IT8019210A0 - Procedimento di sintesi della vindesina. - Google Patents

Procedimento di sintesi della vindesina.

Info

Publication number: IT8019210A0
Authority: IT; Italy
Prior art keywords: vindesine; synthesis procedure; synthesis; procedure; vindesine synthesis
Prior art date: 1979-01-15

Application number

IT8019210A

Other languages

English (en)

Other versions

IT1140506B (it

Inventor

Thompson Gerald Lee

Paschal Gloria Crosland

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-01-15

Filing date

1980-01-14

Publication date

1980-01-14

1980-01-14 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1980-01-14 Publication of IT8019210A0 publication Critical patent/IT8019210A0/it

1986-10-01 Application granted granted Critical

1986-10-01 Publication of IT1140506B publication Critical patent/IT1140506B/it

Links

NDMPLJNOPCLANR-UHFFFAOYSA-N 3,4-dihydroxy-15-(4-hydroxy-18-methoxycarbonyl-5,18-seco-ibogamin-18-yl)-16-methoxy-1-methyl-6,7-didehydro-aspidospermidine-3-carboxylic acid methyl ester Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 NDMPLJNOPCLANR-UHFFFAOYSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 title 1
229960004355 vindesine Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Steroid Compounds (AREA)
Saccharide Compounds (AREA)

IT19210/80A 1979-01-15 1980-01-14 Procedimento di sintesi della vindesina IT1140506B (it)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/003,442 US4210584A (en)	1979-01-15	1979-01-15	Vindesine synthesis

Publications (2)

Publication Number	Publication Date
IT8019210A0 true IT8019210A0 (it)	1980-01-14
IT1140506B IT1140506B (it)	1986-10-01

Family

ID=21705894

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT19210/80A IT1140506B (it)	1979-01-15	1980-01-14	Procedimento di sintesi della vindesina

Country Status (34)

Country	Link
US (1)	US4210584A (it)
EP (1)	EP0014053B1 (it)
JP (1)	JPS5598195A (it)
KR (1)	KR830002840B1 (it)
AR (1)	AR223694A1 (it)
AT (1)	AT371127B (it)
AU (1)	AU5452280A (it)
BE (1)	BE881078A (it)
BG (1)	BG33295A3 (it)
CA (1)	CA1148945A (it)
CH (1)	CH645383A5 (it)
CS (1)	CS214691B2 (it)
DD (1)	DD148779A5 (it)
DE (1)	DE3065852D1 (it)
DK (1)	DK148961C (it)
ES (2)	ES487682A0 (it)
FI (1)	FI800071A7 (it)
FR (1)	FR2446290A1 (it)
GB (1)	GB2040934B (it)
GR (1)	GR72464B (it)
HU (1)	HU182083B (it)
IE (1)	IE49376B1 (it)
IL (1)	IL59119A (it)
IT (1)	IT1140506B (it)
LU (1)	LU82079A1 (it)
MY (1)	MY8500570A (it)
NZ (1)	NZ192574A (it)
PH (1)	PH15343A (it)
PL (1)	PL124350B1 (it)
PT (1)	PT70681A (it)
RO (1)	RO77532A (it)
SU (1)	SU906381A3 (it)
YU (1)	YU5680A (it)
ZA (1)	ZA80157B (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60112895A (ja) *	1983-11-24	1985-06-19	Nippon Oil & Fats Co Ltd	金属圧延用潤滑油
FR2651348B1 (it) *	1989-08-04	1993-01-22	Adir
TW258739B (it) *	1992-04-04	1995-10-01	Hoechst Ag
HK1049443A1 (zh) *	1999-11-12	2003-05-16	Angiotech Pharmaceuticals, Inc.	用放射活性疗法和细胞循环抑制剂联合治疗疾病的组合物和方法
WO2004060346A2 (en)	2002-12-30	2004-07-22	Angiotech International Ag	Drug delivery from rapid gelling polymer composition
CN106831826B (zh) *	2016-12-31	2018-07-06	广州白云山汉方现代药业有限公司	一种从长春花中制备长春地辛的方法
CN106831827B (zh) *	2016-12-31	2019-03-29	广州白云山汉方现代药业有限公司	一种长春地辛的分离纯化方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2756235A (en) *	1954-08-27	1956-07-24	Lilly Co Eli	Method of producing lysergic acid amide
AR204004A1 (es)	1973-04-02	1975-11-12	Lilly Co Eli	Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina

