ITPD910102A1 - Processo per la preparazione di microsfere contenenti componenti biologicamente attivi. - Google Patents
Processo per la preparazione di microsfere contenenti componenti biologicamente attivi.Info
- Publication number
- ITPD910102A1 ITPD910102A1 IT000102A ITPD910102A ITPD910102A1 IT PD910102 A1 ITPD910102 A1 IT PD910102A1 IT 000102 A IT000102 A IT 000102A IT PD910102 A ITPD910102 A IT PD910102A IT PD910102 A1 ITPD910102 A1 IT PD910102A1
- Authority
- IT
- Italy
- Prior art keywords
- biologically active
- preparation
- active components
- microspheres containing
- containing biologically
- Prior art date
Links
- 239000004005 microsphere Substances 0.000 title abstract 3
- 150000002148 esters Chemical class 0.000 abstract 3
- 229920002674 hyaluronan Polymers 0.000 abstract 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 2
- 229960003160 hyaluronic acid Drugs 0.000 abstract 2
- 238000013270 controlled release Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gynecology & Obstetrics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITPD910102A IT1247472B (it) | 1991-05-31 | 1991-05-31 | Processo per la preparazione di microsfere contenenti componenti biologicamente attivi. |
| EP92401433A EP0517565B1 (en) | 1991-05-31 | 1992-05-26 | Process for the preparation of microspheres containing biologically active components |
| DE69231507T DE69231507T2 (de) | 1991-05-31 | 1992-05-26 | Verfahren zur Zubereitung von biologisch aktiven Komponenten enthaltenden Mikrospheren |
| AT92401433T ATE196991T1 (de) | 1991-05-31 | 1992-05-26 | Verfahren zur zubereitung von biologisch aktiven komponenten enthaltenden mikrospheren |
| ES92401433T ES2153355T3 (es) | 1991-05-31 | 1992-05-26 | Procedimiento para la preparacion de microesferas que contienen compuestos biologicamente activos. |
| EP99202579A EP0979648A3 (en) | 1991-05-31 | 1992-05-26 | Microspheres of esters of hyaluronic acid for controlled release of an active |
| JP4139012A JPH07179363A (ja) | 1991-05-31 | 1992-05-29 | 生物学的に活性な成分を含有するミクロスフェアの製造方法 |
| CA002070095A CA2070095C (en) | 1991-05-31 | 1992-05-29 | Microspheres containing biologically-active components, processes for the preparation and uses |
| US08/169,558 US6066340A (en) | 1991-05-31 | 1993-12-20 | Process for the preparation of microspheres containing biologically active components |
| US09/231,353 US6039970A (en) | 1991-05-31 | 1999-01-13 | Process for the preparation of microspheres containing biologically active components |
| GR20000402482T GR3034789T3 (en) | 1991-05-31 | 2000-11-08 | Process for the preparation of microspheres containing biologically active components. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITPD910102A IT1247472B (it) | 1991-05-31 | 1991-05-31 | Processo per la preparazione di microsfere contenenti componenti biologicamente attivi. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITPD910102A0 ITPD910102A0 (it) | 1991-05-31 |
| ITPD910102A1 true ITPD910102A1 (it) | 1992-12-01 |
| IT1247472B IT1247472B (it) | 1994-12-17 |
Family
ID=11389598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITPD910102A IT1247472B (it) | 1991-05-31 | 1991-05-31 | Processo per la preparazione di microsfere contenenti componenti biologicamente attivi. |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6066340A (it) |
| EP (2) | EP0979648A3 (it) |
| JP (1) | JPH07179363A (it) |
| AT (1) | ATE196991T1 (it) |
| CA (1) | CA2070095C (it) |
| DE (1) | DE69231507T2 (it) |
| ES (1) | ES2153355T3 (it) |
| GR (1) | GR3034789T3 (it) |
| IT (1) | IT1247472B (it) |
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| JPH0827018A (ja) * | 1994-07-22 | 1996-01-30 | Sanwa Kagaku Kenkyusho Co Ltd | 生理活性ペプチド又は蛋白質を含有する薬剤組成物 |
| EP0817620B1 (en) * | 1995-03-28 | 2002-01-30 | Fidia Advanced Biopolymers, S.R.L. | Nanospheres comprising a biocompatible polysaccharide |
