ITMI20041703A1 - Metodo di preparazione del mofetil micofenolato per transesterificazione enzimatica - Google Patents

Metodo di preparazione del mofetil micofenolato per transesterificazione enzimatica

Info

Publication number: ITMI20041703A1
Authority: IT; Italy
Prior art keywords: mofethy; mycophenolate; preparation; enzymatic transesterification; transesterification
Prior art date: 2004-09-03

Application number

IT001703A

Other languages

English (en)

Inventor

Paride Grisenti

Paolo Prestileo

Original Assignee

Poli Ind Chimica Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-09-03

Filing date

2004-09-03

Publication date

2004-12-03

2004-09-03 Application filed by Poli Ind Chimica Spa filed Critical Poli Ind Chimica Spa

2004-09-03 Priority to IT001703A priority Critical patent/ITMI20041703A1/it

2004-12-03 Publication of ITMI20041703A1 publication Critical patent/ITMI20041703A1/it

2005-07-25 Priority to US11/661,913 priority patent/US7727751B2/en

2005-07-26 Priority to DE602005004557T priority patent/DE602005004557T2/de

2005-07-26 Priority to AT05772045T priority patent/ATE384802T1/de

2005-07-26 Priority to DK05772045T priority patent/DK1784497T3/da

2005-07-26 Priority to CN2005800296809A priority patent/CN101035904B/zh

2005-07-26 Priority to EP05772045A priority patent/EP1784497B1/en

2005-07-26 Priority to PCT/EP2005/053629 priority patent/WO2006024582A1/en

2005-07-26 Priority to HR20080081T priority patent/HRP20080081T3/xx

2005-07-26 Priority to JP2007529349A priority patent/JP4880604B2/ja

2005-07-26 Priority to HK07112465.4A priority patent/HK1107120B/xx

2005-08-09 Priority to ARP050103327A priority patent/AR050289A1/es

2005-08-24 Priority to TW094128930A priority patent/TWI354703B/zh

2007-03-27 Priority to NO20071602A priority patent/NO20071602L/no

Links

230000002255 enzymatic effect Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 title 1
229940014456 mycophenolate Drugs 0.000 title 1
HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 title 1
238000005809 transesterification reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)

IT001703A 2004-09-03 2004-09-03 Metodo di preparazione del mofetil micofenolato per transesterificazione enzimatica ITMI20041703A1 (it)

Priority Applications (14)

Application Number	Priority Date	Filing Date	Title
IT001703A ITMI20041703A1 (it)	2004-09-03	2004-09-03	Metodo di preparazione del mofetil micofenolato per transesterificazione enzimatica
US11/661,913 US7727751B2 (en)	2004-09-03	2005-07-25	Method for the preparation of mycophenolate mofetil by enzyme tranesterification
HK07112465.4A HK1107120B (en)	2004-09-03	2005-07-26	A method for the preparation of mycophenolate mofetil by enzimatic transesterification
EP05772045A EP1784497B1 (en)	2004-09-03	2005-07-26	Method for the preparation of mycophenolate mofetil by enzimatic transesterification
AT05772045T ATE384802T1 (de)	2004-09-03	2005-07-26	Verfahren zur herstellung von mycophenolat- mofetil mittels enzymatischer umesterung
DK05772045T DK1784497T3 (da)	2004-09-03	2005-07-26	Fremgangsmåde til fremstilling af mycophenolatmofetil ved enzymatisk transesterificering
CN2005800296809A CN101035904B (zh)	2004-09-03	2005-07-26	通过酶催化的酯交换反应制备霉酚酸吗啉乙酯的方法
DE602005004557T DE602005004557T2 (de)	2004-09-03	2005-07-26	Verfahren zur herstellung von mycophenolat-mofetil mittels enzymatischer umesterung
PCT/EP2005/053629 WO2006024582A1 (en)	2004-09-03	2005-07-26	A method for the preparation of mycophenolate mofetil by enzimatic transesterification
HR20080081T HRP20080081T3 (hr)	2004-09-03	2005-07-26	Postupak dobivanja mikofenolat mofetila enzimskomtransesterifikacijom
JP2007529349A JP4880604B2 (ja)	2004-09-03	2005-07-26	酵素エステル交換反応によるミコフェノール酸モフェチルの調製方法
ARP050103327A AR050289A1 (es)	2004-09-03	2005-08-09	Un metodo para la preparacion de micofenolato de mofetilo por transesterificacion enzimatica
TW094128930A TWI354703B (en)	2004-09-03	2005-08-24	A method for the preparation of mycophenolate mofe
NO20071602A NO20071602L (no)	2004-09-03	2007-03-27	Fremgangsmate for fremstilling av mycofenolatmofetil ved enzymatisk transsesterifisering

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT001703A ITMI20041703A1 (it)	2004-09-03	2004-09-03	Metodo di preparazione del mofetil micofenolato per transesterificazione enzimatica

