ITPI20110007A1 - Inibitori altamente selettivi dell'attivita' di adams - Google Patents

Inibitori altamente selettivi dell'attivita' di adams

Info

Publication number
ITPI20110007A1
ITPI20110007A1 IT000007A ITPI20110007A ITPI20110007A1 IT PI20110007 A1 ITPI20110007 A1 IT PI20110007A1 IT 000007 A IT000007 A IT 000007A IT PI20110007 A ITPI20110007 A IT PI20110007A IT PI20110007 A1 ITPI20110007 A1 IT PI20110007A1
Authority
IT
Italy
Prior art keywords
highly selective
selective inhibitors
adams
activity
adams activity
Prior art date
Application number
IT000007A
Other languages
English (en)
Inventor
Francesca Casalini
Elisa Nuti
Elisabetta Orlandini
Armando Rossello
Original Assignee
Univ Pisa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pisa filed Critical Univ Pisa
Priority to ITPI2011A000007A priority Critical patent/IT1404729B1/it
Publication of ITPI20110007A1 publication Critical patent/ITPI20110007A1/it
Application granted granted Critical
Publication of IT1404729B1 publication Critical patent/IT1404729B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/62—Barbituric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
ITPI2011A000007A 2011-01-27 2011-01-27 Inibitori altamente selettivi dell'attivita' di adams IT1404729B1 (it)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ITPI2011A000007A IT1404729B1 (it) 2011-01-27 2011-01-27 Inibitori altamente selettivi dell'attivita' di adams

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITPI2011A000007A IT1404729B1 (it) 2011-01-27 2011-01-27 Inibitori altamente selettivi dell'attivita' di adams

Publications (2)

Publication Number Publication Date
ITPI20110007A1 true ITPI20110007A1 (it) 2012-07-28
IT1404729B1 IT1404729B1 (it) 2013-11-29

Family

ID=43975512

Family Applications (1)

Application Number Title Priority Date Filing Date
ITPI2011A000007A IT1404729B1 (it) 2011-01-27 2011-01-27 Inibitori altamente selettivi dell'attivita' di adams

Country Status (1)

Country Link
IT (1) IT1404729B1 (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11807624B2 (en) 2018-05-01 2023-11-07 Amgen Inc. Substituted pyrimidinones as agonists of the APJ receptor

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566384B1 (en) * 1996-08-07 2003-05-20 Darwin Discovery Ltd. Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
WO2003066596A1 (en) * 2002-02-04 2003-08-14 F. Hoffmann-La Roche Ag Pyridineamido derivatives as inhibitors of monoamine oxidase (mao-b)
US20030181441A1 (en) * 1998-08-12 2003-09-25 McCLURE Kim Tace inhibitors
WO2003099763A1 (en) * 2002-05-29 2003-12-04 F. Hoffmann-La Roche Ag N-acylaminobenzene dervatives as selective monoamine oxidase b inhibitors
US20070066646A1 (en) * 2005-08-02 2007-03-22 Genmedica Therapeutics Sl Compounds for Inhibiting Copper-Containing Amine Oxidases and Uses Thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566384B1 (en) * 1996-08-07 2003-05-20 Darwin Discovery Ltd. Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
US20030181441A1 (en) * 1998-08-12 2003-09-25 McCLURE Kim Tace inhibitors
WO2003066596A1 (en) * 2002-02-04 2003-08-14 F. Hoffmann-La Roche Ag Pyridineamido derivatives as inhibitors of monoamine oxidase (mao-b)
WO2003099763A1 (en) * 2002-05-29 2003-12-04 F. Hoffmann-La Roche Ag N-acylaminobenzene dervatives as selective monoamine oxidase b inhibitors
US20070066646A1 (en) * 2005-08-02 2007-03-22 Genmedica Therapeutics Sl Compounds for Inhibiting Copper-Containing Amine Oxidases and Uses Thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BASSO A ET AL: "Solid-phase synthesis of aryl ethers on high loading dendrimer resin", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 41, no. 19, 1 May 2000 (2000-05-01), pages 3763 - 3767, XP004203251, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(00)00479-2 *
LE G T ET AL: "INHIBITORS OF TACE AND CASPASE-1 AS ANTI-INFLAMMATORY DRUGS", CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, vol. 12, no. 25, 1 January 2005 (2005-01-01), pages 2963 - 2977, XP009063671, ISSN: 0929-8673, DOI: 10.2174/092986705774462851 *
LEONETTI FRANCESCO ET AL: "Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 50, no. 20, 1 October 2007 (2007-10-01), pages 4909 - 4916, XP002576709, ISSN: 0022-2623, [retrieved on 20070907], DOI: 10.1021/JM070725E *
PEVARELLO P ET AL: "Synthesis and Anticonvulsant Activity of a New Class of 2-Ä(Arylalkyl)aminoÜalkanamide Derivatives", JOURNAL OF MEDICINAL AND PHARMACEUTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 41, 1 January 1998 (1998-01-01), pages 579 - 590, XP009074018 *

Also Published As

Publication number Publication date
IT1404729B1 (it) 2013-11-29

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