ITRM20080636A1 - Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli. - Google Patents

Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli.

Info

Publication number
ITRM20080636A1
ITRM20080636A1 IT000636A ITRM20080636A ITRM20080636A1 IT RM20080636 A1 ITRM20080636 A1 IT RM20080636A1 IT 000636 A IT000636 A IT 000636A IT RM20080636 A ITRM20080636 A IT RM20080636A IT RM20080636 A1 ITRM20080636 A1 IT RM20080636A1
Authority
IT
Italy
Prior art keywords
hyaluronic acid
group
hydrogels
procedure
production
Prior art date
Application number
IT000636A
Other languages
English (en)
Inventor
Gaetano Giammona
Fabio Salvatore Palumbo
Giovanna Pitarresi
Original Assignee
Univ Palermo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Palermo filed Critical Univ Palermo
Priority to IT000636A priority Critical patent/ITRM20080636A1/it
Priority to US13/131,098 priority patent/US8858999B2/en
Priority to SI200930470T priority patent/SI2370474T1/sl
Priority to HK12103035.7A priority patent/HK1162546B/en
Priority to PL09795949T priority patent/PL2370474T3/pl
Priority to RU2011126353/13A priority patent/RU2523182C2/ru
Priority to CA2744892A priority patent/CA2744892C/en
Priority to PCT/EP2009/066060 priority patent/WO2010061005A1/en
Priority to JP2011537999A priority patent/JP5607061B2/ja
Priority to BRPI0920965-4A priority patent/BRPI0920965B1/pt
Priority to ES09795949T priority patent/ES2397987T3/es
Priority to MX2011005528A priority patent/MX2011005528A/es
Priority to CN200980147761.7A priority patent/CN102227448B/zh
Priority to DK09795949.8T priority patent/DK2370474T3/da
Priority to EP09795949A priority patent/EP2370474B1/en
Publication of ITRM20080636A1 publication Critical patent/ITRM20080636A1/it
Priority to US14/507,474 priority patent/US9410000B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
    • B23K9/00—Arc welding or cutting
    • B23K9/10—Other electric circuits therefor; Protective circuits; Remote controls

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Plasma & Fusion (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Arc Welding Control (AREA)
IT000636A 2008-11-28 2008-11-28 Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli. ITRM20080636A1 (it)

Priority Applications (16)

Application Number Priority Date Filing Date Title
IT000636A ITRM20080636A1 (it) 2008-11-28 2008-11-28 Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli.
US13/131,098 US8858999B2 (en) 2008-11-28 2009-01-30 Method to produce hyaluronic acid functionalized derivatives and formation of hydrogels thereof
PCT/EP2009/066060 WO2010061005A1 (en) 2008-11-28 2009-11-30 Method to produce hyaluronic acid functionalized derivatives and formation of hydrogels thereof
BRPI0920965-4A BRPI0920965B1 (pt) 2008-11-28 2009-11-30 Método para produzir derivados funcionalizados de ácido hialurônico e a formação de hidrogéis a partir dos mesmos
PL09795949T PL2370474T3 (pl) 2008-11-28 2009-11-30 Sposób wytwarzania funkcjonalizowanych pochodnych kwasu hialuronowego i wytwarzanie z nich hydrożeli
RU2011126353/13A RU2523182C2 (ru) 2008-11-28 2009-11-30 Способ получения функционализованных производных гиалуроновой кислоты и образования их гидрогелей
CA2744892A CA2744892C (en) 2008-11-28 2009-11-30 Method to produce hyaluronic acid functionalized derivatives and formation of hydrogels thereof
SI200930470T SI2370474T1 (sl) 2008-11-28 2009-11-30 Postopek izdelave funkcionaliziranih derivatov hiarulonske kisline in tvorba hidrogelov le-teh
JP2011537999A JP5607061B2 (ja) 2008-11-28 2009-11-30 ヒアルロン酸官能基化誘導体の製造方法及びそのヒドロゲル形成
HK12103035.7A HK1162546B (en) 2008-11-28 2009-11-30 Method to produce hyaluronic acid functionalized derivatives and formation of hydrogels thereof
ES09795949T ES2397987T3 (es) 2008-11-28 2009-11-30 Método para producir derivados funcionalizados de ácido hialurónico y formación de hidrogeles de los mismos
MX2011005528A MX2011005528A (es) 2008-11-28 2009-11-30 Metodo para producir derivados funcionalizados con acido hialuronico y formacion de sus hidrogeles.
CN200980147761.7A CN102227448B (zh) 2008-11-28 2009-11-30 生产透明质酸官能化衍生物的方法及透明质酸官能化衍生物的水凝胶的形成
DK09795949.8T DK2370474T3 (da) 2008-11-28 2009-11-30 Fremgangsmåde til fremstilling af hyaluronsyrefunktionaliserede derivater og dannelse af hydrogeler deraf
EP09795949A EP2370474B1 (en) 2008-11-28 2009-11-30 Method to produce hyaluronic acid functionalized derivatives and formation of hydrogels thereof
US14/507,474 US9410000B2 (en) 2008-11-28 2014-11-13 Method to produce hyaluronic acid functionalized derivatives and formation of hydrogels

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000636A ITRM20080636A1 (it) 2008-11-28 2008-11-28 Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli.

Publications (1)

Publication Number Publication Date
ITRM20080636A1 true ITRM20080636A1 (it) 2010-05-29

Family

ID=41210473

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000636A ITRM20080636A1 (it) 2008-11-28 2008-11-28 Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli.

Country Status (14)

Country Link
US (2) US8858999B2 (it)
EP (1) EP2370474B1 (it)
JP (1) JP5607061B2 (it)
CN (1) CN102227448B (it)
BR (1) BRPI0920965B1 (it)
CA (1) CA2744892C (it)
DK (1) DK2370474T3 (it)
ES (1) ES2397987T3 (it)
IT (1) ITRM20080636A1 (it)
MX (1) MX2011005528A (it)
PL (1) PL2370474T3 (it)
RU (1) RU2523182C2 (it)
SI (1) SI2370474T1 (it)
WO (1) WO2010061005A1 (it)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2861734B1 (fr) 2003-04-10 2006-04-14 Corneal Ind Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus
EP3498299A1 (en) 2007-11-16 2019-06-19 Aclaris Therapeutics, Inc. Compositions and methods for treating purpura
US8394782B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
US8450475B2 (en) 2008-08-04 2013-05-28 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
JP5722217B2 (ja) 2008-09-02 2015-05-20 アラーガン・ホールディングス・フランス・ソシエテ・パール・アクシオン・サンプリフィエＡｌｌｅｒｇａｎ Ｈｏｌｄｉｎｇｓ Ｆｒａｎｃｅ Ｓ．Ａ．Ｓ． ヒアルロン酸および／またはその誘導体の糸、その作製方法、ならびにその使用
ITRM20080636A1 (it) 2008-11-28 2010-05-29 Univ Palermo Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli.
CZ302503B6 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Zpusob prípravy derivátu kyseliny hyaluronové oxidovaného v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd a zpusob jeho modifikace
CZ302504B6 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Derivát kyseliny hyaluronové oxidovaný v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd, zpusob jeho prípravy a zpusob jeho modifikace
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
CA2792729C (en) 2010-03-12 2016-06-28 Allergan Industrie, Sas Fluid compositions for improving skin conditions
HUE030138T2 (en) 2010-03-22 2017-04-28 Allergan Inc Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation
IT1401498B1 (it) 2010-07-30 2013-07-26 Mero Srl Idrogelo a base di acido ialuronico e suo uso in ortopedia
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
CZ304072B6 (cs) * 2011-04-26 2013-09-25 Contipro Biotech S.R.O. Amfoterní materiál na bázi sítované kyseliny hyaluronové, zpusob jeho prípravy, materiály obsahující aktivní cinidla uzavrené v síti hyaluronanu, zpusob jejich prípravy a jejich pouzití
AU2012262047A1 (en) 2011-06-03 2014-01-16 Allergan, Inc. Dermal filler compositions including antioxidants
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
JP5714456B2 (ja) * 2011-09-07 2015-05-07 株式会社シード 重合性ヒアルロン酸誘導体、ならびにその重合体を含むヒアルロン酸ヒドロゲルおよびコンタクトレンズ
CZ2012136A3 (cs) 2012-02-28 2013-06-05 Contipro Biotech S.R.O. Deriváty na bázi kyseliny hyaluronové schopné tvorit hydrogely, zpusob jejich prípravy, hydrogely na bázi techto derivátu, zpusob jejich prípravy a pouzití
KR101240518B1 (ko) * 2012-03-26 2013-03-11 주식회사 제네웰 생체 적합성 고분자를 이용한 이식용 재료
WO2013181566A1 (en) * 2012-05-31 2013-12-05 Cornell University Polysaccharide-based hydrogels and hybrid hydrogels and precursors thereof, methods of making same, and uses thereof
CZ304512B6 (cs) 2012-08-08 2014-06-11 Contipro Biotech S.R.O. Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití
CZ304266B6 (cs) 2012-11-27 2014-02-05 Contipro Biotech S.R.O. Nekonečná vlákna na bázi hyaluronanu selektivně oxidovaného v poloze 6 N-acetyl-D-glukosaminové části, jejich příprava, použití, nitě, střiže, příze, textilie a způsob jejich úpravy
CZ2012842A3 (cs) 2012-11-27 2014-08-20 Contipro Biotech S.R.O. Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití
HK1220119A1 (zh) 2013-03-15 2017-04-28 Matthew R. Dreher 可成像栓塞微球
US9623157B2 (en) 2013-03-15 2017-04-18 Lake Region Manufacturing, Inc. Modified hyaluronate hydrophilic compositions, coatings and methods
US20140275340A1 (en) * 2013-03-15 2014-09-18 Lake Region Manufacturing, Inc. d/b/a Lake Region Medical Modified hyaluronate hydrophilic compositions, coatings and methods
CZ2014150A3 (cs) 2014-03-11 2015-05-20 Contipro Biotech S.R.O. Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití
CN103910886B (zh) * 2014-03-24 2016-04-06 海南大学 半胱氨酸功能化的透明质酸结合物及其合成方法以及在可注射原位形成的水凝胶中的应用
DK3139961T3 (en) * 2014-05-07 2018-07-16 Nemysis Ltd HYDROGELS OF METHACRYL HYALURONIC ACID DERIVATIVES FOR ORAL ENZYMY THERAPY
CZ2014451A3 (cs) 2014-06-30 2016-01-13 Contipro Pharma A.S. Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití
WO2016051219A1 (en) 2014-09-30 2016-04-07 Allergan Industrie, Sas Stable hydrogel compositions including additives
WO2016128783A1 (en) 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions and methods for improving skin appearance
EP3653232A1 (en) 2015-02-13 2020-05-20 Allergan Industrie, SAS Implants for sculpting, augmenting or correcting facial features such as the chin
CZ309295B6 (cs) 2015-03-09 2022-08-10 Contipro A.S. Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití
US20180154332A1 (en) * 2015-04-29 2018-06-07 Darryl W. Brousmiche High purity chromatographic materials comprising ion paired-bonded phases for supercritical fluid chromatography
CZ306479B6 (cs) 2015-06-15 2017-02-08 Contipro A.S. Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin
CZ306662B6 (cs) 2015-06-26 2017-04-26 Contipro A.S. Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití
WO2017031214A1 (en) 2015-08-19 2017-02-23 University Of Iowa Research Foundation Preventative therapy for post-traumatic osteoarthritis
EP3156044A1 (en) * 2015-10-16 2017-04-19 Merz Pharma GmbH & Co. KGaA In situ cross-linkable polysaccharide compositions and uses thereof
DK4279537T3 (da) 2015-12-29 2026-04-20 Galderma Holding SA Kulhydrat-tværbinder
CN105770983B (zh) * 2016-03-14 2019-02-19 武汉纺织大学 一种透明质酸生物粘合剂的制备方法
JP6675247B2 (ja) * 2016-03-28 2020-04-01 株式会社シード フィブロイン−ヒアルロン酸ハイドロゲル複合体
CZ308106B6 (cs) 2016-06-27 2020-01-08 Contipro A.S. Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití
CN106279729A (zh) * 2016-08-26 2017-01-04 北京大清生物技术有限公司 一种透明质酸交联凝胶及其制备方法与应用
FR3060239A1 (fr) * 2016-12-14 2018-06-15 Ge Energy Products France Snc Procede de determination d'un profil de reponse en statisme d'une machine electrique reliee a un reseau electrique
JP2018153296A (ja) * 2017-03-16 2018-10-04 Jsr株式会社 不飽和化合物を含有する組成物
IL269506B2 (en) 2017-03-22 2024-04-01 Genentech Inc Hydrogel cross-linked hyaluronic acid prodrug compositions and methods
US10263552B2 (en) * 2017-08-08 2019-04-16 Rolls-Royce North American Technologies Inc. Anticipatory control using output shaft speed
CN108187130B (zh) * 2017-09-15 2020-08-18 海宁侏罗纪生物科技有限公司 一种用于生物损伤修复或止血的试剂及其应用
IT201700122135A1 (it) * 2017-10-26 2019-04-26 Jointherapeutics S R L Acido ialuronico funzionalizzato o suo derivato nel trattamento di stati infiammatori
US20210015967A1 (en) * 2018-03-23 2021-01-21 Kaohsiung Medical University Method for preparing hyaluronic acid hydrogel microparticles and use thereof in repairing articular cartilage defects
EP3659632A1 (en) 2018-11-29 2020-06-03 Nestlé Skin Health SA Post-crosslinking partial degradation of amide crosslinked hydrogels
US12624015B2 (en) 2019-06-24 2026-05-12 University Of Iowa Research Foundation JNK inhibitors as anticancer agents
CN110384822B (zh) * 2019-08-19 2021-11-16 江苏人冠医疗科技有限公司 眼用粘合封闭胶及其制备方法
CN110433320A (zh) * 2019-09-12 2019-11-12 深圳刚华健医疗有限公司 一种医用敷料的制备方法
CN112812200B (zh) * 2019-11-18 2023-06-16 孛朗孚(杭州)生物科技有限公司 巯基改性高分子化合物及其制备方法和用途
EP4069753A1 (en) 2019-12-02 2022-10-12 Galderma Holding SA High molecular weight esthetic compositions
US11904006B2 (en) 2019-12-11 2024-02-20 University Of Iowa Research Foundation Poly(diaminosulfide) particle-based vaccine
US12296054B2 (en) 2020-06-01 2025-05-13 Lg Chem, Ltd. Method of preparing polymeric microparticles, polymeric microparticles, medical composition, cosmetic composition, medical articles and cosmetic articles using the same
IT202000028445A1 (it) 2020-11-25 2022-05-25 Univ Degli Studi Di Palermo Nanosistema per la diagnosi ed il trattamento fototermico di tumori
TR202022151A2 (tr) * 2020-12-29 2022-07-21 Vsy Biyoteknoloji Ve Ilac Sanayi Anonim Sirketi Enjekte edi̇lebi̇li̇r fotoçapraz bağli hi̇yaluroni̇k asi̇t hi̇drojeller, bunlarin üreti̇m yöntemi̇ ve osteoartri̇t tedavi̇si̇ i̇çi̇n kullanimi
WO2023148619A1 (en) 2022-02-01 2023-08-10 Galderma Holding SA Methods of producing crosslinked hyaluronic acid hydrogels
CN115636884B (zh) * 2022-12-23 2023-03-28 北京格林意锐医药科技有限责任公司 一种透明质酸钠衍生物制备方法及交联透明质酸钠和用途
US20260028458A1 (en) 2024-07-24 2026-01-29 Galderma Holding SA High-durability glycosaminoglycan gels and methods of making the same

