ITUA20164043A1 - Processo per la preparazione di 3β-idrossi-17-(1H-benzimidazol-1-il)androsta-5,16-diene - Google Patents

Processo per la preparazione di 3β-idrossi-17-(1H-benzimidazol-1-il)androsta-5,16-diene

Info

Publication number
ITUA20164043A1
ITUA20164043A1 ITUA2016A004043A ITUA20164043A ITUA20164043A1 IT UA20164043 A1 ITUA20164043 A1 IT UA20164043A1 IT UA2016A004043 A ITUA2016A004043 A IT UA2016A004043A IT UA20164043 A ITUA20164043 A IT UA20164043A IT UA20164043 A1 ITUA20164043 A1 IT UA20164043A1
Authority
IT
Italy
Prior art keywords
androsta
benzimidazol
diene
hydroxy
preparation
Prior art date
Application number
ITUA2016A004043A
Other languages
English (en)
Inventor
Francesco Barbieri
Roberto Lenna
Original Assignee
Ind Chimica Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind Chimica Srl filed Critical Ind Chimica Srl
Priority to ITUA2016A004043A priority Critical patent/ITUA20164043A1/it
Priority to ES201890072A priority patent/ES2697706R1/es
Priority to CH01484/18A priority patent/CH714035B1/it
Priority to PCT/IB2017/053147 priority patent/WO2017208132A1/en
Publication of ITUA20164043A1 publication Critical patent/ITUA20164043A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
ITUA2016A004043A 2016-06-01 2016-06-01 Processo per la preparazione di 3β-idrossi-17-(1H-benzimidazol-1-il)androsta-5,16-diene ITUA20164043A1 (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ITUA2016A004043A ITUA20164043A1 (it) 2016-06-01 2016-06-01 Processo per la preparazione di 3β-idrossi-17-(1H-benzimidazol-1-il)androsta-5,16-diene
ES201890072A ES2697706R1 (es) 2016-06-01 2017-05-29 Proceso Para La Preparación De Galeterona.
CH01484/18A CH714035B1 (it) 2016-06-01 2017-05-29 Processo per la preparazione di 3Beta-idrossi-17-(1H-benzimidazol-1-il)androsta-5,16-diene.
PCT/IB2017/053147 WO2017208132A1 (en) 2016-06-01 2017-05-29 Process for the preparation of galeterone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITUA2016A004043A ITUA20164043A1 (it) 2016-06-01 2016-06-01 Processo per la preparazione di 3β-idrossi-17-(1H-benzimidazol-1-il)androsta-5,16-diene

Publications (1)

Publication Number Publication Date
ITUA20164043A1 true ITUA20164043A1 (it) 2017-12-01

Family

ID=57184596

Family Applications (1)

Application Number Title Priority Date Filing Date
ITUA2016A004043A ITUA20164043A1 (it) 2016-06-01 2016-06-01 Processo per la preparazione di 3β-idrossi-17-(1H-benzimidazol-1-il)androsta-5,16-diene

Country Status (1)

Country Link
IT (1) ITUA20164043A1 (it)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010091306A1 (en) * 2009-02-05 2010-08-12 Tokai Pharmaceuticals Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
US20110034428A1 (en) * 2009-08-07 2011-02-10 Tokai Pharmaceuticals, Inc. Treatment of Prostate Cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010091306A1 (en) * 2009-02-05 2010-08-12 Tokai Pharmaceuticals Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
US20110034428A1 (en) * 2009-08-07 2011-02-10 Tokai Pharmaceuticals, Inc. Treatment of Prostate Cancer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANDERSON ET AL: "TOOLS FOR PURIFYING THE PRODUCT: COLUMN CHROMATOGRAPHY, CRYSTALLIZATION AND RESLURRYING", PRACTICAL PROCESS RESEARCH AND DEVELOPMENT, ACADEMIC PRESS, SAN DIEGO, US, 1 January 2000 (2000-01-01), pages 223 - 247, XP002382432 *
HANDRATTA VENKATESH D ET AL: "Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens: Synthesis, in Vitro Biological Activity, Pharmacokinetics, and Antitumor Activity in the LAPC4 Human Prostate Cancer Xenograft Model", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 48, no. 8, 25 March 2005 (2005-03-25), pages 2972 - 2984, XP002535274, ISSN: 0022-2623, DOI: 10.1021/JM040202W *

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