ITMI20042007A1 - "modulatori del ricettore gpr17 e loro impieghi terapeutici" - Google Patents

"modulatori del ricettore gpr17 e loro impieghi terapeutici"

Info

Publication number
ITMI20042007A1
ITMI20042007A1 IT002007A ITMI20042007A ITMI20042007A1 IT MI20042007 A1 ITMI20042007 A1 IT MI20042007A1 IT 002007 A IT002007 A IT 002007A IT MI20042007 A ITMI20042007 A IT MI20042007A IT MI20042007 A1 ITMI20042007 A1 IT MI20042007A1
Authority
IT
Italy
Prior art keywords
gpr17
recipe
modulators
therapeutic uses
therapeutic
Prior art date
Application number
IT002007A
Other languages
English (en)
Inventor
Maria Pia Abbracchio
Paolo Ciana
Claudia Martini
Gianenrico Rovati
Maria Letizia Trincavelli
Claudia Verderio
Original Assignee
Consiglio Nazionale Ricerche
Univ Degli Studi Milano
Univ Pisa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consiglio Nazionale Ricerche, Univ Degli Studi Milano, Univ Pisa filed Critical Consiglio Nazionale Ricerche
Priority to IT002007A priority Critical patent/ITMI20042007A1/it
Publication of ITMI20042007A1 publication Critical patent/ITMI20042007A1/it
Priority to PCT/EP2005/011157 priority patent/WO2006045476A2/en
Priority to JP2007537181A priority patent/JP2008516617A/ja
Priority to US11/665,835 priority patent/US8158593B2/en
Priority to EP05795031A priority patent/EP1807701A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Cardiology (AREA)
  • Plant Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
IT002007A 2004-10-21 2004-10-21 "modulatori del ricettore gpr17 e loro impieghi terapeutici" ITMI20042007A1 (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IT002007A ITMI20042007A1 (it) 2004-10-21 2004-10-21 "modulatori del ricettore gpr17 e loro impieghi terapeutici"
PCT/EP2005/011157 WO2006045476A2 (en) 2004-10-21 2005-10-17 Gpr17 modulators, method of screening and uses thereof
JP2007537181A JP2008516617A (ja) 2004-10-21 2005-10-17 Gpr17調節因子、そのスクリーニング方法、およびその使用
US11/665,835 US8158593B2 (en) 2004-10-21 2005-10-17 GPR17 modulators, method of screening and uses thereof
EP05795031A EP1807701A2 (en) 2004-10-21 2005-10-17 Gpr17 modulators, method of screening and uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT002007A ITMI20042007A1 (it) 2004-10-21 2004-10-21 "modulatori del ricettore gpr17 e loro impieghi terapeutici"

Publications (1)

Publication Number Publication Date
ITMI20042007A1 true ITMI20042007A1 (it) 2005-01-21

Family

ID=35598398

Family Applications (1)

Application Number Title Priority Date Filing Date
IT002007A ITMI20042007A1 (it) 2004-10-21 2004-10-21 "modulatori del ricettore gpr17 e loro impieghi terapeutici"

Country Status (5)

Country Link
US (1) US8158593B2 (it)
EP (1) EP1807701A2 (it)
JP (1) JP2008516617A (it)
IT (1) ITMI20042007A1 (it)
WO (1) WO2006045476A2 (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1402549B1 (it) 2010-11-03 2013-09-13 Univ Pisa Composti e composizioni che modulano gpr17 e loro usi terapeutici e diagnostici
JP2014527420A (ja) * 2011-06-29 2014-10-16 ザ・ジョンズ・ホプキンス・ユニバーシティ 3次元インターフェイス及びデータベースのためのシステム
EP2567698B1 (en) 2011-09-07 2014-02-12 Rheinische Friedrich-Wilhelms-Universität Bonn GPR 17 agonists and screening assay
US9879030B2 (en) 2012-05-09 2018-01-30 Universita′ Degli Studi Di Milano GPR17 receptor modulators
DE102016213926B4 (de) * 2016-07-28 2018-10-31 Siemens Healthcare Gmbh Verfahren zur Bestimmung eines Diffusionstensors mittels eines Magnetresonanztomographen und Vorrichtung
TWI754702B (zh) 2016-12-28 2022-02-11 德商Ucb製藥有限公司 (氮雜)吲哚-和苯並呋喃-3-磺醯胺類
CA3098623A1 (en) 2018-05-07 2019-11-14 Alnylam Pharmaceuticals, Inc. Extrahepatic delivery
TWI857957B (zh) 2018-06-19 2024-10-11 德商Ucb製藥有限公司 吡啶基及吡基-(氮)吲哚磺醯胺
EP3584244A1 (en) 2018-06-20 2019-12-25 UCB Pharma GmbH Substituted alkoxypyridinyl indolsulfonamides
EP3983384B1 (en) 2019-06-17 2023-10-11 UCB Pharma GmbH N-(phenyl)-indole-3-sulfonamide derivatives and related compounds as gpr17 modulators for treating cns disorders such as multiple sclerosis
GB2700773A (en) 2024-05-23 2026-03-11 Pheno Therapeutics Ltd Compounds
WO2025243044A1 (en) 2024-05-23 2025-11-27 Pheno Therapeutics Limited Compounds
GB2642355B (en) 2024-07-05 2026-07-08 Pheno Therapeutics Ltd Polymorphs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2118372T3 (es) * 1992-11-17 1998-09-16 Icos Corp Nuevos receptores siete transmembrana v28.
WO1996039438A1 (en) 1995-06-06 1996-12-12 Human Genome Sciences, Inc. G-protein receptor hibeb69
GB0003902D0 (en) 2000-02-18 2000-04-05 Glaxo Group Ltd Assay
WO2001068842A2 (en) 2000-03-14 2001-09-20 Bayer Aktiengesellschaft Regulation of human p2y-like gpcr protein
WO2005040829A2 (en) 2003-10-21 2005-05-06 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 17 (gpr17)

Also Published As

Publication number Publication date
US20090156521A1 (en) 2009-06-18
JP2008516617A (ja) 2008-05-22
US8158593B2 (en) 2012-04-17
EP1807701A2 (en) 2007-07-18
WO2006045476A3 (en) 2006-07-20
WO2006045476A2 (en) 2006-05-04

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