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003002125A2 (en) * 2001-06-29 2003-01-09 Astion A/S Combination of aminosugars and cysteine or cysteine derivatives
EP1666518A1 (en) * 2003-09-08 2006-06-07 Chugai Seiyaku Kabushiki Kaisha Hyaluronic acid modification products and drug carriers using them
WO2007083870A1 (en) * 2006-01-19 2007-07-26 Seoul National University Of Technology Center For Industry Collaboration Chitosan or hyaluronic acid-poly(ethylene oxide)- and chitosan-hyaluronic acid-poly(ethylene oxide)-based hydrogel and manufacturing method therefor
US20070224277A1 (en) * 2005-12-23 2007-09-27 Janos Borbely Hyaluronic acid-based cross-linked nanoparticles

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06279501A (ja) * 1993-03-29 1994-10-04 Asahi Chem Ind Co Ltd カーボネート化セルロース誘導体及びその製造方法
JPH06279502A (ja) * 1993-03-29 1994-10-04 Asahi Chem Ind Co Ltd カーボネート化セルロース誘導体の製法
IT1268955B1 (it) * 1994-03-11 1997-03-18 Fidia Advanced Biopolymers Srl Esteri attivi di polisaccaridi carbossilici
WO1997018244A1 (en) * 1995-11-15 1997-05-22 Seikagaku Corporation Photocured cross-linked-hyaluronic acid gel and method of preparation thereof
RU2191782C2 (ru) * 2000-09-21 2002-10-27 Институт нефтехимии и катализа АН РБ и УНЦ РАН Способ получения модифицированной гиалуроновой кислоты
JP2004292465A (ja) * 2000-11-30 2004-10-21 Denki Kagaku Kogyo Kk ヒドロキサム酸誘導体とヒアルロン酸の結合体
ITTS20010013A1 (it) * 2001-06-04 2002-12-04 Ct Ricerche Poly Tec H A R L S Nuovi derivati di ialuronano.
GB2408741B (en) * 2003-12-04 2008-06-18 Ind Tech Res Inst Hyaluronic acid derivative with urethane linkage
TW200536861A (en) * 2004-04-02 2005-11-16 Denki Kagaku Kogyo Kk Hyaluronic acid/methotrexate compound
TW200612991A (en) * 2004-09-07 2006-05-01 Chugai Pharmaceutical Co Ltd Process for producing water-soluble hyaluronic acid modification
ITRM20080636A1 (it) 2008-11-28 2010-05-29 Univ Palermo Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003002125A2 (en) * 2001-06-29 2003-01-09 Astion A/S Combination of aminosugars and cysteine or cysteine derivatives
EP1666518A1 (en) * 2003-09-08 2006-06-07 Chugai Seiyaku Kabushiki Kaisha Hyaluronic acid modification products and drug carriers using them
US20070224277A1 (en) * 2005-12-23 2007-09-27 Janos Borbely Hyaluronic acid-based cross-linked nanoparticles
WO2007083870A1 (en) * 2006-01-19 2007-07-26 Seoul National University Of Technology Center For Industry Collaboration Chitosan or hyaluronic acid-poly(ethylene oxide)- and chitosan-hyaluronic acid-poly(ethylene oxide)-based hydrogel and manufacturing method therefor

