ITRM20120350A1 - Nanocostrutti con attività farmacologica. - Google Patents

Nanocostrutti con attività farmacologica. Download PDF

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Publication number
ITRM20120350A1
ITRM20120350A1 IT000350A ITRM20120350A ITRM20120350A1 IT RM20120350 A1 ITRM20120350 A1 IT RM20120350A1 IT 000350 A IT000350 A IT 000350A IT RM20120350 A ITRM20120350 A IT RM20120350A IT RM20120350 A1 ITRM20120350 A1 IT RM20120350A1
Authority
IT
Italy
Prior art keywords
nanoconstruct
disease
peptide
nfat
amphiphilic polymer
Prior art date
Application number
IT000350A
Other languages
English (en)
Italian (it)
Inventor
Miriam Colombo
Fabio Ruggero Maria Corsi
Francesca Granucci
Davide Prosperi
Ivan Zanoni
Original Assignee
Univ Degli Studi Milano
Uni Degli Studi Di Milano B Icocca
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Degli Studi Milano, Uni Degli Studi Di Milano B Icocca filed Critical Univ Degli Studi Milano
Priority to IT000350A priority Critical patent/ITRM20120350A1/it
Priority to KR20157004399A priority patent/KR20150041633A/ko
Priority to HK15110893.0A priority patent/HK1210038A1/xx
Priority to CA2879148A priority patent/CA2879148A1/en
Priority to CN201380038523.9A priority patent/CN104519914A/zh
Priority to US14/415,916 priority patent/US20150224061A1/en
Priority to PCT/IB2013/055943 priority patent/WO2014013473A1/en
Priority to IN344DEN2015 priority patent/IN2015DN00344A/en
Priority to MX2015000848A priority patent/MX2015000848A/es
Priority to EP13773359.8A priority patent/EP2874663B1/en
Priority to JP2015522237A priority patent/JP2015528007A/ja
Publication of ITRM20120350A1 publication Critical patent/ITRM20120350A1/it

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
    • A61K47/6935—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
    • A—HUMAN NECESSITIES
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
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    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Inorganic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
IT000350A 2012-07-19 2012-07-19 Nanocostrutti con attività farmacologica. ITRM20120350A1 (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IT000350A ITRM20120350A1 (it) 2012-07-19 2012-07-19 Nanocostrutti con attività farmacologica.
KR20157004399A KR20150041633A (ko) 2012-07-19 2013-07-19 약리학적 활성을 갖는 나노구조물
HK15110893.0A HK1210038A1 (en) 2012-07-19 2013-07-19 Nanoconstructs with pharmacological activity
CA2879148A CA2879148A1 (en) 2012-07-19 2013-07-19 Nanoconstructs with pharmacological activity
CN201380038523.9A CN104519914A (zh) 2012-07-19 2013-07-19 具有药理学活性的纳米构建物
US14/415,916 US20150224061A1 (en) 2012-07-19 2013-07-19 Nanoconstructs with pharmacological activity
PCT/IB2013/055943 WO2014013473A1 (en) 2012-07-19 2013-07-19 Nanoconstructs with pharmacological activity
IN344DEN2015 IN2015DN00344A (2) 2012-07-19 2013-07-19
MX2015000848A MX2015000848A (es) 2012-07-19 2013-07-19 Nanoconstructores con actividad farmacologica.
EP13773359.8A EP2874663B1 (en) 2012-07-19 2013-07-19 Nanoconstructs with pharmacological activity
JP2015522237A JP2015528007A (ja) 2012-07-19 2013-07-19 薬理活性を有するナノ構造物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000350A ITRM20120350A1 (it) 2012-07-19 2012-07-19 Nanocostrutti con attività farmacologica.

Publications (1)

Publication Number Publication Date
ITRM20120350A1 true ITRM20120350A1 (it) 2014-01-20

Family

ID=46982752

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000350A ITRM20120350A1 (it) 2012-07-19 2012-07-19 Nanocostrutti con attività farmacologica.

Country Status (11)

Country Link
US (1) US20150224061A1 (2)
EP (1) EP2874663B1 (2)
JP (1) JP2015528007A (2)
KR (1) KR20150041633A (2)
CN (1) CN104519914A (2)
CA (1) CA2879148A1 (2)
HK (1) HK1210038A1 (2)
IN (1) IN2015DN00344A (2)
IT (1) ITRM20120350A1 (2)
MX (1) MX2015000848A (2)
WO (1) WO2014013473A1 (2)

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Publication number Priority date Publication date Assignee Title
WO2017080408A1 (zh) 2015-11-10 2017-05-18 苏州宝时得电动工具有限公司 自动工作系统及其控制方法及自动行走设备
WO2017091700A1 (en) 2015-11-25 2017-06-01 The Regents Of The University Of Colorado, A Body Corporate Use of microrna-146a and nanoceria conjugate to improve wound healing and promote tissue regeneration
ES2908466T3 (es) * 2016-08-05 2022-04-29 Shenzhen Profound View Pharma Tech Co Ltd Sustancia que contiene agrupación de oro y método de preparación y uso de la misma
EA201991489A1 (ru) * 2016-12-21 2019-12-30 Нанобиотикс Наночастицы для применения для лечения нейронального нарушения
IL299915A (en) * 2017-01-04 2023-03-01 Nanotics Llc Methods for assembling cleaning particles
JP6887665B2 (ja) * 2017-03-01 2021-06-16 国立大学法人 琉球大学 新規免疫抑制剤
CN113116924A (zh) * 2021-04-20 2021-07-16 中国人民解放军陆军军医大学 氧化铈纳米颗粒在制备增强细胞毒性cd8+t细胞活性的药物中的应用
CN113562773B (zh) * 2021-06-21 2023-09-26 北京大学深圳医院 一种CoFe2O4量子点纳米材料的合成方法及其在抗非小细胞型肺癌中的应用
EP4359513A1 (en) * 2021-06-23 2024-05-01 Università Degli Studi Di Milano - Bicocca A molecule capable of inhibiting the integration of calcineurin with a substrate and uses thereof
CN113655105B (zh) * 2021-08-30 2023-05-26 赣南医学院 一种电化学生物传感器的制备方法及其在大肠杆菌检测中的应用

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US9333163B2 (en) * 2008-10-06 2016-05-10 Massachusetts Institute Of Technology Particles with multiple functionalized surface domains
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WO2007097593A1 (en) * 2006-02-24 2007-08-30 Atgen Co., Ltd. Magnetic nano-composite for contrast agent, intelligent contrast agent, drug delivery agent for simultaneous diagnosis and treatment, and separation agent for target substance

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KR20150041633A (ko) 2015-04-16
MX2015000848A (es) 2015-07-17
JP2015528007A (ja) 2015-09-24
IN2015DN00344A (2) 2015-06-12
HK1210038A1 (en) 2016-04-15
CA2879148A1 (en) 2014-01-23
US20150224061A1 (en) 2015-08-13
EP2874663A1 (en) 2015-05-27
WO2014013473A1 (en) 2014-01-23
EP2874663B1 (en) 2018-01-10
CN104519914A (zh) 2015-04-15

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