ITRM20020014A1 - Derivati di acidi a-feniltiocarbossilici e a-fenilossicarbossilici utili per il trattamento di patologie che rispondono all'attivazione del - Google Patents

Derivati di acidi a-feniltiocarbossilici e a-fenilossicarbossilici utili per il trattamento di patologie che rispondono all'attivazione del

Info

Publication number
ITRM20020014A1
ITRM20020014A1 IT2002RM000014A ITRM20020014A ITRM20020014A1 IT RM20020014 A1 ITRM20020014 A1 IT RM20020014A1 IT 2002RM000014 A IT2002RM000014 A IT 2002RM000014A IT RM20020014 A ITRM20020014 A IT RM20020014A IT RM20020014 A1 ITRM20020014 A1 IT RM20020014A1
Authority
IT
Italy
Prior art keywords
phylyoxycarboxyl
phenylthiocarboxyl
respond
diseases
activation
Prior art date
Application number
IT2002RM000014A
Other languages
English (en)
Inventor
Maria Ornella Tinti
Fabio Giannessi
Arduino Arduini
Fabrizio Giorgi
Emanuela Tassoni
Anna Floriana Sciarroni
Monica Bandera
Pompeo Pessotto
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Priority to IT2002RM000014A priority Critical patent/ITRM20020014A1/it
Publication of ITRM20020014A0 publication Critical patent/ITRM20020014A0/it
Priority to US10/501,472 priority patent/US20050054671A1/en
Priority to DE60335083T priority patent/DE60335083D1/de
Priority to EP03729547A priority patent/EP1474387B1/en
Priority to TW092101061A priority patent/TW200305410A/zh
Priority to HK05108606.4A priority patent/HK1076625B/xx
Priority to ARP030100103A priority patent/AR038146A1/es
Priority to JP2003559979A priority patent/JP2005514456A/ja
Priority to BR0306824-2A priority patent/BR0306824A/pt
Priority to AU2003209679A priority patent/AU2003209679B2/en
Priority to AT03729547T priority patent/ATE489361T1/de
Priority to CA002472223A priority patent/CA2472223A1/en
Priority to PL03372666A priority patent/PL372666A1/xx
Priority to KR1020047010634A priority patent/KR100975961B1/ko
Priority to MXPA04006803A priority patent/MXPA04006803A/es
Priority to PCT/IT2003/000011 priority patent/WO2003059875A2/en
Priority to CNB038022893A priority patent/CN100522940C/zh
Publication of ITRM20020014A1 publication Critical patent/ITRM20020014A1/it
Priority to US11/889,930 priority patent/US20080027098A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
IT2002RM000014A 2002-01-15 2002-01-15 Derivati di acidi a-feniltiocarbossilici e a-fenilossicarbossilici utili per il trattamento di patologie che rispondono all'attivazione del ITRM20020014A1 (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT2002RM000014A ITRM20020014A1 (it) 2002-01-15 2002-01-15 Derivati di acidi a-feniltiocarbossilici e a-fenilossicarbossilici utili per il trattamento di patologie che rispondono all'attivazione del
CNB038022893A CN100522940C (zh) 2002-01-15 2003-01-15 用于治疗对PPARα活化有反应的疾病的α-苯硫基羧酸和α-苯氧基-羧酸的衍生物
BR0306824-2A BR0306824A (pt) 2002-01-15 2003-01-15 Derivados de ácidos alfa-feniltiocarboxìlico e alfa-fenilóxi-carboxìlico úteis para o tratamento de doenças respondendo à ativação de pparalfa
