ITRM20040561A1 - Uso della acetil l-carnitina in combinazione con propionil l-carnitina e sildenafil per il trattamento della disfunzione erettile. - Google Patents

Uso della acetil l-carnitina in combinazione con propionil l-carnitina e sildenafil per il trattamento della disfunzione erettile.

Info

Publication number: ITRM20040561A1
Authority: IT; Italy
Prior art keywords: carnitine; sildenafil; propionyl; acetyl; treatment
Prior art date: 2004-11-11

Application number

IT000561A

Other languages

English (en)

Inventor

Giorgio Cavallini

Aleardo Koverech

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-11-11

Filing date

2004-11-11

Publication date

2005-02-11

2004-11-11 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

2004-11-11 Priority to IT000561A priority Critical patent/ITRM20040561A1/it

2005-02-11 Publication of ITRM20040561A1 publication Critical patent/ITRM20040561A1/it

2005-10-19 Priority to PL05798477T priority patent/PL1811988T3/pl

2005-10-19 Priority to DE602005019251T priority patent/DE602005019251D1/de

2005-10-19 Priority to JP2007540521A priority patent/JP5080263B2/ja

2005-10-19 Priority to KR1020077013019A priority patent/KR101455275B1/ko

2005-10-19 Priority to DK05798477.5T priority patent/DK1811988T3/da

2005-10-19 Priority to PT05798477T priority patent/PT1811988E/pt

2005-10-19 Priority to SI200530953T priority patent/SI1811988T1/sl

2005-10-19 Priority to US11/719,011 priority patent/US8003652B2/en

2005-10-19 Priority to EP05798477A priority patent/EP1811988B1/en

2005-10-19 Priority to MX2007005518A priority patent/MX2007005518A/es

2005-10-19 Priority to PCT/EP2005/011238 priority patent/WO2006050794A1/en

2005-10-19 Priority to AT05798477T priority patent/ATE456950T1/de

2005-10-19 Priority to ES05798477T priority patent/ES2339265T3/es

2005-10-19 Priority to CA2585654A priority patent/CA2585654C/en

2010-04-23 Priority to CY20101100362T priority patent/CY1110239T1/el

Links

BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 title abstract 4
208000010228 Erectile Dysfunction Diseases 0.000 title abstract 2
RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 title abstract 2
UFAHZIUFPNSHSL-MRVPVSSYSA-N O-propanoyl-L-carnitine Chemical compound CCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C UFAHZIUFPNSHSL-MRVPVSSYSA-N 0.000 title abstract 2
201000001881 impotence Diseases 0.000 title abstract 2
229960003310 sildenafil Drugs 0.000 title abstract 2
235000005911 diet Nutrition 0.000 abstract 1
230000000378 dietary effect Effects 0.000 abstract 1
230000009429 distress Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000642 iatrogenic effect Effects 0.000 abstract 1
210000001931 lesser pelvis Anatomy 0.000 abstract 1
210000004977 neurovascular bundle Anatomy 0.000 abstract 1
210000003899 penis Anatomy 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Reproductive Health (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IT000561A 2004-11-11 2004-11-11 Uso della acetil l-carnitina in combinazione con propionil l-carnitina e sildenafil per il trattamento della disfunzione erettile. ITRM20040561A1 (it)

Priority Applications (16)

