ITTO20040264A1 - Nuovi derivati pirrolici ad attivita' angiotensina-ii antagonista - Google Patents

Nuovi derivati pirrolici ad attivita' angiotensina-ii antagonista

Info

Publication number: ITTO20040264A1
Authority: IT; Italy
Prior art keywords: antagonist activity; branched; hydrogen; linear; alkyl group
Prior art date: 2004-04-28

Application number

IT000264A

Other languages

English (en)

Inventor

Roberto Artusi

Antonio Giordani

Francesco Makovec

Lucio Claudio Rovati

Simona Zanzola

Original Assignee

Rotta Res Lab Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-04-28

Filing date

2004-04-28

Publication date

2004-07-28

2004-04-28 Application filed by Rotta Res Lab Spa filed Critical Rotta Res Lab Spa

2004-04-28 Priority to IT000264A priority Critical patent/ITTO20040264A1/it

2004-07-28 Publication of ITTO20040264A1 publication Critical patent/ITTO20040264A1/it

2005-04-27 Priority to ES05747406T priority patent/ES2370401T3/es

2005-04-27 Priority to EP05747406A priority patent/EP1753746B8/en

2005-04-27 Priority to PT05747406T priority patent/PT1753746E/pt

2005-04-27 Priority to PCT/EP2005/051911 priority patent/WO2005105789A2/en

2005-04-27 Priority to JP2007510037A priority patent/JP4898661B2/ja

2005-04-27 Priority to CA002564303A priority patent/CA2564303A1/en

2005-04-27 Priority to US11/568,362 priority patent/US7906501B2/en

2005-04-27 Priority to AT05747406T priority patent/ATE517889T1/de

Links

230000000694 effects Effects 0.000 title abstract 2
229940123413 Angiotensin II antagonist Drugs 0.000 title 1
239000002333 angiotensin II receptor antagonist Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
101150059573 AGTR1 gene Proteins 0.000 abstract 1
206010003178 Arterial thrombosis Diseases 0.000 abstract 1
208000032131 Diabetic Neuropathies Diseases 0.000 abstract 1
206010012667 Diabetic glaucoma Diseases 0.000 abstract 1
206010012689 Diabetic retinopathy Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
208000013544 Platelet disease Diseases 0.000 abstract 1
206010063897 Renal ischaemia Diseases 0.000 abstract 1
206010047249 Venous thrombosis Diseases 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
208000037849 arterial hypertension Diseases 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
206010008118 cerebral infarction Diseases 0.000 abstract 1
208000026106 cerebrovascular disease Diseases 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
230000002107 myocardial effect Effects 0.000 abstract 1
208000010125 myocardial infarction Diseases 0.000 abstract 1
230000002018 overexpression Effects 0.000 abstract 1
230000001575 pathological effect Effects 0.000 abstract 1
230000002093 peripheral effect Effects 0.000 abstract 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
208000002815 pulmonary hypertension Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
239000011734 sodium Substances 0.000 abstract 1
208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Peptides Or Proteins (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

IT000264A 2004-04-28 2004-04-28 Nuovi derivati pirrolici ad attivita' angiotensina-ii antagonista ITTO20040264A1 (it)

Priority Applications (9)

Application Number	Priority Date	Filing Date	Title
IT000264A ITTO20040264A1 (it)	2004-04-28	2004-04-28	Nuovi derivati pirrolici ad attivita' angiotensina-ii antagonista
ES05747406T ES2370401T3 (es)	2004-04-28	2005-04-27	Derivados novedosos de pirrol con actividad antagonista de angiotensina ii.
EP05747406A EP1753746B8 (en)	2004-04-28	2005-04-27	Novel pyrrole derivatives with angiotensin ii antagonist activity
PT05747406T PT1753746E (pt)	2004-04-28	2005-04-27	Novos derivados de pirrole com actividade de antagonista de angiotensina ii
PCT/EP2005/051911 WO2005105789A2 (en)	2004-04-28	2005-04-27	Novel pyrrole derivatives with angiotensin ii antagonist activity
JP2007510037A JP4898661B2 (ja)	2004-04-28	2005-04-27	アンギオテンシンｉｉアンタゴニスト活性を有する新規ピロール誘導体
CA002564303A CA2564303A1 (en)	2004-04-28	2005-04-27	Novel pyrrole derivatives with angiotensin ii antagonist activity
US11/568,362 US7906501B2 (en)	2004-04-28	2005-04-27	Pyrrole derivatives with angiotensin II antagonist activity
AT05747406T ATE517889T1 (de)	2004-04-28	2005-04-27	Neue pyrrolderivate mit angiotensin-ii- antagonistischer wirkung