1979
- 1979-01-15 US US06/003,442 patent/US4210584A/en not_active Expired - Lifetime
1980
- 1980-01-10 GB GB8000870A patent/GB2040934B/en not_active Expired
- 1980-01-10 BE BE1/9677A patent/BE881078A/fr not_active IP Right Cessation
- 1980-01-10 GR GR60929A patent/GR72464B/el unknown
- 1980-01-10 CS CS80235A patent/CS214691B2/cs unknown
- 1980-01-10 CA CA000343455A patent/CA1148945A/en not_active Expired
- 1980-01-10 PT PT70681A patent/PT70681A/pt unknown
- 1980-01-10 ZA ZA00800157A patent/ZA80157B/xx unknown
- 1980-01-10 NZ NZ192574A patent/NZ192574A/xx unknown
- 1980-01-10 EP EP80300095A patent/EP0014053B1/en not_active Expired
- 1980-01-10 FI FI800071A patent/FI800071A7/fi not_active Application Discontinuation
- 1980-01-10 FR FR8000466A patent/FR2446290A1/fr active Granted
- 1980-01-10 AU AU54522/80A patent/AU5452280A/en not_active Abandoned
- 1980-01-10 DE DE8080300095T patent/DE3065852D1/de not_active Expired
- 1980-01-10 YU YU00056/80A patent/YU5680A/xx unknown
- 1980-01-11 HU HU8052A patent/HU182083B/hu not_active IP Right Cessation
- 1980-01-11 AT AT0014080A patent/AT371127B/de not_active IP Right Cessation
- 1980-01-11 JP JP250480A patent/JPS5598195A/ja active Granted
- 1980-01-13 IL IL59119A patent/IL59119A/xx unknown
- 1980-01-14 DK DK14780A patent/DK148961C/da not_active IP Right Cessation
- 1980-01-14 PL PL1980221359A patent/PL124350B1/pl unknown
- 1980-01-14 PH PH23506A patent/PH15343A/en unknown
- 1980-01-14 CH CH28780A patent/CH645383A5/fr not_active IP Right Cessation
- 1980-01-14 AR AR279615A patent/AR223694A1/es active
- 1980-01-14 ES ES487682A patent/ES487682A0/es active Granted
- 1980-01-14 IE IE60/80A patent/IE49376B1/en unknown
- 1980-01-14 LU LU82079A patent/LU82079A1/fr unknown
- 1980-01-14 SU SU802872553A patent/SU906381A3/ru active
- 1980-01-14 BG BG046233A patent/BG33295A3/xx unknown
- 1980-01-14 IT IT19210/80A patent/IT1140506B/it active
- 1980-01-15 KR KR1019800000134A patent/KR830002840B1/ko not_active Expired
- 1980-01-15 RO RO8099874A patent/RO77532A/ro unknown
- 1980-01-15 DD DD80218466A patent/DD148779A5/de unknown
- 1980-01-15 ES ES487726A patent/ES8101612A1/es not_active Expired
1985
- 1985-12-30 MY MY570/85A patent/MY8500570A/xx unknown

