ITFE20050003A1 - Agonisti pieni e parziali ed antagonisti del recettore per nocicettina/orfanina fq ad elevata potenza. - Google Patents

Agonisti pieni e parziali ed antagonisti del recettore per nocicettina/orfanina fq ad elevata potenza.

Info

Publication number
ITFE20050003A1
ITFE20050003A1 IT000003A ITFE20050003A ITFE20050003A1 IT FE20050003 A1 ITFE20050003 A1 IT FE20050003A1 IT 000003 A IT000003 A IT 000003A IT FE20050003 A ITFE20050003 A IT FE20050003A IT FE20050003 A1 ITFE20050003 A1 IT FE20050003A1
Authority
IT
Italy
Prior art keywords
nocicettina
orphanine
receptor
partial
full
Prior art date
Application number
IT000003A
Other languages
English (en)
Inventor
Girolamo Calo'
Remo Guerrini
Domenico Regoli
Severo Salvadori
Original Assignee
Ufpeptides S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ufpeptides S R L filed Critical Ufpeptides S R L
Priority to IT000003A priority Critical patent/ITFE20050003A1/it
Priority to SI200631947T priority patent/SI1851241T1/sl
Priority to AU2006215639A priority patent/AU2006215639B2/en
Priority to CNA2006800049929A priority patent/CN101128482A/zh
Priority to DK06708285.9T priority patent/DK1851241T3/en
Priority to HUE06708285A priority patent/HUE025000T2/en
Priority to CN201510080020.9A priority patent/CN104689293A/zh
Priority to EP06708285.9A priority patent/EP1851241B1/en
Priority to JP2007554583A priority patent/JP5281292B2/ja
Priority to RS20150443A priority patent/RS54095B1/sr
Priority to ES06708285.9T priority patent/ES2541308T3/es
Priority to CA2598121A priority patent/CA2598121C/en
Priority to MX2007009523A priority patent/MX2007009523A/es
Priority to HRP20150731TT priority patent/HRP20150731T1/hr
Priority to US11/884,241 priority patent/US8227414B2/en
Priority to UAA200709286A priority patent/UA91844C2/ru
Priority to PT67082859T priority patent/PT1851241E/pt
Priority to EA200701732A priority patent/EA011325B1/ru
Priority to KR1020077018487A priority patent/KR101294895B1/ko
Priority to PCT/EP2006/050958 priority patent/WO2006087340A2/en
Priority to BRPI0606998A priority patent/BRPI0606998B8/pt
Priority to PL06708285T priority patent/PL1851241T3/pl
Publication of ITFE20050003A1 publication Critical patent/ITFE20050003A1/it
Priority to NI200700205A priority patent/NI200700205A/es
Priority to CU20070195A priority patent/CU23823A3/es
Priority to IL185235A priority patent/IL185235A/en
Priority to MA30190A priority patent/MA29288B1/fr
Priority to ZA200707714A priority patent/ZA200707714B/xx
Priority to CR9379A priority patent/CR9379A/es
Priority to NO20074702A priority patent/NO341856B1/no
Priority to CY20151100579T priority patent/CY1116456T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
IT000003A 2005-02-15 2005-02-15 Agonisti pieni e parziali ed antagonisti del recettore per nocicettina/orfanina fq ad elevata potenza. ITFE20050003A1 (it)

Priority Applications (30)

