ITCE970001A1 - Nifedipina per uso topico - Google Patents
Nifedipina per uso topico Download PDFInfo
- Publication number
- ITCE970001A1 ITCE970001A1 ITCE970001A ITCE970001A1 IT CE970001 A1 ITCE970001 A1 IT CE970001A1 IT CE970001 A ITCE970001 A IT CE970001A IT CE970001 A1 ITCE970001 A1 IT CE970001A1
- Authority
- IT
- Italy
- Prior art keywords
- drug
- ointment
- suppositories
- nifedipine
- pathologies
- Prior art date
Links
- 230000000699 topical effect Effects 0.000 title claims description 4
- 239000003814 drug Substances 0.000 claims description 9
- 229960001597 nifedipine Drugs 0.000 claims description 9
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims description 9
- 239000002674 ointment Substances 0.000 claims description 9
- 230000007170 pathology Effects 0.000 claims description 9
- 229940079593 drug Drugs 0.000 claims description 8
- 239000000829 suppository Substances 0.000 claims description 7
- 206010057071 Rectal tenesmus Diseases 0.000 claims description 6
- 239000000499 gel Substances 0.000 claims description 6
- 241000792859 Enema Species 0.000 claims description 4
- 239000007920 enema Substances 0.000 claims description 4
- 229940095399 enema Drugs 0.000 claims description 4
- 206010002153 Anal fissure Diseases 0.000 claims description 3
- 208000016583 Anus disease Diseases 0.000 claims description 3
- 208000009531 Fissure in Ano Diseases 0.000 claims description 3
- 201000000120 anal spasm Diseases 0.000 claims description 3
- 208000014617 hemorrhoid Diseases 0.000 claims description 3
- 206010009895 Colitis ischaemic Diseases 0.000 claims description 2
- 208000005392 Spasm Diseases 0.000 claims description 2
- 201000008222 ischemic colitis Diseases 0.000 claims description 2
- 208000012271 tenesmus Diseases 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 1
- 238000002052 colonoscopy Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 210000005072 internal anal sphincter Anatomy 0.000 description 4
- 206010020852 Hypertonia Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 2
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 description 1
- 229940127291 Calcium channel antagonist Drugs 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000000480 calcium channel blocker Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 210000001087 myotubule Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000008756 pathogenetic mechanism Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
DESCRIZIONE dell'invenzione industriale avente per titolo:
NEFEDIPINA PER USO TOPICO .
RIASSUNTO
La Nifedipina,una dìidropirìdìna, e' un farmaco calcioantagonista che, attualmente ,e' usato per patologie cardiovascolari e solo per via orale il suo uso per via topica, sotto forma, cioè' ,di supposte, gel, pomata, unguento o clistere medicato reca notevole beneficio in alcune patologie quali la ragade anale, tenesmo rettale, spasmo anale ed in circa il 20 % delle emorroidi.
TESTO DELLA DESCRIZIONE
Circa il 30/40 % della popolazione, almeno una volta nella vita, soffre di patologie proctologiche.i disturbi che ne derivano sono generalmente piu' fastidiosi che pericolosi, molti di essi vengono risolti in modo improprio con intervento chirurgico.
La genesi di molte di queste patologie e’ legata ad un ipertono dello sfintere anale interno.Risolvendo, quindi, ipertono si possono curare diverse patologie proctologiche su base funzionale e molti disturbi dovuti a patologie organiche ( p. es. il tenesmo rettale in corso di Rettocolite Ulcerosa ).
La Nifedipina e’ un farmaco che attualmente e' utilizzato, prevalentemente, per patologie cardiavascolari e non ha tra le proprie indicazioni la cura delle patologie summenzionate .
La sua azione si estrinseca attraverso l’inibizione del flusso del Ca + nel sarcoplasma della muscolatura liscia con conseguente risparmio di ossigeno nonché’ una diminuzione della contrazione meccanica delle fibre muscolari.
L'uso, quindi, per via topica (sotto forma cioè’ di supposte o gel, pomata, unguento o clistere medicato ) provoca rilasciamento dello sfintere interno anale con notevole beneficio in tutte quelle condizioni patologiche che danno ipertono dello sfintere anale interno.
L' assorbimento topico della Nifedipina, per il meccanismo farmacocinetico sopra descritto, porta ad un rilasciamento dello sfintere anale interno, il cui ipertono e' responsabile del meccanismo patogenetico delle seguenti patologie: Ragade anale, Tenesmo rettale.Spasmo anale,
circa il 20 % delle emorroidi.
Anche altro tipo di patologia, quali coliti ischemiche.tenesmo vescicole e spasmo vescicole, potrebbero trovare giovamento dall'uso, sotto forma di supposte , della Nifedipina.
Inoltre l'uso di Nifedipina veicolata in forma di supposte o gel può' essere utile anche per la preparazione a manovre endoscopiche come la Colomcopìa, la Cistoosstcopia. ecc.
Claims (4)
- RIVENDICAZIONI 1) Uso terapeutico del farmaco Nifedipina per via topica in patologie quali: Ragade anale, Tenesmo rettale, Spasmo anale, Emorroidi.
- 2) Uso terapeutico , sotto forma di supposte, del farmaco Nifedipina anche in patologie quali:Coliti ischemiche. Tenesmo e e Spasmo vescicole.
- 3) Uso del farmaco Nifedipina , sotto forma di gel o pomate, oltre che per terapie topiche, anche per preparazione a manovre endoscopiche quali colonscopie, cistoscople.
