ITMI991483A0 - Derivati tassanici e procedimenti per la loro preparazione - Google Patents

Derivati tassanici e procedimenti per la loro preparazione

Info

Publication number
ITMI991483A0
ITMI991483A0 IT99MI001483A ITMI991483A ITMI991483A0 IT MI991483 A0 ITMI991483 A0 IT MI991483A0 IT 99MI001483 A IT99MI001483 A IT 99MI001483A IT MI991483 A ITMI991483 A IT MI991483A IT MI991483 A0 ITMI991483 A0 IT MI991483A0
Authority
IT
Italy
Prior art keywords
procedures
preparation
taxan derivatives
taxan
derivatives
Prior art date
Application number
IT99MI001483A
Other languages
English (en)
Inventor
Ezio Bombardelli
Bruno Gabetta
Alessandro Pontiroli
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Priority to IT1999MI001483A priority Critical patent/ITMI991483A1/it
Publication of ITMI991483A0 publication Critical patent/ITMI991483A0/it
Priority to HU0202016A priority patent/HUP0202016A3/hu
Priority to AT00943970T priority patent/ATE277932T1/de
Priority to JP2001507843A priority patent/JP4823456B2/ja
Priority to SI200030931T priority patent/SI1529777T1/sl
Priority to AT04022031T priority patent/ATE350372T1/de
Priority to ES04022031T priority patent/ES2278254T3/es
Priority to PT00943970T priority patent/PT1192162E/pt
Priority to PCT/EP2000/006185 priority patent/WO2001002407A2/en
Priority to CNB2005101194984A priority patent/CN100418958C/zh
Priority to IL14744500A priority patent/IL147445A0/xx
Priority to ES00943970T priority patent/ES2228560T3/es
Priority to RU2002100127/04A priority patent/RU2245882C2/ru
Priority to DK04022031T priority patent/DK1529777T3/da
Priority to US10/019,252 priority patent/US6906101B1/en
Priority to DK00943970T priority patent/DK1192162T3/da
Priority to EP00943970A priority patent/EP1192162B1/en
Priority to CNB00809683XA priority patent/CN1158286C/zh
Priority to DE60032827T priority patent/DE60032827T2/de
Priority to HK02108618.3A priority patent/HK1047096B/xx
Priority to SK5033-2009A priority patent/SK287046B6/sk
Priority to EP04022031A priority patent/EP1529777B1/en
Priority to PT04022031T priority patent/PT1529777E/pt
Priority to US11/820,012 priority patent/USRE40901E1/en
Priority to PL352278A priority patent/PL205921B1/pl
Priority to SI200030508T priority patent/SI1192162T1/xx
Priority to CNB2004100346720A priority patent/CN1234696C/zh
Priority to AU58235/00A priority patent/AU771737B2/en
Priority to SK1-2002A priority patent/SK287045B6/sk
Priority to KR1020027000042A priority patent/KR100778156B1/ko
Priority to CZ20020022A priority patent/CZ301764B6/cs
Priority to CA2373530A priority patent/CA2373530C/en
Priority to CA2676424A priority patent/CA2676424C/en
Priority to DE60014374T priority patent/DE60014374T2/de
Publication of ITMI991483A1 publication Critical patent/ITMI991483A1/it
Priority to NO20020017A priority patent/NO328150B1/no
Priority to IL147445A priority patent/IL147445A/en
Priority to HK05101243.8A priority patent/HK1068879B/xx
Priority to IL172973A priority patent/IL172973A/en
Priority to HK06109438.5A priority patent/HK1089158B/xx
Priority to NO20093014A priority patent/NO332194B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT1999MI001483A 1999-07-06 1999-07-06 Derivati tassanici e procedimenti per la loro preparazione ITMI991483A1 (it)

Priority Applications (40)

