ITRM930468A0 - Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico. - Google Patents

Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.

Info

Publication number
ITRM930468A0
ITRM930468A0 IT93RM468A ITRM930468A ITRM930468A0 IT RM930468 A0 ITRM930468 A0 IT RM930468A0 IT 93RM468 A IT93RM468 A IT 93RM468A IT RM930468 A ITRM930468 A IT RM930468A IT RM930468 A0 ITRM930468 A0 IT RM930468A0
Authority
IT
Italy
Prior art keywords
acil
contain
treatment
pharmaceutical compositions
endotoxic shock
Prior art date
Application number
IT93RM468A
Other languages
English (en)
Inventor
Piero Foresta
Maria Ornella Tinti
Nazareno Scafetta
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of ITRM930468A0 publication Critical patent/ITRM930468A0/it
Priority to ITRM930468A priority Critical patent/IT1261828B/it
Priority to DE69401684T priority patent/DE69401684T2/de
Priority to DK94830344.1T priority patent/DK0634392T3/da
Priority to AT94830344T priority patent/ATE148689T1/de
Priority to EP94830344A priority patent/EP0634392B1/en
Priority to ES94830344T priority patent/ES2098115T3/es
Priority to US08/274,686 priority patent/US5625085A/en
Priority to JP16199794A priority patent/JP3940179B2/ja
Publication of ITRM930468A1 publication Critical patent/ITRM930468A1/it
Application granted granted Critical
Publication of IT1261828B publication Critical patent/IT1261828B/it
Priority to US08/827,448 priority patent/US6180667B1/en
Priority to GR970400962T priority patent/GR3023306T3/el
Priority to HK98104943.3A priority patent/HK1005865B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ITRM930468A 1993-07-14 1993-07-14 Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico. IT1261828B (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
ITRM930468A IT1261828B (it) 1993-07-14 1993-07-14 Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
DE69401684T DE69401684T2 (de) 1993-07-14 1994-07-08 Acyl L-Carnitinester und diese enthaltende pharmazeutische Zusammensetzungen zur Behandlung von endotoxischem Schock
DK94830344.1T DK0634392T3 (da) 1993-07-14 1994-07-08 Estere af acyl L-carnitiner og farmaceutiske præparater med indhold af disse til behandling af endotoksisk shock
AT94830344T ATE148689T1 (de) 1993-07-14 1994-07-08 Acyl l-carnitinester und diese enthaltende pharmazeutische zusammensetzungen zur behandlung von endotoxischem schock
EP94830344A EP0634392B1 (en) 1993-07-14 1994-07-08 Esters of acyl L-carnitines and pharmaceutical compositions containing same for treating endotoxic shock
ES94830344T ES2098115T3 (es) 1993-07-14 1994-07-08 Esteres de acil l-carnitina y composiciones farmaceuticas que los contienen para tratamiento de shock endotoxico.
US08/274,686 US5625085A (en) 1993-07-14 1994-07-14 Esters of acyl L-carnitines and pharmaceutical compositons containing same for treating endotoxic shock
JP16199794A JP3940179B2 (ja) 1993-07-14 1994-07-14 アシル−ｌ−カルニチン類のエステルおよび内毒素ショック治療用医薬組成物
US08/827,448 US6180667B1 (en) 1993-07-14 1997-03-28 Esters of acyl L-carnitines and pharmaceutical compositions containing same for treating endotoxic shock
GR970400962T GR3023306T3 (en) 1993-07-14 1997-05-02 Esters of acyl L-carnitines and pharmaceutical compositions containing same for treating endotoxic shock.
HK98104943.3A HK1005865B (en) 1993-07-14 1998-06-05 Esters of acyl l-carnitines and pharmaceutical compositions containing same for treating endotoxic shock

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM930468A IT1261828B (it) 1993-07-14 1993-07-14 Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.