AT03729547T ATE489361T1 (de) 2002-01-15 2003-01-15 Derivate von alpha-phenylthiocarbon- und alpha- phenyloxycarbonsäuren, die für die behandlung von auf die aktivierung von ppar alpha ansprechende krankheiten geeignet sind
EP03729547A EP1474387B1 (en) 2002-01-15 2003-01-15 Derivatives of alpha-phenylthiocarboxylic and alpha-phenyloxy-carboxylic acids useful for the treatment of diseases responding to ppar alpha activation
TW092101061A TW200305410A (en) 2002-01-15 2003-01-15 Derivatives of α -phenylthiocarboxylic and α -phenyloxycarboxylic acids useful for the treatment of diseases responding to PRAR α activation
HK05108606.4A HK1076625B (en) 2002-01-15 2003-01-15 Derivatives of a-phenylthiocarboxylic and sg(a)-phenyloxy-carboxylic acids useful for the treatment of diseases responding to ppara activation
ARP030100103A AR038146A1 (es) 2002-01-15 2003-01-15 Derivados de acidos alfa-feniltiocarboxilico y alfa-feniloxi-carboxilico util para el tratamiento de enfermedades que responden a la activacion de pparalfa
JP2003559979A JP2005514456A (ja) 2002-01-15 2003-01-15 ＰＰＡＲα活性化に応答する疾患の治療に有用なα−フェニルチオカルボン酸およびα−フェニルオキシカルボン酸の誘導体
US10/501,472 US20050054671A1 (en) 2002-01-15 2003-01-15 Derivatives of alpha-phenylthiocarboxylic and $g(a)-phenyloxy-carboxylic acids useful for the treatment of diseases responding to pparalpha activation
AU2003209679A AU2003209679B2 (en) 2002-01-15 2003-01-15 Derivatives of alpha-phenylthiocarboxylic and alpha-phenyloxy-carboxylic acids useful for the treatment of diseases responding to PPARalpha activation
DE60335083T DE60335083D1 (de) 2002-01-15 2003-01-15 Derivate von alpha-phenylthiocarbon- und alpha-phenyloxycarbonsäuren, die für die behandlung von auf die aktivierung von ppar alpha ansprechende krankheiten geeignet sind
CA002472223A CA2472223A1 (en) 2002-01-15 2003-01-15 Derivatives of alpha-phenylthiocarboxylic and alpha-phenyloxy-carboxylic acids useful for the treatment of diseases responding to pparalpha activation
PL03372666A PL372666A1 (en) 2002-01-15 2003-01-15 Derivatives of alpha-phenylthiocarboxylic and alpha-phenyloxy-carboxylic acids useful for the treatment of diseases responding to ppar alpha activation
KR1020047010634A KR100975961B1 (ko) 2002-01-15 2003-01-15 ＰＰＡＲα활성화에 반응하는 질병의 치료에 유용한α－페닐티오카르복시산 및＄Ｇ（ａ）－페닐옥시－카르복시산의 유도체
MXPA04006803A MXPA04006803A (es) 2002-01-15 2003-01-15 Derivados de acidos alfa-feniltiocarboxilicos y alfa-feniloxi-carboxilicos para tratamiento de enfermedades que responden a activacion del receptor alfa activado del proliferador de peroxisoma.
PCT/IT2003/000011 WO2003059875A2 (en) 2002-01-15 2003-01-15 DERIVATIVES OF α-PHENYLTHIOCARBOXYLIC AND α-PHENYLOXY-CARBOXYLIC ACIDS USEFUL FOR THE TREATMENT OF DISEASES RESPONDING TO PPARα ACTIVATION
US11/889,930 US20080027098A1 (en) 2002-01-15 2007-08-17 Derivatives of alpha-phenylthiocarboxylic and alpha-phenyloxy-carboxylic acids useful for the treatment of diseases responding to PPARalpha activation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2002RM000014A ITRM20020014A1 (it) 2002-01-15 2002-01-15 Derivati di acidi a-feniltiocarbossilici e a-fenilossicarbossilici utili per il trattamento di patologie che rispondono all'attivazione del

