ITRM920457A0 - Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteinaumana. - Google Patents

Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteinaumana.

Info

Publication number
ITRM920457A0
ITRM920457A0 IT92RM457A ITRM920457A ITRM920457A0 IT RM920457 A0 ITRM920457 A0 IT RM920457A0 IT 92RM457 A IT92RM457 A IT 92RM457A IT RM920457 A ITRM920457 A IT RM920457A IT RM920457 A0 ITRM920457 A0 IT RM920457A0
Authority
IT
Italy
Prior art keywords
glycoprotein
epitope
recognize
human
monoclonal antibodies
Prior art date
Application number
IT92RM457A
Other languages
English (en)
Inventor
Maurizio Cianfriglia
Original Assignee
Ist Superiore Sanita
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ist Superiore Sanita filed Critical Ist Superiore Sanita
Publication of ITRM920457A0 publication Critical patent/ITRM920457A0/it
Priority to ITRM920457A priority Critical patent/IT1257893B/it
Priority to ES93912996T priority patent/ES2130271T3/es
Priority to JP6501138A priority patent/JPH08501925A/ja
Priority to NZ253139A priority patent/NZ253139A/en
Priority to DE69322783T priority patent/DE69322783T2/de
Priority to SK1554-94A priority patent/SK280272B6/sk
Priority to KR1019940704598A priority patent/KR100301189B1/ko
Priority to FI945865A priority patent/FI945865A7/fi
Priority to RU94046414A priority patent/RU2126836C1/ru
Priority to EP93912996A priority patent/EP0648276B1/en
Priority to AU43266/93A priority patent/AU672798B2/en
Priority to HU9403614A priority patent/HU216877B/hu
Priority to PCT/EP1993/001533 priority patent/WO1993025700A1/en
Priority to AT93912996T priority patent/ATE174967T1/de
Priority to CA002134752A priority patent/CA2134752A1/en
Priority to CZ943181A priority patent/CZ284847B6/cs
Priority to US08/356,272 priority patent/US5766946A/en
Priority to DK93912996T priority patent/DK0648276T3/da
Publication of ITRM920457A1 publication Critical patent/ITRM920457A1/it
Priority to NO944887A priority patent/NO944887D0/no
Application granted granted Critical
Publication of IT1257893B publication Critical patent/IT1257893B/it
Priority to GR990400860T priority patent/GR3029773T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ITRM920457A 1992-06-17 1992-06-17 Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteina umana. IT1257893B (it)

Priority Applications (20)

Application Number Priority Date Filing Date Title
ITRM920457A IT1257893B (it) 1992-06-17 1992-06-17 Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteina umana.
AU43266/93A AU672798B2 (en) 1992-06-17 1993-06-16 Monoclonal antibodies to glycoprotein P
PCT/EP1993/001533 WO1993025700A1 (en) 1992-06-17 1993-06-16 Monoclonal antibodies to glycoprotein p
NZ253139A NZ253139A (en) 1992-06-17 1993-06-16 Monoclonal antibody that recognises human glycoprotein p (pgp), its production and diagnostic kits and compositions containing it
DE69322783T DE69322783T2 (de) 1992-06-17 1993-06-16 Monoklonale Antikörper gegen Glykoprotein P
SK1554-94A SK280272B6 (sk) 1992-06-17 1993-06-16 Monoklonálna protilátka, spôsob prípravy monokloná
KR1019940704598A KR100301189B1 (ko) 1992-06-17 1993-06-16 당단백질피(p)에대한단일클론항체
FI945865A FI945865A7 (fi) 1992-06-17 1993-06-16 Glykoprofeiini P:lle kohdistettuja monoklonaalisia vasta-aineita
RU94046414A RU2126836C1 (ru) 1992-06-17 1993-06-16 Моноклональное антитело к гликопротеину р человека
EP93912996A EP0648276B1 (en) 1992-06-17 1993-06-16 Monoclonal antibodies to glycoprotein p
ES93912996T ES2130271T3 (es) 1992-06-17 1993-06-16 Anticuerpos monoclonales para glicoproteina p.
HU9403614A HU216877B (hu) 1992-06-17 1993-06-16 Eljárás P-glikoprotein specifikus monoklonális antitestek és ezt termelő sejtvonalak előállítására
JP6501138A JPH08501925A (ja) 1992-06-17 1993-06-16 糖蛋白ｐに対するモノクローナル抗体
AT93912996T ATE174967T1 (de) 1992-06-17 1993-06-16 Monoklonale antikörper gegen glykoprotein p
CA002134752A CA2134752A1 (en) 1992-06-17 1993-06-16 Monoclonal antibodies to glycoprotein p
CZ943181A CZ284847B6 (cs) 1992-06-17 1993-06-16 Monoklonální protilátky proti glykoproteinu P
US08/356,272 US5766946A (en) 1992-06-17 1993-06-16 Monoclonal antibodies to glycoprotein P
DK93912996T DK0648276T3 (da) 1992-06-17 1993-06-16 Monoklone antistoffer mod glycoprotein P
NO944887A NO944887D0 (no) 1992-06-17 1994-12-16 Monoklonale antistoffer mot glykoprotein
GR990400860T GR3029773T3 (en) 1992-06-17 1999-03-23 Monoclonal antibodies to glycoprotein p.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM920457A IT1257893B (it) 1992-06-17 1992-06-17 Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteina umana.

