ITRM20020194A1 - Composizione utile per aumentare la concentrazione e la motilita' degli spermatozoi e migliorarne la morfologia nell'uomo. - Google Patents

Composizione utile per aumentare la concentrazione e la motilita' degli spermatozoi e migliorarne la morfologia nell'uomo.

Info

Publication number: ITRM20020194A1
Authority: IT; Italy
Prior art keywords: spermatozoi; motility; morphology; man; concentration
Prior art date: 2002-04-09

Application number

IT2002RM000194A

Other languages

English (en)

Inventor

Giorgio Cavallini

Giulio Biagiotti

Aleardo Kovereck

Francesca Sardelli

Original Assignee

Sigma Tau Healthscience Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-09

Filing date

2002-04-09

Publication date

2003-10-09

2002-04-09 Application filed by Sigma Tau Healthscience Spa filed Critical Sigma Tau Healthscience Spa

2002-04-09 Priority to IT2002RM000194A priority Critical patent/ITRM20020194A1/it

2002-04-09 Publication of ITRM20020194A0 publication Critical patent/ITRM20020194A0/it

2003-04-08 Priority to HK05110357.1A priority patent/HK1078460B/xx

2003-04-08 Priority to ES03720869T priority patent/ES2350338T3/es

2003-04-08 Priority to KR10-2004-7013385A priority patent/KR20040098005A/ko

2003-04-08 Priority to AT03720869T priority patent/ATE476974T1/de

2003-04-08 Priority to PT03720869T priority patent/PT1492521E/pt

2003-04-08 Priority to JP2003581766A priority patent/JP4663987B2/ja

2003-04-08 Priority to AU2003224443A priority patent/AU2003224443B2/en

2003-04-08 Priority to CNB038050935A priority patent/CN1330301C/zh

2003-04-08 Priority to SI200331892T priority patent/SI1492521T1/sl

2003-04-08 Priority to EP03720869A priority patent/EP1492521B1/en

2003-04-08 Priority to US10/510,450 priority patent/US20050107470A1/en

2003-04-08 Priority to PCT/IT2003/000214 priority patent/WO2003084526A1/en

2003-04-08 Priority to MXPA04009763A priority patent/MXPA04009763A/es

2003-04-08 Priority to PL372924A priority patent/PL214859B1/pl

2003-04-08 Priority to CA2478674A priority patent/CA2478674C/en

2003-04-08 Priority to DK03720869.1T priority patent/DK1492521T3/da

2003-04-08 Priority to DE60333742T priority patent/DE60333742D1/de

2003-04-08 Priority to BR0309055-8A priority patent/BR0309055A/pt

2003-10-09 Publication of ITRM20020194A1 publication Critical patent/ITRM20020194A1/it

2008-09-09 Priority to US12/230,992 priority patent/US8415392B2/en

2010-11-03 Priority to CY20101100989T priority patent/CY1111273T1/el

Links

230000004899 motility Effects 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 2
PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 abstract 1
206010067162 Asthenospermia Diseases 0.000 abstract 1
RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 abstract 1
UFAHZIUFPNSHSL-MRVPVSSYSA-N O-propanoyl-L-carnitine Chemical compound CCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C UFAHZIUFPNSHSL-MRVPVSSYSA-N 0.000 abstract 1
206010050208 Teratospermia Diseases 0.000 abstract 1
208000002312 Teratozoospermia Diseases 0.000 abstract 1
206010003883 azoospermia Diseases 0.000 abstract 1
208000008634 oligospermia Diseases 0.000 abstract 1
230000036616 oligospermia Effects 0.000 abstract 1
231100000528 oligospermia Toxicity 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Reproductive Health (AREA)
Emergency Medicine (AREA)
General Chemical & Material Sciences (AREA)
Polymers & Plastics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Mycology (AREA)
Nutrition Science (AREA)
Food Science & Technology (AREA)
Organic Chemistry (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

IT2002RM000194A 2002-04-09 2002-04-09 Composizione utile per aumentare la concentrazione e la motilita' degli spermatozoi e migliorarne la morfologia nell'uomo. ITRM20020194A1 (it)

Priority Applications (21)