Application Number Priority Date Filing Date Title
IT000003A ITFE20050003A1 (it) 2005-02-15 2005-02-15 Agonisti pieni e parziali ed antagonisti del recettore per nocicettina/orfanina fq ad elevata potenza.
PT67082859T PT1851241E (pt) 2005-02-15 2006-02-15 Agonistas totais e parciais altamente potentes e antagonistas do recetor da nociceptina/orfanina
UAA200709286A UA91844C2 (ru) 2005-02-15 2006-02-15 Высокоактивные полные и частичные агонисты и антагонисты рецептора ноцицептина/орфанина fq
CNA2006800049929A CN101128482A (zh) 2005-02-15 2006-02-15 孤啡肽受体的高效全部和部分激动剂和拮抗剂
DK06708285.9T DK1851241T3 (en) 2005-02-15 2006-02-15 Highly effective whole and partial agonists and antagonists of the nociceptin / orphanin FQ receptor
HUE06708285A HUE025000T2 (en) 2005-02-15 2006-02-15 Very effective, complete and partial agonists and antagonists of the nociceptin / orphanin FQ receptor
CN201510080020.9A CN104689293A (zh) 2005-02-15 2006-02-15 一种具有孤啡肽(n/ofq)多肽类似物的药物组合物
EP06708285.9A EP1851241B1 (en) 2005-02-15 2006-02-15 Highly potent full and partial agonists and antagonists of the nociceptin/orphanin fq receptor
JP2007554583A JP5281292B2 (ja) 2005-02-15 2006-02-15 ノシセプチン／オーファニンｆｑ受容体に対する高い活性の全体的及び部分的なアゴニスト及びアンタゴニスト
RS20150443A RS54095B1 (sr) 2005-02-15 2006-02-15 Visoko potentni potpuni i delimični agonisti i antagonisti nociceptinskih/orfaninskih fq receptora
ES06708285.9T ES2541308T3 (es) 2005-02-15 2006-02-15 Agonistas y antagonistas completos y parciales altamente potentes del receptor de nociceptina/orfanina FQ
CA2598121A CA2598121C (en) 2005-02-15 2006-02-15 Highly potent full and partial agonists and antagonists of the nociceptin/orphanin fq receptor
MX2007009523A MX2007009523A (es) 2005-02-15 2006-02-15 Agonistas y antagonistas completos y parciales altamente potentes del receptor nociceptina/orfanina fq.
HRP20150731TT HRP20150731T1 (hr) 2005-02-15 2006-02-15 Visoko potentni potpuni i djelomiäśni agonisti i antagonisti nociceptinskih/orfaninskih fq receptora
US11/884,241 US8227414B2 (en) 2005-02-15 2006-02-15 Highly potent full and partial agonists and antagonists of the nociceptin/orphanin FQ receptor
SI200631947T SI1851241T1 (sl) 2005-02-15 2006-02-15 Močno potentni polni in delni agonisti in antagonisti receptorja nociceptina/orfanina fq
PL06708285T PL1851241T3 (pl) 2005-02-15 2006-02-15 Bardzo silni pełni i częściowi agoniści i antagoniści receptora nocyceptyny/orfaniny FQ
EA200701732A EA011325B1 (ru) 2005-02-15 2006-02-15 Высокоэффективные полные и частичные агонисты и антагонисты рецептора ноцицептина/орфанина fq
KR1020077018487A KR101294895B1 (ko) 2005-02-15 2006-02-15 노시셉틴/오파닌 에프큐 수용체의 고강력 완전 및 부분작동물질 및 길항물질
PCT/EP2006/050958 WO2006087340A2 (en) 2005-02-15 2006-02-15 Highly potent full and partial agonists and antagonists of the nociceptin/orphanin fq receptor
BRPI0606998A BRPI0606998B8 (pt) 2005-02-15 2006-02-15 agonistas e antagonistas totais e parciais de alta atividade farmacológica do receptor nociceptina/orfanina fq
AU2006215639A AU2006215639B2 (en) 2005-02-15 2006-02-15 Highly potent full and partial agonists and antagonists of the nociceptin/orphanin FQ receptor
NI200700205A NI200700205A (es) 2005-02-15 2007-08-09 Agonistas y antagonistas completos y parciales altamente potentes del receptor nociceptina/orfanina fq.
CU20070195A CU23823A3 (es) 2005-02-15 2007-08-13 Agonistas y antagonistas completos y parciales altamente potentes del receptor nociceptina/orfanina fq
IL185235A IL185235A (en) 2005-02-15 2007-08-13 An analogue of nociceptin / orphanin fq protein and its uses
MA30190A MA29288B1 (fr) 2005-02-15 2007-08-31 Agonistes et antagonistes complets et partiels tres puissants du recepteur de la nociceptine/orphanine fq
ZA200707714A ZA200707714B (en) 2005-02-15 2007-09-07 Highly potent full and partial agonists and antagonists of the nociceptin/orphanin FQ receptor
CR9379A CR9379A (es) 2005-02-15 2007-09-13 Agonistas y antagonistas completos y parciales altamente potentes del receptor nociceptina/orfanina fq
NO20074702A NO341856B1 (no) 2005-02-15 2007-09-14 Høyst potente fullstendig eller delvis agonister og antagonister av nociceptin/orfanin FQ reseptoren
CY20151100579T CY1116456T1 (el) 2005-02-15 2015-07-06 Υψηλης ικανοτητας, πληρεις και τμηματικοι αγωνιστες και ανταγωνιστες του υποδοχεα nociceptin/orphanin fq

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000003A ITFE20050003A1 (it) 2005-02-15 2005-02-15 Agonisti pieni e parziali ed antagonisti del recettore per nocicettina/orfanina fq ad elevata potenza.