Application Number	Priority Date	Filing Date	Title
IT000561A ITRM20040561A1 (it)	2004-11-11	2004-11-11	Uso della acetil l-carnitina in combinazione con propionil l-carnitina e sildenafil per il trattamento della disfunzione erettile.
CA2585654A CA2585654C (en)	2004-11-11	2005-10-19	Use of acetyl l-carnitine in combination with propionyl l-carnitine and sildenafil for the treatment of erectile dysfunction
PT05798477T PT1811988E (pt)	2004-11-11	2005-10-19	Utilização de acetil l-carnitina em combinação com propionilo l-carnitina e sildenafil para o tratamento da disfunção eréctil
US11/719,011 US8003652B2 (en)	2004-11-11	2005-10-19	Use of acetyl L-carnitine in combination with propionyl L-carnitine and Sildenafil for the treatment of erectile dysfunction
JP2007540521A JP5080263B2 (ja)	2004-11-11	2005-10-19	勃起不全の治療のためのプロピオニルｌ−カルニチンおよびシルデナフィルと組み合わせてのアセチルｌ−カルニチンの使用
KR1020077013019A KR101455275B1 (ko)	2004-11-11	2005-10-19	발기 부전의 치료를 위한 아세틸 엘 카르니틴과 프로피오닐엘 카르니틴 및 실데나필과의 병용된 용도
DK05798477.5T DK1811988T3 (da)	2004-11-11	2005-10-19	Anvendelse af acetyl-L-carnitin i kombination med propionyl-L-carnitin og sildenafil til behandling af erektil dysfunktion
PL05798477T PL1811988T3 (pl)	2004-11-11	2005-10-19	Zastosowanie acetylo-L-karnityny w połączeniu z propionylo-L-karnityną i sildenafilem do leczenia zaburzenia erekcji
SI200530953T SI1811988T1 (sl)	2004-11-11	2005-10-19	Uporaba acetil l-karnitina v kombinaciji s propionil l-karnitinom in sildenafilom za zdravljenje erektilne disfunkcije
DE602005019251T DE602005019251D1 (de)	2004-11-11	2005-10-19	Verwendung von acetyl l-carnitin in kombination mit propionyl l-carnitin und sildenafil zur behandlung von erektiler dysfunktion
EP05798477A EP1811988B1 (en)	2004-11-11	2005-10-19	Use of acetyl l-carnitine in combination with propionyl l-carnitine and sildenafil for the treatment of erectile dysfunction
MX2007005518A MX2007005518A (es)	2004-11-11	2005-10-19	Uso de acetil l-carnitina en combinacion con propionil l-carnitina y sildenafil para el tratamiento de disfuncion erectil.
PCT/EP2005/011238 WO2006050794A1 (en)	2004-11-11	2005-10-19	Use of acetyl l-carnitine in combination with propionyl l-carnitine and sildenafil for the treatment of erectile dysfunction
AT05798477T ATE456950T1 (de)	2004-11-11	2005-10-19	Verwendung von acetyl l-carnitin in kombination mit propionyl l-carnitin und sildenafil zur behandlung von erektiler dysfunktion
ES05798477T ES2339265T3 (es)	2004-11-11	2005-10-19	Uso de acetil l-carnitina en combinacion con propionil l-carnitina y sildenafil para el tratamiento de la difuncion erectil.
CY20101100362T CY1110239T1 (el)	2004-11-11	2010-04-23	Χρηση ακετυλο-l-kapnιτινη σε συνδυασμο με προπιονυλο-l-καρνιτινη και σιλδεναφιλη για τη θεραπευτικη αγωγη της στυτικης δυσλειτουργιας

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT000561A ITRM20040561A1 (it)	2004-11-11	2004-11-11	Uso della acetil l-carnitina in combinazione con propionil l-carnitina e sildenafil per il trattamento della disfunzione erettile.

Publications (1)

Publication Number	Publication Date
ITRM20040561A1 true ITRM20040561A1 (it)	2005-02-11

Family

ID=35501123

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT000561A ITRM20040561A1 (it)	2004-11-11	2004-11-11	Uso della acetil l-carnitina in combinazione con propionil l-carnitina e sildenafil per il trattamento della disfunzione erettile.

Country Status (16)

Country	Link
US (1)	US8003652B2 (it)
EP (1)	EP1811988B1 (it)
JP (1)	JP5080263B2 (it)
KR (1)	KR101455275B1 (it)
AT (1)	ATE456950T1 (it)
CA (1)	CA2585654C (it)
CY (1)	CY1110239T1 (it)
DE (1)	DE602005019251D1 (it)
DK (1)	DK1811988T3 (it)
ES (1)	ES2339265T3 (it)
IT (1)	ITRM20040561A1 (it)
MX (1)	MX2007005518A (it)
PL (1)	PL1811988T3 (it)
PT (1)	PT1811988E (it)
SI (1)	SI1811988T1 (it)
WO (1)	WO2006050794A1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2010222347A (ja) *	2009-02-24	2010-10-07	Daiichi Sankyo Healthcare Co Ltd	Ｐｄｅ５阻害剤及びカルニチンを含有する医薬組成物
WO2012000634A1 (de)	2010-06-29	2012-01-05	Georg Bambach	Pharmazeutische zusammensetzung zur behandlung von erektiler dysfunktion
WO2018070971A1 (ru) *	2016-10-10	2018-04-19	Товарыство З Обмэжэною Видповидальнистю Науково-Выробныча Фирма "Микрохим"	Фармацевтическая композиция в форме оромукозного спрея для лечения эректильной дисфункции и легочной артериальной гипертензии

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE462791T1 (de)	1999-08-13	2010-04-15	Deutsches Krebsforsch	Parvovirus ns1 varianten
IT1306722B1 (it) *	1999-10-08	2001-10-02	Sigma Tau Healthscience Spa	Composizione per la prevenzione e/o il trattamento di disfunzionicircolatorie, comprendente derivati della l-carnitina ed estratti di
JP2001233770A (ja) *	2000-02-23	2001-08-28	Dountsuendorufaa Udo	勃起機能不全治療用の経口薬の組合わせ
ITRM20010621A1 (it) *	2001-10-18	2003-04-18	Aldo Fassi	Sali metallici non igroscopici e idrosolubili di alcanoil l-carnitine, integratori dietetici che li contengono e kit dietetici, per contrast
ITRM20010708A1 (it) *	2001-12-04	2003-06-04	Sigma Tau Ind Farmaceuti	Uso di una alcanoil l-carnitina per il trattamento della disfunzione erettile.
ITRM20020620A1 (it) *	2002-12-13	2004-06-14	Sigma Tau Ind Farmaceuti	Uso delle carnitine per la prevenzione e/o il trattamento dei disturbi causati dall'andropausa.

2004
- 2004-11-11 IT IT000561A patent/ITRM20040561A1/it unknown
2005
- 2005-10-19 ES ES05798477T patent/ES2339265T3/es not_active Expired - Lifetime
- 2005-10-19 KR KR1020077013019A patent/KR101455275B1/ko not_active Expired - Fee Related
- 2005-10-19 DE DE602005019251T patent/DE602005019251D1/de not_active Expired - Lifetime
- 2005-10-19 WO PCT/EP2005/011238 patent/WO2006050794A1/en not_active Ceased
- 2005-10-19 MX MX2007005518A patent/MX2007005518A/es active IP Right Grant
- 2005-10-19 SI SI200530953T patent/SI1811988T1/sl unknown
- 2005-10-19 PL PL05798477T patent/PL1811988T3/pl unknown
- 2005-10-19 AT AT05798477T patent/ATE456950T1/de active
- 2005-10-19 JP JP2007540521A patent/JP5080263B2/ja not_active Expired - Fee Related
- 2005-10-19 CA CA2585654A patent/CA2585654C/en not_active Expired - Fee Related
- 2005-10-19 US US11/719,011 patent/US8003652B2/en not_active Expired - Fee Related
- 2005-10-19 DK DK05798477.5T patent/DK1811988T3/da active
- 2005-10-19 EP EP05798477A patent/EP1811988B1/en not_active Expired - Lifetime
- 2005-10-19 PT PT05798477T patent/PT1811988E/pt unknown
2010
- 2010-04-23 CY CY20101100362T patent/CY1110239T1/el unknown

Also Published As

Publication number	Publication date
KR20070085961A (ko)	2007-08-27
WO2006050794A1 (en)	2006-05-18
US20080090906A1 (en)	2008-04-17
DK1811988T3 (da)	2010-05-17
US8003652B2 (en)	2011-08-23
PT1811988E (pt)	2010-04-08
JP5080263B2 (ja)	2012-11-21
ATE456950T1 (de)	2010-02-15
JP2008531466A (ja)	2008-08-14
EP1811988B1 (en)	2010-02-03
CY1110239T1 (el)	2015-01-14
PL1811988T3 (pl)	2010-07-30
KR101455275B1 (ko)	2014-10-27
ES2339265T3 (es)	2010-05-18
CA2585654C (en)	2013-04-02
SI1811988T1 (sl)	2010-10-29
CA2585654A1 (en)	2006-05-18
DE602005019251D1 (de)	2010-03-25
EP1811988A1 (en)	2007-08-01
MX2007005518A (es)	2007-05-18

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