ITMI20032024A1 - Procedimento per la preparazione dello z-flupentixol - Google Patents

Procedimento per la preparazione dello z-flupentixol

Info

Publication number: ITMI20032024A1
Authority: IT; Italy
Prior art keywords: flupentixol; preparation; procedure; isomers; separation
Prior art date: 2003-10-17

Application number

IT002024A

Other languages

English (en)

Inventor

Giacomo Bruno

Stefano Maiorana

Annibale Salvi

Flavio Villani

Original Assignee

Laboratorio Chimico Int Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-17

Filing date

2003-10-17

Publication date

2005-04-18

2003-10-17 Application filed by Laboratorio Chimico Int Spa filed Critical Laboratorio Chimico Int Spa

2003-10-17 Priority to IT002024A priority Critical patent/ITMI20032024A1/it

2004-09-29 Priority to DE602004012430T priority patent/DE602004012430T2/de

2004-09-29 Priority to PT04769498T priority patent/PT1673365E/pt

2004-09-29 Priority to SI200430674T priority patent/SI1673365T1/sl

2004-09-29 Priority to PL04769498T priority patent/PL1673365T3/pl

2004-09-29 Priority to CA2536667A priority patent/CA2536667C/en

2004-09-29 Priority to DK04769498T priority patent/DK1673365T3/da

2004-09-29 Priority to PCT/IB2004/003155 priority patent/WO2005037820A1/en

2004-09-29 Priority to ES04769498T priority patent/ES2302032T3/es

2004-09-29 Priority to EP04769498A priority patent/EP1673365B1/en

2004-09-29 Priority to CN2004800304514A priority patent/CN1867558B/zh

2004-09-29 Priority to AT04769498T priority patent/ATE388949T1/de

2005-04-18 Publication of ITMI20032024A1 publication Critical patent/ITMI20032024A1/it

2008-06-06 Priority to CY20081100599T priority patent/CY1108121T1/el

Links

NJMYODHXAKYRHW-DVZOWYKESA-N cis-flupenthixol Chemical compound C1CN(CCO)CCN1CC\C=C\1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C2/1 NJMYODHXAKYRHW-DVZOWYKESA-N 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
-1 decanoate ester Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000000926 separation method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
- C07D335/12—Thioxanthenes
- C07D335/20—Thioxanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Inorganic Compounds Of Heavy Metals (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

IT002024A 2003-10-17 2003-10-17 Procedimento per la preparazione dello z-flupentixol ITMI20032024A1 (it)

Priority Applications (13)

Application Number	Priority Date	Filing Date	Title
IT002024A ITMI20032024A1 (it)	2003-10-17	2003-10-17	Procedimento per la preparazione dello z-flupentixol
CA2536667A CA2536667C (en)	2003-10-17	2004-09-29	Process for the preparation of z-flupentixol
PT04769498T PT1673365E (pt)	2003-10-17	2004-09-29	Processo para a preparação de z-flupentixol
SI200430674T SI1673365T1 (sl)	2003-10-17	2004-09-29	Postopek za pripravo Z-flupentiksola.
PL04769498T PL1673365T3 (pl)	2003-10-17	2004-09-29	Sposób wytwarzania Z-flupentiksolu
DE602004012430T DE602004012430T2 (de)	2003-10-17	2004-09-29	Verfahren zur herstellung von z-flupentixol
DK04769498T DK1673365T3 (da)	2003-10-17	2004-09-29	Fremgangsmåde til fremstillingen af Z-flupentixol
PCT/IB2004/003155 WO2005037820A1 (en)	2003-10-17	2004-09-29	Process for the preparation of z-flupentixol
ES04769498T ES2302032T3 (es)	2003-10-17	2004-09-29	Procedimiento para la preparacion de z-flupentixol.
EP04769498A EP1673365B1 (en)	2003-10-17	2004-09-29	Process for the preparation of z-flupentixol
CN2004800304514A CN1867558B (zh)	2003-10-17	2004-09-29	Z-氟哌噻吨的制备方法
AT04769498T ATE388949T1 (de)	2003-10-17	2004-09-29	Verfahren zur herstellung von z-flupentixol
CY20081100599T CY1108121T1 (el)	2003-10-17	2008-06-06	Διαδικασια παρασκευης ζ-φλουπεντιξολης

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT002024A ITMI20032024A1 (it)	2003-10-17	2003-10-17	Procedimento per la preparazione dello z-flupentixol

Publications (1)

