ITPD910102A1 - Processo per la preparazione di microsfere contenenti componenti biologicamente attivi. - Google Patents
Processo per la preparazione di microsfere contenenti componenti biologicamente attivi.Info
- Publication number
- ITPD910102A1 ITPD910102A1 IT000102A ITPD910102A ITPD910102A1 IT PD910102 A1 ITPD910102 A1 IT PD910102A1 IT 000102 A IT000102 A IT 000102A IT PD910102 A ITPD910102 A IT PD910102A IT PD910102 A1 ITPD910102 A1 IT PD910102A1
- Authority
- IT
- Italy
- Prior art keywords
- biologically active
- preparation
- active components
- microspheres containing
- containing biologically
- Prior art date
Links
- 239000004005 microsphere Substances 0.000 title abstract 3
- 150000002148 esters Chemical class 0.000 abstract 3
- 229920002674 hyaluronan Polymers 0.000 abstract 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 2
- 229960003160 hyaluronic acid Drugs 0.000 abstract 2
- 238000013270 controlled release Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gynecology & Obstetrics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITPD910102A IT1247472B (it) | 1991-05-31 | 1991-05-31 | Processo per la preparazione di microsfere contenenti componenti biologicamente attivi. |
| DE69231507T DE69231507T2 (de) | 1991-05-31 | 1992-05-26 | Verfahren zur Zubereitung von biologisch aktiven Komponenten enthaltenden Mikrospheren |
| AT92401433T ATE196991T1 (de) | 1991-05-31 | 1992-05-26 | Verfahren zur zubereitung von biologisch aktiven komponenten enthaltenden mikrospheren |
| EP99202579A EP0979648A3 (en) | 1991-05-31 | 1992-05-26 | Microspheres of esters of hyaluronic acid for controlled release of an active |
| ES92401433T ES2153355T3 (es) | 1991-05-31 | 1992-05-26 | Procedimiento para la preparacion de microesferas que contienen compuestos biologicamente activos. |
| EP92401433A EP0517565B1 (en) | 1991-05-31 | 1992-05-26 | Process for the preparation of microspheres containing biologically active components |
| CA002070095A CA2070095C (en) | 1991-05-31 | 1992-05-29 | Microspheres containing biologically-active components, processes for the preparation and uses |
| JP4139012A JPH07179363A (ja) | 1991-05-31 | 1992-05-29 | 生物学的に活性な成分を含有するミクロスフェアの製造方法 |
| US08/169,558 US6066340A (en) | 1991-05-31 | 1993-12-20 | Process for the preparation of microspheres containing biologically active components |
| US09/231,353 US6039970A (en) | 1991-05-31 | 1999-01-13 | Process for the preparation of microspheres containing biologically active components |
| GR20000402482T GR3034789T3 (en) | 1991-05-31 | 2000-11-08 | Process for the preparation of microspheres containing biologically active components. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITPD910102A IT1247472B (it) | 1991-05-31 | 1991-05-31 | Processo per la preparazione di microsfere contenenti componenti biologicamente attivi. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITPD910102A0 ITPD910102A0 (it) | 1991-05-31 |
| ITPD910102A1 true ITPD910102A1 (it) | 1992-12-01 |
| IT1247472B IT1247472B (it) | 1994-12-17 |
Family
ID=11389598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITPD910102A IT1247472B (it) | 1991-05-31 | 1991-05-31 | Processo per la preparazione di microsfere contenenti componenti biologicamente attivi. |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6066340A (it) |
| EP (2) | EP0517565B1 (it) |
| JP (1) | JPH07179363A (it) |
| AT (1) | ATE196991T1 (it) |
| CA (1) | CA2070095C (it) |
| DE (1) | DE69231507T2 (it) |
| ES (1) | ES2153355T3 (it) |
| GR (1) | GR3034789T3 (it) |
| IT (1) | IT1247472B (it) |
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| JPH0827018A (ja) * | 1994-07-22 | 1996-01-30 | Sanwa Kagaku Kenkyusho Co Ltd | 生理活性ペプチド又は蛋白質を含有する薬剤組成物 |
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| US7276251B2 (en) * | 1997-04-01 | 2007-10-02 | Lg Life Sciences, Ltd., Inc. | Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid |
| IT1294797B1 (it) | 1997-07-28 | 1999-04-15 | Fidia Advanced Biopolymers Srl | Uso dei derivati dell'acido ialuronico nella preparazione di biomateriali aventi attivita' emostatica fisica e tamponante |
| AU3055099A (en) | 1998-05-20 | 1999-12-06 | Charna Chemicals Ltd. | A pharmaceutical formulation for nasal administration |
| US6824793B1 (en) | 1998-06-01 | 2004-11-30 | Chiron Corporation | Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants |
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| ATE481108T1 (de) | 1999-02-26 | 2010-10-15 | Novartis Vaccines & Diagnostic | Verwendung von bioadhaesiven und adjuvantien für die mukosale anwendung von antigenen |
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| IT1219587B (it) | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
| US5073543A (en) * | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| US5008116A (en) * | 1988-11-14 | 1991-04-16 | Frederick Cahn | Immunostimulatory microsphere |
| JP3187410B2 (ja) * | 1989-08-10 | 2001-07-11 | 住友製薬株式会社 | 脳内投与用徐放性製剤 |
| GB2237510B (en) * | 1989-11-04 | 1993-09-15 | Danbiosyst Uk | Small particle drug compositions for nasal administration |
| US5707644A (en) * | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| GB9202464D0 (en) * | 1992-02-05 | 1992-03-18 | Danbiosyst Uk | Composition for nasal administration |
| US5879359A (en) * | 1992-08-03 | 1999-03-09 | Fidia S.P.A. | Biodegradable guide channels comprised of esters of hyaluronic acid for use in tissue repair as surgical aids |
| IT1268955B1 (it) * | 1994-03-11 | 1997-03-18 | Fidia Advanced Biopolymers Srl | Esteri attivi di polisaccaridi carbossilici |
| US5833891A (en) * | 1996-10-09 | 1998-11-10 | The University Of Kansas | Methods for a particle precipitation and coating using near-critical and supercritical antisolvents |
| US5874029A (en) * | 1996-10-09 | 1999-02-23 | The University Of Kansas | Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent |
| EP0907721A1 (en) * | 1996-05-28 | 1999-04-14 | Brown University Research Foundation | Hyaluronan based biodegradable scaffolds for tissue repair |
-
1991
- 1991-05-31 IT ITPD910102A patent/IT1247472B/it active IP Right Grant
-
1992
- 1992-05-26 ES ES92401433T patent/ES2153355T3/es not_active Expired - Lifetime
- 1992-05-26 AT AT92401433T patent/ATE196991T1/de not_active IP Right Cessation
- 1992-05-26 EP EP92401433A patent/EP0517565B1/en not_active Expired - Lifetime
- 1992-05-26 EP EP99202579A patent/EP0979648A3/en not_active Withdrawn
- 1992-05-26 DE DE69231507T patent/DE69231507T2/de not_active Expired - Lifetime
- 1992-05-29 JP JP4139012A patent/JPH07179363A/ja active Pending
- 1992-05-29 CA CA002070095A patent/CA2070095C/en not_active Expired - Lifetime
-
1993
- 1993-12-20 US US08/169,558 patent/US6066340A/en not_active Expired - Lifetime
-
1999
- 1999-01-13 US US09/231,353 patent/US6039970A/en not_active Expired - Lifetime
-
2000
- 2000-11-08 GR GR20000402482T patent/GR3034789T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0517565A2 (en) | 1992-12-09 |
| ITPD910102A0 (it) | 1991-05-31 |
| CA2070095A1 (en) | 1992-12-01 |
| ATE196991T1 (de) | 2000-11-15 |
| EP0979648A2 (en) | 2000-02-16 |
| US6039970A (en) | 2000-03-21 |
| DE69231507T2 (de) | 2001-05-03 |
| JPH07179363A (ja) | 1995-07-18 |
| CA2070095C (en) | 2000-04-25 |
| US6066340A (en) | 2000-05-23 |
| ES2153355T3 (es) | 2001-03-01 |
| IT1247472B (it) | 1994-12-17 |
| GR3034789T3 (en) | 2001-02-28 |
| DE69231507D1 (de) | 2000-11-23 |
| EP0517565B1 (en) | 2000-10-18 |
| EP0517565A3 (en) | 1992-12-30 |
| EP0979648A3 (en) | 2000-10-04 |
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Legal Events
| Date | Code | Title | Description |
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| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19990614 |