ITRM20040534A1 - Mutanti della proteina nucleofosmina (npm), sequenze geniche corrispondenti e relativi usi. - Google Patents

Mutanti della proteina nucleofosmina (npm), sequenze geniche corrispondenti e relativi usi.

Info

Publication number
ITRM20040534A1
ITRM20040534A1 IT000534A ITRM20040534A ITRM20040534A1 IT RM20040534 A1 ITRM20040534 A1 IT RM20040534A1 IT 000534 A IT000534 A IT 000534A IT RM20040534 A ITRM20040534 A IT RM20040534A IT RM20040534 A1 ITRM20040534 A1 IT RM20040534A1
Authority
IT
Italy
Prior art keywords
nucleophosmine
npm
mutants
protein
genetic sequences
Prior art date
Application number
IT000534A
Other languages
English (en)
Inventor
Brunangelo Falini
Cristina Mecucci
Original Assignee
Brunangelo Falini
Cristina Mecucci
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brunangelo Falini, Cristina Mecucci filed Critical Brunangelo Falini
Priority to IT000534A priority Critical patent/ITRM20040534A1/it
Publication of ITRM20040534A1 publication Critical patent/ITRM20040534A1/it
Priority to DK10184598.0T priority patent/DK2319865T3/en
Priority to EP07021463.0A priority patent/EP1944316B1/en
Priority to DK07021463.0T priority patent/DK1944316T3/en
Priority to PCT/IT2005/000634 priority patent/WO2006046270A2/en
Priority to US11/666,542 priority patent/US8222370B2/en
Priority to PT70214630T priority patent/PT1944316E/pt
Priority to PL07021463T priority patent/PL1944316T3/pl
Priority to ES10184598.0T priority patent/ES2654564T3/es
Priority to EP10184598.0A priority patent/EP2319865B1/en
Priority to SI200531981T priority patent/SI1944316T1/sl
Priority to CN200580045036.0A priority patent/CN101160320B/zh
Priority to ES17181518T priority patent/ES2755875T3/es
Priority to HUE07021463A priority patent/HUE025263T2/en
Priority to ES07021463.0T priority patent/ES2542339T3/es
Priority to EP05813231.7A priority patent/EP1807448B1/en
Priority to ES05813231.7T priority patent/ES2607987T3/es
Priority to CA2585965A priority patent/CA2585965C/en
Priority to EP17181518.6A priority patent/EP3284750B1/en
Priority to US11/982,679 priority patent/US8501924B2/en
Priority to HK09100376.5A priority patent/HK1121171B/en
Priority to US13/959,739 priority patent/US9725767B2/en
Priority to US14/750,331 priority patent/US10155989B2/en
Priority to CY20151100605T priority patent/CY1116527T1/el
Priority to US15/844,912 priority patent/US10487366B2/en
Priority to HK18106934.6A priority patent/HK1247222B/en
Priority to US16/598,935 priority patent/US20200032354A1/en
Priority to US17/729,970 priority patent/US20230212680A1/en
Priority to US18/759,252 priority patent/US20250154599A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57505—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the blood, e.g. leukaemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
    • G01N2333/4704—Inhibitors; Supressors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT000534A 2004-10-29 2004-10-29 Mutanti della proteina nucleofosmina (npm), sequenze geniche corrispondenti e relativi usi. ITRM20040534A1 (it)

Priority Applications (29)

