ITTO970444A0 - - Google Patents

Info

Publication number
ITTO970444A0
ITTO970444A0 ITTO970444A ITTO970444A ITTO970444A0 IT TO970444 A0 ITTO970444 A0 IT TO970444A0 IT TO970444 A ITTO970444 A IT TO970444A IT TO970444 A ITTO970444 A IT TO970444A IT TO970444 A0 ITTO970444 A0 IT TO970444A0
Authority
IT
Italy
Application number
ITTO970444A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ITTO970444A0 publication Critical patent/ITTO970444A0/it
Publication of ITTO970444A1 publication Critical patent/ITTO970444A1/it
Application granted granted Critical
Publication of IT1291709B1 publication Critical patent/IT1291709B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT97TO000444A 1996-05-28 1997-05-26 Analoghi di buprenorfina aventi proprieta' analgesiche. IT1291709B1 (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019960018134A KR100204659B1 (ko) 1996-05-28 1996-05-28 신규한 부프레노핀계 진통제용 화합물

Publications (3)

Publication Number Publication Date
ITTO970444A0 true ITTO970444A0 (it) 1997-05-26
ITTO970444A1 ITTO970444A1 (it) 1998-11-26
IT1291709B1 IT1291709B1 (it) 1999-01-21

Family

ID=19459878

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97TO000444A IT1291709B1 (it) 1996-05-28 1997-05-26 Analoghi di buprenorfina aventi proprieta' analgesiche.

Country Status (8)

Country Link
US (1) US5849915A (it)
JP (1) JP2938405B2 (it)
KR (1) KR100204659B1 (it)
CN (1) CN1168377A (it)
DE (1) DE19722470C2 (it)
FR (1) FR2749305B1 (it)
GB (1) GB2313596B (it)
IT (1) IT1291709B1 (it)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2138502C1 (ru) * 1999-03-29 1999-09-27 Закрытое акционерное общество "РМА-Фарм" Способ получения 17-циклопропилметил-6,14-эндо-этано-7-(2-гидрокси-3,3-диметилбут-2-ил)тетр агидро-17-норорипавина
CN1233645C (zh) * 2001-09-14 2005-12-28 中国人民解放军军事医学科学院毒物药物研究所 新的东罂粟碱衍生物及其医药用途
US7119100B2 (en) * 2001-09-14 2006-10-10 Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences, P.L.A. China Oripavine derivatives and their uses as pharmaceuticals
US7220842B2 (en) * 2004-04-05 2007-05-22 Dade Behring Inc. Immunoassays for buprenorphine and norbuprenorphine
KR20060021542A (ko) * 2004-09-03 2006-03-08 한미약품 주식회사 부프레노르핀 유도체 및 이의 약학적으로 허용가능한 염
EP1981891B1 (en) 2006-01-05 2009-09-02 Mallinckrodt, Inc. The use of oripavine as a starting material for buprenorphine
GB0606124D0 (en) * 2006-03-28 2006-05-03 Reckitt Benckiser Healthcare Buprenorphine derivatives and uses thereof
CN101492451B (zh) * 2008-01-24 2011-12-21 复旦大学 8α取代芳基-4,5-环氧吗啡喃衍生物或其盐、制备方法和用途
KR20110014974A (ko) * 2008-03-31 2011-02-14 썬 파마슈티컬 인더스트리스 리미티드 모르피난 유사체의 개선된 제조 방법
CA2738089C (en) * 2008-09-30 2017-07-18 Mallinckrodt Inc. Processes for the hydrogenation of opiate alkaloid derivatives
EP2342208B1 (en) * 2008-09-30 2014-06-04 Mallinckrodt LLC Recycling process for increasing the yield of a grignard reaction in the preparation of opiate alkaloid derivatives
NZ607842A (en) * 2008-09-30 2013-12-20 Mallinckrodt Llc Processes for the selective amination of ketomorphinans
US8232397B2 (en) * 2008-09-30 2012-07-31 Mallinckrodt Llc Processes for the production of buprenorphine with reduced impurity formation
TWI541246B (zh) * 2008-12-08 2016-07-11 歐陸斯迪公司 二氫羥戊甲嗎啡
WO2010121369A1 (en) 2009-04-24 2010-10-28 Brock University Processes for the preparation of morphinane and morphinone compounds
FR2975912B1 (fr) 2011-05-30 2013-06-14 Flamel Tech Sa Composition a liberation controlee de buprenorphine
ES2692885T3 (es) 2011-10-03 2018-12-05 Johnson Matthey Plc Proceso para preparar buprenorfina
AU2013369037C1 (en) 2012-12-31 2017-06-08 Rhodes Technologies Process for preparing 7beta-substituted 6alpha,14alpha -ethenomorphinans and 7beta-substituted 6alpha,14alpha-ethanomorphinans
US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
GB201309654D0 (en) 2013-05-30 2013-07-17 Euro Celtique Sa Method

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1136214A (en) * 1965-06-15 1968-12-11 Reckitt & Sons Ltd Thebaine and oripavine derivatives
US3474101A (en) * 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
GB1116595A (en) * 1964-07-08 1968-06-06 Reckitt & Sons Ltd Codeine and morphine derivatives
PT95069B (pt) * 1989-08-24 1997-10-31 Searle & Co Processo para a preparacao de (+)-isomeros de derivados de endoetano/endoetanoepoximofinano, uteis como agentes anti-tussicos
US5552406A (en) * 1994-06-17 1996-09-03 The Mclean Hospital Corporation Method for treating pain and brain perfusion abnormalities using mixed opioid agonist-antagonists

Also Published As

Publication number Publication date
GB9710996D0 (en) 1997-07-23
FR2749305B1 (fr) 1999-10-22
KR970073584A (ko) 1997-12-10
DE19722470C2 (de) 1999-05-06
JPH1059849A (ja) 1998-03-03
DE19722470A1 (de) 1997-12-18
US5849915A (en) 1998-12-15
GB2313596A (en) 1997-12-03
ITTO970444A1 (it) 1998-11-26
CN1168377A (zh) 1997-12-24
KR100204659B1 (ko) 1999-06-15
GB2313596B (en) 1998-08-05
IT1291709B1 (it) 1999-01-21
JP2938405B2 (ja) 1999-08-23
FR2749305A1 (fr) 1997-12-05

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Legal Events

Date Code Title Description
0001 Granted