ITMI20071267A1 - Uso di coniugati dell'acido ialuronico nel trattamento locale di malattie cutanee iperproliferative - Google Patents
Uso di coniugati dell'acido ialuronico nel trattamento locale di malattie cutanee iperproliferativeInfo
- Publication number
- ITMI20071267A1 ITMI20071267A1 IT001267A ITMI20071267A ITMI20071267A1 IT MI20071267 A1 ITMI20071267 A1 IT MI20071267A1 IT 001267 A IT001267 A IT 001267A IT MI20071267 A ITMI20071267 A IT MI20071267A IT MI20071267 A1 ITMI20071267 A1 IT MI20071267A1
- Authority
- IT
- Italy
- Prior art keywords
- conjugates
- hyaluronic acid
- skin diseases
- local treatment
- hyperproliferative skin
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title 1
- 229920002674 hyaluronan Polymers 0.000 title 1
- 229960003160 hyaluronic acid Drugs 0.000 title 1
- 230000003463 hyperproliferative effect Effects 0.000 title 1
- 208000017520 skin disease Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6955—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a plaster, a bandage, a dressing or a patch
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001267A ITMI20071267A1 (it) | 2007-06-22 | 2007-06-22 | Uso di coniugati dell'acido ialuronico nel trattamento locale di malattie cutanee iperproliferative |
| PCT/IB2008/001706 WO2009001209A1 (en) | 2007-06-22 | 2008-06-19 | Use of conjugates of hyaluronic acid in the local treatment of hyperproliferative skin diseases |
| CA2692191A CA2692191C (en) | 2007-06-22 | 2008-06-19 | Use of conjugates of hyaluronic acid in the local treatment of hyperproliferative skin diseases |
| PT87763116T PT2167134E (pt) | 2007-06-22 | 2008-06-19 | Uso de conjugados de ácido hialurónico no tratamento local de doenças de pele hiperproliferativas |
| EP08776311A EP2167134B1 (en) | 2007-06-22 | 2008-06-19 | Use of conjugates of hyaluronic acid in the local treatment of hyperproliferative skin diseases |
| JP2010512804A JP2010530869A (ja) | 2007-06-22 | 2008-06-19 | 過剰増殖性皮膚疾患の局所治療におけるヒアルロン酸のコンジュゲートの使用 |
| ES08776311T ES2394127T3 (es) | 2007-06-22 | 2008-06-19 | Uso de conjugados del ácido hialurónico en el tratamiento local de enfermedades hiperproliferativas de la piel |
| CN2008801013571A CN101835495B (zh) | 2007-06-22 | 2008-06-19 | 透明质酸结合物在局部治疗过度增殖皮肤病中的应用 |
| US12/666,286 US9283284B2 (en) | 2007-06-22 | 2008-06-19 | Use of conjugates of hyaluronic acid in the local treatment of hyperproliferative skin diseases |
| AU2008269431A AU2008269431B2 (en) | 2007-06-22 | 2008-06-19 | Use of conjugates of hyaluronic acid in the local treatment of hyperproliferative skin diseases |
| IL202875A IL202875A (en) | 2007-06-22 | 2009-12-21 | Use of Hyaluronic Acid Conjugates or History and Anti-Malignant Medications for Topical Treatment of Actinic Radiation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001267A ITMI20071267A1 (it) | 2007-06-22 | 2007-06-22 | Uso di coniugati dell'acido ialuronico nel trattamento locale di malattie cutanee iperproliferative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ITMI20071267A1 true ITMI20071267A1 (it) | 2008-12-23 |
Family
ID=39938375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT001267A ITMI20071267A1 (it) | 2007-06-22 | 2007-06-22 | Uso di coniugati dell'acido ialuronico nel trattamento locale di malattie cutanee iperproliferative |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9283284B2 (it) |
| EP (1) | EP2167134B1 (it) |
| JP (1) | JP2010530869A (it) |
| CN (1) | CN101835495B (it) |
| AU (1) | AU2008269431B2 (it) |
| CA (1) | CA2692191C (it) |
| ES (1) | ES2394127T3 (it) |
| IL (1) | IL202875A (it) |
| IT (1) | ITMI20071267A1 (it) |
| PT (1) | PT2167134E (it) |
| WO (1) | WO2009001209A1 (it) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1399351B1 (it) | 2009-06-16 | 2013-04-16 | Fidia Farmaceutici | Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi |
| WO2016071365A1 (en) | 2014-11-03 | 2016-05-12 | Spherium Biomed, S.L. | Topical pharmaceutical compositions of paclitaxel |
| EP3302569A1 (en) * | 2015-05-29 | 2018-04-11 | Albatross Technologies Limited | Cross-linked hyaluronic acid for drug delivery and pharmaceutical preparation using same |
| CN114588270B (zh) | 2015-09-16 | 2024-08-06 | Dfb索里亚有限责任公司 | 包含紫杉烷类纳米颗粒的组合物及其用途 |
| WO2018170196A1 (en) | 2017-03-15 | 2018-09-20 | Dfb Soria, Llc | Topical therapy for the treatment of skin malignancies using nanoparticles of taxanes |
