IT8249720A0 - 2-/4-/4,4-dialchil-2,6-piperidinadion-1-il)butil/-1-piperazinil/piri dine ad attivita' antipsicotica relativo procedimento di preparazione e preparati farmaceutici che le con tengono - Google Patents
2-/4-/4,4-dialchil-2,6-piperidinadion-1-il)butil/-1-piperazinil/piri dine ad attivita' antipsicotica relativo procedimento di preparazione e preparati farmaceutici che le con tengonoInfo
- Publication number
- IT8249720A0 IT8249720A0 IT8249720A IT4972082A IT8249720A0 IT 8249720 A0 IT8249720 A0 IT 8249720A0 IT 8249720 A IT8249720 A IT 8249720A IT 4972082 A IT4972082 A IT 4972082A IT 8249720 A0 IT8249720 A0 IT 8249720A0
- Authority
- IT
- Italy
- Prior art keywords
- piperidinadion
- piperazinil
- piri
- dine
- dialkyl
- Prior art date
Links
- 230000000561 anti-psychotic effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/334,689 US4361565A (en) | 1981-12-28 | 1981-12-28 | 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyridines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8249720A0 true IT8249720A0 (it) | 1982-12-22 |
| IT1158040B IT1158040B (it) | 1987-02-18 |
Family
ID=23308356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT49720/82A IT1158040B (it) | 1981-12-28 | 1982-12-22 | 2-/4-/4,4-dialchil-2,6-piperidinadion-1-il)butil/1-piperazinil/piridine ad attivita' antipsicotica relativo procedimento di preparazione e preparati farmaceutici che le contengono |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4361565A (it) |
| JP (1) | JPS58118583A (it) |
| KR (1) | KR880002011B1 (it) |
| AT (1) | AT380880B (it) |
| AU (1) | AU560667B2 (it) |
| BE (1) | BE895505A (it) |
| CA (1) | CA1237722A (it) |
| CH (1) | CH653682A5 (it) |
| CY (1) | CY1378A (it) |
| DE (1) | DE3248138A1 (it) |
| DK (1) | DK162284C (it) |
| ES (1) | ES8402832A1 (it) |
| FI (1) | FI70892C (it) |
| FR (1) | FR2518994B1 (it) |
| GB (1) | GB2114121B (it) |
| GR (1) | GR77101B (it) |
| HK (1) | HK5188A (it) |
| HU (1) | HU190827B (it) |
| IE (1) | IE54620B1 (it) |
| IT (1) | IT1158040B (it) |
| KE (1) | KE3714A (it) |
| LU (1) | LU84562A1 (it) |
| NL (1) | NL8204974A (it) |
| PT (1) | PT76037B (it) |
| SE (1) | SE449748B (it) |
| SG (1) | SG29687G (it) |
| ZA (1) | ZA828546B (it) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT387221B (de) * | 1980-09-08 | 1988-12-27 | Bristol Myers Co | Verfahren zur herstellung des neuen |
| AT387773B (de) * | 1983-09-12 | 1989-03-10 | Bristol Myers Co | Verfahren zur herstellung von 1-heteroaryl-4-((2,5-pyrrolidindion-1-yl)aklyl) iperazin-derivaten |
| US4524206A (en) * | 1983-09-12 | 1985-06-18 | Mead Johnson & Company | 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives |
| US4619930A (en) * | 1985-01-16 | 1986-10-28 | Bristol-Myers Company | Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use |
| CA1278792C (en) * | 1985-05-06 | 1991-01-08 | Joseph P. Yevich | Antipsychotic fused-ring pyridinylpiperazine derivatives |
| US4677104A (en) * | 1985-05-06 | 1987-06-30 | Bristol-Myers Company | Antipsychotic fused-ring pyridinylpiperazine derivatives |
| US4757073A (en) * | 1986-09-30 | 1988-07-12 | Bristol-Myers Company | Antipsychotic cyclic imide derivatives of 2-(4-butylipiperazin-1-yl) pyridines, compositions and use |
| AU2717288A (en) * | 1987-11-12 | 1989-06-01 | American Home Products Corporation | Polycyclicamines with psychotropic activity |
