ITRM20020402A0 - Derivati fluoro-alchil-ciclopeptidi ad attivita' anti-integrine. - Google Patents

Derivati fluoro-alchil-ciclopeptidi ad attivita' anti-integrine.

Info

Publication number
ITRM20020402A0
ITRM20020402A0 IT2002RM000402A ITRM20020402A ITRM20020402A0 IT RM20020402 A0 ITRM20020402 A0 IT RM20020402A0 IT 2002RM000402 A IT2002RM000402 A IT 2002RM000402A IT RM20020402 A ITRM20020402 A IT RM20020402A IT RM20020402 A0 ITRM20020402 A0 IT RM20020402A0
Authority
IT
Italy
Prior art keywords
fluoro
alkyl
integrin activity
cyclopeptide derivatives
cyclopeptide
Prior art date
Application number
IT2002RM000402A
Other languages
English (en)
Inventor
Claudio Pisano
Giuseppe Giannini
Pozzo Alma Dal
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Priority to IT2002RM000402A priority Critical patent/ITRM20020402A1/it
Publication of ITRM20020402A0 publication Critical patent/ITRM20020402A0/it
Priority to PL03374607A priority patent/PL374607A1/xx
Priority to DE60312178T priority patent/DE60312178T2/de
Priority to PT03771244T priority patent/PT1539803E/pt
Priority to ES03771244T priority patent/ES2282690T3/es
Priority to AU2003253258A priority patent/AU2003253258A1/en
Priority to CNB038146436A priority patent/CN100381461C/zh
Priority to EP03771244A priority patent/EP1539803B1/en
Priority to AT03771244T priority patent/ATE355298T1/de
Priority to KR1020057001696A priority patent/KR20050026543A/ko
Priority to DK03771244T priority patent/DK1539803T3/da
Priority to SI200330707T priority patent/SI1539803T1/sl
Priority to HK05111138.5A priority patent/HK1079218B/xx
Priority to CA002486795A priority patent/CA2486795A1/en
Priority to PCT/IT2003/000446 priority patent/WO2004011487A2/en
Priority to MXPA05001065A priority patent/MXPA05001065A/es
Priority to US10/522,268 priority patent/US20060205637A1/en
Priority to BR0311667-0A priority patent/BR0311667A/pt
Priority to JP2004524061A priority patent/JP2006515563A/ja
Publication of ITRM20020402A1 publication Critical patent/ITRM20020402A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
IT2002RM000402A 2002-07-29 2002-07-29 Derivati fluoro-alchil-ciclopeptidi ad attivita' anti-integrine. ITRM20020402A1 (it)

Priority Applications (19)

Application Number Priority Date Filing Date Title
IT2002RM000402A ITRM20020402A1 (it) 2002-07-29 2002-07-29 Derivati fluoro-alchil-ciclopeptidi ad attivita' anti-integrine.
JP2004524061A JP2006515563A (ja) 2002-07-29 2003-07-18 抗インテグリン活性を有するフルオロ−アルキル−シクロペプチド誘導体
AT03771244T ATE355298T1 (de) 2002-07-29 2003-07-18 Fluoralkylcyclopeptidderivate mit antiintegrinwirkung
DK03771244T DK1539803T3 (da) 2002-07-29 2003-07-18 Fluoralkyl-cyklopeptidderivater med anti-integrin-aktivitet
PT03771244T PT1539803E (pt) 2002-07-29 2003-07-18 Derivados de fluoro- alquil-ciclopéptidos com actividade anti-integrina
ES03771244T ES2282690T3 (es) 2002-07-29 2003-07-18 Dereivados fluoroqlquilociclopeptidicos que tienen una actividad anti-integrina.
AU2003253258A AU2003253258A1 (en) 2002-07-29 2003-07-18 Fluoro-alkyl-cyclopeptide derivatives having anti-integrin activity
CNB038146436A CN100381461C (zh) 2002-07-29 2003-07-18 具有抗整合素活性的氟-烷基-环肽衍生物
EP03771244A EP1539803B1 (en) 2002-07-29 2003-07-18 Fluoro-alkyl-cyclopeptide derivatives having anti-integrin activity
PL03374607A PL374607A1 (en) 2002-07-29 2003-07-18 Fluoro-alkyl-cyclopeptide derivatives having anti-integrin activity
KR1020057001696A KR20050026543A (ko) 2002-07-29 2003-07-18 항-인테그린 활성을 갖는 플루오로알킬사이클로펩티드유도체
DE60312178T DE60312178T2 (de) 2002-07-29 2003-07-18 Fluoralkylcyclopeptidderivate mit antiintegrinwirkung
SI200330707T SI1539803T1 (sl) 2002-07-29 2003-07-18 Derivati fluoro-alkil-ciklopeptida z antiintegrinsko uäśinkovitostjo
HK05111138.5A HK1079218B (en) 2002-07-29 2003-07-18 Fluoro-alkyl-cyclopeptide derivatives endowed with anti-integrin activity
CA002486795A CA2486795A1 (en) 2002-07-29 2003-07-18 Fluoro-alkyl-cyclopeptide derivatives having anti-integrin activity
PCT/IT2003/000446 WO2004011487A2 (en) 2002-07-29 2003-07-18 Fluoro-alkyl-cyclopeptide derivatives having anti-integrin activity
MXPA05001065A MXPA05001065A (es) 2002-07-29 2003-07-18 Derivados de fluoro-alquil-ciclopeptido que tienen actividad de antiintegrina.
US10/522,268 US20060205637A1 (en) 2002-07-29 2003-07-18 Fluoro-alkyl-cyclopeptide derivatives having anti-integrin activity
BR0311667-0A BR0311667A (pt) 2002-07-29 2003-07-18 Derivados de flúor-alquil-ciclopeptìdeo dotados com atividade de antiintegrina