Also Published As

Publication number	Publication date
IE49376B1 (en)	1985-10-02
DD148779A5 (de)	1981-06-10
FI800071A7 (fi)	1981-01-01
JPS6332796B2 (it)	1988-07-01
ES8101611A1 (es)	1980-12-16
DK14780A (da)	1980-07-16
CS214691B2 (en)	1982-05-28
EP0014053B1 (en)	1983-12-14
HU182083B (en)	1983-12-28
CA1148945A (en)	1983-06-28
KR830002840B1 (ko)	1983-12-27
RO77532A (ro)	1982-02-26
ES487726A0 (es)	1980-12-16
BG33295A3 (bg)	1983-01-14
FR2446290A1 (fr)	1980-08-08
KR830001961A (ko)	1983-05-21
DK148961C (da)	1986-05-20
ES8101612A1 (es)	1980-12-16
AR223694A1 (es)	1981-09-15
IT1140506B (it)	1986-10-01
ES487682A0 (es)	1980-12-16
PL124350B1 (en)	1983-01-31
YU5680A (en)	1983-02-28
JPS5598195A (en)	1980-07-25
LU82079A1 (fr)	1980-04-23
ZA80157B (en)	1981-08-26
FR2446290B1 (it)	1983-06-24
GB2040934A (en)	1980-09-03
US4210584A (en)	1980-07-01
PL221359A1 (it)	1980-12-15
IL59119A0 (en)	1980-05-30
GR72464B (it)	1983-11-10
GB2040934B (en)	1983-03-09
MY8500570A (en)	1985-12-31
NZ192574A (en)	1982-03-16
SU906381A3 (ru)	1982-02-15
PH15343A (en)	1982-12-02
IL59119A (en)	1983-06-15
ATA14080A (de)	1982-10-15
CH645383A5 (fr)	1984-09-28
DK148961B (da)	1985-12-02
AT371127B (de)	1983-06-10
PT70681A (en)	1980-02-01
EP0014053A1 (en)	1980-08-06
BE881078A (fr)	1980-07-10
AU5452280A (en)	1980-07-24
IE800060L (en)	1980-07-15
DE3065852D1 (en)	1984-01-19

Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19960123

Publication	Publication Date	Title
IT1209179B (it)	1989-07-16	Procedimento di misura.
FI850198A0 (fi)	1985-01-16	Expressionsplasmid.
FI812463L (fi)	1981-08-07	Behaollare
IT8067445A0 (it)	1980-03-21	Procedimento per la preparazione della monacolina k.
NL7810782A (nl)	1979-05-02	Vliegtuig.
NO147704C (no)	1983-06-01	Hydrosyklonseparator.
ES256673Y (es)	1981-12-16	Guardavistas.
NO150428C (no)	1984-10-17	Dobbelskrog-vannfartoey
IT7824169A0 (it)	1978-06-02	Trasformatore.
NL7801421A (nl)	1978-09-27	Preparaten.
FI73548B (fi)	1987-06-30	Oeverstroemskyddskrets foer effekttransistor.
IT8022594A0 (it)	1980-06-06	Derivati della paromomicina.
NO783145L (no)	1979-03-20	Bjelkebeslag.
IT8021565A0 (it)	1980-04-22	Orologio da polso di spessore ridotto.
IT8023190A0 (it)	1980-07-02	Glicosidi antraciclinici.
NO147633C (no)	1983-05-25	Halvt neddykkbart fartoey.
FI800071A7 (fi)	1981-01-01	Uusi vindesiinin synteesi.
IT8083454A0 (it)	1980-10-23	Harzburgite e procedimento per lapreparazione della stessa.
FI73539B (fi)	1987-06-30	Multiplexanslutningsenhet foer en digitalstation.
IT1079385B (it)	1985-05-08	Procedimento di raffinazione della sodio-saccarina
NO145147C (no)	1982-01-20	Baerefrekvens-lydoverfoeringssystem.
IT8019983A0 (it)	1980-02-18	Analoghi della 6.9-nitrilo-prostaglandina.
NL186477C (nl)	1990-12-03	Gloeilamp.
NO812109L (no)	1981-06-19	Z-profilfoeringsinnretning.
IT7920646A0 (it)	1979-02-28	Derivato della diidro-dibenzazepina-3-sostituita.