Also Published As

Publication number Publication date
JP2012510535A (ja) 2012-05-10
MX2011005528A (es) 2011-08-17
DK2370474T3 (da) 2013-01-14
EP2370474B1 (en) 2012-10-24
PL2370474T3 (pl) 2013-03-29
US9410000B2 (en) 2016-08-09
US20110236486A1 (en) 2011-09-29
ES2397987T3 (es) 2013-03-12
SI2370474T1 (sl) 2013-02-28
JP5607061B2 (ja) 2014-10-15
BRPI0920965A2 (pt) 2016-09-06
BRPI0920965B1 (pt) 2019-07-09
CN102227448B (zh) 2014-04-02
US8858999B2 (en) 2014-10-14
EP2370474A1 (en) 2011-10-05
US20150183891A1 (en) 2015-07-02
CA2744892A1 (en) 2010-06-03
CA2744892C (en) 2016-10-25
WO2010061005A1 (en) 2010-06-03
CN102227448A (zh) 2011-10-26
HK1162546A1 (en) 2012-08-31
RU2011126353A (ru) 2013-01-10
RU2523182C2 (ru) 2014-07-20

Similar Documents

Publication Publication Date Title
EP3613734A3 (en) Process for producing pyrrole compound
BRPI0810124A2 (pt) Método de transformação de material de fibra de planta
BRPI0905080B8 (pt) composição de sulfoalquil éter ciclodextrina (sae-cd), processos para preparar uma composição de sulfoalquil éter ciclodextrina (sae-cd), processo para preparar uma composição e produto
ATE519785T1 (de) Verfahren zur verringerung des mittleren molekulargewichts von celluloseethern
BR112015005640A2 (pt) processo e eletrodos de elevada área de superfície para redução eletroquímica de dióxido de carbono
EA201001445A1 (ru) ПОЛУЧЕНИЕ 6-АМИНОКАПРОНОВОЙ КИСЛОТЫ ИЗ α-КЕТОПИМЕЛИНОВОЙ КИСЛОТЫ
BR112018011801A2 (pt) ?método de produção de composições, composição e produto ingerível?
DE602007004086D1 (de) Acrylierte hyaluronsäure
BR112012018527A2 (pt) aparelho e método para comunicação entre processos entre aplicações diferentes em um terminal móvel
WO2023004432A3 (en) Compositions and methods for production of value-added chemicals
BR112014013854A2 (pt) método para o tratamento de um subproduto da produção de etanol
NZ593787A (en) Lyophilised dabigatran
MX2020002288A (es) Metodo de produccion para xilooligosacarido acido y xilooligosacarido acido.
BR112015001655A2 (pt) método para purificar pelo menos uma saponina em uma solução, componente de produto de saponina qs-21 purificada, e, composição imunogênica
MX2020002287A (es) Metodo de produccion para polisulfato de pentosan.
MX2011009056A (es) Proceso para la preparacio de ajoeno.
AU2010271717A8 (en) Process for producing crystals of polymorphic 2-(3-cyano-4-isobutyloxyphenyl) -4-methyl-5-thiazolecaboxylic acid by poor-solvent addition method
BR112012018250A2 (pt) processo para preparação de uma partícula
BR112015007737A2 (pt) complexo oxo-nitrogenado de cobalto, sistema catalítico compreendendo o dito complexo oxo-nitrogenado e processo para a (co)polimerização de dienos conjugados
NZ594419A (en) Process for purifying guar
MX2012007749A (es) Metodo para extruir un polimero.
NO20082928L (no) Fremgangsmate for sol-gel prosessering
BR112012014468A2 (pt) Método para tratamento de café
EP3886194A3 (en) Fluorinated aromatic small molecules as functional additives for dispersion of conductive polymers
FR3038609B1 (fr) Nouveaux hydrogels de structure silylee et procede d'obtention