Application Number Priority Date Filing Date Title
IT1999MI001483A ITMI991483A1 (it) 1999-07-06 1999-07-06 Derivati tassanici e procedimenti per la loro preparazione
DE60014374T DE60014374T2 (de) 1999-07-06 2000-07-03 Taxan-derivate und verfahren zu ihrer herstellung
DE60032827T DE60032827T2 (de) 1999-07-06 2000-07-03 Verfahren und Oxazolidin Zwischenprodukt zur Herstellung von Taxanen
HK02108618.3A HK1047096B (en) 1999-07-06 2000-07-03 Taxane derivatives and processes for the preparation thereof
JP2001507843A JP4823456B2 (ja) 1999-07-06 2000-07-03 タクサン誘導体及びその製造方法
SI200030931T SI1529777T1 (sl) 1999-07-06 2000-07-03 Postopek inoksazolidinski intermediat za pripravo taksanov
AT04022031T ATE350372T1 (de) 1999-07-06 2000-07-03 Verfahren und oxazolidin zwischenprodukt zur herstellung von taxanen
ES04022031T ES2278254T3 (es) 1999-07-06 2000-07-03 Procedimiento e intermedio oxazolidina para la sintesis de taxanos.
PT00943970T PT1192162E (pt) 1999-07-06 2000-07-03 Derivados de taxano e processos para a sua preparacao
PCT/EP2000/006185 WO2001002407A2 (en) 1999-07-06 2000-07-03 Taxane derivatives and processes for the preparation thereof
CNB2005101194984A CN100418958C (zh) 1999-07-06 2000-07-03 合成紫杉烷衍生物的中间体
IL14744500A IL147445A0 (en) 1999-07-06 2000-07-03 Taxane derivatives and processes for the preparation thereof
ES00943970T ES2228560T3 (es) 1999-07-06 2000-07-03 Derivados de taxano y procedimientos de preparacion de los mismos.
RU2002100127/04A RU2245882C2 (ru) 1999-07-06 2000-07-03 Производные таксана, способы их получения и фармацевтическая композиция
DK04022031T DK1529777T3 (da) 1999-07-06 2000-07-03 Fremgangsmåde og oxazolidin-mellemprodukt til syntese af taxaner
US10/019,252 US6906101B1 (en) 1999-07-06 2000-07-03 Taxane derivatives and processes for the preparation thereof
AT00943970T ATE277932T1 (de) 1999-07-06 2000-07-03 Taxan-derivate und verfahren zu ihrer herstellung
EP00943970A EP1192162B1 (en) 1999-07-06 2000-07-03 Taxane derivatives and processes for the preparation thereof
CNB00809683XA CN1158286C (zh) 1999-07-06 2000-07-03 紫杉烷衍生物及其制备方法
HU0202016A HUP0202016A3 (en) 1999-07-06 2000-07-03 Taxane derivatives, the use of them for producing anti-cancer medicaments, these medicaments and processes for preparation of these derivatives
SK5033-2009A SK287046B6 (sk) 1999-07-06 2000-07-03 Spôsob prípravy oxazolidínového medziproduktu na syntézu taxánových derivátov
DK00943970T DK1192162T3 (da) 1999-07-06 2000-07-03 Taxanderivater og fremgangsmåder til fremstilling deraf
CNB2004100346720A CN1234696C (zh) 1999-07-06 2000-07-03 紫杉烷衍生物及其制备方法
PT04022031T PT1529777E (pt) 1999-07-06 2000-07-03 Processo e intermediário oxazolidina para a síntese de taxanos
US11/820,012 USRE40901E1 (en) 1999-07-06 2000-07-03 Taxane derivatives and processes for the preparation thereof
PL352278A PL205921B1 (pl) 1999-07-06 2000-07-03 Pochodna 1,14-węglanu 14β-hydroksybakatyny V i jej zastosowanie oraz kompozycja farmaceutyczna zawierająca tę pochodną
SI200030508T SI1192162T1 (en) 1999-07-06 2000-07-03 Taxane derivatives and processes for the preparation thereof
EP04022031A EP1529777B1 (en) 1999-07-06 2000-07-03 Process and oxazolidine intermediate for the synthesis of taxanes
AU58235/00A AU771737B2 (en) 1999-07-06 2000-07-03 Taxane derivatives and processes for the preparation thereof
SK1-2002A SK287045B6 (sk) 1999-07-06 2000-07-03 Taxánový derivát, spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahom, jeho použitie a medziprodukty
KR1020027000042A KR100778156B1 (ko) 1999-07-06 2000-07-03 탁산 유도체 및 그 제조방법
CZ20020022A CZ301764B6 (cs) 1999-07-06 2000-07-03 Taxanové deriváty a zpusob jejich výroby
CA2373530A CA2373530C (en) 1999-07-06 2000-07-03 Taxane derivatives and processes for the preparation thereof
CA2676424A CA2676424C (en) 1999-07-06 2000-07-03 Taxane derivatives and processes for the preparation thereof
IL147445A IL147445A (en) 1999-07-06 2002-01-03 Derivatives of ß14 - HYDROXY - 1, 14 - CARBONTOBACCATINE Process for its preparation and medicinal preparations containing it
NO20020017A NO328150B1 (no) 1999-07-06 2002-01-03 Taxanderivater og fremgangsmater ved fremstilling derav
HK05101243.8A HK1068879B (zh) 1999-07-06 2005-02-16 紫杉烷衍生物及其制备方法
IL172973A IL172973A (en) 1999-07-06 2006-01-04 Process for the preparation of (4s, 5r) - n - boc - 2 - (2' 4 - dimethoxyphenyl) - 4 - isobutyl - 1 - oxazolidine - 5 - carboxylic acid
HK06109438.5A HK1089158B (en) 1999-07-06 2006-08-25 Intermediated for the synthesis of taxane derivatives
NO20093014A NO332194B1 (no) 1999-07-06 2009-09-17 Prosess og oxazolidinintermediat for syntese av taxaner