Application Number	Priority Date	Filing Date	Title
IT2002RM000194A ITRM20020194A1 (it)	2002-04-09	2002-04-09	Composizione utile per aumentare la concentrazione e la motilita' degli spermatozoi e migliorarne la morfologia nell'uomo.
BR0309055-8A BR0309055A (pt)	2002-04-09	2003-04-08	Uso combinado de l-carnitina, acetil l-carnitina e propionil l-carnitina para o tratamento da oligoastenoteratospermia
EP03720869A EP1492521B1 (en)	2002-04-09	2003-04-08	Combined use of l-carnitine, acetyl l-carnitine and propionyl l-carnitine for the treatment of oligoasthenoteratospermia
PCT/IT2003/000214 WO2003084526A1 (en)	2002-04-09	2003-04-08	Combined use of l-carnitine, acetyl l-carnitine and propionyl l-carnitine for the treatment of oligoasthenoteratospermia
KR10-2004-7013385A KR20040098005A (ko)	2002-04-09	2003-04-08	무력성 기형 정자 부족증의 치료를 위한 ｌ－카르니틴,아세틸 ｌ－카르니틴 및 프로피오닐 ｌ－카르니틴의 복합용도
AT03720869T ATE476974T1 (de)	2002-04-09	2003-04-08	Verwendung einer kombination von l-carnitin, acetyl l-carnitin und propionyl l-carnitin zur behandlung von oligoasthenoteratospermia
PT03720869T PT1492521E (pt)	2002-04-09	2003-04-08	Utilização combinada de l-carnitina, acetil l-carnitina e propionil l-carnitina para o tratamento da oligoastenoteratozoospermia
JP2003581766A JP4663987B2 (ja)	2002-04-09	2003-04-08	精子減少・無力・奇形症の治療のためのｌ−カルニチン、アセチルｌ−カルニチンおよびプロピオニルｌ−カルニチンの併用
AU2003224443A AU2003224443B2 (en)	2002-04-09	2003-04-08	Combined use of L-carnitine, acetyl L-carnitine and propionyl L-carnitine for the treatment of oligoasthenoteratospermia
CNB038050935A CN1330301C (zh)	2002-04-09	2003-04-08	L－肉碱、乙酰l－肉碱和丙酰l－肉碱在制备治疗精子减少精子活力不足畸形精子的联合药物中的应用
SI200331892T SI1492521T1 (sl)	2002-04-09	2003-04-08	Kombinirana uporaba l-karnitina, acetil l-karnitina in propil l-karnitina za zdravljenje oligoastenoteratospermije
HK05110357.1A HK1078460B (en)	2002-04-09	2003-04-08	Use of l-carnitine, acetyl l-carnitine and propionyl l-carnitine in the manufacture of a combined medicament for the treatment of oligoasthenoteratospermia
US10/510,450 US20050107470A1 (en)	2002-04-09	2003-04-08	Combined use of l-carnitine, acetyl l-carnitine and propionyl l-carnitine for the treatment of oligoasthenoteratospermia
ES03720869T ES2350338T3 (es)	2002-04-09	2003-04-08	Uso combinado del l-carnitina, acetil l-carnitina y propionil l-carnitina para el tratamiento de oligoastenoteratospermia.
MXPA04009763A MXPA04009763A (es)	2002-04-09	2003-04-08	Uso combinado del l-carnitina, acetil l-carnitina y propionil l-carnitina para el tratamiento de oligoastenoteratospermia.
PL372924A PL214859B1 (pl)	2002-04-09	2003-04-08	Laczne zastosowanie L-karnityny, acetylo L-karnityny i propionylo L-karnityny do leczenia oligoastenoteratospermii
CA2478674A CA2478674C (en)	2002-04-09	2003-04-08	Combined use of l-carnitine, acetyl l-carnitine and propionyl l-carnitine for the treatment of oligoasthenoteratospermia
DK03720869.1T DK1492521T3 (da)	2002-04-09	2003-04-08	Kombineret brug af L-carnitin, acetyl-L-carnitin og propionyl-L-carnitin i behandling af oligoasthenoteratospermi
DE60333742T DE60333742D1 (de)	2002-04-09	2003-04-08	Verwendung einer kombination von l-carnitin, acetyl l-carnitin und propionyl l-carnitin zur behandlung von oligoasthenoteratospermia
US12/230,992 US8415392B2 (en)	2002-04-09	2008-09-09	Combined use of L-carnitine, acetyle L-carnitine and propionyl L-carnitine for the treatment of oligoasthenoteratospermia
CY20101100989T CY1111273T1 (el)	2002-04-09	2010-11-03	Συνδυασμενη χρηση της l-καρνιτινης, ακετυλο l-καρνιτινης και προπιονυλο l-καρνιτινης για τη θεραπεια της ολιγοασθενοτερατοσπερμιας

