ITTO20020582A0 - Nuovo uso della rapamicina e di suoi analoghi strutturali - Google Patents

Nuovo uso della rapamicina e di suoi analoghi strutturali

Info

Publication number
ITTO20020582A0
ITTO20020582A0 IT2002TO000582A ITTO20020582A ITTO20020582A0 IT TO20020582 A0 ITTO20020582 A0 IT TO20020582A0 IT 2002TO000582 A IT2002TO000582 A IT 2002TO000582A IT TO20020582 A ITTO20020582 A IT TO20020582A IT TO20020582 A0 ITTO20020582 A0 IT TO20020582A0
Authority
IT
Italy
Prior art keywords
rapamicin
new use
structural analogues
analogues
structural
Prior art date
Application number
IT2002TO000582A
Other languages
English (en)
Inventor
Nicoletta Bianchi
Roberto Gambari
Carlo Mischiati
Monica Borgatti
Original Assignee
Univ Ferrara
Associazione Veneta Per La Lotta Alla Talassemia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ferrara, Associazione Veneta Per La Lotta Alla Talassemia filed Critical Univ Ferrara
Priority to IT2002TO000582A priority Critical patent/ITTO20020582A1/it
Publication of ITTO20020582A0 publication Critical patent/ITTO20020582A0/it
Priority to EP03740879A priority patent/EP1521578B1/en
Priority to US10/519,990 priority patent/US7541380B2/en
Priority to AU2003281257A priority patent/AU2003281257A1/en
Priority to AT03740879T priority patent/ATE433749T1/de
Priority to PCT/IB2003/002632 priority patent/WO2004004697A2/en
Priority to DE60328022T priority patent/DE60328022D1/de
Publication of ITTO20020582A1 publication Critical patent/ITTO20020582A1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IT2002TO000582A 2002-07-04 2002-07-04 Nuovo uso della rapamicina e di suoi analoghi strutturali ITTO20020582A1 (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT2002TO000582A ITTO20020582A1 (it) 2002-07-04 2002-07-04 Nuovo uso della rapamicina e di suoi analoghi strutturali
EP03740879A EP1521578B1 (en) 2002-07-04 2003-07-03 A novel use of rapamycin and structural analogues thereof
US10/519,990 US7541380B2 (en) 2002-07-04 2003-07-03 Use of rapamycin and structural analogues thereof
AU2003281257A AU2003281257A1 (en) 2002-07-04 2003-07-03 A novel use of rapamycin and structural analogues thereof
AT03740879T ATE433749T1 (de) 2002-07-04 2003-07-03 Neue verwendung von rapamycin und strukturellen analoga hiervon
PCT/IB2003/002632 WO2004004697A2 (en) 2002-07-04 2003-07-03 A novel use of rapamycin and structural analogues thereof
DE60328022T DE60328022D1 (de) 2002-07-04 2003-07-03 Neue verwendung von rapamycin und strukturellen analoga hiervon

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2002TO000582A ITTO20020582A1 (it) 2002-07-04 2002-07-04 Nuovo uso della rapamicina e di suoi analoghi strutturali

Publications (2)

Publication Number Publication Date
ITTO20020582A0 true ITTO20020582A0 (it) 2002-07-04
ITTO20020582A1 ITTO20020582A1 (it) 2004-01-05

Family

ID=11459463

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2002TO000582A ITTO20020582A1 (it) 2002-07-04 2002-07-04 Nuovo uso della rapamicina e di suoi analoghi strutturali

Country Status (7)

Country Link
US (1) US7541380B2 (it)
EP (1) EP1521578B1 (it)
AT (1) ATE433749T1 (it)
AU (1) AU2003281257A1 (it)
DE (1) DE60328022D1 (it)
IT (1) ITTO20020582A1 (it)
WO (1) WO2004004697A2 (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1658074B1 (en) * 2003-08-01 2012-11-07 Fibrogen, Inc. Inhibitors of 2-oxoglutarate dioxygenase as gamma globin inducers
US10391059B2 (en) 2009-11-11 2019-08-27 Rapamycin Holdings, Inc. Oral rapamycin nanoparticle preparations and use
US9283211B1 (en) 2009-11-11 2016-03-15 Rapamycin Holdings, Llc Oral rapamycin preparation and use for stomatitis
US9700544B2 (en) * 2013-12-31 2017-07-11 Neal K Vail Oral rapamycin nanoparticle preparations
FR3057774B1 (fr) * 2016-10-21 2025-11-07 Museum Nat Dhistoire Naturelle Derives de la purine pour leur utilisation dans le traitement ou la prevention de maladies dues a une mutation non-sens
US11298343B2 (en) 2017-10-27 2022-04-12 St. Jude Children's Research Hospital Method for treating thalassemia

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1320168B1 (it) * 2000-03-13 2003-11-18 Univ Ferrara Oligonucleotidi sintetici in grado di indurre il differenziamentoeritroide.

Also Published As

Publication number Publication date
US20060154950A1 (en) 2006-07-13
US7541380B2 (en) 2009-06-02
AU2003281257A8 (en) 2004-01-23
WO2004004697A8 (en) 2005-03-17
WO2004004697A3 (en) 2004-03-25
ATE433749T1 (de) 2009-07-15
EP1521578A2 (en) 2005-04-13
WO2004004697A2 (en) 2004-01-15
DE60328022D1 (de) 2009-07-30
EP1521578B1 (en) 2009-06-17
AU2003281257A1 (en) 2004-01-23
ITTO20020582A1 (it) 2004-01-05

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