ITMI920631A1 - Derivati mercapto acetamidici - Google Patents

Derivati mercapto acetamidici

Info

Publication number: ITMI920631A1
Authority: IT; Italy
Prior art keywords: alkyl; aralkyl; acute; derivatives; above compounds
Prior art date: 1992-03-18

Application number

IT000631A

Other languages

English (en)

Inventor

Giancarlo B Fregnan

Marco Inglesi

Massimo Nicola

Guido Vandoni

Original Assignee

Edmond Pharma Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-18

Filing date

1992-03-18

Publication date

1993-09-18

1992-03-18 Application filed by Edmond Pharma Srl filed Critical Edmond Pharma Srl

1992-03-18 Priority to ITMI920631A priority Critical patent/IT1254530B/it

1992-03-18 Publication of ITMI920631A0 publication Critical patent/ITMI920631A0/it

1993-02-26 Priority to DE69312849T priority patent/DE69312849T2/de

1993-02-26 Priority to JP5516198A priority patent/JPH06507919A/ja

1993-02-26 Priority to ES93905278T priority patent/ES2106325T3/es

1993-02-26 Priority to AT93905278T priority patent/ATE156487T1/de

1993-02-26 Priority to PCT/EP1993/000449 priority patent/WO1993019024A2/en

1993-02-26 Priority to EP93905278A priority patent/EP0593697B1/en

1993-09-18 Publication of ITMI920631A1 publication Critical patent/ITMI920631A1/it

1995-09-25 Application granted granted Critical

1995-09-25 Publication of IT1254530B publication Critical patent/IT1254530B/it

Links

PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 title 1
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 3
125000003710 aryl alkyl group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
230000001154 acute effect Effects 0.000 abstract 2
206010006451 bronchitis Diseases 0.000 abstract 2
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
101100496169 Arabidopsis thaliana CLH1 gene Proteins 0.000 abstract 1
206010006458 Bronchitis chronic Diseases 0.000 abstract 1
206010014561 Emphysema Diseases 0.000 abstract 1
108010024636 Glutathione Proteins 0.000 abstract 1
FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 abstract 1
101100044057 Mesocricetus auratus SYCP3 gene Proteins 0.000 abstract 1
101100080600 Schizosaccharomyces pombe (strain 972 / ATCC 24843) nse6 gene Proteins 0.000 abstract 1
230000004075 alteration Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
239000000729 antidote Substances 0.000 abstract 1
229940075522 antidotes Drugs 0.000 abstract 1
239000003963 antioxidant agent Substances 0.000 abstract 1
230000005779 cell damage Effects 0.000 abstract 1
208000007451 chronic bronchitis Diseases 0.000 abstract 1
230000001684 chronic effect Effects 0.000 abstract 1
101150111293 cor-1 gene Proteins 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000007760 free radical scavenging Effects 0.000 abstract 1
229960003180 glutathione Drugs 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000000510 mucolytic effect Effects 0.000 abstract 1
230000007170 pathology Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
239000002516 radical scavenger Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)

ITMI920631A 1992-03-18 1992-03-18 Derivati mercapto acetamidici IT1254530B (it)

Priority Applications (7)

Application Number	Priority Date	Filing Date	Title
ITMI920631A IT1254530B (it)	1992-03-18	1992-03-18	Derivati mercapto acetamidici
DE69312849T DE69312849T2 (de)	1992-03-18	1993-02-26	Mercapto-acetamid-derivate
JP5516198A JPH06507919A (ja)	1992-03-18	1993-02-26	メルカプトアセトアミド誘導体
ES93905278T ES2106325T3 (es)	1992-03-18	1993-02-26	Derivados de mercapto-acetamida.
AT93905278T ATE156487T1 (de)	1992-03-18	1993-02-26	Mercapto-acetamid-derivate
PCT/EP1993/000449 WO1993019024A2 (en)	1992-03-18	1993-02-26	Mercapto-acetamide derivatives
EP93905278A EP0593697B1 (en)	1992-03-18	1993-02-26	Mercapto-acetamide derivatives

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI920631A IT1254530B (it)	1992-03-18	1992-03-18	Derivati mercapto acetamidici

Publications (3)

Publication Number	Publication Date
ITMI920631A0 ITMI920631A0 (it)	1992-03-18
ITMI920631A1 true ITMI920631A1 (it)	1993-09-18
IT1254530B IT1254530B (it)	1995-09-25

Family

ID=11362490

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ITMI920631A IT1254530B (it)	1992-03-18	1992-03-18	Derivati mercapto acetamidici

Country Status (7)

Country	Link
EP (1)	EP0593697B1 (it)
JP (1)	JPH06507919A (it)
AT (1)	ATE156487T1 (it)
DE (1)	DE69312849T2 (it)
ES (1)	ES2106325T3 (it)
IT (1)	IT1254530B (it)
WO (1)	WO1993019024A2 (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0935227A (ja) *	1995-07-21	1997-02-07	Sony Corp	磁気ヘッド装置
US7875268B2 (en)	2004-04-06	2011-01-25	L'oreal S.A.	Dimercaptoamides, compositions comprising them as reducing agents, and processes for permanently reshaping keratin fibers therewith
FR2868420B1 (fr) *	2004-04-06	2006-06-16	Oreal	Utilisation de dimercaptoamides pour la deformation permanente des fibres keratiniques
UA95139C2 (ru) *	2009-11-11	2011-07-11	Владислав Лазаревич Розенфельд	Профилактическое средство-антиоксидант, для защиты тканей организма от последствий табакокурения

