IT7849984A0 - Procedimento per la preparazione di amiloride e di altri suoi derivati 6-sostituiti - Google Patents

Procedimento per la preparazione di amiloride e di altri suoi derivati 6-sostituiti

Info

Publication number
IT7849984A0
IT7849984A0 IT7849984A IT4998478A IT7849984A0 IT 7849984 A0 IT7849984 A0 IT 7849984A0 IT 7849984 A IT7849984 A IT 7849984A IT 4998478 A IT4998478 A IT 4998478A IT 7849984 A0 IT7849984 A0 IT 7849984A0
Authority
IT
Italy
Prior art keywords
amiloride
procedure
preparation
substituted derivatives
derivatives
Prior art date
Application number
IT7849984A
Other languages
English (en)
Other versions
IT1105454B (it
Original Assignee
Rahway New Jersey U S A Merck
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rahway New Jersey U S A Merck filed Critical Rahway New Jersey U S A Merck
Publication of IT7849984A0 publication Critical patent/IT7849984A0/it
Application granted granted Critical
Publication of IT1105454B publication Critical patent/IT1105454B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IT49984/78A 1977-06-29 1978-06-22 Procedimento per la preparazione di amiloride e di altri suoi derivati 6-sostituiti IT1105454B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/811,011 US4196292A (en) 1977-06-29 1977-06-29 6-Substituted amiloride derivatives

Publications (2)

Publication Number Publication Date
IT7849984A0 true IT7849984A0 (it) 1978-06-22
IT1105454B IT1105454B (it) 1985-11-04

Family

ID=25205286

Family Applications (1)

Application Number Title Priority Date Filing Date
IT49984/78A IT1105454B (it) 1977-06-29 1978-06-22 Procedimento per la preparazione di amiloride e di altri suoi derivati 6-sostituiti

Country Status (12)

Country Link
US (1) US4196292A (it)
EP (1) EP0000200B1 (it)
JP (1) JPS5412389A (it)
AT (1) AT362795B (it)
DE (1) DE2861684D1 (it)
DK (1) DK290278A (it)
ES (1) ES471244A1 (it)
FI (1) FI781966A7 (it)
HU (1) HU178302B (it)
IT (1) IT1105454B (it)
NO (1) NO782230L (it)
PL (1) PL119097B1 (it)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362724A (en) * 1980-05-19 1982-12-07 Merck & Co., Inc. Method of treating edema and hypertension and pharmaceutical composition therefor in which the active ingredient comprises a novel substituted pyrazinyl-1,2,4-oxadiazole and a kaliuretic diuretic
US4594349A (en) * 1982-01-04 1986-06-10 Beyer Jr Karl H Hyperuretic agents
US4952582A (en) * 1982-01-04 1990-08-28 Beyer Jr Karl H Pyrazinoylguanidine and derivatives thereof having few polar substituents and being useful as hyperuretic agents
WO1990009792A1 (en) * 1989-03-03 1990-09-07 The General Hospital Corporation Topical application of amiloride or analogues thereof for treatment of inflammation
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6858614B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
RU2671976C2 (ru) 2012-12-17 2018-11-08 Пэрион Сайенсиз, Инк. Соединения 3,5-диамино-6-хлор-n-(n-(4-фенилбутил)карбамимидоил)пиразин-2-карбоксамида
HUE032891T2 (hu) 2012-12-17 2017-11-28 Parion Sciences Inc Klórpirazin-karboxamid-származékok nem kielégítõ nyálkahártya-hidratáció által elõsegített megbetegedések kezelésére
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB286896A (en) * 1927-03-29 1928-03-15 Arthur William Howarth Improvements in smokers' pipes
US3305552A (en) * 1965-11-22 1967-02-21 Merck & Co Inc 3-aminopyrazinoic acids and process for their preparation
US3507865A (en) * 1967-04-27 1970-04-21 Merck & Co Inc 3-hydroxy- and 3-mercaptopyrazinamidoguanidines the corresponding ethers and thioethers and processes for their preparation
US3573306A (en) * 1969-03-05 1971-03-30 Merck & Co Inc Process for preparation of n-substituted 3,5-diamino-6-halopyrazinamides

Also Published As

Publication number Publication date
HU178302B (en) 1982-04-28
DK290278A (da) 1978-12-30
PL207947A1 (pl) 1979-10-22
PL119097B1 (en) 1981-11-30
ATA469078A (de) 1980-11-15
NO782230L (no) 1979-01-02
EP0000200A1 (en) 1979-01-10
DE2861684D1 (en) 1982-04-29
JPS5412389A (en) 1979-01-30
AT362795B (de) 1981-06-10
FI781966A7 (fi) 1978-12-30
ES471244A1 (es) 1979-10-01
US4196292A (en) 1980-04-01
EP0000200B1 (en) 1982-03-24
IT1105454B (it) 1985-11-04

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