- 4) Uso del farmaco Nifedipina, come rivendicato in precedenza, sotto forma farmaceutica di supposte, gel, unguento, pomata o clistere medicato a vari gradi di concentrazione del farmaco e delle sostanze, di solito usate in Farmaceutica quali veicolanti di un farmaco in supposte, gel , unguento, pomata o clistere medicato.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITCE970001 IT1297886B1 (it) | 1997-02-28 | 1997-02-28 | Nifedipina per uso topico |
| AU61149/98A AU6114998A (en) | 1997-02-28 | 1998-02-26 | Topical nifedipine preparations for the conservative treatment of functional pathologies of the anal canal |
| PCT/IT1998/000040 WO1998037886A1 (en) | 1997-02-28 | 1998-02-26 | Topical nifedipine preparations for the conservative treatment of functional pathologies of the anal canal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITCE970001 IT1297886B1 (it) | 1997-02-28 | 1997-02-28 | Nifedipina per uso topico |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITCE970001A1 true ITCE970001A1 (it) | 1998-08-28 |
| IT1297886B1 IT1297886B1 (it) | 1999-12-20 |
Family
ID=11347314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITCE970001 IT1297886B1 (it) | 1997-02-28 | 1997-02-28 | Nifedipina per uso topico |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU6114998A (it) |
| IT (1) | IT1297886B1 (it) |
| WO (1) | WO1998037886A1 (it) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1250927A2 (en) | 1997-02-24 | 2002-10-23 | S.L.A. Pharma AG | Pharmaceutical composition for topical application comprising nifedipine |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3211892B2 (ja) | 1994-05-27 | 2001-09-25 | セイジィ ファーマスーティカルス インコーポレーテッド | 肛門疾患を治療する窒素酸化物供与体及び方法 |
| EP1168912B1 (en) * | 1999-03-23 | 2007-05-09 | Hibernation Therapeutics Limited | Organ arrest, protection and preservation |
| AU769131B2 (en) * | 1999-03-23 | 2004-01-15 | Hibernation Therapeutics,a KF LLC | Organ arrest, protection and preservation |
| ES2151454B1 (es) * | 1999-05-06 | 2001-07-01 | Szlec Christopher Dura | Pomada para el tratamiento de la fisura anal cronica y otros procesos inflamatorios del ano. |
| ITRM20040631A1 (it) * | 2004-12-22 | 2005-03-22 | Carmine Antropoli | Composizione farmaceutica comprendente nifepidina e mesalazina per il trattamento del tenesmo ano rettale. |
| JP2009538834A (ja) | 2006-05-29 | 2009-11-12 | ハイバーネイション セラピューティクス リミテッド | 組織維持の改善 |
| ES2539762T3 (es) | 2006-07-25 | 2015-07-03 | Hibernation Therapeutics, A Kf Llc | Tratamiento de traumatismos |
| WO2008106724A1 (en) | 2007-03-02 | 2008-09-12 | Hibernation Therapeutics Limited | Transplants |
| WO2015006831A1 (en) | 2013-07-17 | 2015-01-22 | Hts Therapeutics Pty Ltd | A method for reducing, inflammation, coagulation and adhesions |
| US9700549B2 (en) | 2013-10-03 | 2017-07-11 | David Wise | Compositions and methods for treating pelvic pain and other conditions |
| US20160331735A1 (en) * | 2015-05-11 | 2016-11-17 | Ashraf LATIF | Novel formulations for treatment of pain, neuropathy, wounds, and ulcers |
| IT201800002413A1 (it) * | 2018-02-05 | 2019-08-05 | Carmine Antropoli | "composizione a base di nifedipina per uso nel trattamento delle ragadi anali e proctalgie" |
| WO2020176004A1 (ru) * | 2019-02-25 | 2020-09-03 | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НоваМедика" | Гель для ректального и наружного применения |
| IT202000029480A1 (it) * | 2020-12-02 | 2022-06-02 | Teia Research Soc A Responsabilita Limitata Semplificata | Composizione farmaceutica per il trattamento delle ragadi anali e delle emorroidi |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL109036A (en) * | 1993-03-19 | 1998-12-27 | Cellegy Pharamaceuticals Inc | Preparations for detachment of the epithelial barrier function and use of means for the preparation of such preparations |
| WO1995006466A1 (en) * | 1993-09-01 | 1995-03-09 | Koren Laboratories Pty. Limited | Treatment of anorectal disorders |
| DE19539361A1 (de) * | 1995-10-23 | 1997-04-24 | Basf Ag | Verfahren zur Herstellung von mehrschichtigen, festen Arzneiformen zur oralen oder rektalen Verabreichung |
-
1997
- 1997-02-28 IT ITCE970001 patent/IT1297886B1/it active IP Right Grant
-
1998
- 1998-02-26 AU AU61149/98A patent/AU6114998A/en not_active Abandoned
- 1998-02-26 WO PCT/IT1998/000040 patent/WO1998037886A1/en not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1250927A2 (en) | 1997-02-24 | 2002-10-23 | S.L.A. Pharma AG | Pharmaceutical composition for topical application comprising nifedipine |
Also Published As
| Publication number | Publication date |
|---|---|
| AU6114998A (en) | 1998-09-18 |
| WO1998037886A1 (en) | 1998-09-03 |
| IT1297886B1 (it) | 1999-12-20 |
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| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |