ITTO20110067A1 - Immunoglobuline intere di isotipo igg atte a riconoscere un epitopo di neutralizzazione eterosubtipica sulla regione stelo (stem region) dell'emoagglutinina e loro uso come medicamento antinfluenzale - Google Patents

Immunoglobuline intere di isotipo igg atte a riconoscere un epitopo di neutralizzazione eterosubtipica sulla regione stelo (stem region) dell'emoagglutinina e loro uso come medicamento antinfluenzale

Info

Publication number
ITTO20110067A1
ITTO20110067A1 IT000067A ITTO20110067A ITTO20110067A1 IT TO20110067 A1 ITTO20110067 A1 IT TO20110067A1 IT 000067 A IT000067 A IT 000067A IT TO20110067 A ITTO20110067 A IT TO20110067A IT TO20110067 A1 ITTO20110067 A1 IT TO20110067A1
Authority
IT
Italy
Prior art keywords
stem
isotipo
eterosubtipic
emoagglutinine
antinfluenual
Prior art date
Application number
IT000067A
Other languages
English (en)
Inventor
Roberto Burioni
Massimo Clementi
Original Assignee
Pomona Ricerca Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pomona Ricerca Srl filed Critical Pomona Ricerca Srl
Priority to IT000067A priority Critical patent/ITTO20110067A1/it
Priority to EP11721645.7A priority patent/EP2552485B1/en
Priority to SI201131130A priority patent/SI2552485T1/sl
Priority to CN201180015849.0A priority patent/CN102958539B/zh
Priority to PCT/IB2011/051284 priority patent/WO2011117848A1/en
Priority to HRP20170490TT priority patent/HRP20170490T1/hr
Priority to US13/637,030 priority patent/US20130022608A1/en
Priority to EA201290955A priority patent/EA029198B1/ru
Publication of ITTO20110067A1 publication Critical patent/ITTO20110067A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
IT000067A 2010-03-26 2011-01-26 Immunoglobuline intere di isotipo igg atte a riconoscere un epitopo di neutralizzazione eterosubtipica sulla regione stelo (stem region) dell'emoagglutinina e loro uso come medicamento antinfluenzale ITTO20110067A1 (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT000067A ITTO20110067A1 (it) 2011-01-26 2011-01-26 Immunoglobuline intere di isotipo igg atte a riconoscere un epitopo di neutralizzazione eterosubtipica sulla regione stelo (stem region) dell'emoagglutinina e loro uso come medicamento antinfluenzale
EP11721645.7A EP2552485B1 (en) 2010-03-26 2011-03-25 Full-length immunoglobulins of the igg isotype capable of recognizing a heterosubtype neutralizing epitope on the hemagglutinin stem region and their use as anti-influenza medicament
SI201131130A SI2552485T1 (sl) 2010-03-26 2011-03-25 Imunoglobulini polne dolžine igg izotipa, sposobni prepoznave heteropodtipskega nevtralizacijskega epitopa na hemagglutininskem izvornem področju in njih uporaba kot zdravilo proti gripi
CN201180015849.0A CN102958539B (zh) 2010-03-26 2011-03-25 能够识别血凝素干区上的杂亚型中和表位的IgG同种型全长免疫球蛋白和其作为抗-流感药物的应用
PCT/IB2011/051284 WO2011117848A1 (en) 2010-03-26 2011-03-25 Full-length immunoglobulins of the igg isotvpe capable of recognizing a heterosubtvpe neutralizing epitope on the hemagglutinin stem region and their use as anti-influenza medicament
HRP20170490TT HRP20170490T1 (hr) 2010-03-26 2011-03-25 Imunoglobulini pune dužine igg izotipa sposobni za prepoznavanje heterosubtipnog epitopa neutralizacije na području stabljike hemaglutinina i njihova uporaba kao lijek protiv gripe
US13/637,030 US20130022608A1 (en) 2010-03-26 2011-03-25 FULL-LENGTH IgG IMMUNOGLOBULINS CAPABLE OF RECOGNIZING A HETEROSUBTYPE NEUTRALIZING EPITOPE ON THE HEMAGGLUTININ STEM REGION AND USES THEREOF
EA201290955A EA029198B1 (ru) 2010-03-26 2011-03-25 Полноразмерные иммуноглобулины изотипа igg, способные к распознаванию нейтрализующего эпитопа в области стебля гемагглютинина различных подтипов и их использование в качестве лекарственного средства против гриппа