Publications (3)

Publication Number Publication Date
ITRM930468A0 true ITRM930468A0 (it) 1993-07-14
ITRM930468A1 ITRM930468A1 (it) 1995-01-14
IT1261828B IT1261828B (it) 1996-06-03

Family

ID=11401861

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM930468A IT1261828B (it) 1993-07-14 1993-07-14 Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.

Country Status (9)

Country Link
US (2) US5625085A (it)
EP (1) EP0634392B1 (it)
JP (1) JP3940179B2 (it)
AT (1) ATE148689T1 (it)
DE (1) DE69401684T2 (it)
DK (1) DK0634392T3 (it)
ES (1) ES2098115T3 (it)
GR (1) GR3023306T3 (it)
IT (1) IT1261828B (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1261828B (it) * 1993-07-14 1996-06-03 Sigma Tau Ind Farmaceuti Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
US5741816A (en) * 1994-06-20 1998-04-21 Tanabe Seiyaku Co., Ltd. Hair-growth agent
US20050232911A1 (en) * 2004-04-19 2005-10-20 Schreiber Brian D Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid
US7777071B2 (en) * 2006-08-11 2010-08-17 Ssv Therapeutics, Inc. Production of carnitine conjugate intermediates
US20110015154A1 (en) * 2009-07-20 2011-01-20 Kellermann Gottfried H Supporting acetylcholine function
US20110098265A1 (en) * 2009-10-28 2011-04-28 Neuroscience, Inc. Methods for reducing cravings and impulses associated with addictive and compulsive behaviors
CN115141112A (zh) * 2022-06-25 2022-10-04 东北制药集团股份有限公司 一种乙酰左旋肉碱杂质、其制备及检测方法和用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1116037B (it) 1979-04-23 1986-02-10 Sigma Tau Ind Farmaceuti Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
IT1201481B (it) * 1985-10-08 1989-02-02 Prodotti Antibiotici Spa Pantotenil derivati
IT1184655B (it) * 1985-10-14 1987-10-28 Sigma Tau Ind Farmaceuti Imiego di acetil l-carnitina nel trattamento terapeutico degli stati di shock
IT1231751B (it) * 1989-04-12 1991-12-21 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina
IT1240760B (it) 1990-02-12 1993-12-17 Sigma Tau Ind Farmaceuti Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma.
IT1242020B (it) * 1990-11-20 1994-02-02 Sigma Tau Ind Farmaceuti Ftalidilidene derivati della carnitina e di alcanoil carnitine e composizioni farmaceutiche che li contengono.
IT1248321B (it) * 1991-05-15 1995-01-05 Sigma Tau Ind Farmaceuti Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie
IT1254135B (it) 1992-01-16 1995-09-08 Sigma Tau Ind Farmaceuti Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antibatterica.
IT1254136B (it) * 1992-01-16 1995-09-08 Sigma Tau Ind Farmaceuti Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antimicotica.
IT1258370B (it) * 1992-03-02 1996-02-26 Sigma Tau Ind Farmaceuti Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono.
IT1256705B (it) 1992-12-21 1995-12-12 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
IT1261230B (it) 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione.
IT1261828B (it) * 1993-07-14 1996-06-03 Sigma Tau Ind Farmaceuti Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
IT1261489B (it) 1993-07-29 1996-05-23 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r amminocarnitina e s amminocarnitina.

Also Published As

Publication number Publication date
GR3023306T3 (en) 1997-08-29
ITRM930468A1 (it) 1995-01-14
JPH0776561A (ja) 1995-03-20
IT1261828B (it) 1996-06-03
US5625085A (en) 1997-04-29
ATE148689T1 (de) 1997-02-15
ES2098115T3 (es) 1997-04-16
DK0634392T3 (da) 1997-04-28
EP0634392A2 (en) 1995-01-18
DE69401684D1 (de) 1997-03-20
HK1005865A1 (en) 1999-01-29
EP0634392B1 (en) 1997-02-05
DE69401684T2 (de) 1997-05-28
EP0634392A3 (en) 1995-05-03
US6180667B1 (en) 2001-01-30
JP3940179B2 (ja) 2007-07-04

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960613