ITMI20002012A0 - Coniugati di glutatione con derivati della distancina ad attivita' antitumorale. - Google Patents

Coniugati di glutatione con derivati della distancina ad attivita' antitumorale.

Info

Publication number
ITMI20002012A0
ITMI20002012A0 IT2000MI002012A ITMI20002012A ITMI20002012A0 IT MI20002012 A0 ITMI20002012 A0 IT MI20002012A0 IT 2000MI002012 A IT2000MI002012 A IT 2000MI002012A IT MI20002012 A ITMI20002012 A IT MI20002012A IT MI20002012 A0 ITMI20002012 A0 IT MI20002012A0
Authority
IT
Italy
Prior art keywords
distancin
derivatives
tumor activity
glutathione conjugates
glutathione
Prior art date
Application number
IT2000MI002012A
Other languages
English (en)
Inventor
Paolo Cozzi
Italo Beria
Maria Cristina Geroni
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Priority to IT2000MI002012A priority Critical patent/IT1318696B1/it
Publication of ITMI20002012A0 publication Critical patent/ITMI20002012A0/it
Priority to US10/380,375 priority patent/US6838547B2/en
Priority to JP2002526905A priority patent/JP2004509133A/ja
Priority to EP01972032A priority patent/EP1330470A1/en
Priority to PCT/EP2001/010397 priority patent/WO2002022655A1/en
Priority to AU2001291843A priority patent/AU2001291843A1/en
Publication of ITMI20002012A1 publication Critical patent/ITMI20002012A1/it
Application granted granted Critical
Publication of IT1318696B1 publication Critical patent/IT1318696B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT2000MI002012A 2000-09-15 2000-09-15 Coniugati di glutatione con derivati della distamicina ad attivita'antitumorale. IT1318696B1 (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IT2000MI002012A IT1318696B1 (it) 2000-09-15 2000-09-15 Coniugati di glutatione con derivati della distamicina ad attivita'antitumorale.
US10/380,375 US6838547B2 (en) 2000-09-15 2001-09-07 Glutathiaone conjugates with distamycin derivatives having antitumoral activity
JP2002526905A JP2004509133A (ja) 2000-09-15 2001-09-07 抗腫瘍活性を有する、ジスタマイシン誘導体とのグルタチオン結合体
EP01972032A EP1330470A1 (en) 2000-09-15 2001-09-07 Glutathione conjugates with distamycin derivatives having antitumor activity
PCT/EP2001/010397 WO2002022655A1 (en) 2000-09-15 2001-09-07 Glutathione conjugates with distamycin derivatives having antitumoral activity
AU2001291843A AU2001291843A1 (en) 2000-09-15 2001-09-07 Glutathione conjugates with distamycin derivatives having antitumoral activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000MI002012A IT1318696B1 (it) 2000-09-15 2000-09-15 Coniugati di glutatione con derivati della distamicina ad attivita'antitumorale.

Publications (3)

Publication Number Publication Date
ITMI20002012A0 true ITMI20002012A0 (it) 2000-09-15
ITMI20002012A1 ITMI20002012A1 (it) 2002-03-15
IT1318696B1 IT1318696B1 (it) 2003-08-27

Family

ID=11445804

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2000MI002012A IT1318696B1 (it) 2000-09-15 2000-09-15 Coniugati di glutatione con derivati della distamicina ad attivita'antitumorale.

Country Status (6)

Country Link
US (1) US6838547B2 (it)
EP (1) EP1330470A1 (it)
JP (1) JP2004509133A (it)
AU (1) AU2001291843A1 (it)
IT (1) IT1318696B1 (it)
WO (1) WO2002022655A1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2524269A1 (en) 2003-05-02 2004-11-18 Elan Pharmaceuticals, Inc. 4- bromo - 5 - (2- chloro - benzoylamino) - 1h - pyrazole - 3 - carboxylic acid amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases
ATE435649T1 (de) * 2003-05-02 2009-07-15 Elan Pharm Inc 4-brom-5-(2-chlor-benzoylamino)-1h-pyrazol-3- carbonsäure(phenyl)amid-derivate und verwandte verbindungen als bradykinin b1 receptor antagonisten zur behandlung von entzündlichen erkrankungen
CA2573999A1 (en) * 2004-07-16 2006-04-06 Sunesis Pharmaceuticals, Inc. Thienopyrimidines useful as aurora kinase inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU605512B2 (en) 1986-10-07 1991-01-17 Boehringer Mannheim Italia S.P.A. Pharmaceutical compositions having antineoplastic activity
JP2926405B2 (ja) * 1988-02-20 1999-07-28 コニカ株式会社 高コントラストな画像を得ることができるハロゲン化銀写真感光材料
JP2919867B2 (ja) * 1989-09-27 1999-07-19 千寿製薬株式会社 抗腫瘍剤
EP0543576A1 (en) * 1991-11-21 1993-05-26 Konica Corporation A developer composition and a method for forming an image which uses the same
IT1272234B (it) * 1994-05-02 1997-06-16 Consiglio Nazionale Ricerche Derivati glutationici delle antracicline e procedimento per ottenerli.
US5880097A (en) * 1996-01-04 1999-03-09 Terrapin Techologies, Inc. Tethered prodrugs
GB9623522D0 (en) * 1996-11-11 1997-01-08 Pharmacia & Upjohn Spa Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9806689D0 (en) 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9816652D0 (en) * 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB0011059D0 (en) * 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione

Also Published As

Publication number Publication date
EP1330470A1 (en) 2003-07-30
AU2001291843A1 (en) 2002-03-26
US6838547B2 (en) 2005-01-04
JP2004509133A (ja) 2004-03-25
ITMI20002012A1 (it) 2002-03-15
WO2002022655A1 (en) 2002-03-21
US20040038905A1 (en) 2004-02-26
IT1318696B1 (it) 2003-08-27

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