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI001483A ITMI991483A1 (it) 1999-07-06 1999-07-06 Derivati tassanici e procedimenti per la loro preparazione

Publications (2)

Publication Number Publication Date
ITMI991483A0 true ITMI991483A0 (it) 1999-07-06
ITMI991483A1 ITMI991483A1 (it) 2001-01-06

Family

ID=11383284

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1999MI001483A ITMI991483A1 (it) 1999-07-06 1999-07-06 Derivati tassanici e procedimenti per la loro preparazione

Country Status (22)

Country Link
US (2) USRE40901E1 (it)
EP (2) EP1192162B1 (it)
JP (1) JP4823456B2 (it)
KR (1) KR100778156B1 (it)
CN (3) CN1158286C (it)
AT (2) ATE350372T1 (it)
AU (1) AU771737B2 (it)
CA (2) CA2373530C (it)
CZ (1) CZ301764B6 (it)
DE (2) DE60032827T2 (it)
DK (2) DK1529777T3 (it)
ES (2) ES2278254T3 (it)
HU (1) HUP0202016A3 (it)
IL (3) IL147445A0 (it)
IT (1) ITMI991483A1 (it)
NO (2) NO328150B1 (it)
PL (1) PL205921B1 (it)
PT (2) PT1529777E (it)
RU (1) RU2245882C2 (it)
SI (2) SI1192162T1 (it)
SK (2) SK287046B6 (it)
WO (1) WO2001002407A2 (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1318678B1 (it) * 2000-08-10 2003-08-27 Indena Spa Procedimento per la preparazione di derivati della baccatina iii.
IT1320107B1 (it) 2000-11-28 2003-11-18 Indena Spa Procedimento per la preparazione di derivati tassanici.
ITMI20021921A1 (it) * 2002-09-10 2004-03-11 Indena Spa Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.
US8557861B2 (en) * 2004-09-28 2013-10-15 Mast Therapeutics, Inc. Low oil emulsion compositions for delivering taxoids and other insoluble drugs
TWI376239B (en) * 2006-02-01 2012-11-11 Andrew Xian Chen Vitamin e succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof
US7232916B1 (en) 2006-05-11 2007-06-19 Indena S.P.A. Process for the preparation of a taxane derivative
DE602006021546D1 (de) * 2006-05-12 2011-06-09 Indena Spa Verfahren zur Herstellung eines Taxanderivats
ITMI20062479A1 (it) * 2006-12-21 2008-06-22 Indena Spa Processo per la preparazione di secotassani
EP2080763A1 (en) 2008-01-18 2009-07-22 INDENA S.p.A. Crystalline form I of ortataxel
ES2389518T3 (es) * 2008-01-18 2012-10-26 Indena S.P.A. Formas sólidas de ortataxel
RU2428175C2 (ru) * 2008-06-02 2011-09-10 Закрытое Акционерное Общество "Биокад" Способ получения парентерального фармацевтического раствора
CN104650109B (zh) * 2013-11-22 2019-01-01 江苏天士力帝益药业有限公司 紫杉烷类化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5698712A (en) * 1992-03-06 1997-12-16 Indena S.P.A. Baccatine III derivatives
FR2688499B1 (fr) * 1992-03-10 1994-05-06 Rhone Poulenc Rorer Sa Procede de preparation de la beta-phenylisoserine et de ses analogues.
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
US5750508A (en) 1993-06-16 1998-05-12 Glycomed Incorporated Sialic acid/fucose based medicaments
IT1275936B1 (it) 1995-03-17 1997-10-24 Indena Spa Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni