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000067A ITTO20110067A1 (it) 2011-01-26 2011-01-26 Immunoglobuline intere di isotipo igg atte a riconoscere un epitopo di neutralizzazione eterosubtipica sulla regione stelo (stem region) dell'emoagglutinina e loro uso come medicamento antinfluenzale

Publications (1)

Publication Number Publication Date
ITTO20110067A1 true ITTO20110067A1 (it) 2012-07-27

Family

ID=43975646

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000067A ITTO20110067A1 (it) 2010-03-26 2011-01-26 Immunoglobuline intere di isotipo igg atte a riconoscere un epitopo di neutralizzazione eterosubtipica sulla regione stelo (stem region) dell'emoagglutinina e loro uso come medicamento antinfluenzale

Country Status (1)

Country Link
IT (1) ITTO20110067A1 (it)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009115972A1 (en) * 2008-03-17 2009-09-24 Pomona Biotechnologies Llc Monoclonal antibodies capable of reacting with a plurality of influenza virus a subtypes
WO2009144667A1 (en) * 2008-05-27 2009-12-03 Pomona Biotechnologies Llc Monoclonal antibodies having homosubtype cross -neutralization properties against influenza a viruses subtype h1
WO2010140114A1 (en) * 2009-06-01 2010-12-09 Pomona Biotechnologies Llc Monoclonal antibodies as a medicament for the therapeutic and/or prophylactic treatment of swine -origin influenza a (h1n1) virus (s-oiv) infections

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009115972A1 (en) * 2008-03-17 2009-09-24 Pomona Biotechnologies Llc Monoclonal antibodies capable of reacting with a plurality of influenza virus a subtypes
WO2009144667A1 (en) * 2008-05-27 2009-12-03 Pomona Biotechnologies Llc Monoclonal antibodies having homosubtype cross -neutralization properties against influenza a viruses subtype h1
WO2010140114A1 (en) * 2009-06-01 2010-12-09 Pomona Biotechnologies Llc Monoclonal antibodies as a medicament for the therapeutic and/or prophylactic treatment of swine -origin influenza a (h1n1) virus (s-oiv) infections

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BECK ALAIN ET AL: "Therapeutic antibodies and related products: choosing the right structure for success", M-S (MEDECINE SCIENCES), vol. 25, no. 12, December 2009 (2009-12-01), pages 1024 - 1032, XP008138357, ISSN: 0767-0974 *
BURIONI R ET AL: "Monoclonal antibodies isolated from human B cells neutralize a broad range of H1 subtype influenza A viruses including swine-origin Influenza virus (S-OIV)", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 399, no. 1, 30 March 2010 (2010-03-30), pages 144 - 152, XP026923963, ISSN: 0042-6822, [retrieved on 20100224], DOI: DOI:10.1016/J.VIROL.2009.12.014 *
BURIONI ROBERTO ET AL: "Molecular cloning of the first human monoclonal antibodies neutralizing with high potency Swine-origin Influenza A pandemic virus (S-OIV)", NEW MICROBIOLOGICA, vol. 32, no. 4, October 2009 (2009-10-01), pages 319 - 324, XP002644800, ISSN: 1121-7138 *
HENDERIKX PAULA ET AL: "A human immunoglobulin G1 antibody originating from an in vitro-selected Fab phage antibody binds avidly to tumor-associated MUC1 and is efficiently internalized", AMERICAN JOURNAL OF PATHOLOGY, vol. 160, no. 5, May 2002 (2002-05-01), pages 1597 - 1608, XP002644798, ISSN: 0002-9440 *
JOSTOCK T ET AL: "Rapid generation of functional human IgG antibodies derived from Fab-on-phage display libraries", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 289, no. 1-2, 1 June 2004 (2004-06-01), pages 65 - 80, XP004520880, ISSN: 0022-1759, DOI: DOI:10.1016/J.JIM.2004.03.014 *

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