IT8048625A0 - Derivati di epossisuccinil ammino acido dotati di attivita'inibitrice su tiol proteasi - Google Patents

Derivati di epossisuccinil ammino acido dotati di attivita'inibitrice su tiol proteasi

Info

Publication number
IT8048625A0
IT8048625A0 IT8048625A IT4862580A IT8048625A0 IT 8048625 A0 IT8048625 A0 IT 8048625A0 IT 8048625 A IT8048625 A IT 8048625A IT 4862580 A IT4862580 A IT 4862580A IT 8048625 A0 IT8048625 A0 IT 8048625A0
Authority
IT
Italy
Prior art keywords
epoxysuccinyl
derivatives
amino acid
inhibiting activity
thiol protease
Prior art date
Application number
IT8048625A
Other languages
English (en)
Other versions
IT1143918B (it
Inventor
Masaharu Tamai
Shigeo Morimoto
Takashi Adachi
Kiyoshi Oguma
Kazunori Hanada
Sadafumi Omura
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Publication of IT8048625A0 publication Critical patent/IT8048625A0/it
Application granted granted Critical
Publication of IT1143918B publication Critical patent/IT1143918B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IT48625/80A 1979-05-17 1980-05-08 Derivati di epossisuccinil ammino acido dotati di attivita2 inibitrice su tiol proteasi IT1143918B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6085879A JPS55153778A (en) 1979-05-17 1979-05-17 Epoxysuccinylamino acid derivative

Publications (2)

Publication Number Publication Date
IT8048625A0 true IT8048625A0 (it) 1980-05-08
IT1143918B IT1143918B (it) 1986-10-29

Family

ID=13154490

Family Applications (1)

Application Number Title Priority Date Filing Date
IT48625/80A IT1143918B (it) 1979-05-17 1980-05-08 Derivati di epossisuccinil ammino acido dotati di attivita2 inibitrice su tiol proteasi

Country Status (6)

Country Link
US (1) US4418075A (it)
JP (1) JPS55153778A (it)
DE (1) DE3017684A1 (it)
FR (1) FR2456739A1 (it)
GB (1) GB2052484B (it)
IT (1) IT1143918B (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57169478A (en) * 1981-04-10 1982-10-19 Nippon Chemiphar Co Ltd Piperazine derivative
JPS6276A (ja) * 1985-03-26 1987-01-06 Toyo Jozo Co Ltd 酵素阻害性新規物質
EP0269311A3 (en) * 1986-11-17 1990-06-06 Merck & Co. Inc. Methods of treating bone diseases by administration of a cysteine proteinase inhibitor
US4927965A (en) * 1988-11-03 1990-05-22 Merck & Co., Inc. N-(N-succinyl-L-leucyl)agmatine, related compounds and use in pharmacology
US5545672A (en) * 1993-02-11 1996-08-13 The University Of Texas System Treatment of insulin resistance and type 2 diabetes mellitus with a thiol protease inhibitor
US5556853A (en) * 1993-10-29 1996-09-17 Takeda Chemical Industries, Ltd. Epoxysuccinic acid derivatives
EP0753003B1 (en) * 1994-04-13 1999-06-16 Takeda Chemical Industries, Ltd. Aziridine derivatives, their production and use
US5705660A (en) * 1994-08-22 1998-01-06 Board Of Regents, University Of Nebraska-Lincoln Method for the synthesis of α-oxiranyl amino acids
US5733911A (en) * 1996-01-26 1998-03-31 Hitachi Chemical Co., Ltd. Method for inducing death of neoplastic cells using piperazne derivatives
EP1931656B1 (en) * 2005-09-28 2011-02-09 Robert Ternansky Novel drugs for dementia
CN101808634A (zh) 2006-06-13 2010-08-18 利兰·斯坦福青年大学托管委员会 半胱氨酸蛋白酶的环氧化物抑制剂
US20100216875A1 (en) * 2006-12-20 2010-08-26 Gregory Hook Methods of treating alzheimer's disease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS548759B2 (it) * 1973-03-06 1979-04-18
GB1469797A (en) * 1974-11-07 1977-04-06 Pfizer Ltd Antibacterial cephalosporin derivatives
GB1595168A (en) 1977-03-03 1981-08-12 Taisho Pharmaceutical Co Ltd Expoxysuccinic acid derivatives

Also Published As

Publication number Publication date
US4418075A (en) 1983-11-29
JPS55153778A (en) 1980-11-29
DE3017684C2 (it) 1988-08-25
FR2456739B1 (it) 1983-06-17
DE3017684A1 (de) 1980-11-20
IT1143918B (it) 1986-10-29
FR2456739A1 (fr) 1980-12-12
GB2052484B (en) 1983-06-08
GB2052484A (en) 1981-01-28
JPS6320820B2 (it) 1988-04-30

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