Also Published As

Publication number Publication date
HUP0202016A3 (en) 2005-02-28
SI1529777T1 (sl) 2007-04-30
CA2373530A1 (en) 2001-01-11
CN1359384A (zh) 2002-07-17
DE60032827T2 (de) 2007-11-08
CN100418958C (zh) 2008-09-17
USRE40901E1 (en) 2009-09-01
AU5823500A (en) 2001-01-22
CN1158286C (zh) 2004-07-21
PT1529777E (pt) 2007-01-31
WO2001002407A3 (en) 2001-06-28
JP2003503502A (ja) 2003-01-28
IL172973A (en) 2010-11-30
DK1529777T3 (da) 2007-05-14
ES2228560T3 (es) 2005-04-16
NO332194B1 (no) 2012-07-23
IL147445A0 (en) 2002-08-14
HUP0202016A2 (en) 2002-10-28
AU771737B2 (en) 2004-04-01
PL352278A1 (en) 2003-08-11
SK287045B6 (sk) 2009-10-07
SI1192162T1 (en) 2005-02-28
EP1529777A3 (en) 2005-05-18
CA2676424A1 (en) 2001-01-11
JP4823456B2 (ja) 2011-11-24
EP1192162A2 (en) 2002-04-03
ES2278254T3 (es) 2007-08-01
ATE350372T1 (de) 2007-01-15
KR100778156B1 (ko) 2007-11-27
CZ200222A3 (cs) 2002-05-15
ATE277932T1 (de) 2004-10-15
PL205921B1 (pl) 2010-06-30
SK287046B6 (sk) 2009-10-07
PT1192162E (pt) 2004-12-31
CZ301764B6 (cs) 2010-06-16
CA2373530C (en) 2010-06-29
HK1047096A1 (en) 2003-02-07
IL172973A0 (en) 2006-06-11
NO20093014L (no) 2002-02-27
CN1539831A (zh) 2004-10-27
EP1529777B1 (en) 2007-01-03
HK1089158A1 (zh) 2006-11-24
NO20020017L (no) 2002-02-27
WO2001002407A2 (en) 2001-01-11
ITMI991483A1 (it) 2001-01-06
DK1192162T3 (da) 2005-01-17
CA2676424C (en) 2011-09-27
CN1234696C (zh) 2006-01-04
DE60014374T2 (de) 2006-02-16
DE60032827D1 (de) 2007-02-15
NO328150B1 (no) 2009-12-21
NO20020017D0 (no) 2002-01-03
RU2245882C2 (ru) 2005-02-10
EP1529777A2 (en) 2005-05-11
EP1192162B1 (en) 2004-09-29
KR20020022759A (ko) 2002-03-27
US6906101B1 (en) 2005-06-14
CN1769275A (zh) 2006-05-10
SK12002A3 (en) 2002-04-04
DE60014374D1 (de) 2004-11-04
HK1068879A1 (en) 2005-05-06
IL147445A (en) 2006-07-05

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