IT7920671A0 - Processo per la separazione dei due isomeri ottici del moprololo e composizioni farmaceutiche dell'antipodo levogiro. - Google Patents

Processo per la separazione dei due isomeri ottici del moprololo e composizioni farmaceutiche dell'antipodo levogiro.

Info

Publication number
IT7920671A0
IT7920671A0 IT7920671A IT2067179A IT7920671A0 IT 7920671 A0 IT7920671 A0 IT 7920671A0 IT 7920671 A IT7920671 A IT 7920671A IT 2067179 A IT2067179 A IT 2067179A IT 7920671 A0 IT7920671 A0 IT 7920671A0
Authority
IT
Italy
Prior art keywords
moprolol
levorotary
antipode
separation
pharmaceutical compositions
Prior art date
Application number
IT7920671A
Other languages
English (en)
Other versions
IT1113029B (it
Inventor
Ferrari Giorgio
Vecchietti Vittorio
Original Assignee
Simes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Simes filed Critical Simes
Publication of IT7920671A0 publication Critical patent/IT7920671A0/it
Priority to IT20671/79A priority Critical patent/IT1113029B/it
Priority to GB7934830A priority patent/GB2069480B/en
Priority to FR7927361A priority patent/FR2450246B1/fr
Priority to EP80100750A priority patent/EP0015418B1/en
Priority to DE8080100750T priority patent/DE3060670D1/de
Priority to AT80100750T priority patent/ATE1351T1/de
Priority to CA000346412A priority patent/CA1142548A/en
Priority to IL59492A priority patent/IL59492A0/xx
Priority to ES489027A priority patent/ES489027A0/es
Priority to HU80477A priority patent/HU179631B/hu
Priority to JP55024201A priority patent/JPS5917103B2/ja
Priority to GR61323A priority patent/GR67267B/el
Priority to US06/434,362 priority patent/US4683245A/en
Priority to GB08234538A priority patent/GB2119366B/en
Application granted granted Critical
Publication of IT1113029B publication Critical patent/IT1113029B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT20671/79A 1979-03-01 1979-03-01 Processo per la separazione dei due isomeri ottici del moprololo e composizioni farmaceutiche dell'antipodo levogiro IT1113029B (it)

Priority Applications (14)

Application Number Priority Date Filing Date Title
IT20671/79A IT1113029B (it) 1979-03-01 1979-03-01 Processo per la separazione dei due isomeri ottici del moprololo e composizioni farmaceutiche dell'antipodo levogiro
GB7934830A GB2069480B (en) 1979-03-01 1979-10-08 Process for the separation of the two optical isomers of moprolol and pharmaceutical compositions of the levorotatory antipode thereof
FR7927361A FR2450246B1 (fr) 1979-03-01 1979-11-06 Procede de separation des isomeres optiques du 1-(o-methoxy-phenoxy)-3-isopropyl-amino-propane-2-ol et compositions pharmaceutiques contenant l'antipode levogyre, utile notamment comme agent b-bloquant
EP80100750A EP0015418B1 (en) 1979-03-01 1980-02-14 Process for the separation of the two optical isomers of 1-(o-methoxyphenoxy)-3-isopropylamino-propan-2-ol, optical isomers obtained thereby and pharmaceutical compositions of the levorotatory antipode thereof
DE8080100750T DE3060670D1 (en) 1979-03-01 1980-02-14 Process for the separation of the two optical isomers of 1-(o-methoxyphenoxy)-3-isopropylamino-propan-2-ol, optical isomers obtained thereby and pharmaceutical compositions of the levorotatory antipode thereof
AT80100750T ATE1351T1 (de) 1979-03-01 1980-02-14 Verfahren zur trennung der zwei optischen isomere des 1-(o-methoxyphenoxy)-3-isopropylamino-propan3-ols, erhaltene optische isomere und pharmazeutische zusammensetzungen, die das linksdrehende isomer enthalten.
CA000346412A CA1142548A (en) 1979-03-01 1980-02-26 Process for the separation of the two optical isomers of moprolol and pharmaceutical compositions of the levorotatory antipode thereof
IL59492A IL59492A0 (en) 1979-03-01 1980-02-28 Process for the separation of the two optical isomers of moprolol and pharmaceutical compositions of the levorotatory antipode thereof
ES489027A ES489027A0 (es) 1979-03-01 1980-02-28 Procedimiento para la separacion de los dos isomeros opticos del moprolol
HU80477A HU179631B (en) 1979-03-01 1980-02-29 Process for resolving two optically active isomeres of 1-bracket-o-methoxy-phenoxy-bracket closed-3-isopropyl-amino-propan-2-ol
JP55024201A JPS5917103B2 (ja) 1979-03-01 1980-02-29 モプロロ−ルの光学分割法
GR61323A GR67267B (it) 1979-03-01 1980-03-01
US06/434,362 US4683245A (en) 1979-03-01 1982-10-14 Laevorotatory antipode of moprolol as an antihypertensive
GB08234538A GB2119366B (en) 1979-03-01 1982-12-03 The levorotatory isomer of moprolol and pharmaceutical compositions thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20671/79A IT1113029B (it) 1979-03-01 1979-03-01 Processo per la separazione dei due isomeri ottici del moprololo e composizioni farmaceutiche dell'antipodo levogiro