| WO2018170207A1 (en) * | 2017-03-15 | 2018-09-20 | Dfb Soria, Llc | Topical therapy for the treatment of skin keratoses using nanoparticles of taxanes |
| US11497726B2 (en) | 2018-03-16 | 2022-11-15 | Dfb Soria, Ll. | Topical therapy for the treatment of cervical intraepithelial neoplasia (CIN) and cervical cancer using nanoparticles of taxanes |
| CN109078192B (zh) * | 2018-08-30 | 2021-07-16 | 中山大学 | 一种小肠靶向吸收、生物降解的糖原衍生物、其制备方法及其负载茶多糖的纳米粒 |
| IT201800009731A1 (it) | 2018-10-25 | 2020-04-25 | Fidia Farm Spa | Coniugato paclitaxel - acido ialuronico nel trattamento del carcinoma vescicale non infiltrante |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH666897A5 (fr) | 1983-10-11 | 1988-08-31 | Fidia Spa | Fractions d'acide hyaluronique non inflammatoire, procedes et compositions pharmaceutiques. |
| US4851521A (en) | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| IT1219587B (it) | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
| US5910489A (en) * | 1990-09-18 | 1999-06-08 | Hyal Pharmaceutical Corporation | Topical composition containing hyaluronic acid and NSAIDS |
| CA2061703C (en) * | 1992-02-20 | 2002-07-02 | Rudolf E. Falk | Formulations containing hyaluronic acid |
| US6103704A (en) | 1991-07-03 | 2000-08-15 | Hyal Pharmaceutical Corporation | Therapeutic methods using hyaluronic acid |
| IT1263393B (it) | 1993-07-30 | 1996-08-05 | Fidia Advanced Biopolymers Srl | Processo per la preparazione e purificazione di acido ialuronico ad alto peso molecolare |
| ITPD940054A1 (it) | 1994-03-23 | 1995-09-23 | Fidia Advanced Biopolymers Srl | Polisaccaridi solfatati |
| US6515016B2 (en) * | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
| ATE229038T1 (de) | 1997-04-04 | 2002-12-15 | Fidia Advanced Biopolymers Srl | N-sulfatierte hyaluronsäureverbindungen, ihre derivate und verfahren zu ihrer herstellung |
| ITPD980169A1 (it) | 1998-07-06 | 2000-01-06 | Fidia Advanced Biopolymers Srl | Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione. |
| US20040127470A1 (en) * | 1998-12-23 | 2004-07-01 | Pharmacia Corporation | Methods and compositions for the prevention or treatment of neoplasia comprising a Cox-2 inhibitor in combination with an epidermal growth factor receptor antagonist |
| IT1317359B1 (it) | 2000-08-31 | 2003-06-16 | Fidia Advanced Biopolymers Srl | Polisaccaridi percarbossilati, quali l'acido ialuronico, processo perla loro preparazione e loro impiego in campo farmaceutico e |
| IT1317358B1 (it) | 2000-08-31 | 2003-06-16 | Fidia Advanced Biopolymers Srl | Derivati cross-linkati dell'acido ialuronico. |
| ITPD20020271A1 (it) * | 2002-10-18 | 2004-04-19 | Fidia Farmaceutici | Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati. |
| US20070149618A1 (en) * | 2004-02-17 | 2007-06-28 | Action Medicines, S.L. | Methods of use for 2,5-dihydroxybenzene sulfonic acid compounds for the treatment of cancer, rosacea and psoriasis |
| ITPD20050242A1 (it) * | 2005-08-03 | 2007-02-04 | Fidia Farmaceutici | Bioconiugati antitumorali dell'acido ialuronico o dei suoi derivati, ottenibili per coniugazione chimica diretta o indiretta, e loro impiego in campo farmaceutico |
-
2007
- 2007-06-22 IT IT001267A patent/ITMI20071267A1/it unknown
-
2008
- 2008-06-19 US US12/666,286 patent/US9283284B2/en active Active
- 2008-06-19 WO PCT/IB2008/001706 patent/WO2009001209A1/en not_active Ceased
- 2008-06-19 JP JP2010512804A patent/JP2010530869A/ja active Pending
- 2008-06-19 CA CA2692191A patent/CA2692191C/en active Active
- 2008-06-19 PT PT87763116T patent/PT2167134E/pt unknown
- 2008-06-19 AU AU2008269431A patent/AU2008269431B2/en not_active Ceased
- 2008-06-19 ES ES08776311T patent/ES2394127T3/es active Active
- 2008-06-19 EP EP08776311A patent/EP2167134B1/en active Active
- 2008-06-19 CN CN2008801013571A patent/CN101835495B/zh active Active
-
2009
- 2009-12-21 IL IL202875A patent/IL202875A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CN101835495B (zh) | 2012-03-14 |
| CN101835495A (zh) | 2010-09-15 |
| AU2008269431A1 (en) | 2008-12-31 |
| JP2010530869A (ja) | 2010-09-16 |
| PT2167134E (pt) | 2012-12-11 |
| AU2008269431B2 (en) | 2013-03-07 |
| CA2692191A1 (en) | 2008-12-31 |
| CA2692191C (en) | 2016-01-05 |
| US9283284B2 (en) | 2016-03-15 |
| US20100204175A1 (en) | 2010-08-12 |
| WO2009001209A1 (en) | 2008-12-31 |
| ES2394127T3 (es) | 2013-01-22 |
| EP2167134A1 (en) | 2010-03-31 |
| EP2167134B1 (en) | 2012-08-29 |
| IL202875A (en) | 2016-02-29 |
| WO2009001209A8 (en) | 2009-03-26 |
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