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2502153A1 (fr) *	1981-03-19	1982-09-24	Rech Pharmaceutiq Medicale	Acides (2-oxo-3-tetrahydrothienylcarbamoyl)-alkylthio) acetiques, leurs sels et leurs esters, leur procede de preparation et les compositions pharmaceutiques en contenant
IT1140394B (it) *	1981-12-23	1986-09-24	Maggioni Farma	Dipeptidi contenenti un residuo di metionina ad attivita' epatoprotettrice
IT1173441B (it) *	1984-03-14	1987-06-24	Edmond Pharma Srl	Sali di eritromicina con derivati dell'acido acetico,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
IT1215238B (it) *	1985-02-22	1990-01-31	Chiesi Farma Spa	Derivati di omocisteina tiolattone,loro procedimento di preparazione e formulazioni farmaceutiche

1992
- 1992-03-18 IT ITMI920631A patent/IT1254530B/it active
1993
- 1993-02-26 WO PCT/EP1993/000449 patent/WO1993019024A2/en not_active Ceased
- 1993-02-26 DE DE69312849T patent/DE69312849T2/de not_active Expired - Fee Related
- 1993-02-26 JP JP5516198A patent/JPH06507919A/ja active Pending
- 1993-02-26 EP EP93905278A patent/EP0593697B1/en not_active Expired - Lifetime
- 1993-02-26 AT AT93905278T patent/ATE156487T1/de active
- 1993-02-26 ES ES93905278T patent/ES2106325T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69312849T2 (de)	1998-01-08
WO1993019024A2 (en)	1993-09-30
DE69312849D1 (de)	1997-09-11
ITMI920631A0 (it)	1992-03-18
EP0593697A1 (en)	1994-04-27
ATE156487T1 (de)	1997-08-15
EP0593697B1 (en)	1997-08-06
JPH06507919A (ja)	1994-09-08
WO1993019024A3 (en)	1993-10-28
ES2106325T3 (es)	1997-11-01
IT1254530B (it)	1995-09-25

Publication	Publication Date	Title
PH12970A (en)	1979-10-24	Proline derivatives and compositions containing the same
DE69920496D1 (de)	2004-10-28	Piperidin- und pyrrolidin-derivate enthaltend ein stickstoffoxid donor zur behandlung von stress
EA200100755A1 (ru)	2001-12-24	4-оксо-1,4-дигидро-3-хинолинкарбоксамиды как антивирусные агенты
MEP24608A (en)	2010-10-10	Azetidine derivatives, preparation thereof and pharmaceutical compositions containing same
RO90232A (ro)	1986-12-10	Procedeu pentru prepararea unor derivati de 2-cian-benzimidazol
DK1054874T3 (da)	2002-12-30	Substituerede aminophenylisoxazolinderivater, der er anvendelige som antimokrobielle midler
OA06929A (fr)	1983-05-31	Carboxyalkyl dipeptides, procédés pour leur production et compositions pharmaceutiques les contenant.
KR890000489A (ko)	1989-03-15	6 환 화합물
DE69127690D1 (de)	1997-10-23	Antiatherosklerotische und antithrombotische 1-benzopyran-4-on- und 2-amino-1,3-benzoxazin-4-on-derivate
EP0048763A4 (en)	1982-07-06	ACYLAMINO ACIDS CONTAINING SULFUR.
DE69808282D1 (de)	2002-10-31	Verwendung von Thienopyrimidinen als Fungizide
TR199800718T2 (xx)	1998-08-21	Herbisid s�lfonamidleri
ES2174298T3 (es)	2002-11-01	Derivados de aminotiazol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
BR8704389A (pt)	1988-04-19	Composicao de pintura e processo para a protecao de uma substancia de pintura
DK534381A (da)	1982-06-06	Fremgangsmaade til fremstilling af 2-oxoazetidinderivater
DK1468692T3 (da)	2006-08-28	Anvendelse af 2,6-di-alkyl-4-silyl-phenoler til behandling af xantom
NO20001198L (no)	2000-05-08	Pyrrolopyrrolondervater som inhibitorer av nøytrofil elastase
DE69312849D1 (de)	1997-09-11	Mercapto-acetamid-derivate
SE8303913L (sv)	1984-01-09	Heterocykliska foreningar
PT89935A (pt)	1989-11-10	Processo para a preparacao de novos compostos cefem
AU3872685A (en)	1985-08-22	3-phenyl-2-propeneamine derivatives
DK659089A (da)	1989-12-22	Mevalonolactoner af pyrazolopyridintypen
ES2183500T3 (es)	2003-03-16	Nuevos compuestos y composiciones farmaceuticas que los contienen.
MX9302388A (es)	1993-10-01	Oxazolidinonas fungicidas y composicion fungicida que las contiene
DE69017627D1 (de)	1995-04-13	Isochinolinderivate und ihre Salze als Proteasehemmer.