ITRM920919A1 - Preparato ad attivita' antinfiammatoria, anticoagulante e antitumorale - Google Patents

Preparato ad attivita' antinfiammatoria, anticoagulante e antitumorale

Info

Publication number
ITRM920919A1
ITRM920919A1 IT000919A ITRM920919A ITRM920919A1 IT RM920919 A1 ITRM920919 A1 IT RM920919A1 IT 000919 A IT000919 A IT 000919A IT RM920919 A ITRM920919 A IT RM920919A IT RM920919 A1 ITRM920919 A1 IT RM920919A1
Authority
IT
Italy
Prior art keywords
pct
agulant
inflammatory
prepared
tumoral activity
Prior art date
Application number
IT000919A
Other languages
English (en)
Inventor
Antonino Sirna
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of ITRM920919A0 publication Critical patent/ITRM920919A0/it
Priority to ITRM920919A priority Critical patent/IT1257184B/it
Priority to PCT/EP1993/003645 priority patent/WO1994014959A1/en
Priority to DK94904167T priority patent/DK0675956T3/da
Priority to US08/448,561 priority patent/US5908827A/en
Priority to CA002151156A priority patent/CA2151156A1/en
Priority to AU58335/94A priority patent/AU690093B2/en
Priority to PT94904167T priority patent/PT675956E/pt
Priority to DE69332861T priority patent/DE69332861T2/de
Priority to ES94904167T priority patent/ES2193152T3/es
Priority to EP94904167A priority patent/EP0675956B1/en
Priority to UA95062918A priority patent/UA46702C2/uk
Priority to KR1019950702407A priority patent/KR100193107B1/ko
Priority to AT94904167T priority patent/ATE236976T1/de
Priority to JP6514813A priority patent/JP3025014B2/ja
Priority to ZA939621A priority patent/ZA939621B/xx
Priority to IL10814993A priority patent/IL108149A/xx
Priority to RU95113418/13A priority patent/RU2177480C2/ru
Publication of ITRM920919A1 publication Critical patent/ITRM920919A1/it
Priority to NO19952494A priority patent/NO315800B1/no
Priority to FI953091A priority patent/FI114478B/fi
Application granted granted Critical
Publication of IT1257184B publication Critical patent/IT1257184B/it
Priority to FI20040608A priority patent/FI116059B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ITRM920919A 1992-12-22 1992-12-22 Preparato ad attivita' antinfiammatoria, anticoagulante e antitumorale IT1257184B (it)

Priority Applications (20)