Publications (2)

Publication Number Publication Date
IT7920671A0 true IT7920671A0 (it) 1979-03-01
IT1113029B IT1113029B (it) 1986-01-20

Family

ID=11170328

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20671/79A IT1113029B (it) 1979-03-01 1979-03-01 Processo per la separazione dei due isomeri ottici del moprololo e composizioni farmaceutiche dell'antipodo levogiro

Country Status (13)

Country Link
US (1) US4683245A (it)
EP (1) EP0015418B1 (it)
JP (1) JPS5917103B2 (it)
AT (1) ATE1351T1 (it)
CA (1) CA1142548A (it)
DE (1) DE3060670D1 (it)
ES (1) ES489027A0 (it)
FR (1) FR2450246B1 (it)
GB (1) GB2069480B (it)
GR (1) GR67267B (it)
HU (1) HU179631B (it)
IL (1) IL59492A0 (it)
IT (1) IT1113029B (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR75395B (it) * 1980-11-14 1984-07-13 Lilly Co Eli
JPS5931693A (ja) * 1982-08-13 1984-02-20 Kanegafuchi Chem Ind Co Ltd 光学活性オキサゾリジノン誘導体の製造方法
US4463176A (en) * 1982-09-13 1984-07-31 Mead Johnson & Company Process for resolution of optical isomers
IT1163107B (it) * 1983-02-15 1987-04-08 Simes Composizioni farmaceutiche e loro uso nel trattamento del glaucoma
AT380232B (de) * 1984-03-27 1986-04-25 Chemie Linz Ag Verfahren zur herstellung von neuen s(-)-3-(3-acetyl-4-(3-tert. butylamino-2hydroxypropoxy)-phenyl)-1,1-diaethylharnstoff und dessen pharmazeutisch vertraeglichen saeureadditionssalzen
US5089616A (en) * 1991-04-23 1992-02-18 Warner-Lambert Company Process for the preparation of [1S-(1R*,2S*,3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl-N-[(1-cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide
US5942527A (en) * 1997-08-27 1999-08-24 K & K Biosciences, Inc. Hydrazones, hydrazines, semicarbazones and thiosemicarbazones derived from pyridyl ketones as anticonvulsant drugs and excitatory amino acid antagonists
ITMI20040145A1 (it) * 2004-01-30 2004-04-30 Acraf L-moprololo lpiu' tartrato
CN116573981B (zh) * 2023-04-21 2025-05-06 中南大学 一种β受体阻滞剂类外消旋体药物的拆分方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1128052A (en) * 1965-06-08 1968-09-25 Ici Ltd Alkanolamine derivatives
NL301580A (it) * 1962-12-11
GB1069343A (en) * 1963-09-10 1967-05-17 Ici Ltd Propanolamine derivatives
US3483221A (en) * 1964-09-10 1969-12-09 Ciba Geigy Corp 1 - (isopropylamino)-2-hydroxy-3-(alkenyloxyphenoxy) - propanes and the salts thereof
BE755071A (fr) * 1969-09-17 1971-02-22 Warner Lambert Pharmaceutical Procede de resolution de la dl-5-/3-(terbutylamino)-2- hydroxy-propoxy/-3,4-dihydro-1(2h) naphtalenone
ZA742728B (en) * 1973-05-08 1975-04-30 Simes Pharmaceutical composition for the treatment of coronaric ailments
GB1535435A (en) * 1975-12-11 1978-12-13 Tanabe Seiyaku Co Benzyl alcohol derivatives

Also Published As

Publication number Publication date
JPS5917103B2 (ja) 1984-04-19
EP0015418B1 (en) 1982-07-21
IL59492A0 (en) 1980-05-30
ATE1351T1 (de) 1982-08-15
DE3060670D1 (en) 1982-09-09
GB2069480A (en) 1981-08-26
HU179631B (en) 1982-11-29
FR2450246A1 (fr) 1980-09-26
FR2450246B1 (fr) 1983-10-07
JPS55149233A (en) 1980-11-20
US4683245A (en) 1987-07-28
EP0015418A1 (en) 1980-09-17
IT1113029B (it) 1986-01-20
GB2069480B (en) 1983-11-02
ES8100237A1 (es) 1980-11-01
ES489027A0 (es) 1980-11-01
CA1142548A (en) 1983-03-08
GR67267B (it) 1981-06-26

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Legal Events

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ITCP Complementary protection certificate

Free format text: CCP 322

TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970225