Application Number Priority Date Filing Date Title
IT000534A ITRM20040534A1 (it) 2004-10-29 2004-10-29 Mutanti della proteina nucleofosmina (npm), sequenze geniche corrispondenti e relativi usi.
EP17181518.6A EP3284750B1 (en) 2004-10-29 2005-10-28 Nucleophosmin protein (npm) mutants, corresponding gene sequences and uses thereof
ES17181518T ES2755875T3 (es) 2004-10-29 2005-10-28 Mutantes de la proteína nucleofosmina (NPM), secuencias genéticas correspondientes y usos de los mismos
ES07021463.0T ES2542339T3 (es) 2004-10-29 2005-10-28 Mutantes de la proteína nucleofosmina (NPM), secuencias genéticas correspondientes y usos de los mismos
DK07021463.0T DK1944316T3 (en) 2004-10-29 2005-10-28 Nucleophosminprotein- (NPM) mutants, corresponding gene sequences and uses thereof
PCT/IT2005/000634 WO2006046270A2 (en) 2004-10-29 2005-10-28 Nucleophosmin protein (npm) mutants, corresponding gene sequences and uses thereof
US11/666,542 US8222370B2 (en) 2004-10-29 2005-10-28 Nucleophosmin protein (NPM) mutants, corresponding gene sequences and uses thereof
PT70214630T PT1944316E (pt) 2004-10-29 2005-10-28 Mutantes da proteína nucleofosmina (npm), sequências génicas correspondentes e utilizações destes
PL07021463T PL1944316T3 (pl) 2004-10-29 2005-10-28 Mutanty białka nukleofosminy (NPM), odpowiadające sekwencje genów i ich zastosowanie
ES10184598.0T ES2654564T3 (es) 2004-10-29 2005-10-28 Mutantes de la proteína nucleofosmina (NPM), secuencias genéticas correspondientes y usos de los mismos
EP10184598.0A EP2319865B1 (en) 2004-10-29 2005-10-28 Nucleophosmin protein (NPM) mutants, corresponding gene sequences and uses thereof
SI200531981T SI1944316T1 (sl) 2004-10-29 2005-10-28 Mutanti nukleofosminske beljakovine (NPM), ustrezne genske sekvence in njihove uporabe
CN200580045036.0A CN101160320B (zh) 2004-10-29 2005-10-28 核磷蛋白质(npm)突变体、其相应基因序列及其用途
DK10184598.0T DK2319865T3 (en) 2004-10-29 2005-10-28 NUCLEOPHOSMINE PROTEIN (NPM) MUTANTS, INCLUDING GENE SEQUENCES AND APPLICATIONS THEREOF
HUE07021463A HUE025263T2 (en) 2004-10-29 2005-10-28 Nucleophosmin protein (NPM) mutants, corresponding gene sequences and uses thereof
EP07021463.0A EP1944316B1 (en) 2004-10-29 2005-10-28 Nucleophosmin protein (NPM) mutants, corresponding gene sequences and uses thereof
EP05813231.7A EP1807448B1 (en) 2004-10-29 2005-10-28 Nucleophosmin protein (npm) mutants, corresponding gene sequences and uses thereof
ES05813231.7T ES2607987T3 (es) 2004-10-29 2005-10-28 Mutantes de la proteína nucleofosmina (NPM), secuencias génicas correspondientes y usos de los mismos
CA2585965A CA2585965C (en) 2004-10-29 2005-10-28 Nucleophosmin protein (npm) mutants, corresponding gene sequences and uses thereof
US11/982,679 US8501924B2 (en) 2004-10-29 2007-11-02 Nucleophosmin protein (NPM) mutants, corresponding gene sequences and uses thereof
HK09100376.5A HK1121171B (en) 2004-10-29 2009-01-14 Nucleophosmin protein (npm) mutants, corresponding gene sequences and uses thereof
US13/959,739 US9725767B2 (en) 2004-10-29 2013-08-06 Nucleophosmin protein (NPM) mutants, corresponding gene sequences and uses thereof
US14/750,331 US10155989B2 (en) 2004-10-29 2015-06-25 Nucleophosmin protein (NPM) mutants, corresponding gene sequences and uses thereof
CY20151100605T CY1116527T1 (el) 2004-10-29 2015-07-10 Μεταλλαγματα της πρωτεϊνης νουκλεοφοσμινη (νρμ), αντιστοιχες γονιδιακες αλληλουχιες και χρησεις αυτων
US15/844,912 US10487366B2 (en) 2004-10-29 2017-12-18 Nucleophosmin protein (NPM) mutants, corresponding gene sequences and uses thereof
HK18106934.6A HK1247222B (en) 2004-10-29 2018-05-28 Nucleophosmin protein (npm) mutants, corresponding gene sequences and uses thereof
US16/598,935 US20200032354A1 (en) 2004-10-29 2019-10-10 Nucleophosmin protein (npm) mutants, corresponding gene sequences and uses thereof
US17/729,970 US20230212680A1 (en) 2004-10-29 2022-04-26 Nucleophosmin protein (npm) mutants, corresponding gene sequences and uses thereof
US18/759,252 US20250154599A1 (en) 2004-10-29 2024-06-28 Nucleophosmin protein (npm) mutants, corresponding gene sequences and uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000534A ITRM20040534A1 (it) 2004-10-29 2004-10-29 Mutanti della proteina nucleofosmina (npm), sequenze geniche corrispondenti e relativi usi.

Publications (1)

Publication Number Publication Date
ITRM20040534A1 true ITRM20040534A1 (it) 2005-01-29

Family

ID=36096144

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000534A ITRM20040534A1 (it) 2004-10-29 2004-10-29 Mutanti della proteina nucleofosmina (npm), sequenze geniche corrispondenti e relativi usi.

Country Status (13)

