ITTO20120669A1 - Poliuretani anfifilici termosensibili e soluzione acquosa iniettabile a base di tale materiale. - Google Patents

Poliuretani anfifilici termosensibili e soluzione acquosa iniettabile a base di tale materiale. Download PDF

Info

Publication number: ITTO20120669A1
Authority: IT; Italy
Prior art keywords: composition according; solution; reaction mixture; polyurethane; weight
Prior art date: 2012-07-27

Application number

IT000669A

Other languages

English (en)

Italian (it)

Inventor

Monica Boffito

Gianluca Ciardelli

Susanna Sartori

Piero Serafini

Original Assignee

Torino Politecnico

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-07-27

Filing date

2012-07-27

Publication date

2012-10-26

2012-07-27 Application filed by Torino Politecnico filed Critical Torino Politecnico

2012-07-27 Priority to IT000669A priority Critical patent/ITTO20120669A1/it

2012-10-26 Publication of ITTO20120669A1 publication Critical patent/ITTO20120669A1/it

2013-07-11 Priority to BR112015001635A priority patent/BR112015001635A2/pt

2013-07-11 Priority to PCT/IT2013/000196 priority patent/WO2014016857A1/en

2013-07-11 Priority to EP13756713.7A priority patent/EP2877514A1/en

2013-07-11 Priority to CA2877096A priority patent/CA2877096A1/en

2013-07-11 Priority to JP2015523661A priority patent/JP2015524864A/ja

2013-07-11 Priority to KR20157001768A priority patent/KR20150037873A/ko

2013-07-11 Priority to US14/417,736 priority patent/US20150250889A1/en

2013-07-11 Priority to MX2015001035A priority patent/MX2015001035A/es

2013-07-11 Priority to CN201380038838.3A priority patent/CN104507994A/zh

2013-07-11 Priority to IN16KON2015 priority patent/IN2015KN00016A/en

2013-07-11 Priority to RU2015106123A priority patent/RU2015106123A/ru

2015-01-26 Priority to CL2015000195A priority patent/CL2015000195A1/es

Links

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XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
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WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 4
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Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/48—Polyethers
- C08G18/4833—Polyethers containing oxyethylene units
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
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- C08G18/08—Processes
- C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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- C08G18/32—Polyhydroxy compounds; Polyamines; Hydroxyamines
- C08G18/3203—Polyhydroxy compounds
- C08G18/3212—Polyhydroxy compounds containing cycloaliphatic groups
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
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- C08G18/72—Polyisocyanates or polyisothiocyanates
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
- C08G18/72—Polyisocyanates or polyisothiocyanates
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- C08G18/7657—Polyisocyanates or polyisothiocyanates cyclic aromatic containing two or more aromatic rings
- C08G18/7664—Polyisocyanates or polyisothiocyanates cyclic aromatic containing two or more aromatic rings containing alkylene polyphenyl groups
- C08G18/7671—Polyisocyanates or polyisothiocyanates cyclic aromatic containing two or more aromatic rings containing alkylene polyphenyl groups containing only one alkylene bisphenyl group
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- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
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Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Transplantation (AREA)
Oral & Maxillofacial Surgery (AREA)
Pharmacology & Pharmacy (AREA)
Dispersion Chemistry (AREA)
Inorganic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Engineering & Computer Science (AREA)
Materials For Medical Uses (AREA)
Medicinal Preparation (AREA)
Polyurethanes Or Polyureas (AREA)
Compositions Of Macromolecular Compounds (AREA)
Thermotherapy And Cooling Therapy Devices (AREA)
Cosmetics (AREA)

IT000669A 2012-07-27 2012-07-27 Poliuretani anfifilici termosensibili e soluzione acquosa iniettabile a base di tale materiale. ITTO20120669A1 (it)

Priority Applications (13)