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2002RM000194A ITRM20020194A1 (it)	2002-04-09	2002-04-09	Composizione utile per aumentare la concentrazione e la motilita' degli spermatozoi e migliorarne la morfologia nell'uomo.

Publications (2)

Publication Number	Publication Date
ITRM20020194A0 ITRM20020194A0 (it)	2002-04-09
ITRM20020194A1 true ITRM20020194A1 (it)	2003-10-09

Family

ID=11456235

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT2002RM000194A ITRM20020194A1 (it)	2002-04-09	2002-04-09	Composizione utile per aumentare la concentrazione e la motilita' degli spermatozoi e migliorarne la morfologia nell'uomo.

Country Status (19)

Country	Link
US (2)	US20050107470A1 (it)
EP (1)	EP1492521B1 (it)
JP (1)	JP4663987B2 (it)
KR (1)	KR20040098005A (it)
CN (1)	CN1330301C (it)
AT (1)	ATE476974T1 (it)
AU (1)	AU2003224443B2 (it)
BR (1)	BR0309055A (it)
CA (1)	CA2478674C (it)
CY (1)	CY1111273T1 (it)
DE (1)	DE60333742D1 (it)
DK (1)	DK1492521T3 (it)
ES (1)	ES2350338T3 (it)
IT (1)	ITRM20020194A1 (it)
MX (1)	MXPA04009763A (it)
PL (1)	PL214859B1 (it)
PT (1)	PT1492521E (it)
SI (1)	SI1492521T1 (it)
WO (1)	WO2003084526A1 (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7776913B2 (en)	2002-12-13	2010-08-17	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Carnitines for treating or preventing disorders caused by andropause
US8377454B2 (en) *	2009-05-01	2013-02-19	Parviz Gharagozloo	Treating male infertility secondary to sperm oxidative stress
US20110015154A1 (en) *	2009-07-20	2011-01-20	Kellermann Gottfried H	Supporting acetylcholine function
US20110098265A1 (en) *	2009-10-28	2011-04-28	Neuroscience, Inc.	Methods for reducing cravings and impulses associated with addictive and compulsive behaviors
CN108041588A (zh) *	2017-12-08	2018-05-18	冯纪敏	一种含有海藻糖的组合物及其应用
CN109999042B (zh) *	2019-05-16	2021-05-18	北京华睿鼎信科技有限公司	包含脱氢表雄酮或其硫酸酯、左卡尼汀、乙酰左卡尼汀或它们的可药用盐的组合物及其应用
CN118435893B (zh) *	2024-05-17	2025-12-19	北部湾大学	L-乙酰肉碱提升香港牡蛎繁殖性能的方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1249462B (it) *	1991-10-21	1995-02-23	Sigma Tau Ind Farmaceuti	Impiego di l-carnitina e acil l-carnitine nel trattamento delle oligoastenospermie idiopatiche.
IT1291127B1 (it) *	1997-04-01	1998-12-29	Sigma Tau Ind Farmaceuti	Integratore alimentare per soggetti dediti ad intensa e prolungata attivita' fisica
IT1295408B1 (it) *	1997-10-03	1999-05-12	Sigma Tau Ind Farmaceuti	Associazione di l-carnitina e alcanoil l-carnitine per il trattamento dell'alcoolismo
GB9721746D0 (en)	1997-10-15	1997-12-10	Panos Therapeutics Limited	Compositions
US6090848A (en) *	1997-12-01	2000-07-18	Sigma-Tau Healthscience S.P.A.	Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans
ITRM20010029A1 (it) *	2001-01-23	2002-07-23	Aldo Fassi	Sali metallici di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per
ITRM20020055A1 (it)	2002-02-04	2003-08-04	Aldo Fassi	Sali metallici di carnitine, integratori dietetici/nutritivi che li contengono e kit dietetici per contrastare disturbi sessuali in soggetti