Publications (1)

Publication Number Publication Date
ITFE20050003A1 true ITFE20050003A1 (it) 2006-08-16

Family

ID=36685750

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000003A ITFE20050003A1 (it) 2005-02-15 2005-02-15 Agonisti pieni e parziali ed antagonisti del recettore per nocicettina/orfanina fq ad elevata potenza.

Country Status (29)

Country Link
US (1) US8227414B2 (it)
EP (1) EP1851241B1 (it)
JP (1) JP5281292B2 (it)
KR (1) KR101294895B1 (it)
CN (2) CN101128482A (it)
AU (1) AU2006215639B2 (it)
BR (1) BRPI0606998B8 (it)
CA (1) CA2598121C (it)
CR (1) CR9379A (it)
CU (1) CU23823A3 (it)
CY (1) CY1116456T1 (it)
DK (1) DK1851241T3 (it)
EA (1) EA011325B1 (it)
ES (1) ES2541308T3 (it)
HR (1) HRP20150731T1 (it)
HU (1) HUE025000T2 (it)
IL (1) IL185235A (it)
IT (1) ITFE20050003A1 (it)
MA (1) MA29288B1 (it)
MX (1) MX2007009523A (it)
NI (1) NI200700205A (it)
NO (1) NO341856B1 (it)
PL (1) PL1851241T3 (it)
PT (1) PT1851241E (it)
RS (1) RS54095B1 (it)
SI (1) SI1851241T1 (it)
UA (1) UA91844C2 (it)
WO (1) WO2006087340A2 (it)
ZA (1) ZA200707714B (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITNA20090026A1 (it) * 2009-05-14 2010-11-15 Agostino Bruno D Agonisti del recettore nop e loro usi terapeutici
CN112730849B (zh) * 2021-01-14 2023-03-10 山西医科大学第二医院 内源性孤啡肽作为糖尿病合并无症状性心肌缺血的血清生物标志物的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040259775A1 (en) * 2002-04-29 2004-12-23 Euro-Celtique S.A. Conformationally constrained peptides that bind the ORL-1 receptor
ITMI20022022A1 (it) 2002-09-24 2004-03-25 Girolamo Calo' Analoghi di nocicettina.
ITMI20031349A1 (it) 2003-07-01 2005-01-02 Ufpeptides S R L Antagonisti del recettore nop e loro usi terapeutici.
CN1634980A (zh) * 2004-10-10 2005-07-06 兰州大学 孤啡肽的类似物

Also Published As

Publication number Publication date
US8227414B2 (en) 2012-07-24
UA91844C2 (ru) 2010-09-10
IL185235A (en) 2014-08-31
RS54095B1 (sr) 2015-10-30
JP5281292B2 (ja) 2013-09-04
KR20070119614A (ko) 2007-12-20
WO2006087340A8 (en) 2007-06-21
US20100273710A1 (en) 2010-10-28
EP1851241A2 (en) 2007-11-07
HRP20150731T1 (hr) 2015-08-14
BRPI0606998B1 (pt) 2018-04-10
CN101128482A (zh) 2008-02-20
CA2598121C (en) 2014-11-25
PL1851241T3 (pl) 2015-09-30
HUE025000T2 (en) 2016-01-28
MA29288B1 (fr) 2008-02-01
DK1851241T3 (en) 2015-06-29
AU2006215639B2 (en) 2011-05-26
IL185235A0 (en) 2008-02-09
CR9379A (es) 2008-04-25
NO341856B1 (no) 2018-02-12
AU2006215639A1 (en) 2006-08-24
MX2007009523A (es) 2007-09-07
ZA200707714B (en) 2008-06-25
WO2006087340A2 (en) 2006-08-24
KR101294895B1 (ko) 2013-08-08
BRPI0606998A2 (pt) 2014-01-21
CA2598121A1 (en) 2006-08-24
SI1851241T1 (sl) 2015-08-31
EA011325B1 (ru) 2009-02-27
NO20074702L (no) 2007-10-29
NI200700205A (es) 2008-06-17
BRPI0606998B8 (pt) 2021-05-25
EA200701732A1 (ru) 2008-02-28
CU23823A3 (es) 2012-06-21
EP1851241B1 (en) 2015-04-08
PT1851241E (pt) 2015-08-28
WO2006087340A3 (en) 2006-10-26
CY1116456T1 (el) 2017-03-15
JP2008530058A (ja) 2008-08-07
ES2541308T3 (es) 2015-07-17
CN104689293A (zh) 2015-06-10

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