| US4855430A (en) * | 1987-11-12 | 1989-08-08 | American Home Products Corporation | Polycyclicamine with psychotropic activity |
| US4880930A (en) * | 1987-11-30 | 1989-11-14 | New James S | Psychotropic acyclic amide derivatives |
| US5116970A (en) * | 1988-02-18 | 1992-05-26 | New James S | Psychotropic heterobicycloalkylpiperazine derivatives: 2. fused pyridazinones |
| US5001130A (en) * | 1988-02-18 | 1991-03-19 | Bristol-Myers Company | Psychotropic heterobicycloalkylpiperazine derivatives |
| US5098904A (en) * | 1990-06-27 | 1992-03-24 | Bristol-Myers Squibb Company | Cerebral function enhancing pyrimidinyl derivatives |
| DK0482696T3 (da) * | 1990-10-23 | 1996-05-20 | Akzo Nobel Nv | 4-(4- eller 6-(trifluormethyl-2-pyridinyl))-1-piperazinylalkyl-substituerede lactamer |
| AU9134191A (en) * | 1990-12-24 | 1992-07-22 | Merrell Dow Pharmaceuticals Inc. | Use of certain glutarimide derivatives in the treatment of depression and mania |
| SE9201138D0 (sv) * | 1992-04-09 | 1992-04-09 | Astra Ab | Novel phthalimidoalkylpiperazines |
| US7045519B2 (en) | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| US6417185B1 (en) | 1998-06-19 | 2002-07-09 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| WO2008121019A1 (ru) * | 2007-03-29 | 2008-10-09 | Obschestvo S Ogranishennoi Otvetstvennostu 'farmving' | Средство противогистаминного антиаллергического действия и способ его получения |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3398151A (en) * | 1966-02-01 | 1968-08-20 | Mead Johnson & Co | Azaspirodecanediones and azaspiroundecanediones |
| BE759371A (fr) * | 1969-11-24 | 1971-05-24 | Bristol Myers Co | Azaspirodecanediones heterocycliques et procedes pour leur preparation |
| US3976776A (en) * | 1972-12-06 | 1976-08-24 | Mead Johnson & Company | Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones |
| US4182763A (en) * | 1978-05-22 | 1980-01-08 | Mead Johnson & Company | Buspirone anti-anxiety method |
| AU521110B2 (en) * | 1978-06-20 | 1982-03-18 | Synthelabo | Phenylpiperazine derivatives |
| US4305944A (en) * | 1980-09-08 | 1981-12-15 | Mead Johnson & Company | N-[(4-[3-cyano substituted pyridyl]piperazino)alkyl]-azaspirodecanediones |
-
1981
- 1981-12-28 US US06/334,689 patent/US4361565A/en not_active Expired - Fee Related
-
1982
- 1982-11-19 ZA ZA828546A patent/ZA828546B/xx unknown
- 1982-11-22 CA CA000416080A patent/CA1237722A/en not_active Expired
- 1982-12-02 AU AU91084/82A patent/AU560667B2/en not_active Ceased
- 1982-12-03 KR KR8205431A patent/KR880002011B1/ko not_active Expired
- 1982-12-08 GR GR70020A patent/GR77101B/el unknown
- 1982-12-22 IT IT49720/82A patent/IT1158040B/it active
- 1982-12-23 GB GB08236592A patent/GB2114121B/en not_active Expired
- 1982-12-23 IE IE3068/82A patent/IE54620B1/en not_active IP Right Cessation
- 1982-12-23 AT AT0467682A patent/AT380880B/de not_active IP Right Cessation
- 1982-12-23 DK DK573282A patent/DK162284C/da active
- 1982-12-23 NL NL8204974A patent/NL8204974A/nl unknown
- 1982-12-23 ES ES518511A patent/ES8402832A1/es not_active Expired
- 1982-12-23 FI FI824443A patent/FI70892C/fi not_active IP Right Cessation
- 1982-12-23 JP JP57225099A patent/JPS58118583A/ja active Granted
- 1982-12-23 CY CY137882A patent/CY1378A/xx unknown
- 1982-12-24 FR FR8221751A patent/FR2518994B1/fr not_active Expired
- 1982-12-27 CH CH7565/82A patent/CH653682A5/de not_active IP Right Cessation
- 1982-12-27 PT PT76037A patent/PT76037B/pt not_active IP Right Cessation
