Publication of IT201900004041A1 publication Critical patent/IT201900004041A1/it

Links

VWUXBMIQPBEWFH-WCCTWKNTSA-N Fulvestrant Chemical class OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)CC2=C1 VWUXBMIQPBEWFH-WCCTWKNTSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IT102019000004041A 2019-03-20 2019-03-20 Procedimento per la preparazione di un derivato del fulvestrant IT201900004041A1 (it)

Priority Applications (8)

Application Number	Priority Date	Filing Date	Title
IT102019000004041A IT201900004041A1 (it)	2019-03-20	2019-03-20	Procedimento per la preparazione di un derivato del fulvestrant
IL285262A IL285262B2 (en)	2019-03-20	2020-03-11	Process for preparing fulvestrant-3-boronic acid
PCT/EP2020/056463 WO2020187658A1 (en)	2019-03-20	2020-03-11	Process for the preparation of fulvestrant 3-boronic acid
ES20708504T ES2944707T3 (es)	2019-03-20	2020-03-11	Proceso para la preparación de ácido 3-borónico de fulvestrant
JP2021549727A JP7668739B2 (ja)	2019-03-20	2020-03-11	フルベストラント誘導体の調製方法
CN202080015029.0A CN113439086B (zh)	2019-03-20	2020-03-11	用于制备氟维司群3-硼酸的方法
US17/426,689 US20220106352A1 (en)	2019-03-20	2020-03-11	Process for the preparation of fulvestrant 3-boronic acid
EP20708504.4A EP3941926B1 (en)	2019-03-20	2020-03-11	Process for the preparation of fulvestrant 3-boronic acid

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT102019000004041A IT201900004041A1 (it)	2019-03-20	2019-03-20	Procedimento per la preparazione di un derivato del fulvestrant

Publications (1)

Publication Number	Publication Date
IT201900004041A1 true IT201900004041A1 (it)	2020-09-20

Family

ID=67107971

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT102019000004041A IT201900004041A1 (it)	2019-03-20	2019-03-20	Procedimento per la preparazione di un derivato del fulvestrant

Country Status (8)

Country	Link
US (1)	US20220106352A1 (it)
EP (1)	EP3941926B1 (it)
JP (1)	JP7668739B2 (it)
CN (1)	CN113439086B (it)
ES (1)	ES2944707T3 (it)
IL (1)	IL285262B2 (it)
IT (1)	IT201900004041A1 (it)
WO (1)	WO2020187658A1 (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT202100008066A1 (it) *	2021-03-31	2022-10-01	Ind Chimica Srl	PROCESSO PER LA PREPARAZIONE DI ACIDO B-[(7α,17β)-17-IDROSSI-7-[9-[(4,4,5,5,5-PENTAFLUOROPENTIL)SULFINIL]NONIL]ESTRA-1,3,5(10)-TRIEN-3-IL]-BORONICO E INTERMEDI DEL PROCESSO
IT202100012062A1 (it) *	2021-05-11	2022-11-11	Ind Chimica Srl	PROCESSO PER LA PREPARAZIONE DI ACIDO B-[(7α,17β)-17-IDROSSI-7-[9-[(4,4,5,5,5-PENTAFLUOROPENTIL)SULFINIL]NONIL]ESTRA-1,3,5(10)-TRIEN-3-IL]-BORONICO E INTERMEDI DEL PROCESSO
CH720542B1 (it) *	2021-10-29	2025-09-15	Ind Chimica Srl	PROCESSO PER LA PREPARAZIONE DI ACIDO Beta-[(7alpha,17beta)-17-IDROSSI-7-[9-[(4,4,5,5,5-PENTAFLUOROPENTIL)SULFINIL]NONIL]ESTRA-1,3,5(10)-TRIEN-3-IL]-BORONICO E INTERMEDI DEL PROCESSO
FR3128712B1 (fr) *	2021-10-29	2024-10-25	Ind Chimica Srl	Procédé de préparation d'acide B-[(7α,17β)-17-hydroxy-7-[9-[(4,4,5,5,5-pentafluoro¬pentyl)sulfinyl]nonyl]œstra-1,3,5(10)-trién-3-yl]-boronique et intermédiaires dudit procédé
EP4444318A4 (en) *	2021-12-06	2026-01-28	Amneal Pharmaceuticals Llc	COMPOUNDS FOR CANCER TREATMENT

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2008065100A1 (en) *	2006-11-30	2008-06-05	Solvay Pharmaceuticals Gmbh	Substituted estratrien derivatives as 17beta hsd inhibitors
WO2016004166A1 (en)	2014-07-02	2016-01-07	Xavier University Of Louisiana	Boron-based prodrug strategy for increased bioavailability and lower-dosage requirements for drug molecules containing at least one phenol (or aromatic hydroxyl) group

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2017192991A1 (en) *	2016-05-06	2017-11-09	Xavier University Of Louisiana	Selective estrogen receptor down-regulators (serds)
CN107474095A (zh) *	2016-06-08	2017-12-15	重庆圣华曦药业股份有限公司	一种氟维司群有关物质e的制备方法

2019
- 2019-03-20 IT IT102019000004041A patent/IT201900004041A1/it unknown
2020
- 2020-03-11 ES ES20708504T patent/ES2944707T3/es active Active
- 2020-03-11 WO PCT/EP2020/056463 patent/WO2020187658A1/en not_active Ceased
- 2020-03-11 CN CN202080015029.0A patent/CN113439086B/zh active Active
- 2020-03-11 US US17/426,689 patent/US20220106352A1/en not_active Abandoned
- 2020-03-11 IL IL285262A patent/IL285262B2/en unknown
- 2020-03-11 EP EP20708504.4A patent/EP3941926B1/en active Active
- 2020-03-11 JP JP2021549727A patent/JP7668739B2/ja active Active

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2008065100A1 (en) *	2006-11-30	2008-06-05	Solvay Pharmaceuticals Gmbh	Substituted estratrien derivatives as 17beta hsd inhibitors
WO2016004166A1 (en)	2014-07-02	2016-01-07	Xavier University Of Louisiana	Boron-based prodrug strategy for increased bioavailability and lower-dosage requirements for drug molecules containing at least one phenol (or aromatic hydroxyl) group

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J. MED. CHEM., vol. 59, 2016, pages 8134 - 8140
JIAWANG LIU ET AL.: "Fulvestrant-3 boronic acid (ZB716) : An Orally bioavailable Selective Estrogen Receptor Downregulator(SERD)", J. MED. CHEM., vol. 59, 2016, pages 8134 - 8140, XP055439165, DOI: doi:10.1021/acs.jmedchem.6b00753
JIAWANG LIU ET AL: "Fulvestrant-3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD)", JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, no. 17, 29 August 2016 (2016-08-29), US, pages 8134 - 8140, XP055645152, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b00753 *

Also Published As

Publication number	Publication date
IL285262B2 (en)	2025-07-01
ES2944707T3 (es)	2023-06-23
IL285262B1 (en)	2025-03-01
CN113439086A (zh)	2021-09-24
CN113439086B (zh)	2024-03-01
EP3941926A1 (en)	2022-01-26
JP2022522670A (ja)	2022-04-20
JP7668739B2 (ja)	2025-04-25
IL285262A (en)	2021-09-30
WO2020187658A1 (en)	2020-09-24
EP3941926B1 (en)	2023-04-26
US20220106352A1 (en)	2022-04-07

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