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2002RM000402A ITRM20020402A1 (it) 2002-07-29 2002-07-29 Derivati fluoro-alchil-ciclopeptidi ad attivita' anti-integrine.

Publications (2)

Publication Number Publication Date
ITRM20020402A0 true ITRM20020402A0 (it) 2002-07-29
ITRM20020402A1 ITRM20020402A1 (it) 2004-01-29

Family

ID=11456429

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2002RM000402A ITRM20020402A1 (it) 2002-07-29 2002-07-29 Derivati fluoro-alchil-ciclopeptidi ad attivita' anti-integrine.

Country Status (18)

Country Link
US (1) US20060205637A1 (it)
EP (1) EP1539803B1 (it)
JP (1) JP2006515563A (it)
KR (1) KR20050026543A (it)
CN (1) CN100381461C (it)
AT (1) ATE355298T1 (it)
AU (1) AU2003253258A1 (it)
BR (1) BR0311667A (it)
CA (1) CA2486795A1 (it)
DE (1) DE60312178T2 (it)
DK (1) DK1539803T3 (it)
ES (1) ES2282690T3 (it)
IT (1) ITRM20020402A1 (it)
MX (1) MXPA05001065A (it)
PL (1) PL374607A1 (it)
PT (1) PT1539803E (it)
SI (1) SI1539803T1 (it)
WO (1) WO2004011487A2 (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20050328A1 (it) 2005-03-03 2006-09-04 Univ Degli Studi Milano Composti peptidomimetrici e preparazione di derivati biologicamente attivi
MX2007006653A (es) * 2005-10-05 2009-02-17 Sicor Inc Separacion de isomeros de fulvestrant.
US9345739B2 (en) 2007-11-08 2016-05-24 The General Hospital Corporation Methods and compositions for the treatment of proteinuric diseases
CN101990425B (zh) 2008-04-08 2016-01-20 默克专利股份有限公司 包含环肽的组合物和使用方法
JP2016515120A (ja) * 2013-03-15 2016-05-26 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． 抗アルファｖベータ５抗体を用いた急性腎損傷の治療及び予防
CN117126233A (zh) * 2022-05-20 2023-11-28 杭州禾泰健宇生物科技有限公司 一种类肽化合物及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4310643A1 (de) * 1993-04-01 1994-10-06 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
US5770565A (en) * 1994-04-13 1998-06-23 La Jolla Cancer Research Center Peptides for reducing or inhibiting bone resorption
DE19613933A1 (de) * 1996-04-06 1997-10-09 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
DE19725368A1 (de) * 1997-06-16 1998-12-17 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren und deren Verwendung für bildgebende Verfahren

Also Published As

Publication number Publication date
SI1539803T1 (sl) 2007-06-30
KR20050026543A (ko) 2005-03-15
WO2004011487A8 (en) 2004-12-16
DK1539803T3 (da) 2007-06-18
HK1079218A1 (en) 2006-03-31
WO2004011487A3 (en) 2004-03-18
CN1662552A (zh) 2005-08-31
ITRM20020402A1 (it) 2004-01-29
DE60312178D1 (de) 2007-04-12
PT1539803E (pt) 2007-05-31
CA2486795A1 (en) 2004-02-05
EP1539803B1 (en) 2007-02-28
EP1539803A2 (en) 2005-06-15
PL374607A1 (en) 2005-10-31
AU2003253258A1 (en) 2004-02-16
ATE355298T1 (de) 2006-03-15
CN100381461C (zh) 2008-04-16
BR0311667A (pt) 2005-02-22
DE60312178T2 (de) 2007-09-27
ES2282690T3 (es) 2007-10-16
WO2004011487A2 (en) 2004-02-05
JP2006515563A (ja) 2006-06-01
MXPA05001065A (es) 2005-06-06
US20060205637A1 (en) 2006-09-14

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