Application Number Priority Date Filing Date Title
ITRM920919A IT1257184B (it) 1992-12-22 1992-12-22 Preparato ad attivita' antinfiammatoria, anticoagulante e antitumorale
UA95062918A UA46702C2 (uk) 1992-12-22 1993-12-21 Поліпептид, спосіб одержання поліпептиду (варіанти),фрагмент днк (варіанти), експресуючий вектор (варіанти), штам e.coli, лінія клітин (варіанти), білок, фармацевтична композиція (варіанти)
AT94904167T ATE236976T1 (de) 1992-12-22 1993-12-21 Neues protein aus urin, komponent b genannt
US08/448,561 US5908827A (en) 1992-12-22 1993-12-21 Protein from urine named component B
CA002151156A CA2151156A1 (en) 1992-12-22 1993-12-21 New protein from urine named component b
AU58335/94A AU690093B2 (en) 1992-12-22 1993-12-21 New protein from urine named component B
PT94904167T PT675956E (pt) 1992-12-22 1993-12-21 Proteina nova da urina denominada componente b
DE69332861T DE69332861T2 (de) 1992-12-22 1993-12-21 Neues protein aus urin, komponent b genannt
ES94904167T ES2193152T3 (es) 1992-12-22 1993-12-21 Nueva proteina de la orina denominada componente b.
EP94904167A EP0675956B1 (en) 1992-12-22 1993-12-21 New protein from urine named component b
PCT/EP1993/003645 WO1994014959A1 (en) 1992-12-22 1993-12-21 New protein from urine named component b
KR1019950702407A KR100193107B1 (ko) 1992-12-22 1993-12-21 성분b로 명명된 신규 단백질
DK94904167T DK0675956T3 (da) 1992-12-22 1993-12-21 Nyt protein fra urin betegnet komponent B
JP6514813A JP3025014B2 (ja) 1992-12-22 1993-12-21 成分ｂと命名された新規な蛋白質
ZA939621A ZA939621B (en) 1992-12-22 1993-12-22 Protein named component B
IL10814993A IL108149A (en) 1992-12-22 1993-12-22 Component b protein, its preparation and pharmaceutical compositions containing it
RU95113418/13A RU2177480C2 (ru) 1992-12-22 1993-12-22 Полипептид, способ получения (варианты), днк (варианты), вектор (варианты), клетка, применение полипептида, фармацевтическая композиция (варианты)
NO19952494A NO315800B1 (no) 1992-12-22 1995-06-21 Polypeptid fra urin med betegnelse komponent B, fremgangsmate for fremstilling av dette, DNA-molekyl, ekspresjonsvektor, vertscelle, pattedyrscelle, anvendelse av polypeptidet for fremstilling av et medikament samt farmasoytisk preparat
FI953091A FI114478B (fi) 1992-12-22 1995-06-21 Menetelmä virtsasta peräisin olevan komponentti B: ksi kutsutun proteiinin valmistamiseksi
FI20040608A FI116059B (fi) 1992-12-22 2004-04-29 Analogiamenetelmä komponentti B:ksi kutsutun rekombinanttiproteiinin valmistamiseksi sekä DNA-molekyyli, ilmentämisvektori ja isäntäsolu

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM920919A IT1257184B (it) 1992-12-22 1992-12-22 Preparato ad attivita' antinfiammatoria, anticoagulante e antitumorale

Publications (3)

Publication Number Publication Date
ITRM920919A0 ITRM920919A0 (it) 1992-12-22
ITRM920919A1 true ITRM920919A1 (it) 1994-06-22
IT1257184B IT1257184B (it) 1996-01-10

Family

ID=11401349

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM920919A IT1257184B (it) 1992-12-22 1992-12-22 Preparato ad attivita' antinfiammatoria, anticoagulante e antitumorale

Country Status (19)

Country Link
US (1) US5908827A (it)
EP (1) EP0675956B1 (it)
JP (1) JP3025014B2 (it)
KR (1) KR100193107B1 (it)
AT (1) ATE236976T1 (it)
AU (1) AU690093B2 (it)
CA (1) CA2151156A1 (it)
DE (1) DE69332861T2 (it)
DK (1) DK0675956T3 (it)
ES (1) ES2193152T3 (it)
FI (2) FI114478B (it)
IL (1) IL108149A (it)
IT (1) IT1257184B (it)
NO (1) NO315800B1 (it)
PT (1) PT675956E (it)
RU (1) RU2177480C2 (it)
UA (1) UA46702C2 (it)
WO (1) WO1994014959A1 (it)
ZA (1) ZA939621B (it)

Families Citing this family (41)