2002
- 2002-04-09 IT IT2002RM000194A patent/ITRM20020194A1/it unknown
2003
- 2003-04-08 CA CA2478674A patent/CA2478674C/en not_active Expired - Lifetime
- 2003-04-08 DK DK03720869.1T patent/DK1492521T3/da active
- 2003-04-08 AT AT03720869T patent/ATE476974T1/de active
- 2003-04-08 JP JP2003581766A patent/JP4663987B2/ja not_active Expired - Lifetime
- 2003-04-08 SI SI200331892T patent/SI1492521T1/sl unknown
- 2003-04-08 CN CNB038050935A patent/CN1330301C/zh not_active Expired - Lifetime
- 2003-04-08 AU AU2003224443A patent/AU2003224443B2/en not_active Expired
- 2003-04-08 DE DE60333742T patent/DE60333742D1/de not_active Expired - Lifetime
- 2003-04-08 MX MXPA04009763A patent/MXPA04009763A/es active IP Right Grant
- 2003-04-08 PT PT03720869T patent/PT1492521E/pt unknown
- 2003-04-08 EP EP03720869A patent/EP1492521B1/en not_active Expired - Lifetime
- 2003-04-08 BR BR0309055-8A patent/BR0309055A/pt not_active Application Discontinuation
- 2003-04-08 KR KR10-2004-7013385A patent/KR20040098005A/ko not_active Ceased
- 2003-04-08 WO PCT/IT2003/000214 patent/WO2003084526A1/en not_active Ceased
- 2003-04-08 US US10/510,450 patent/US20050107470A1/en not_active Abandoned
- 2003-04-08 PL PL372924A patent/PL214859B1/pl unknown
- 2003-04-08 ES ES03720869T patent/ES2350338T3/es not_active Expired - Lifetime
2008
- 2008-09-09 US US12/230,992 patent/US8415392B2/en not_active Expired - Fee Related
2010
- 2010-11-03 CY CY20101100989T patent/CY1111273T1/el unknown

Also Published As

Publication number	Publication date
DE60333742D1 (de)	2010-09-23
US8415392B2 (en)	2013-04-09
CA2478674A1 (en)	2003-10-16
PL214859B1 (pl)	2013-09-30
SI1492521T1 (sl)	2010-12-31
ES2350338T3 (es)	2011-01-21
PT1492521E (pt)	2010-11-11
AU2003224443A1 (en)	2003-10-20
JP4663987B2 (ja)	2011-04-06
MXPA04009763A (es)	2004-12-13
KR20040098005A (ko)	2004-11-18
CN1638754A (zh)	2005-07-13
AU2003224443B2 (en)	2008-09-11
BR0309055A (pt)	2005-02-22
CY1111273T1 (el)	2015-08-05
PL372924A1 (en)	2005-08-08
US20050107470A1 (en)	2005-05-19
ITRM20020194A0 (it)	2002-04-09
JP2006505499A (ja)	2006-02-16
EP1492521B1 (en)	2010-08-11
CN1330301C (zh)	2007-08-08
WO2003084526A1 (en)	2003-10-16
DK1492521T3 (da)	2010-11-22
EP1492521A1 (en)	2005-01-05
US20090012169A1 (en)	2009-01-08
HK1078460A1 (en)	2006-03-17
ATE476974T1 (de)	2010-08-15
CA2478674C (en)	2010-10-19

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NO20002798D0 (no)	2000-05-31	Sammensetninger og metoder for Õ øke konsentrasjonen og/eller bevegeligheten av spermatozoa hos mennesker
SE0102055D0 (sv)	2001-06-08	New Compounds
GB0215526D0 (en)	2002-08-14	Anticancer compounds
DK1492521T3 (da)	2010-11-22	Kombineret brug af L-carnitin, acetyl-L-carnitin og propionyl-L-carnitin i behandling af oligoasthenoteratospermi
PE20010744A1 (es)	2001-07-23	Uso de (2s,3s,5r)-2-(3,5-difluorofenil)-3,5-dimetil-2-morfolinol para el tratamiento de la obesidad
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