- 1982-12-27 HU HU824172A patent/HU190827B/hu not_active IP Right Cessation
- 1982-12-27 DE DE19823248138 patent/DE3248138A1/de active Granted
- 1982-12-27 SE SE8207426A patent/SE449748B/sv not_active IP Right Cessation
- 1982-12-28 BE BE0/209827A patent/BE895505A/fr not_active IP Right Cessation
- 1982-12-29 LU LU84562A patent/LU84562A1/fr unknown
-
1987
- 1987-03-27 SG SG296/87A patent/SG29687G/en unknown
- 1987-03-31 KE KE3714A patent/KE3714A/xx unknown
-
1988
- 1988-01-21 HK HK51/88A patent/HK5188A/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IT8249719A0 (it) | 2-/4-/(4,4-dialchil-2,6-piperidindi on-1-il)-butil/1-piperazinil/pirimi dine ad attivita' ansiolitica selettiva, procedimento per la loro preparazione e preparati farmaceutici che le contengono | |
| IT8467767A0 (it) | Preparati farmaceutici ad attivita antimicrobica e procedimento per laloro preparazione | |
| DK361786A (da) | Granulaere farmaceutiske praeparater med forskudt afgivelse | |
| MX9203170A (es) | Composicion farmaceutica con actividad analgesica. | |
| IT1158040B (it) | 2-/4-/4,4-dialchil-2,6-piperidinadion-1-il)butil/1-piperazinil/piridine ad attivita' antipsicotica relativo procedimento di preparazione e preparati farmaceutici che le contengono | |
| MX9203167A (es) | Composicion farmaceutica con actividad analgesica. | |
| FI881061A7 (fi) | Hitaasti vapauttavia valmisteita ruoansulatuskanavan ulkopuolisesti annettaviksi ja niiden käyttö. | |
| DK175685A (da) | Jernholdige farmaceutiske praeparater | |
| DK184087D0 (da) | Farmaceutiske praeparater med forbedret biotilgaengelighed | |
| IT8422142A0 (it) | Procedimento di preparazione. cefem composti ad azione farmaceutica e relativo | |
| DK259186D0 (da) | Nasale farmaceutiske praeparater | |
| IT8521938A0 (it) | Sostanza anti-neoplastica, suoi preparati farmaceutici e relativo metodo di impiego | |
| IT8321461A0 (it) | Ammidine ad attivita' farmaceutica e relativo procedimento di fabbricazione. | |
| DK163057C (da) | Isoindsolinyl-alkyl-piperaziner, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme | |
| DE3576118D1 (de) | Pharmazeutische praeparate. | |
| DK527487D0 (da) | Farmaceutiske praeparater med forlaenget afgivelse | |
| IT8219409A0 (it) | Derivati, tiolici dell'eritromicina ad attivita' terapeutica, relativo procedimento di preparazione e composizioni farmaceutiche che licontengono. | |
| NO883609D0 (no) | Farmasoeytiske preparater for topisk anvendelse. | |
| IT1185513B (it) | Procedimento per l'ottenimento di preparati farmaceutici con effetto ritardato | |
| IT8567216A0 (it) | Composti pteridinici relativi procedimenti di preparazione e preparati farmaceutici che li contengono | |
| IT8123546A0 (it) | Composto ad attivita' antiulcera, procedimento per la sua preparazione e composizioni farmaceutiche relative | |
| FI853368A7 (fi) | Uusia pseudo-oligosakkarideja, joilla on -glukosidaasia estävä vaikutus, menetelmä niiden valmistamiseksi, niiden käyttö ja farmaseuttisia valmisteita. | |
| IT8547765A0 (it) | Derivato di cefalosporina,composizione farmaceutica che lo contiene e relativo procedimento di preparazione ed applicazione | |
| IT8421431A0 (it) | Preparati farmaceutici con azione antitumorale | |
| IT8424081A0 (it) | 1,3-diesteri del2-0-alchilglicerolo dotati di attivita' ipolipemizzante, procedimento di preparazione e composizioni farmaceutiche che licontengono. |