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ATE234110T1 (de) * 1996-04-24 2003-03-15 Applied Research Systems Komponente b als wundheilendes mittel
AU8536698A (en) * 1997-06-09 1998-12-30 Wolf-Georg Forssmann Lus-1 human protein, its production and use
DK1093380T3 (da) * 1998-07-09 2003-01-27 Applied Research Systems Komponent B som angiogent middel i kombination med humane vækstfaktorer
US6962700B1 (en) 2000-09-13 2005-11-08 Atopix Pharmaceuticals Corporation Method of manufacturing immune globulin
ES2359408T3 (es) * 2003-04-16 2011-05-23 Merck Serono Sa Uso de slurp-1 para tratar enfermedades relacionadas con la disfunción de receptores de acetilcolina.
US7343581B2 (en) * 2005-06-27 2008-03-11 Tela Innovations, Inc. Methods for creating primitive constructed standard cells
US7590968B1 (en) 2006-03-01 2009-09-15 Tela Innovations, Inc. Methods for risk-informed chip layout generation
US8653857B2 (en) 2006-03-09 2014-02-18 Tela Innovations, Inc. Circuitry and layouts for XOR and XNOR logic
US9563733B2 (en) 2009-05-06 2017-02-07 Tela Innovations, Inc. Cell circuit and layout with linear finfet structures
US8448102B2 (en) 2006-03-09 2013-05-21 Tela Innovations, Inc. Optimizing layout of irregular structures in regular layout context
US8225239B2 (en) 2006-03-09 2012-07-17 Tela Innovations, Inc. Methods for defining and utilizing sub-resolution features in linear topology
US9009641B2 (en) 2006-03-09 2015-04-14 Tela Innovations, Inc. Circuits with linear finfet structures
US9230910B2 (en) 2006-03-09 2016-01-05 Tela Innovations, Inc. Oversized contacts and vias in layout defined by linearly constrained topology
US7763534B2 (en) 2007-10-26 2010-07-27 Tela Innovations, Inc. Methods, structures and designs for self-aligning local interconnects used in integrated circuits
US8245180B2 (en) 2006-03-09 2012-08-14 Tela Innovations, Inc. Methods for defining and using co-optimized nanopatterns for integrated circuit design and apparatus implementing same
US9035359B2 (en) 2006-03-09 2015-05-19 Tela Innovations, Inc. Semiconductor chip including region including linear-shaped conductive structures forming gate electrodes and having electrical connection areas arranged relative to inner region between transistors of different types and associated methods
US8541879B2 (en) 2007-12-13 2013-09-24 Tela Innovations, Inc. Super-self-aligned contacts and method for making the same
US8247846B2 (en) 2006-03-09 2012-08-21 Tela Innovations, Inc. Oversized contacts and vias in semiconductor chip defined by linearly constrained topology
US7943967B2 (en) 2006-03-09 2011-05-17 Tela Innovations, Inc. Semiconductor device and associated layouts including diffusion contact placement restriction based on relation to linear conductive segments
US8225261B2 (en) 2006-03-09 2012-07-17 Tela Innovations, Inc. Methods for defining contact grid in dynamic array architecture
US7446352B2 (en) 2006-03-09 2008-11-04 Tela Innovations, Inc. Dynamic array architecture
US7917879B2 (en) * 2007-08-02 2011-03-29 Tela Innovations, Inc. Semiconductor device with dynamic array section
US7956421B2 (en) 2008-03-13 2011-06-07 Tela Innovations, Inc. Cross-coupled transistor layouts in restricted gate level layout architecture
US8658542B2 (en) 2006-03-09 2014-02-25 Tela Innovations, Inc. Coarse grid design methods and structures
US8839175B2 (en) 2006-03-09 2014-09-16 Tela Innovations, Inc. Scalable meta-data objects
US7932545B2 (en) 2006-03-09 2011-04-26 Tela Innovations, Inc. Semiconductor device and associated layouts including gate electrode level region having arrangement of six linear conductive segments with side-to-side spacing less than 360 nanometers
US7586800B1 (en) 2006-08-08 2009-09-08 Tela Innovations, Inc. Memory timing apparatus and associated methods
US7979829B2 (en) * 2007-02-20 2011-07-12 Tela Innovations, Inc. Integrated circuit cell library with cell-level process compensation technique (PCT) application and associated methods
US8286107B2 (en) 2007-02-20 2012-10-09 Tela Innovations, Inc. Methods and systems for process compensation technique acceleration
US8667443B2 (en) 2007-03-05 2014-03-04 Tela Innovations, Inc. Integrated circuit cell library for multiple patterning
EP2201035B1 (en) * 2007-09-20 2015-06-17 Commonwealth Scientific and Industrial Research Organisation Novel avian cytokines and genetic sequences encoding same
WO2009051109A1 (ja) * 2007-10-15 2009-04-23 Chugai Seiyaku Kabushiki Kaisha 異種タンパク質を高生産する細胞の作製方法
US8453094B2 (en) 2008-01-31 2013-05-28 Tela Innovations, Inc. Enforcement of semiconductor structure regularity for localized transistors and interconnect
US7939443B2 (en) 2008-03-27 2011-05-10 Tela Innovations, Inc. Methods for multi-wire routing and apparatus implementing same
KR101903975B1 (ko) 2008-07-16 2018-10-04 텔라 이노베이션스, 인코포레이티드 동적 어레이 아키텍쳐에서의 셀 페이징과 배치를 위한 방법 및 그 구현
US9122832B2 (en) 2008-08-01 2015-09-01 Tela Innovations, Inc. Methods for controlling microloading variation in semiconductor wafer layout and fabrication
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EP2239322A1 (en) * 2009-04-07 2010-10-13 Basf Se Use of enzymes to reduce formaldehyde from formaldehyde-containing products
US8661392B2 (en) 2009-10-13 2014-02-25 Tela Innovations, Inc. Methods for cell boundary encroachment and layouts implementing the Same
US9159627B2 (en) 2010-11-12 2015-10-13 Tela Innovations, Inc. Methods for linewidth modification and apparatus implementing the same
EP2740485B1 (en) * 2012-12-07 2018-10-31 Brightpulse Holding LTD. Protein slurp-1 for use in the treatment of ocular diseases