Publications (2)

Publication Number Publication Date
ITRM20020014A0 ITRM20020014A0 (it) 2002-01-15
ITRM20020014A1 true ITRM20020014A1 (it) 2003-07-15

Family

ID=11455954

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2002RM000014A ITRM20020014A1 (it) 2002-01-15 2002-01-15 Derivati di acidi a-feniltiocarbossilici e a-fenilossicarbossilici utili per il trattamento di patologie che rispondono all'attivazione del

Country Status (16)

Country Link
US (2) US20050054671A1 (it)
EP (1) EP1474387B1 (it)
JP (1) JP2005514456A (it)
KR (1) KR100975961B1 (it)
CN (1) CN100522940C (it)
AR (1) AR038146A1 (it)
AT (1) ATE489361T1 (it)
AU (1) AU2003209679B2 (it)
BR (1) BR0306824A (it)
CA (1) CA2472223A1 (it)
DE (1) DE60335083D1 (it)
IT (1) ITRM20020014A1 (it)
MX (1) MXPA04006803A (it)
PL (1) PL372666A1 (it)
TW (1) TW200305410A (it)
WO (1) WO2003059875A2 (it)

Families Citing this family (16)

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US7553867B2 (en) 2002-09-06 2009-06-30 Takeda Pharmaceutical Company Limited Furan or thiophene derivative and medicinal use thereof
ITRM20020629A1 (it) * 2002-12-19 2004-06-20 Sigma Tau Ind Farmaceuti Uso di acidi alfa-feniltiocarbossilici e alfa-fenilossicarbossilici ad attivita' ipoglicemizzante e/o ipolipidemizzante.
UA87467C2 (xx) 2003-09-19 2009-07-27 Янссен Фармацевтика Н.В 4-((феноксіалкіл)тіо)феноксіоцтова кислота та її аналоги$4-((феноксиалкил)тио)феноксиуксусная кислота и ее аналоги
RU2006112342A (ru) * 2003-10-28 2007-12-10 Д-р Редди`с Лабораторис Лтд (IN) Новые соединения и их использование в медицине, способ их получения и содержащие их фармацетические композиции
MX2007001634A (es) 2004-08-11 2007-04-23 Kyorin Seiyaku Kk Nuevo derivado de acido amino benzoico ciclico.
MY147518A (en) * 2004-09-15 2012-12-31 Janssen Pharmaceutica Nv 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
FR2880886B1 (fr) * 2005-01-14 2007-04-06 Merck Sante Soc Par Actions Si Derives de l'acide 6-phenylhex-5-enoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique
WO2006082495A1 (en) * 2005-02-02 2006-08-10 Ranbaxy Laboratories Limited Peroxisome proliferator activated receptor modulators
FR2882359A1 (fr) * 2005-02-24 2006-08-25 Negma Lerads Soc Par Actions S Derives activateurs de ppar, procede de preparation et application en therapeutique
US20090036489A1 (en) * 2005-03-22 2009-02-05 Masahiro Nomura Novel Cyclic Aminophenylalkanoic Acid Derivative
JO3006B1 (ar) 2005-09-14 2016-09-05 Janssen Pharmaceutica Nv املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك
PE20080188A1 (es) 2006-04-18 2008-03-10 Janssen Pharmaceutica Nv Derivados del acido benzoazepin-oxi-acetico como agonistas de ppar-delta usados para aumentar hdl-c, reducir ldl-c y reducir colesterol
ES2745411T3 (es) * 2006-07-27 2020-03-02 Wang Nai Fang Compuestos y composiciones de arilsulfanilo para administración de agentes activos
JP5305818B2 (ja) * 2008-10-03 2013-10-02 キヤノン株式会社 生体情報取得装置
JP5669889B2 (ja) * 2013-06-27 2015-02-18 キヤノン株式会社 生体情報取得装置
CN106179111B (zh) * 2016-07-16 2018-08-14 江南大学 一种由羧酸盐阴离子表面活性剂和二聚季铵盐形成的粘弹溶液

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Also Published As

Publication number Publication date
DE60335083D1 (de) 2011-01-05
KR100975961B1 (ko) 2010-08-16
ITRM20020014A0 (it) 2002-01-15
US20080027098A1 (en) 2008-01-31
KR20040068996A (ko) 2004-08-02
JP2005514456A (ja) 2005-05-19
AU2003209679A1 (en) 2003-07-30
EP1474387B1 (en) 2010-11-24
CA2472223A1 (en) 2003-07-24
CN1620429A (zh) 2005-05-25
AU2003209679B2 (en) 2009-02-19
WO2003059875A3 (en) 2003-12-04
MXPA04006803A (es) 2004-10-11
ATE489361T1 (de) 2010-12-15
WO2003059875A2 (en) 2003-07-24
TW200305410A (en) 2003-11-01
CN100522940C (zh) 2009-08-05
US20050054671A1 (en) 2005-03-10
AR038146A1 (es) 2004-12-29
EP1474387A2 (en) 2004-11-10
PL372666A1 (en) 2005-07-25
HK1076625A1 (zh) 2006-01-20
BR0306824A (pt) 2004-12-21

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