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| IT1294797B1 (it) | 1997-07-28 | 1999-04-15 | Fidia Advanced Biopolymers Srl | Uso dei derivati dell'acido ialuronico nella preparazione di biomateriali aventi attivita' emostatica fisica e tamponante |
| WO1999059543A1 (en) | 1998-05-20 | 1999-11-25 | Highchem Company., Ltd. | A pharmaceutical formulation for nasal administration |
| JP4610735B2 (ja) * | 1998-06-01 | 2011-01-12 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | ワクチン抗原およびアジュバントの粘膜送達のためのヒアルロン酸ポリマーの使用 |
| US6824793B1 (en) | 1998-06-01 | 2004-11-30 | Chiron Corporation | Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants |
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| JP2670680B2 (ja) | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | 生理活性物質含有ポリ乳酸系微小球およびその製造法 |
| IT1219587B (it) | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
| US5073543A (en) * | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| US5008116A (en) * | 1988-11-14 | 1991-04-16 | Frederick Cahn | Immunostimulatory microsphere |
| JP3187410B2 (ja) * | 1989-08-10 | 2001-07-11 | 住友製薬株式会社 | 脳内投与用徐放性製剤 |
| US5707644A (en) * | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| GB2237510B (en) * | 1989-11-04 | 1993-09-15 | Danbiosyst Uk | Small particle drug compositions for nasal administration |
| GB9202464D0 (en) * | 1992-02-05 | 1992-03-18 | Danbiosyst Uk | Composition for nasal administration |
| US5879359A (en) * | 1992-08-03 | 1999-03-09 | Fidia S.P.A. | Biodegradable guide channels comprised of esters of hyaluronic acid for use in tissue repair as surgical aids |
| IT1268955B1 (it) * | 1994-03-11 | 1997-03-18 | Fidia Advanced Biopolymers Srl | Esteri attivi di polisaccaridi carbossilici |
| US5874029A (en) * | 1996-10-09 | 1999-02-23 | The University Of Kansas | Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent |
| US5833891A (en) * | 1996-10-09 | 1998-11-10 | The University Of Kansas | Methods for a particle precipitation and coating using near-critical and supercritical antisolvents |
| EP0907721A1 (en) * | 1996-05-28 | 1999-04-14 | Brown University Research Foundation | Hyaluronan based biodegradable scaffolds for tissue repair |
-
1991
- 1991-05-31 IT ITPD910102A patent/IT1247472B/it active IP Right Grant
-
1992
- 1992-05-26 EP EP99202579A patent/EP0979648A3/en not_active Withdrawn
- 1992-05-26 DE DE69231507T patent/DE69231507T2/de not_active Expired - Lifetime
- 1992-05-26 ES ES92401433T patent/ES2153355T3/es not_active Expired - Lifetime
- 1992-05-26 EP EP92401433A patent/EP0517565B1/en not_active Expired - Lifetime
- 1992-05-26 AT AT92401433T patent/ATE196991T1/de not_active IP Right Cessation
- 1992-05-29 JP JP4139012A patent/JPH07179363A/ja active Pending
- 1992-05-29 CA CA002070095A patent/CA2070095C/en not_active Expired - Lifetime
-
1993
- 1993-12-20 US US08/169,558 patent/US6066340A/en not_active Expired - Lifetime
-
1999
- 1999-01-13 US US09/231,353 patent/US6039970A/en not_active Expired - Lifetime
-
2000
- 2000-11-08 GR GR20000402482T patent/GR3034789T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69231507T2 (de) | 2001-05-03 |
| EP0979648A2 (en) | 2000-02-16 |
| JPH07179363A (ja) | 1995-07-18 |
| ITPD910102A0 (it) | 1991-05-31 |
| CA2070095A1 (en) | 1992-12-01 |
| US6039970A (en) | 2000-03-21 |
| CA2070095C (en) | 2000-04-25 |
| ATE196991T1 (de) | 2000-11-15 |
| GR3034789T3 (en) | 2001-02-28 |
| EP0979648A3 (en) | 2000-10-04 |
| DE69231507D1 (de) | 2000-11-23 |
| US6066340A (en) | 2000-05-23 |
| EP0517565A2 (en) | 1992-12-09 |
| ES2153355T3 (es) | 2001-03-01 |
| IT1247472B (it) | 1994-12-17 |
| EP0517565B1 (en) | 2000-10-18 |
| EP0517565A3 (en) | 1992-12-30 |
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Legal Events
| Date | Code | Title | Description |
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| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19990614 |