Publications (3)

Publication Number Publication Date
ITRM920457A0 true ITRM920457A0 (it) 1992-06-17
ITRM920457A1 ITRM920457A1 (it) 1993-12-17
IT1257893B IT1257893B (it) 1996-02-16

Family

ID=11401066

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM920457A IT1257893B (it) 1992-06-17 1992-06-17 Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteina umana.

Country Status (20)

Country Link
US (1) US5766946A (it)
EP (1) EP0648276B1 (it)
JP (1) JPH08501925A (it)
KR (1) KR100301189B1 (it)
AT (1) ATE174967T1 (it)
AU (1) AU672798B2 (it)
CA (1) CA2134752A1 (it)
CZ (1) CZ284847B6 (it)
DE (1) DE69322783T2 (it)
DK (1) DK0648276T3 (it)
ES (1) ES2130271T3 (it)
FI (1) FI945865A7 (it)
GR (1) GR3029773T3 (it)
HU (1) HU216877B (it)
IT (1) IT1257893B (it)
NO (1) NO944887D0 (it)
NZ (1) NZ253139A (it)
RU (1) RU2126836C1 (it)
SK (1) SK280272B6 (it)
WO (1) WO1993025700A1 (it)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5994088A (en) * 1991-03-08 1999-11-30 Board Of Trustees Of The University Of Illinois Methods and reagents for preparing and using immunological agents specific for P-glycoprotein
AU5420494A (en) * 1992-11-02 1994-05-24 Yves Claude Nicolau Method of reducing multidrug resistance in cells and tissues
US5686578A (en) 1994-08-05 1997-11-11 Immunomedics, Inc. Polyspecific immunoconjugates and antibody composites for targeting the multidrug resistant phenotype
WO1997046254A2 (en) * 1996-06-05 1997-12-11 Eugene Mechetner Reagents and methods for inhibiting cytokine release by blood cells
WO2000014537A2 (en) * 1998-09-04 2000-03-16 Immunomedics, Inc. Immunoconjugate for diagnosis of multidrug resistance
WO2001055218A1 (en) * 2000-01-31 2001-08-02 The Procter & Gamble Company Antibodies to the staphylococcal multidrug resistance (smr) protein
EP1290028B1 (en) 2000-06-05 2009-12-23 The Brigham And Women's Hospital, Inc. A GENE ENCODING A MULTIDRUG RESISTANCE HUMAN P-GLYCOPROTEIN HOMOLOGUE ON CHROMOSOME 7p15-21 AND USES THEREOF
EP1223534A1 (en) * 2001-01-14 2002-07-17 Katz, Emil Peptides representative of polypeptides of interest and antibodies directed thereagainst, and methods, systems and kits for generating and utilizing each
US8663650B2 (en) 2003-02-21 2014-03-04 Ac Immune Sa Methods and compositions comprising supramolecular constructs
US7294701B2 (en) * 2003-04-02 2007-11-13 Technion Research & Development Foundation Ltd. Antibody fragment capable of modulating multidrug resistance and compositions and kits and methods using same
FR2857875A1 (fr) * 2003-07-25 2005-01-28 Univ Reims Champagne Ardenne Vaccin therapeutique cible contre la p-glycoproteine 170 pour inhiber la resistance multidrogues dans le traitement des cancers