Application Number	Priority Date	Filing Date	Title
IT000669A ITTO20120669A1 (it)	2012-07-27	2012-07-27	Poliuretani anfifilici termosensibili e soluzione acquosa iniettabile a base di tale materiale.
RU2015106123A RU2015106123A (ru)	2012-07-27	2013-07-11	Термочувствительный амфифильный полиуретан и водный раствор, вводимый путем инъекции, на основе такого вещества
CA2877096A CA2877096A1 (en)	2012-07-27	2013-07-11	Heat-sensitive amphiphilic polyurethane and aqueous solution capable of being injected based on such material
PCT/IT2013/000196 WO2014016857A1 (en)	2012-07-27	2013-07-11	Heat-sensitive amphiphilic polyurethane and aqueous solution capable of being injected based on such material
EP13756713.7A EP2877514A1 (en)	2012-07-27	2013-07-11	Heat-sensitive amphiphilic polyurethane and aqueous solution capable of being injected based on such material
BR112015001635A BR112015001635A2 (pt)	2012-07-27	2013-07-11	poliuretano anfifílico sensível a calor e solução aquosa capaz de ser injetada, com base em tal material
JP2015523661A JP2015524864A (ja)	2012-07-27	2013-07-11	感熱性両親媒性ポリウレタンおよびこのような材料に基づいた注入されることの可能な水溶液
KR20157001768A KR20150037873A (ko)	2012-07-27	2013-07-11	열-민감성 친양쪽성 폴리우레탄 및 그러한 물질을 기재로 하는 주사가능한 수용액
US14/417,736 US20150250889A1 (en)	2012-07-27	2013-07-11	Heat-sensitive amphiphilic polyurethane and aqueous solution capable of being injected based on such material
MX2015001035A MX2015001035A (es)	2012-07-27	2013-07-11	Poliuretano anfifilico sensible al calor y solucion acuosa capaz de ser inyectada basada en este material.
CN201380038838.3A CN104507994A (zh)	2012-07-27	2013-07-11	热敏性的两亲性聚氨酯和基于此类材料的能够注射的水溶液
IN16KON2015 IN2015KN00016A (2)	2012-07-27	2013-07-11
CL2015000195A CL2015000195A1 (es)	2012-07-27	2015-01-26	Composicion sol-gel sensible al calor capaz de ser inyectada, constituida de una solucion acuosa de por lo menos un poliuretano anfifílico, adaptado para ser sintetizado a traves de una mezcla que comprende al menos uno o dos macrodioles con al menos un bloque peg, y un diisociabato.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT000669A ITTO20120669A1 (it)	2012-07-27	2012-07-27	Poliuretani anfifilici termosensibili e soluzione acquosa iniettabile a base di tale materiale.

Publications (1)

Publication Number	Publication Date
ITTO20120669A1 true ITTO20120669A1 (it)	2012-10-26

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ID=46982769

Family Applications (1)

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IT000669A ITTO20120669A1 (it)	2012-07-27	2012-07-27	Poliuretani anfifilici termosensibili e soluzione acquosa iniettabile a base di tale materiale.

Country Status (13)

Country	Link
US (1)	US20150250889A1 (2)
EP (1)	EP2877514A1 (2)
JP (1)	JP2015524864A (2)
KR (1)	KR20150037873A (2)
CN (1)	CN104507994A (2)
BR (1)	BR112015001635A2 (2)
CA (1)	CA2877096A1 (2)
CL (1)	CL2015000195A1 (2)
IN (1)	IN2015KN00016A (2)
IT (1)	ITTO20120669A1 (2)
MX (1)	MX2015001035A (2)
RU (1)	RU2015106123A (2)
WO (1)	WO2014016857A1 (2)

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CN110724245A (zh) *	2018-07-17	2020-01-24	四川大学	可注射的聚氨酯及其制备方法
WO2020209740A1 (en)	2019-04-12	2020-10-15	Institutul De Chimie Macromoleculară Petru Poni	Non-isocyanate polyurethane thermoreversible hydrogel and method for its preparation