Country Link
US (8) US8222370B2 (it)
EP (4) EP1944316B1 (it)
CN (1) CN101160320B (it)
CA (1) CA2585965C (it)
CY (1) CY1116527T1 (it)
DK (2) DK1944316T3 (it)
ES (4) ES2607987T3 (it)
HU (1) HUE025263T2 (it)
IT (1) ITRM20040534A1 (it)
PL (1) PL1944316T3 (it)
PT (1) PT1944316E (it)
SI (1) SI1944316T1 (it)
WO (1) WO2006046270A2 (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20040534A1 (it) 2004-10-29 2005-01-29 Brunangelo Falini Mutanti della proteina nucleofosmina (npm), sequenze geniche corrispondenti e relativi usi.
KR101660322B1 (ko) * 2011-04-28 2016-09-29 아크레이 가부시키가이샤 ＮＰＭ1 유전자의 ｅｘｏｎ12 변이의 검출용 프로브 및 그 용도
CN102382896A (zh) * 2011-12-06 2012-03-21 苏州苏大赛尔免疫生物技术有限公司 Npm1基因突变检测方法及其试剂盒
WO2017049002A1 (en) * 2015-09-15 2017-03-23 Massachusetts Institute Of Technology A humanized mouse model of de novo human acute myeloid leukemia with a matching human immune system
US20220305102A1 (en) * 2017-06-30 2022-09-29 Academisch Ziekenhuis Leiden (H.O.D.N. Leids Universitair Medisch Centrum) Treatment of haematological malignancies
CA3067772A1 (en) * 2017-06-30 2019-01-03 Marieke GRIFFIOEN Treatment of haematological malignancies
NL2019156B1 (en) * 2017-06-30 2019-01-10 Academisch Ziekenhuis Leiden H O D N Leids Univ Medisch Centrum Treatment of haematological malignancies
WO2019214058A1 (zh) * 2018-05-11 2019-11-14 南京先声医学检验有限公司 引物、引物组合、试剂盒及其应用
CN114591410B (zh) * 2022-03-25 2022-09-20 东北农业大学 玉米miRNA的靶基因序列及其编码蛋白在抗植物粗缩病中的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5529925A (en) * 1993-12-03 1996-06-25 St. Jude Children's Research Hospital Nucleic acid sequences and fusion proteins present in human t(2;5) lymphoma
US7041490B1 (en) * 1997-11-28 2006-05-09 Serono Genetics Institute, S.A. Chlamydia trachomatis polynucleotides and vectors, recombinant host cells, DNA chips or kits containing the same
CN1331117A (zh) * 2000-06-30 2002-01-16 上海博德基因开发有限公司 一种新的多肽——nucleophosmin9.68和编码这种多肽的多核苷酸
AU2003257434A1 (en) 2002-07-09 2004-01-23 Degussa Ag L-amidase from rhizobium huautlense
GB0223341D0 (en) * 2002-10-08 2002-11-13 Groningen Acad Ziekenhuis Organic compounds
US7250496B2 (en) * 2002-11-14 2007-07-31 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory genes and uses thereof
US7314750B2 (en) * 2002-11-20 2008-01-01 Affymetrix, Inc. Addressable oligonucleotide array of the rat genome
CA2509902A1 (en) * 2002-12-13 2004-07-01 Aurelium Biopharma Inc. Nucleophosmin directed diagnostics and therapeutics for multidrug resistant neoplastic disease
US7288529B2 (en) * 2003-04-24 2007-10-30 New York University ALK protein tyrosine kinase, cells and methods embodying and using same
ITRM20040534A1 (it) 2004-10-29 2005-01-29 Brunangelo Falini Mutanti della proteina nucleofosmina (npm), sequenze geniche corrispondenti e relativi usi.

Also Published As

Publication number Publication date
US20150184245A1 (en) 2015-07-02
ES2542339T3 (es) 2015-08-04
ES2755875T3 (es) 2020-04-24
HK1121171A1 (en) 2009-04-17
CA2585965A1 (en) 2006-05-04
WO2006046270A3 (en) 2006-11-30
CA2585965C (en) 2020-11-03
PL1944316T3 (pl) 2015-10-30
SI1944316T1 (sl) 2015-08-31
EP1807448B1 (en) 2016-08-31
HUE025263T2 (en) 2016-02-29
HK1247222A1 (en) 2018-09-21
US8501924B2 (en) 2013-08-06
EP3284750A1 (en) 2018-02-21
ES2607987T3 (es) 2017-04-05
EP1944316B1 (en) 2015-04-15
US20150368726A1 (en) 2015-12-24
US20090297543A1 (en) 2009-12-03
US20180119233A1 (en) 2018-05-03
US20200032354A1 (en) 2020-01-30
US20250154599A1 (en) 2025-05-15
PT1944316E (pt) 2015-08-24
EP2319865B1 (en) 2017-08-30
EP1807448A2 (en) 2007-07-18
DK1944316T3 (en) 2015-07-20
EP1944316A1 (en) 2008-07-16
EP2319865A1 (en) 2011-05-11
US10155989B2 (en) 2018-12-18
CN101160320A (zh) 2008-04-09
US9725767B2 (en) 2017-08-08
US8222370B2 (en) 2012-07-17
ES2654564T3 (es) 2018-02-14
CY1116527T1 (el) 2017-03-15
US10487366B2 (en) 2019-11-26
WO2006046270A2 (en) 2006-05-04
EP3284750B1 (en) 2019-09-11
CN101160320B (zh) 2017-10-24
US20080299560A1 (en) 2008-12-04
DK2319865T3 (en) 2017-12-04
US20230212680A1 (en) 2023-07-06

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