US7807171B2 (en) 2003-07-25 2010-10-05 Ac Immune Sa Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers
US20060068426A1 (en) * 2004-08-20 2006-03-30 Tam James P Cyclic peptides and antibodies thereof
ES2511791T3 (es) 2006-05-31 2014-10-23 Children's Medical Center Corporation Células madre mesenquimales positivas para ABCB5 como moduladoras de inmunidad
FR2906533B1 (fr) 2006-09-28 2013-02-22 Pf Medicament Procede de generation d'anticorps actifs contre un antigene de resistance,anticorps obtenus par ledit procede et leurs utilisations
HUE039385T2 (hu) 2007-04-12 2018-12-28 Brigham & Womens Hospital Inc ABCB5 rákterápiás célzása
EP2603233A1 (en) 2010-08-12 2013-06-19 AC Immune S.A. Vaccine engineering
JP6027011B2 (ja) 2010-10-26 2016-11-16 エーシー イミューン ソシエテ アノニム 疎水性部分によって修飾されたペプチドを含むリポソームベースの構築物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206352A (en) * 1986-03-28 1993-04-27 Board Of Trustees Of The University Of Illinois Compositions for clones containing DNA sequences associated with multidrug resistance in human cells
US5773280A (en) * 1992-03-20 1998-06-30 The Board Of Trustees Of The University Of Illinois Monoclonal antibody to a human MDR1 multidrug resistance gene product, and uses
US5434075A (en) * 1992-03-20 1995-07-18 Board Of Trustees Of The University Of Illinois Monoclonal antibody to a human MDR1 multidrug resistance gene product, and uses
EP0569141A3 (en) * 1992-04-14 1994-10-26 Hybritech Inc Method for inhibiting the growth of multidrug-resistant tumors by antibodies.
US5369009A (en) * 1992-04-17 1994-11-29 Dana Farber Cancer Institute Antibodies for P-glycoprotein encoded by the mdr1 gene and uses thereof

Also Published As

Publication number Publication date
NZ253139A (en) 1996-09-25
CZ318194A3 (en) 1995-07-12
FI945865L (fi) 1995-02-08
HU9403614D0 (en) 1995-02-28
NO944887L (no) 1994-12-16
EP0648276A1 (en) 1995-04-19
NO944887D0 (no) 1994-12-16
FI945865A7 (fi) 1995-02-08
FI945865A0 (fi) 1994-12-13
JPH08501925A (ja) 1996-03-05
ES2130271T3 (es) 1999-07-01
SK155494A3 (en) 1995-07-11
DK0648276T3 (da) 1999-08-23
AU672798B2 (en) 1996-10-17
HUT70469A (en) 1995-10-30
CA2134752A1 (en) 1993-12-23
ITRM920457A1 (it) 1993-12-17
CZ284847B6 (cs) 1999-03-17
ATE174967T1 (de) 1999-01-15
RU2126836C1 (ru) 1999-02-27
GR3029773T3 (en) 1999-06-30
AU4326693A (en) 1994-01-04
DE69322783D1 (de) 1999-02-04
US5766946A (en) 1998-06-16
EP0648276B1 (en) 1998-12-23
DE69322783T2 (de) 1999-06-10
WO1993025700A1 (en) 1993-12-23
RU94046414A (ru) 1996-11-10
SK280272B6 (sk) 1999-10-08
KR100301189B1 (ko) 2001-10-22
IT1257893B (it) 1996-02-16
HU216877B (hu) 1999-09-28

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Legal Events

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970627