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT000264A ITTO20040264A1 (it)	2004-04-28	2004-04-28	Nuovi derivati pirrolici ad attivita' angiotensina-ii antagonista

Publications (1)

Publication Number	Publication Date
ITTO20040264A1 true ITTO20040264A1 (it)	2004-07-28

Family

ID=34968865

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT000264A ITTO20040264A1 (it)	2004-04-28	2004-04-28	Nuovi derivati pirrolici ad attivita' angiotensina-ii antagonista

Country Status (9)

Country	Link
US (1)	US7906501B2 (it)
EP (1)	EP1753746B8 (it)
JP (1)	JP4898661B2 (it)
AT (1)	ATE517889T1 (it)
CA (1)	CA2564303A1 (it)
ES (1)	ES2370401T3 (it)
IT (1)	ITTO20040264A1 (it)
PT (1)	PT1753746E (it)
WO (1)	WO2005105789A2 (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2012221800B2 (en)	2011-02-23	2016-10-27	Lupin Limited	Heteroaryl derivatives as alpha7 nAChR modulators
WO2013132380A1 (en)	2012-03-06	2013-09-12	Lupin Limited	Thiazole derivatives as alpha 7 nachr modulators

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1334092C (en) *	1986-07-11	1995-01-24	David John Carini	Angiotensin ii receptor blocking imidazoles
US5015651A (en)	1988-01-07	1991-05-14	E. I. Du Pont De Nemours And Company	Treatment of hypertension with 1,2,4-angiotensin II antagonists
DE4036706A1 (de) *	1990-11-17	1992-05-21	Hoechst Ag	Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie

2004
- 2004-04-28 IT IT000264A patent/ITTO20040264A1/it unknown
2005
- 2005-04-27 EP EP05747406A patent/EP1753746B8/en not_active Expired - Lifetime
- 2005-04-27 ES ES05747406T patent/ES2370401T3/es not_active Expired - Lifetime
- 2005-04-27 CA CA002564303A patent/CA2564303A1/en not_active Abandoned
- 2005-04-27 JP JP2007510037A patent/JP4898661B2/ja not_active Expired - Fee Related
- 2005-04-27 WO PCT/EP2005/051911 patent/WO2005105789A2/en not_active Ceased
- 2005-04-27 AT AT05747406T patent/ATE517889T1/de active
- 2005-04-27 US US11/568,362 patent/US7906501B2/en not_active Expired - Fee Related
- 2005-04-27 PT PT05747406T patent/PT1753746E/pt unknown

Also Published As

Publication number	Publication date
ES2370401T8 (es)	2012-04-09
EP1753746B1 (en)	2011-07-27
US7906501B2 (en)	2011-03-15
EP1753746B8 (en)	2012-02-15
PT1753746E (pt)	2011-08-25
JP2007534724A (ja)	2007-11-29
CA2564303A1 (en)	2005-11-10
JP4898661B2 (ja)	2012-03-21
US20070244170A1 (en)	2007-10-18
EP1753746A2 (en)	2007-02-21
ATE517889T1 (de)	2011-08-15
ES2370401T3 (es)	2011-12-15
WO2005105789A3 (en)	2006-02-02
WO2005105789A2 (en)	2005-11-10

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