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US4359415A (en) * 1981-06-03 1982-11-16 University Of Tennessee Research Corporation Isolation of an antineoplastic protein fraction and an antineoplastic peptide fraction from human urine
US4470970A (en) * 1981-07-02 1984-09-11 Burzynski Stanislaw R Purified antineoplaston fractions and methods of treating neoplastic disease
SU1751206A1 (ru) * 1990-06-04 1992-07-30 Всесоюзный научно-исследовательский противочумный институт "Микроб" Рекомбинантна плазмидна ДНК РЕК 8, кодирующа фибринолизин YeRSINIa реSтIS, способ ее конструировани и штамм бактерий ЕSснеRIснIа coLI - продуцент фибринолизина YeRSINIa реSтIS
US5298604A (en) * 1992-07-27 1994-03-29 Sloane Nathan H Parital primary amino acid sequence of the antineoplastic protein (ANUP); a cytokine present in granulocytes

Also Published As

Publication number Publication date
IT1257184B (it) 1996-01-10
RU2177480C2 (ru) 2001-12-27
AU5833594A (en) 1994-07-19
FI116059B (fi) 2005-09-15
JPH08509359A (ja) 1996-10-08
DK0675956T3 (da) 2003-07-07
ATE236976T1 (de) 2003-04-15
KR950704486A (ko) 1995-11-20
NO952494D0 (no) 1995-06-21
IL108149A0 (en) 1994-04-12
IL108149A (en) 2005-05-17
NO315800B1 (no) 2003-10-27
DE69332861D1 (de) 2003-05-15
UA46702C2 (uk) 2002-06-17
ES2193152T3 (es) 2003-11-01
WO1994014959A1 (en) 1994-07-07
ZA939621B (en) 1995-06-22
PT675956E (pt) 2003-07-31
FI953091L (fi) 1995-06-21
FI20040608A7 (fi) 2004-04-29
EP0675956A1 (en) 1995-10-11
KR100193107B1 (ko) 1999-06-15
JP3025014B2 (ja) 2000-03-27
FI114478B (fi) 2004-10-29
DE69332861T2 (de) 2004-01-29
AU690093B2 (en) 1998-04-23
CA2151156A1 (en) 1994-07-07
US5908827A (en) 1999-06-01
NO952494L (no) 1995-08-21
FI953091A0 (fi) 1995-06-21
ITRM920919A0 (it) 1992-12-22
EP0675956B1 (en) 2003-04-09

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Legal Events

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19961217