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2012
- 2012-07-27 IT IT000669A patent/ITTO20120669A1/it unknown
2013
- 2013-07-11 EP EP13756713.7A patent/EP2877514A1/en not_active Withdrawn
- 2013-07-11 IN IN16KON2015 patent/IN2015KN00016A/en unknown
- 2013-07-11 BR BR112015001635A patent/BR112015001635A2/pt not_active IP Right Cessation
- 2013-07-11 RU RU2015106123A patent/RU2015106123A/ru not_active Application Discontinuation
- 2013-07-11 KR KR20157001768A patent/KR20150037873A/ko not_active Withdrawn
- 2013-07-11 CA CA2877096A patent/CA2877096A1/en not_active Abandoned
- 2013-07-11 US US14/417,736 patent/US20150250889A1/en not_active Abandoned
- 2013-07-11 MX MX2015001035A patent/MX2015001035A/es unknown
- 2013-07-11 JP JP2015523661A patent/JP2015524864A/ja not_active Abandoned
- 2013-07-11 CN CN201380038838.3A patent/CN104507994A/zh active Pending
- 2013-07-11 WO PCT/IT2013/000196 patent/WO2014016857A1/en not_active Ceased
2015
- 2015-01-26 CL CL2015000195A patent/CL2015000195A1/es unknown

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Also Published As

Publication number	Publication date
IN2015KN00016A (2)	2015-07-31
WO2014016857A1 (en)	2014-01-30
MX2015001035A (es)	2015-06-23
EP2877514A1 (en)	2015-06-03
CA2877096A1 (en)	2014-01-30
RU2015106123A (ru)	2016-09-20
US20150250889A1 (en)	2015-09-10
CL2015000195A1 (es)	2015-05-08
KR20150037873A (ko)	2015-04-08
BR112015001635A2 (pt)	2017-07-04
JP2015524864A (ja)	2015-08-27
CN104507994A (zh)	2015-04-08

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Chung et al.	2009	Self-assembled and nanostructured hydrogels for drug delivery and tissue engineering
CN102181060B (zh)	2012-09-12	聚乙烯醇-聚肽-聚乙二醇接枝共聚物及其制备方法
Sosnik et al.	2004	Ethoxysilane-capped PEO–PPO–PEO triblocks: a new family of reverse thermo-responsive polymers
Xu et al.	2020	Redox and pH dual-responsive injectable hyaluronan hydrogels with shape-recovery and self-healing properties for protein and cell delivery
Han et al.	2004	Preparation and biodegradation of thermosensitive chitosan hydrogel as a function of pH and temperature
Huynh et al.	2011	Biodegradable pH/temperature-sensitive oligo (β-amino ester urethane) hydrogels for controlled release of doxorubicin
US20140329267A1 (en)	2014-11-06	Self-healing material and method for the preparation thereof
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CN103524697A (zh)	2014-01-22	一种聚氨酯脲水凝胶及其制备方法
Huynh et al.	2012	Synthesis and characterization of poly (amino urea urethane)-based block copolymer and its potential application as injectable pH/temperature-sensitive hydrogel for protein carrier
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Diaconu et al.	2017	Hyaluronic acid gels with tunable properties by conjugating with a synthetic copolymer
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Phan et al.	2017	Engineering highly swellable dual-responsive protein-based injectable hydrogels: the effects of molecular structure and composition in vivo
CN105396137A (zh)	2016-03-16	一种可注射温敏性物理水凝胶及其制备方法
Wu et al.	2015	Injectable chitosan/dextran-polylactide/glycerophosphate hydrogels and their biodegradation
Rahmani et al.	2021	One-pot synthesis of dibenzaldehyde-terminated poly (ethylene glycol) for preparation of dynamic chitosan-based amphiphilic hydrogels
Yoshida et al.	2017	Biodegradable injectable polymer systems exhibiting a longer and controllable duration time of the gel state
CN101570582A (zh)	2009-11-04	一种具有水溶性和生物降解性的电活性聚合物及其制备方法和应用
Tong et al.	2019	In situ forming and reversibly cross-linkable hydrogels based on copolypept (o) ides and polysaccharides
Jun et al.	2008	In situ gel forming stereocomplex composed of four-arm PEG-PDLA and PEG-PLLA block copolymers
ES2370093T3 (es)	2011-12-12	Procedimiento de preparación de derivados (poli(óxido de etileno) poli(óxido de propileno)) termosensibles, útiles para funcionalizar el quitosano.
Chen et al.	2021	In situ forming hydrogels based on oxidized hydroxypropyl cellulose and Jeffamines
KR20150037873A (ko)	2015-04-08	열-민감성 친양쪽성 폴리우레탄 및 그러한 물질을 기재로 하는 주사가능한 수용액