Publication Number	Publication Date
ITMI20032024A1 true ITMI20032024A1 (it)	2005-04-18

Family

ID=34452249

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT002024A ITMI20032024A1 (it)	2003-10-17	2003-10-17	Procedimento per la preparazione dello z-flupentixol

Country Status (12)

Country	Link
EP (1)	EP1673365B1 (it)
CN (1)	CN1867558B (it)
AT (1)	ATE388949T1 (it)
CA (1)	CA2536667C (it)
CY (1)	CY1108121T1 (it)
DE (1)	DE602004012430T2 (it)
DK (1)	DK1673365T3 (it)
ES (1)	ES2302032T3 (it)
IT (1)	ITMI20032024A1 (it)
PL (1)	PL1673365T3 (it)
PT (1)	PT1673365E (it)
WO (1)	WO2005037820A1 (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102002034B (zh) *	2009-08-28	2012-11-28	江苏恩华药业股份有限公司	盐酸氟哌噻吨异构体的分离方法
CN101912397B (zh) *	2010-04-30	2013-03-27	H.隆德贝克有限公司	氟哌噻吨组合物
CN102786511B (zh) *	2011-05-18	2014-10-15	重庆圣华曦药业股份有限公司	一种制备盐酸氟哌噻吨中间体的改进方法
CN103450151B (zh) *	2013-02-04	2014-07-30	四川海思科制药有限公司	一种氟哌噻吨化合物的制备方法
CN105348256B (zh) *	2015-11-16	2018-01-30	成都倍特药业有限公司	一种药用级盐酸氟哌噻吨的制备方法
CN107382962B (zh) *	2016-05-16	2020-11-03	江苏同禾药业有限公司	一种2-三氟甲基-9-烯丙基-9-噻吨醇的制备方法
CN107987053B (zh) *	2017-12-08	2023-04-14	植恩生物技术股份有限公司	一种高纯度z型盐酸氟哌噻吨的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1518325B1 (de) *	1960-03-07	1970-08-27	Smith Kline French Lab	Basisch substituierte Trifluormethylxanthene und deren nicht toxische Saeureadditionssalze und Verfahren zu deren Herstellung
US3282930A (en) *	1962-08-17	1966-11-01	Smith Kline French Lab	Hydroxyalkylenepiperazine derivatives and analogs thereof
US3681346A (en) *	1969-06-20	1972-08-01	Kefalas As	{60 -isomer of the decanoic acid ester of 10-{8 3,-(4-hydroxyethyl-1-piperazinyl)propylidene{9 -2-trifluoro-methyl thiaxanthene, acid addition salts thereof, method of use and compositions

2003
- 2003-10-17 IT IT002024A patent/ITMI20032024A1/it unknown
2004
- 2004-09-29 DE DE602004012430T patent/DE602004012430T2/de not_active Expired - Lifetime
- 2004-09-29 CN CN2004800304514A patent/CN1867558B/zh not_active Expired - Lifetime
- 2004-09-29 WO PCT/IB2004/003155 patent/WO2005037820A1/en not_active Ceased
- 2004-09-29 EP EP04769498A patent/EP1673365B1/en not_active Expired - Lifetime
- 2004-09-29 DK DK04769498T patent/DK1673365T3/da active
- 2004-09-29 PL PL04769498T patent/PL1673365T3/pl unknown
- 2004-09-29 CA CA2536667A patent/CA2536667C/en not_active Expired - Fee Related
- 2004-09-29 ES ES04769498T patent/ES2302032T3/es not_active Expired - Lifetime
- 2004-09-29 PT PT04769498T patent/PT1673365E/pt unknown
- 2004-09-29 AT AT04769498T patent/ATE388949T1/de active
2008
- 2008-06-06 CY CY20081100599T patent/CY1108121T1/el unknown

Also Published As

Publication number	Publication date
ES2302032T3 (es)	2008-07-01
DE602004012430T2 (de)	2009-03-05
PL1673365T3 (pl)	2008-08-29
PT1673365E (pt)	2008-05-20
DK1673365T3 (da)	2008-06-30
CN1867558A (zh)	2006-11-22
CA2536667A1 (en)	2005-04-28
WO2005037820A1 (en)	2005-04-28
CA2536667C (en)	2012-01-10
EP1673365B1 (en)	2008-03-12
DE602004012430D1 (de)	2008-04-24
CY1108121T1 (el)	2014-02-12
CN1867558B (zh)	2013-02-06
EP1673365A1 (en)	2006-06-28
ATE388949T1 (de)	2008-03-15

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