Publications (1)

Publication Number	Publication Date
ITMI20041703A1 true ITMI20041703A1 (it)	2004-12-03

Family

ID=35064927

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT001703A ITMI20041703A1 (it)	2004-09-03	2004-09-03	Metodo di preparazione del mofetil micofenolato per transesterificazione enzimatica

Country Status (13)

Country	Link
US (1)	US7727751B2 (it)
EP (1)	EP1784497B1 (it)
JP (1)	JP4880604B2 (it)
CN (1)	CN101035904B (it)
AR (1)	AR050289A1 (it)
AT (1)	ATE384802T1 (it)
DE (1)	DE602005004557T2 (it)
DK (1)	DK1784497T3 (it)
HR (1)	HRP20080081T3 (it)
IT (1)	ITMI20041703A1 (it)
NO (1)	NO20071602L (it)
TW (1)	TWI354703B (it)
WO (1)	WO2006024582A1 (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA06005659A (es)	2004-04-26	2007-04-10	Teva Gyogyszergyar Zartkoruen	Proceso para preparacion de acido micofenolico y derivados de ester del mismo.
US20080280977A1 (en) *	2005-04-26	2008-11-13	Sandor Molnar	Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid
US20080188653A1 (en)	2007-02-04	2008-08-07	Formosa Laboratories, Inc.	Process for Preparation of Mycophenolate Mofetil
IT1394309B1 (it)	2009-05-22	2012-06-06	Poli Ind Chimica Spa	Nuovo approccio chimico-enzimatico alla sintesi del pimecrolimus
CN102391225B (zh) *	2011-12-07	2013-07-31	中国科学院南海海洋研究所	霉酚酸衍生物a、b、c及其在制备免疫抑制药物中的应用
CN102924413B (zh) *	2012-10-23	2014-12-31	福建科瑞药业有限公司	一种霉酚酸莫啡酯纯化脱色方法
WO2020039263A2 (en)	2018-08-18	2020-02-27	Ftf Pharma Private Limited	Pharmaceutical suspension for oral dosage

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH08217783A (ja) *	1995-02-16	1996-08-27	Mitsubishi Chem Corp	ショ糖脂肪酸エステルの製造方法
IN188985B (it) *	1998-12-09	2002-11-30	Biocon Ltd
CZ292123B6 (cs) *	2001-06-08	2003-08-13	Ivax Pharmaceuticals S.R.O.	Způsob přípravy mykofenolátu mofetilu
WO2003042393A1 (en)	2001-11-16	2003-05-22	Biocon Limited	Enzymatic preparation of mycophenolate mofetil
TWI221414B (en) *	2003-02-21	2004-10-01	Chunghwa Chemical Synthesis &	Method of making mycophenolate mofetil using transesterification

2004
- 2004-09-03 IT IT001703A patent/ITMI20041703A1/it unknown
2005
- 2005-07-25 US US11/661,913 patent/US7727751B2/en not_active Expired - Fee Related
- 2005-07-26 DE DE602005004557T patent/DE602005004557T2/de not_active Expired - Lifetime
- 2005-07-26 EP EP05772045A patent/EP1784497B1/en not_active Expired - Lifetime
- 2005-07-26 HR HR20080081T patent/HRP20080081T3/xx unknown
- 2005-07-26 AT AT05772045T patent/ATE384802T1/de active
- 2005-07-26 JP JP2007529349A patent/JP4880604B2/ja not_active Expired - Fee Related
- 2005-07-26 DK DK05772045T patent/DK1784497T3/da active
- 2005-07-26 WO PCT/EP2005/053629 patent/WO2006024582A1/en not_active Ceased
- 2005-07-26 CN CN2005800296809A patent/CN101035904B/zh not_active Expired - Fee Related
- 2005-08-09 AR ARP050103327A patent/AR050289A1/es not_active Application Discontinuation
- 2005-08-24 TW TW094128930A patent/TWI354703B/zh not_active IP Right Cessation
2007
- 2007-03-27 NO NO20071602A patent/NO20071602L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN101035904A (zh)	2007-09-12
HRP20080081T3 (hr)	2008-03-31
CN101035904B (zh)	2011-02-02
JP4880604B2 (ja)	2012-02-22
DE602005004557T2 (de)	2009-01-22
EP1784497B1 (en)	2008-01-23
WO2006024582A1 (en)	2006-03-09
NO20071602L (no)	2007-05-30
HK1107120A1 (en)	2008-03-28
ATE384802T1 (de)	2008-02-15
EP1784497A1 (en)	2007-05-16
DK1784497T3 (da)	2008-05-13
TWI354703B (en)	2011-12-21
US7727751B2 (en)	2010-06-01
AR050289A1 (es)	2006-10-11
JP2008511309A (ja)	2008-04-17
US20080085542A1 (en)	2008-04-10
TW200621989A (en)	2006-07-01
DE602005004557D1 (de)	2008-03-13

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